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EP3175705
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EP About this file: EP3175705
| EP3175705 - METHOD FOR PRODUCING ARTIFICIAL PIRNAS AND USES THEREOF FOR SILENCING GENE EXPRESSION [Right-click to bookmark this link] | Status | The application is deemed to be withdrawn Status updated on 25.05.2018 Database last updated on 18.11.2024 | |
| Former | The application has been published Status updated on 15.06.2017 | Most recent event Tooltip | 25.05.2018 | Application deemed to be withdrawn | published on 27.06.2018 [2018/26] | Applicant(s) | For all designated states European Molecular Biology Laboratory Meyerhofstrasse 1 69117 Heidelberg / DE | [2017/23] | Inventor(s) | 01 /
Pillai, Ramesh 1 bis rue de la Monta 38120 St. Egreve / FR | 02 /
Homolka, David 9 Rue des Échelles 38120 Saint-Egréve / FR | 03 /
Pandey, Radha Raman 5, Rue Nestor Cornier 38100 Grenoble / FR | [2017/23] | Representative(s) | Krauss, Jan Boehmert & Boehmert Anwaltspartnerschaft mbB Pettenkoferstrasse 22 80336 München / DE | [2017/23] | Application number, filing date | 15197903.6 | 03.12.2015 | [2017/23] | Filing language | EN | Procedural language | EN | Publication | Type: | A1 Application with search report | No.: | EP3175705 | Date: | 07.06.2017 | Language: | EN | [2017/23] | Search report(s) | (Supplementary) European search report - dispatched on: | EP | 11.05.2016 | Classification | IPC: | A01K67/00, C12Q1/68, C12N15/113, C12N15/85 | [2017/23] | CPC: |
C12Q1/6806 (EP);
C12N15/113 (EP);
C12Q1/6883 (EP);
C12N2310/10 (EP);
C12N2330/00 (EP);
C12N2330/31 (EP);
C12Q2600/178 (EP)
(-)
| C-Set: |
C12Q1/6806, C12Q2521/313, C12Q2525/207 (EP)
| Designated contracting states | AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LI, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR [2017/23] | Extension states | BA | Not yet paid | ME | Not yet paid | Validation states | MA | Not yet paid | MD | Not yet paid | Title | German: | VERFAHREN ZUR HERSTELLUNG VON KÜNSTLICHEM PIRNAS UND VERWENDUNGEN DAVON ZUR DÄMPFUNG VON GENEXPRESSION | [2017/23] | English: | METHOD FOR PRODUCING ARTIFICIAL PIRNAS AND USES THEREOF FOR SILENCING GENE EXPRESSION | [2017/23] | French: | PROCÉDÉ POUR PRODUIRE DES PIARN ARTIFICIELS ET LEURS UTILISATIONS POUR INHIBER L'EXPRESSION D'UN GÈNE | [2017/23] | Examination procedure | 08.12.2017 | Application deemed to be withdrawn, date of legal effect [2018/26] | 24.01.2018 | Despatch of communication that the application is deemed to be withdrawn, reason: examination fee not paid in time [2018/26] | Fees paid | Penalty fee | Additional fee for renewal fee | 31.12.2017 | 03 M06 Not yet paid |
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| Responsibility for the accuracy, completeness or quality of the data displayed under the link provided lies entirely with the Unified Patent Court. | Documents cited: | Search | [AD]WO2008109142 (COLD SPRING HARBOR LAB [US], et al) [AD] 1-15* claims *; | [AD]US2014275216 (ECKER DAVID J [US], et al) [AD] 1-15 * claims *; | [XA] - F. CICHOCKI ET AL, "Cutting Edge: KIR Antisense Transcripts Are Processed into a 28-Base PIWI-Like RNA in Human NK Cells", THE JOURNAL OF IMMUNOLOGY, US, (20100714), vol. 185, no. 4, doi:10.4049/jimmunol.1000855, ISSN 0022-1767, pages 2009 - 2012, XP055269446 [X] 11 * page 2010, last paragraph - page 2011; table 1 * [A] 1-10,12-15 DOI: http://dx.doi.org/10.4049/jimmunol.1000855 | [XA] - Y. YAMAMOTO ET AL, "Targeted gene silencing in mouse germ cells by insertion of a homologous DNA into a piRNA generating locus", GENOME RESEARCH, (20121106), vol. 23, no. 2, doi:10.1101/gr.137224.112, ISSN 1088-9051, pages 292 - 299, XP055269448 [X] 11,12 * page 296, "Discussion" * [A] 1-10,13-15 DOI: http://dx.doi.org/10.1101/gr.137224.112 | [XA] - HIROTSUGU ISHIZU ET AL, "Somatic Primary piRNA Biogenesis Driven by cis-Acting RNA Elements and trans-Acting Yb", CELL REPORTS, US, (20150701), vol. 12, no. 3, doi:10.1016/j.celrep.2015.06.035, ISSN 2211-1247, pages 429 - 440, XP055269450 [X] 11 * page 430, column 2; page 432 * [A] 1-10,12-15 DOI: http://dx.doi.org/10.1016/j.celrep.2015.06.035 | [A] - ITOU DAISUKE ET AL, "Induction of DNA Methylation by Artificial piRNA Production in Male Germ Cells", CURRENT BIOLOGY, (20150330), vol. 25, no. 7, doi:10.1016/J.CUB.2015.01.060, ISSN 0960-9822, pages 901 - 906, XP029151652 [A] 1-15 * abstract * DOI: http://dx.doi.org/10.1016/j.cub.2015.01.060 | by applicant | US2009062228 | US2014275216 | - ARAVIN, A.A.; SACHIDANANDAM, R.; BOURC'HIS, D.; SCHAEFER, C.; PEZIC, D.; TOTH, K.F.; BESTOR, T.; HANNON, G.J., "A piRNA pathway primed by individual transposons is linked to de novo DNA methylation in mice", MOLECULAR CELL, (2008), vol. 31, pages 785 - 799 | - BIENIOSSEK, C.; IMASAKI, T.; TAKAGI, Y.; BERGER, I., "MultiBac: expanding the research toolbox for multiprotein complexes", TRENDS IN BIOCHEMICAL SCIENCES, (2012), vol. 37, doi:doi:10.1016/j.tibs.2011.10.005, pages 49 - 57, XP055098836 DOI: http://dx.doi.org/10.1016/j.tibs.2011.10.005 | - BRENNECKE, J.; ARAVIN, A.A.; STARK, A.; DUS, M.; KELLIS, M.; SACHIDANANDAM, R.; HANNON, G.J., "Discrete small RNA-generating loci as master regulators of transposon activity in Drosophila", CELL, (2007), vol. 128, doi:doi:10.1016/j.cell.2007.01.043, pages 1089 - 1103, XP002500305 DOI: http://dx.doi.org/10.1016/j.cell.2007.01.043 | - CORA, E.; PANDEY, R.R.; XIOL, J.; TAYLOR, J.; SACHIDANANDAM, R.; MCCARTHY, A.A.; PILLAI, R.S., "The MID-PIWI module of Piwi proteins specifies nucleotide- and strand-biases of piRNAs", RNA, (2014), vol. 20, pages 773 - 781 | - DE FAZIO, S.; BARTONICEK, N.; DI GIACOMO, M.; ABREU-GOODGER, C.; SANKAR, A.; FUNAYA, C.; ANTONY, C.; MOREIRA, P.N.; ENRIGHT, A.J.;, "The endonuclease activity of Mili fuels piRNA amplification that silences LINE elements", NATURE, (2011), vol. 480, pages 259 - 263 | - DI GIACOMO, M.; COMAZZETTO, S.; SAINI, H.; DE FAZIO, S.; CARRIERI, C.; MORGAN, M.; VASILIAUS-KAITE, L.; BENES, V.; ENRIGHT, A.J.;, "Multiple epigenetic mechanisms and the piRNA pathway enforce LINE silencing during adult spermatogenesis", MOLECULAR CELL, (2013), vol. 50, doi:doi:10.1016/j.molcel.2013.04.026, pages 601 - 608, XP028553282 DOI: http://dx.doi.org/10.1016/j.molcel.2013.04.026 | - FROMM, S.A.; TRUFFAULT, V.; KAMENZ, J.; BRAUN, J.E.; HOFFMANN, N.A.; IZAURRALDE, E.; SPRANGERS, R., "The structural basis of Edc3- and Scd6-mediated activation of the Dcpl:Dcp2 mRNA decapping complex", THE EMBO JOURNAL, (2012), vol. 31, pages 279 - 290 | - GHILDIYAL, M.; ZAMORE, P.D., "Small silencing RNAs: an expanding universe", NATURE REVIEWS GENETICS, (2009), vol. 10, pages 94 - 108 | - GUNAWARDANE, L.S.; SAITO, K.; NISHIDA, K.M.; MIYOSHI, K.; KAWAMURA, Y.; NAGAMI, T.; SIOMI, H.; SIOMI, M.C., "A slicer-mediated mechanism for repeat-associated siRNA 5' end formation in Drosophila", SCIENCE, (2007), vol. 315, pages 1587 - 1590 | - HAN, B.W.; WANG, W.; LI, C.; WENG, Z.; ZAMORE, P.D., "Noncoding RNA. piRNA-guided transposon cleavage initiates Zucchini-dependent, phased piRNA production", SCIENCE, (2015), vol. 348, pages 817 - 821 | - HANDLER, D.; OLIVIERI, D.; NOVATCHKOVA, M.; GRUBER, F.S.; MEIXNER, K.; MECHTLER, K.; STARK, A.; SACHIDANANDAM, R.; BRENNECKE, J., "A systematic analysis of Drosophila TUDOR domaincontaining proteins identifies Vreteno and the Tdrd12 family as essential primary piRNA pathway factors", THE EMBO JOURNAL, (2011), vol. 30, pages 3977 - 3993 | - HOMOLKA, D.; PANDEY, R.R.; GORIAUX, C.; BRASSET, E.; VAURY, C.; SACHIDANANDAM, R.; FAUVARQUE, M.O.; PILLAI, R.S., "PIWI Slicing and RNA Elements in Precursors Instruct Directional Primary piRNA Biogenesis", CELL REPORTS, (2015), vol. 12, pages 418 - 428 | - HOUWING, S.; KAMMINGA, L.M.; BEREZIKOV, E.; CRONEMBOLD, D.; GIRARD, A.; VAN DEN ELST, H.; FILIPPOV, D.V.; BLASER, H.; RAZ, E.; MOE, "A role for Piwi and piRNAs in germ cell maintenance and transposon silencing in Zebrafish", CELL, (2007), vol. 129, pages 69 - 82 | - ISHIZU, H.; IWASAKI, Y.W.; HIRAKATA, S.; OZAKI, H.; IWASAKI, W.; SIOMI, H.; SIOMI, M.C., "Somatic Primary piRNA Biogenesis Driven by cis-Acting RNA Elements and transActing Yb", CELL REPORTS, (2015), vol. 12, doi:doi:10.1016/j.celrep.2015.06.035, pages 429 - 440, XP055269450 DOI: http://dx.doi.org/10.1016/j.celrep.2015.06.035 | - KAWAOKA, S.; HAYASHI, N.; SUZUKI, Y.; ABE, H.; SUGANO, S.; TOMARI, Y.; SHIMADA, T.; KATSUMA, S., "The Bombyx ovary-derived cell line endogenously expresses PIWI/PIWI-interacting RNA complexes", RNA, (2009), vol. 15, pages 1258 - 1264 | - KURAMOCHI-MIYAGAWA, S.; WATANABE, T.; GOTOH, K.; TOTOKI, Y.; TOYODA, A.; IKAWA, M.; ASA-DA, N.; KOJIMA, K.; YAMAGUCHI, Y.; IJIRI,, "DNA methylation ofretrotrans-poson genes is regulated by Piwi family members MILI and MIWI2 in murine fetal testes", GENES & DEVELOPMENT, (2008), vol. 22, pages 908 - 917 | - LI, X.Z.; ROY, C.K.; DONG, X.; BOLCUN-FILAS, E.; WANG, J.; HAN, B.W.; XU, J.; MOORE, M.J; SCHIMENTI, J.C.; WENG, Z. ET AL., "An ancient transcription factor initiates the burst of piRNA production during early meiosis in mouse testes", MOLECULAR CELL, (2013), vol. 50, doi:doi:10.1016/j.molcel.2013.02.016, pages 67 - 81, XP028547917 DOI: http://dx.doi.org/10.1016/j.molcel.2013.02.016 | - MIDTGAARD, S.F.; ASSENHOLT, J.; JONSTRUP, A.T.; VAN, L.B.; JENSEN, T.H.; BRODERSEN, D.E., "Structure of the nuclear exosome component Rrp6p reveals an interplay between the active site and the HRDC domain", PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, (2006), vol. 103, pages 11898 - 11903 | - MOHN, F.; HANDLER, D.; BRENNECKE, J., "Noncoding RNA. piRNA-guided slicing specifies transcripts for Zucchini-dependent, phased piRNA biogenesis", SCIENCE, (2015), vol. 348, pages 812 - 817 | - PANDEY, R.R.; TOKUZAWA, Y.; YANG, Z.; HAYASHI, E.; ICHISAKA, T.; KAJITA, S.; ASANO, Y.; KU-NIEDA, T.; SACHIDANANDAM, R.; CHUMA, S, "Tudor domain containing 12 (TDRD12) is essential for secondary PIWI interacting RNA biogenesis in mice", PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, (2013), vol. 110, pages 16492 - 16497 | - REUTER, M.; BERNINGER, P.; CHUMA, S.; SHAH, H.; HOSOKAWA, M.; FUNAYA, C.; ANTONY, C.; SACHIDANANDAM, R.; PILLAI, R.S., "Miwi catalysis is required for piRNA amplification-independent LINE transposon silencing", NATURE, (2011), vol. 480, pages 264 - 267 | - SAXE, J.P; CHEN, M.; ZHAO, H.; LIN, H., "Tdrkh is essential for spermatogenesis and participates in primary piRNA biogenesis in the germline", THE EMBO JOURNAL, (2013), vol. 32, pages 1869 - 1885 | - SCHUMPERLI, D.; PILLAI, R.S., "The special Sm core structure of the U7 snRNP: far-reaching significance of a small nuclear ribonucleoprotein", CELLULAR AND MOLECULAR LIFE SCIENCES : CMLS, (2004), vol. 61, pages 2560 - 2570 | - WASMUTH, E.V.; JANUSZYK, K.; LIMA, C.D., "Structure of an Rrp6-RNA exosome complex bound to poly(A) RNA", NATURE, (2014), vol. 511, pages 435 - 439 | - XIOL, J.; SPINELLI, P.; LAUSSMANN, M.A.; HOMOLKA, D.; YANG, Z.; CORA, E.; COUTE, Y.; CONN, S.; KADLEC, J.; SACHIDANANDAM, R. ET AL, "RNA clamping by Vasa assembles a piRNA amplifier complex on transposon transcripts", CELL, (2014), vol. 157, pages 1698 - 1711 | - ZUO, Y.; DEUTSCHER, M.P., "Exoribonuclease superfamilies: structural analysis and phylogenetic distribution", NUCLEIC ACIDS RESEARCH, (2001), vol. 29, pages 1017 - 1026 |