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Extract from the Register of European Patents

EP About this file: EP3099685

EP3099685 - NOVEL DIHYDROQUINOLIZINONES FOR THE TREATMENT AND PROPHYLAXIS OF HEPATITIS B VIRUS INFECTION [Right-click to bookmark this link]
StatusNo opposition filed within time limit
Status updated on  22.02.2019
Database last updated on 11.04.2026
FormerThe patent has been granted
Status updated on  16.03.2018
FormerGrant of patent is intended
Status updated on  30.10.2017
FormerRequest for examination was made
Status updated on  04.11.2016
Most recent event   Tooltip01.07.2022Lapse of the patent in a contracting state
New state(s): MK		published on 03.08.2022  [2022/31]
Applicant(s)For all designated states
F. Hoffmann-La Roche AG
Grenzacherstrasse 124
4070 Basel / CH
[2018/16]
Former [2016/49]For all designated states
F.Hoffmann-La Roche AG
Grenzacherstrasse 124
4070 Basel / CH
Inventor(s)01 / HAN, Xingchun
Building No.5
Lane 720 Cailun Road
Shanghai 201203 / CN
02 / JAVANBAKHT, Hassan
Aeschenvorstadt 50
CH-4051 Basel / CH
03 / JIANG, Min
Building No.5
Lane 720 Cailun Road
Shanghai 201203 / CN
04 / LIANG, Chungen
Building No.5
Lane 720 Cailun Road
Shanghai 201203 / CN
05 / WANG, Jianping
Building No.5
Lane 720 Cailun Road
Shanghai 201203 / CN
06 / WANG, Yongguang
Building No.5
Lane 720 Cailun Road
Shanghai 201203 / CN
07 / WANG, Zhanguo
Building No.5
Lane 720 Cailun Road
Shanghai 201203 / CN
08 / WEIKERT, Robert James
Rheingasse 66
CH-4058 Basel / CH
09 / YANG, Song
Building No.5
Lane 720 Cailun Road
Shanghai 201203 / CN
10 / ZHOU, Chengang
Building No.5
Lane 720 Cailun Road
Shanghai 201203 / CN
 [2016/49]
Representative(s)Sauer, Frank
F. Hoffmann-La Roche AG
Patent Department
Grenzacherstrasse 124
4070 Basel / CH
[N/P]
Former [2016/49]Sauer, Frank
F. Hoffmann-La Roche AG Patent Department Grenzacherstrasse 124
4070 Basel / CH
Application number, filing date15701232.928.01.2015
[2016/49]
WO2015EP51663
Priority number, dateWO2014CN7185430.01.2014         Original published format: PCT/CN2014/071854
WO2014CN9420618.12.2014         Original published format: PCT/CN2014/094206
[2016/49]
Filing languageEN
Procedural languageEN
PublicationType: A1 Application with search report
No.:WO2015113990
Date:06.08.2015
Language:EN
[2015/31]
Type: A1 Application with search report 
No.:EP3099685
Date:07.12.2016
Language:EN
The application published by WIPO in one of the EPO official languages on 06.08.2015 takes the place of the publication of the European patent application.
[2016/49]
Type: B1 Patent specification 
No.:EP3099685
Date:18.04.2018
Language:EN
[2018/16]
Search report(s)International search report - published on:EP06.08.2015
ClassificationIPC:C07D471/04, A61K31/435, A61P31/12
[2016/49]
CPC:
A61K31/4745 (EP,US); A61K31/496 (EP,US); A61K31/5377 (EP,US);
A61P1/16 (EP); A61P31/12 (EP); A61P31/20 (EP);
C07D455/06 (EP,US); C07D471/04 (EP,US) (-)
Designated contracting statesAL,   AT,   BE,   BG,   CH,   CY,   CZ,   DE,   DK,   EE,   ES,   FI,   FR,   GB,   GR,   HR,   HU,   IE,   IS,   IT,   LI,   LT,   LU,   LV,   MC,   MK,   MT,   NL,   NO,   PL,   PT,   RO,   RS,   SE,   SI,   SK,   SM,   TR [2016/49]
Extension statesBANot yet paid
MENot yet paid
TitleGerman:NEUARTIGE DIHYDROCHINOLIZINONE ZUR BEHANDLUNG UND PROPHYLAXE VON HEPATITIS-B-VIRUS-INFEKTIONEN[2016/49]
English:NOVEL DIHYDROQUINOLIZINONES FOR THE TREATMENT AND PROPHYLAXIS OF HEPATITIS B VIRUS INFECTION[2016/49]
French:NOUVELLES DIHYDROQUINOLIZINONES POUR LE TRAITEMENT ET LA PROPHYLAXIE D'UNE INFECTION PAR LE VIRUS DE L'HÉPATITE B[2016/49]
Entry into regional phase30.08.2016National basic fee paid 
30.08.2016Designation fee(s) paid 
30.08.2016Examination fee paid 
Examination procedure04.07.2016Date on which the examining division has become responsible
30.08.2016Examination requested  [2016/49]
08.03.2017Amendment by applicant (claims and/or description)
31.10.2017Communication of intention to grant the patent
27.02.2018Receipt of the translation of the claim(s)
12.03.2018Fee for grant paid
12.03.2018Fee for publishing/printing paid
Opposition(s)21.01.2019No opposition filed within time limit [2019/13]
Fees paidRenewal fee
09.01.2017Renewal fee patent year 03
08.01.2018Renewal fee patent year 04
Opt-out from the exclusive  Tooltip
competence of the Unified
Patent Court		 See the Register of the Unified Patent Court for opt-out data
Responsibility for the accuracy, completeness or quality of the data displayed under the link provided lies entirely with the Unified Patent Court.
Lapses during opposition  TooltipHU28.01.2015
AL18.04.2018
AT18.04.2018
CY18.04.2018
CZ18.04.2018
DK18.04.2018
EE18.04.2018
ES18.04.2018
FI18.04.2018
HR18.04.2018
IT18.04.2018
LT18.04.2018
LV18.04.2018
MC18.04.2018
MK18.04.2018
NL18.04.2018
PL18.04.2018
RO18.04.2018
RS18.04.2018
SE18.04.2018
SI18.04.2018
SK18.04.2018
SM18.04.2018
TR18.04.2018
BG18.07.2018
NO18.07.2018
GR19.07.2018
IS18.08.2018
PT20.08.2018
[2022/31]
Former [2021/32]HU28.01.2015
AL18.04.2018
AT18.04.2018
CY18.04.2018
CZ18.04.2018
DK18.04.2018
EE18.04.2018
ES18.04.2018
FI18.04.2018
HR18.04.2018
IT18.04.2018
LT18.04.2018
LV18.04.2018
MC18.04.2018
NL18.04.2018
PL18.04.2018
RO18.04.2018
RS18.04.2018
SE18.04.2018
SI18.04.2018
SK18.04.2018
SM18.04.2018
TR18.04.2018
BG18.07.2018
NO18.07.2018
GR19.07.2018
IS18.08.2018
PT20.08.2018
Former [2021/31]AL18.04.2018
AT18.04.2018
CY18.04.2018
CZ18.04.2018
DK18.04.2018
EE18.04.2018
ES18.04.2018
FI18.04.2018
HR18.04.2018
IT18.04.2018
LT18.04.2018
LV18.04.2018
MC18.04.2018
NL18.04.2018
PL18.04.2018
RO18.04.2018
RS18.04.2018
SE18.04.2018
SI18.04.2018
SK18.04.2018
SM18.04.2018
TR18.04.2018
BG18.07.2018
NO18.07.2018
GR19.07.2018
IS18.08.2018
PT20.08.2018
Former [2021/26]AL18.04.2018
AT18.04.2018
CY18.04.2018
CZ18.04.2018
DK18.04.2018
EE18.04.2018
ES18.04.2018
FI18.04.2018
HR18.04.2018
IT18.04.2018
LT18.04.2018
LV18.04.2018
MC18.04.2018
NL18.04.2018
PL18.04.2018
RO18.04.2018
RS18.04.2018
SE18.04.2018
SI18.04.2018
SK18.04.2018
SM18.04.2018
TR18.04.2018
BG18.07.2018
NO18.07.2018
GR19.07.2018
PT20.08.2018
Former [2020/16]AL18.04.2018
AT18.04.2018
CZ18.04.2018
DK18.04.2018
EE18.04.2018
ES18.04.2018
FI18.04.2018
HR18.04.2018
IT18.04.2018
LT18.04.2018
LV18.04.2018
MC18.04.2018
NL18.04.2018
PL18.04.2018
RO18.04.2018
RS18.04.2018
SE18.04.2018
SI18.04.2018
SK18.04.2018
SM18.04.2018
TR18.04.2018
BG18.07.2018
NO18.07.2018
GR19.07.2018
PT20.08.2018
Former [2019/40]AL18.04.2018
AT18.04.2018
CZ18.04.2018
DK18.04.2018
EE18.04.2018
ES18.04.2018
FI18.04.2018
HR18.04.2018
IT18.04.2018
LT18.04.2018
LV18.04.2018
MC18.04.2018
NL18.04.2018
PL18.04.2018
RO18.04.2018
RS18.04.2018
SE18.04.2018
SI18.04.2018
SK18.04.2018
SM18.04.2018
BG18.07.2018
NO18.07.2018
GR19.07.2018
PT20.08.2018
Former [2019/26]AL18.04.2018
AT18.04.2018
CZ18.04.2018
DK18.04.2018
EE18.04.2018
ES18.04.2018
FI18.04.2018
HR18.04.2018
IT18.04.2018
LT18.04.2018
LV18.04.2018
NL18.04.2018
PL18.04.2018
RO18.04.2018
RS18.04.2018
SE18.04.2018
SI18.04.2018
SK18.04.2018
SM18.04.2018
BG18.07.2018
NO18.07.2018
GR19.07.2018
PT20.08.2018
Former [2019/11]AL18.04.2018
AT18.04.2018
CZ18.04.2018
DK18.04.2018
EE18.04.2018
ES18.04.2018
FI18.04.2018
HR18.04.2018
IT18.04.2018
LT18.04.2018
LV18.04.2018
NL18.04.2018
PL18.04.2018
RO18.04.2018
RS18.04.2018
SE18.04.2018
SK18.04.2018
SM18.04.2018
BG18.07.2018
NO18.07.2018
GR19.07.2018
PT20.08.2018
Former [2019/10]AL18.04.2018
AT18.04.2018
CZ18.04.2018
DK18.04.2018
EE18.04.2018
ES18.04.2018
FI18.04.2018
HR18.04.2018
LT18.04.2018
LV18.04.2018
NL18.04.2018
PL18.04.2018
RO18.04.2018
RS18.04.2018
SE18.04.2018
SK18.04.2018
BG18.07.2018
NO18.07.2018
GR19.07.2018
PT20.08.2018
Former [2019/09]AL18.04.2018
DK18.04.2018
EE18.04.2018
ES18.04.2018
FI18.04.2018
HR18.04.2018
LT18.04.2018
LV18.04.2018
NL18.04.2018
PL18.04.2018
RS18.04.2018
SE18.04.2018
BG18.07.2018
NO18.07.2018
GR19.07.2018
PT20.08.2018
Former [2019/08]AL18.04.2018
DK18.04.2018
ES18.04.2018
FI18.04.2018
HR18.04.2018
LT18.04.2018
LV18.04.2018
NL18.04.2018
PL18.04.2018
RS18.04.2018
SE18.04.2018
BG18.07.2018
NO18.07.2018
GR19.07.2018
PT20.08.2018
Former [2019/03]AL18.04.2018
ES18.04.2018
FI18.04.2018
HR18.04.2018
LT18.04.2018
LV18.04.2018
NL18.04.2018
PL18.04.2018
RS18.04.2018
SE18.04.2018
BG18.07.2018
NO18.07.2018
GR19.07.2018
PT20.08.2018
Former [2018/52]AL18.04.2018
ES18.04.2018
FI18.04.2018
HR18.04.2018
LT18.04.2018
LV18.04.2018
NL18.04.2018
PL18.04.2018
RS18.04.2018
SE18.04.2018
BG18.07.2018
NO18.07.2018
GR19.07.2018
Former [2018/51]AL18.04.2018
ES18.04.2018
FI18.04.2018
HR18.04.2018
LT18.04.2018
LV18.04.2018
NL18.04.2018
PL18.04.2018
RS18.04.2018
SE18.04.2018
BG18.07.2018
NO18.07.2018
Former [2018/50]AL18.04.2018
ES18.04.2018
FI18.04.2018
HR18.04.2018
LT18.04.2018
NL18.04.2018
PL18.04.2018
SE18.04.2018
BG18.07.2018
NO18.07.2018
Former [2018/49]AL18.04.2018
ES18.04.2018
FI18.04.2018
LT18.04.2018
NL18.04.2018
PL18.04.2018
SE18.04.2018
BG18.07.2018
NO18.07.2018
Former [2018/47]AL18.04.2018
ES18.04.2018
FI18.04.2018
LT18.04.2018
NL18.04.2018
NO18.07.2018
Former [2018/46]AL18.04.2018
LT18.04.2018
NL18.04.2018
NO18.07.2018
Former [2018/43]NL18.04.2018
Cited inInternational search[XA]   DATABASE REGISTRY [online] CHEMICAL ABSTRACTS SERVICE, COLUMBUS, OHIO, US; 9 June 2008 (2008-06-09), XP002736278, Database accession no. 1026682-08-5 [X] 1,31 * rn 1026682-08-5 *[A] 2-30,32,33
 [XA]   FECIK ET AL.: "Chiral DNA chirase inhibitors.3. Probing the chiral preference of the active site of DNA Gyrase. Synthesis of 10-fluoro-6-methyl-6,7-dihydro-9-piperazinyl-2H-benzo[a]quinolizin-20-one-3-carboxylic acid analogues.", J. MED. CHEM., vol. 48, no. 4, 26 January 2005 (2005-01-26), pages 1229 - 1236, XP002736276 [X] 1,31 * example 36 * [A] 2-30,32,33

DOI:   http://dx.doi.org/10.1021/jm0401356
 [A]   CHENG P ET AL: "Synthesis and in vitro anti-hepatitis B virus activities of 4-aryl-6-chloro-quinolin-2-one and 5-aryl-7-chloro-1,4-benzodiazepine derivatives", BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, PERGAMON, AMSTERDAM, NL, vol. 18, no. 13, 20 May 2008 (2008-05-20), pages 3787 - 3789, XP022716300, ISSN: 0960-894X, [retrieved on 20080520], DOI: 10.1016/J.BMCL.2008.05.065 [A] 1-33 * the whole document *

DOI:   http://dx.doi.org/10.1016/j.bmcl.2008.05.065
 [A]   LIU Y ET AL: "Synthesis and anti-hepatitis B virus evaluation of novel ethyl 6-hydroxyquinoline-3-carboxylates in vitro", BIOORGANIC & MEDICINAL CHEMISTRY, PERGAMON, GB, vol. 16, no. 13, 17 May 2008 (2008-05-17), pages 6522 - 6527, XP022711157, ISSN: 0968-0896, [retrieved on 20080610], DOI: 10.1016/J.BMC.2008.05.029 [A] 1-33 * the whole document *

DOI:   http://dx.doi.org/10.1016/j.bmc.2008.05.029
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