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Extract from the Register of European Patents

EP About this file: EP3107928

EP3107928 - BLOOD BRAIN BARRIER SHUTTLE [Right-click to bookmark this link]
StatusNo opposition filed within time limit
Status updated on  10.07.2020
Database last updated on 05.10.2024
FormerThe patent has been granted
Status updated on  02.08.2019
FormerGrant of patent is intended
Status updated on  10.04.2019
FormerExamination is in progress
Status updated on  22.09.2017
FormerRequest for examination was made
Status updated on  25.11.2016
Most recent event   Tooltip08.07.2022Lapse of the patent in a contracting state
New state(s): MK		published on 10.08.2022  [2022/32]
Applicant(s)For all designated states
F. Hoffmann-La Roche AG
Grenzacherstrasse 124
4070 Basel / CH
[2016/52]
Inventor(s)01 / FRESKGARD, Per-Ola
Rainenweg 140
CH-4153 Reinach (BL) / CH
02 / SCHMUCKI, Roland
Erlenmattstrasse 16
CH-4058 Basel / CH
03 / URICH, Eduard
Basler Strasse 31
79540 Loerrach / DE
 [2016/52]
Representative(s)Küng, Peter
F. Hoffmann-La Roche AG
Patent Department
Grenzacherstrasse 124
4070 Basel / CH
[2016/52]
Application number, filing date15704558.417.02.2015
[2016/52]
WO2015EP53244
Priority number, dateEP2014015568719.02.2014         Original published format: EP 14155687
[2016/52]
Filing languageEN
Procedural languageEN
PublicationType: A1 Application with search report
No.:WO2015124540
Date:27.08.2015
Language:EN
[2015/34]
Type: A1 Application with search report 
No.:EP3107928
Date:28.12.2016
Language:EN
The application published by WIPO in one of the EPO official languages on 27.08.2015 takes the place of the publication of the European patent application.
[2016/52]
Type: B1 Patent specification 
No.:EP3107928
Date:04.09.2019
Language:EN
[2019/36]
Search report(s)International search report - published on:EP27.08.2015
ClassificationIPC:C07K5/08, C07K7/08, A61K47/42, A61K39/395, A61K38/06, A61K38/10, C12N15/09, A61P25/28
[2016/52]
CPC:
A61K47/64 (EP,KR,US); C07K5/0806 (EP,CN,KR,US); C07K5/0812 (EP,CN,KR,US);
A61K38/06 (EP,CN,KR,US); A61K38/10 (EP,CN,US); A61P25/28 (EP);
C07K16/18 (US); C07K16/28 (US); C07K5/0808 (EP,CN,KR,US);
C07K5/081 (EP,CN,KR,US); C07K5/0815 (EP,CN,KR,US); C07K5/0817 (EP,CN,KR,US);
C07K5/0819 (EP,CN,KR,US); C07K5/0821 (EP,CN,KR,US); C07K5/0823 (EP,CN,KR,US);
A61K38/04 (EP,US); A61K47/50 (US) (-)
Designated contracting statesAL,   AT,   BE,   BG,   CH,   CY,   CZ,   DE,   DK,   EE,   ES,   FI,   FR,   GB,   GR,   HR,   HU,   IE,   IS,   IT,   LI,   LT,   LU,   LV,   MC,   MK,   MT,   NL,   NO,   PL,   PT,   RO,   RS,   SE,   SI,   SK,   SM,   TR [2016/52]
Extension statesBANot yet paid
MENot yet paid
TitleGerman:BLUT-HIRN-SCHRANKE-SHUTTLE[2019/15]
English:BLOOD BRAIN BARRIER SHUTTLE[2016/52]
French:NAVETTE DE LA BARRIÈRE HÉMATO-ENCÉPHALIQUE[2016/52]
Former [2016/52]BLUT-HIRN-SCHRANKEN-SHUTTLE
Entry into regional phase19.09.2016National basic fee paid 
19.09.2016Designation fee(s) paid 
19.09.2016Examination fee paid 
Examination procedure22.07.2016Amendment by applicant (claims and/or description)
22.07.2016Date on which the examining division has become responsible
19.09.2016Examination requested  [2016/52]
25.09.2017Despatch of a communication from the examining division (Time limit: M04)
02.02.2018Reply to a communication from the examining division
12.04.2018Despatch of a communication from the examining division (Time limit: M06)
20.11.2018Despatch of communication that the application is deemed to be withdrawn, reason: reply to the communication from the examining division not received in time
18.01.2019Reply to a communication from the examining division
11.04.2019Communication of intention to grant the patent
22.07.2019Fee for grant paid
22.07.2019Fee for publishing/printing paid
22.07.2019Receipt of the translation of the claim(s)
Opposition(s)05.06.2020No opposition filed within time limit [2020/33]
Request for further processing for:The application is deemed to be withdrawn due to failure to reply to the examination report
18.01.2019Request for further processing filed
18.01.2019Full payment received (date of receipt of payment)
Request granted
04.02.2019Decision despatched
Fees paidRenewal fee
07.02.2017Renewal fee patent year 03
07.02.2018Renewal fee patent year 04
08.02.2019Renewal fee patent year 05
Opt-out from the exclusive  Tooltip
competence of the Unified
Patent Court		 See the Register of the Unified Patent Court for opt-out data
Responsibility for the accuracy, completeness or quality of the data displayed under the link provided lies entirely with the Unified Patent Court.
Lapses during opposition  TooltipHU17.02.2015
AL04.09.2019
AT04.09.2019
CY04.09.2019
CZ04.09.2019
DK04.09.2019
EE04.09.2019
ES04.09.2019
FI04.09.2019
HR04.09.2019
IT04.09.2019
LT04.09.2019
LV04.09.2019
MC04.09.2019
MK04.09.2019
MT04.09.2019
NL04.09.2019
PL04.09.2019
RO04.09.2019
RS04.09.2019
SE04.09.2019
SI04.09.2019
SK04.09.2019
SM04.09.2019
TR04.09.2019
BG04.12.2019
NO04.12.2019
GR05.12.2019
IS05.01.2020
PT06.01.2020
IE17.02.2020
LU17.02.2020
BE29.02.2020
[2022/32]
Former [2022/27]HU17.02.2015
AL04.09.2019
AT04.09.2019
CY04.09.2019
CZ04.09.2019
DK04.09.2019
EE04.09.2019
ES04.09.2019
FI04.09.2019
HR04.09.2019
IT04.09.2019
LT04.09.2019
LV04.09.2019
MC04.09.2019
MT04.09.2019
NL04.09.2019
PL04.09.2019
RO04.09.2019
RS04.09.2019
SE04.09.2019
SI04.09.2019
SK04.09.2019
SM04.09.2019
TR04.09.2019
BG04.12.2019
NO04.12.2019
GR05.12.2019
IS05.01.2020
PT06.01.2020
IE17.02.2020
LU17.02.2020
BE29.02.2020
Former [2021/12]AL04.09.2019
AT04.09.2019
CZ04.09.2019
DK04.09.2019
EE04.09.2019
ES04.09.2019
FI04.09.2019
HR04.09.2019
IT04.09.2019
LT04.09.2019
LV04.09.2019
MC04.09.2019
NL04.09.2019
PL04.09.2019
RO04.09.2019
RS04.09.2019
SE04.09.2019
SI04.09.2019
SK04.09.2019
SM04.09.2019
BG04.12.2019
NO04.12.2019
GR05.12.2019
IS05.01.2020
PT06.01.2020
IE17.02.2020
LU17.02.2020
BE29.02.2020
Former [2021/08]AL04.09.2019
AT04.09.2019
CZ04.09.2019
DK04.09.2019
EE04.09.2019
ES04.09.2019
FI04.09.2019
HR04.09.2019
IT04.09.2019
LT04.09.2019
LV04.09.2019
MC04.09.2019
NL04.09.2019
PL04.09.2019
RO04.09.2019
RS04.09.2019
SE04.09.2019
SI04.09.2019
SK04.09.2019
SM04.09.2019
BG04.12.2019
NO04.12.2019
GR05.12.2019
IS05.01.2020
PT06.01.2020
IE17.02.2020
LU17.02.2020
Former [2020/50]AL04.09.2019
AT04.09.2019
CZ04.09.2019
DK04.09.2019
EE04.09.2019
ES04.09.2019
FI04.09.2019
HR04.09.2019
IT04.09.2019
LT04.09.2019
LV04.09.2019
MC04.09.2019
NL04.09.2019
PL04.09.2019
RO04.09.2019
RS04.09.2019
SE04.09.2019
SI04.09.2019
SK04.09.2019
SM04.09.2019
BG04.12.2019
NO04.12.2019
GR05.12.2019
IS05.01.2020
PT06.01.2020
LU17.02.2020
Former [2020/48]AL04.09.2019
AT04.09.2019
CZ04.09.2019
DK04.09.2019
EE04.09.2019
ES04.09.2019
FI04.09.2019
HR04.09.2019
IT04.09.2019
LT04.09.2019
LV04.09.2019
NL04.09.2019
PL04.09.2019
RO04.09.2019
RS04.09.2019
SE04.09.2019
SI04.09.2019
SK04.09.2019
SM04.09.2019
BG04.12.2019
NO04.12.2019
GR05.12.2019
IS05.01.2020
PT06.01.2020
LU17.02.2020
Former [2020/37]AL04.09.2019
AT04.09.2019
CZ04.09.2019
DK04.09.2019
EE04.09.2019
ES04.09.2019
FI04.09.2019
HR04.09.2019
IT04.09.2019
LT04.09.2019
LV04.09.2019
NL04.09.2019
PL04.09.2019
RO04.09.2019
RS04.09.2019
SE04.09.2019
SI04.09.2019
SK04.09.2019
SM04.09.2019
BG04.12.2019
NO04.12.2019
GR05.12.2019
IS05.01.2020
PT06.01.2020
Former [2020/36]AL04.09.2019
AT04.09.2019
CZ04.09.2019
DK04.09.2019
EE04.09.2019
ES04.09.2019
FI04.09.2019
HR04.09.2019
IT04.09.2019
LT04.09.2019
LV04.09.2019
NL04.09.2019
PL04.09.2019
RO04.09.2019
RS04.09.2019
SE04.09.2019
SK04.09.2019
SM04.09.2019
BG04.12.2019
NO04.12.2019
GR05.12.2019
IS05.01.2020
PT06.01.2020
Former [2020/27]AL04.09.2019
AT04.09.2019
CZ04.09.2019
EE04.09.2019
ES04.09.2019
FI04.09.2019
HR04.09.2019
IT04.09.2019
LT04.09.2019
LV04.09.2019
NL04.09.2019
PL04.09.2019
RO04.09.2019
RS04.09.2019
SE04.09.2019
SK04.09.2019
SM04.09.2019
BG04.12.2019
NO04.12.2019
GR05.12.2019
PT06.01.2020
IS24.02.2020
Former [2020/25]AL04.09.2019
AT04.09.2019
CZ04.09.2019
EE04.09.2019
ES04.09.2019
FI04.09.2019
HR04.09.2019
IT04.09.2019
LT04.09.2019
LV04.09.2019
NL04.09.2019
PL04.09.2019
RO04.09.2019
RS04.09.2019
SE04.09.2019
SK04.09.2019
BG04.12.2019
NO04.12.2019
GR05.12.2019
PT06.01.2020
IS24.02.2020
Former [2020/24]AL04.09.2019
AT04.09.2019
EE04.09.2019
ES04.09.2019
FI04.09.2019
HR04.09.2019
IT04.09.2019
LT04.09.2019
LV04.09.2019
NL04.09.2019
PL04.09.2019
RO04.09.2019
RS04.09.2019
SE04.09.2019
BG04.12.2019
NO04.12.2019
GR05.12.2019
PT06.01.2020
IS24.02.2020
Former [2020/23]AL04.09.2019
AT04.09.2019
EE04.09.2019
ES04.09.2019
FI04.09.2019
HR04.09.2019
IT04.09.2019
LT04.09.2019
LV04.09.2019
NL04.09.2019
PL04.09.2019
RO04.09.2019
RS04.09.2019
SE04.09.2019
BG04.12.2019
NO04.12.2019
GR05.12.2019
PT06.01.2020
Former [2020/22]AL04.09.2019
EE04.09.2019
ES04.09.2019
FI04.09.2019
HR04.09.2019
LT04.09.2019
LV04.09.2019
NL04.09.2019
RS04.09.2019
SE04.09.2019
BG04.12.2019
NO04.12.2019
GR05.12.2019
PT06.01.2020
Former [2020/20]AL04.09.2019
ES04.09.2019
FI04.09.2019
HR04.09.2019
LT04.09.2019
LV04.09.2019
NL04.09.2019
RS04.09.2019
SE04.09.2019
BG04.12.2019
NO04.12.2019
GR05.12.2019
Former [2020/15]AL04.09.2019
ES04.09.2019
FI04.09.2019
HR04.09.2019
LT04.09.2019
LV04.09.2019
RS04.09.2019
SE04.09.2019
BG04.12.2019
NO04.12.2019
GR05.12.2019
Former [2020/11]ES04.09.2019
FI04.09.2019
HR04.09.2019
LT04.09.2019
LV04.09.2019
RS04.09.2019
SE04.09.2019
BG04.12.2019
NO04.12.2019
GR05.12.2019
Former [2020/10]FI04.09.2019
LT04.09.2019
SE04.09.2019
BG04.12.2019
NO04.12.2019
Former [2020/09]FI04.09.2019
LT04.09.2019
NO04.12.2019
Former [2020/08]LT04.09.2019
NO04.12.2019
Cited inInternational search[Y]WO0220822  (UNIV TEXAS [US], et al) [Y] 1-16 * the whole document * * sequences 20, 42 *;
 [XY]US2003104993  (RUEGER DAVID C [US], et al) [X] 1-3,5-7,12-16 * the whole document * * Generic sequence 3; page 7, paragraph [0041] * * table II * [Y] 1-16;
 [XY]US2004191265  (SCHENERMAN MARK A [US], et al) [X] 1-3,5,7,8,12-14,16 * the whole document * * pages 12-14; table III * [Y] 1-16;
 [XY]US2005187147  (NEWMAN MICHAEL J [US], et al) [X] 1-3,5-7,12-16 * the whole document * * claims 1, 13, 82 * * sequences 5, 1406, 1407 * * claims 135, 136 *[Y] 1-16;
 [XY]US2006039929  (FERNANDEZ-SALAS ESTER [US], et al) [X] 1-3,5-7,12-14,16 * the whole document * * page 20, paragraph [179]; sequences 128, 133, 134 * [Y] 1-16;
 [XY]WO2007120648  (NEW RIVER PHARMACEUTICALS INC [US], et al) [X] 1-3,5-7,12-16 * the whole document * * claim 99 * * sequences 11, 16, 20 * [Y] 1-16;
 [XY]CN101497651  (UNIV CAPITAL MEDICAL [CN]) [X] 1-3,5-7,12-16 * the whole document * [Y] 1-16;
 [Y]FR2944020  (ETAT FRANCAIS MINISTERE DE LA [FR]) [Y] 1-16 * the whole document * * claim 6; sequence 47 * * claim 8; sequences 56, 57, 62, 63 * * claims 1-11 * * page 16, line 5 - page 18, line 7 * * EXEMPLES; page 34, line 20 - page 36 *;
 [XY]WO2010121023  (UNIV CALIFORNIA [US], et al) [X] 1-3,5-8,12-16 * the whole document * * sequence 21 * * page 13, paragraph [0044] * * page 14, paragraph [0050] - page 15, paragraph [0052] * [Y] 1-16;
 [XY]US2011003750  (TREGEAR GEOFFREY WILLIAM [AU], et al) [X] 1-3,5-7,12-16 * the whole document * * page 3, paragraph [0015] * * page 12, paragraphs [0058]-[0059] * [Y] 1-16;
 [XY]WO2011046938  (ONEGLOVE LLC [US], et al) [X] 1-3,5-7,12-16 * (10); page 63 - page 64 * * page 97; table 2 * [Y] 1-16;
 [XY]WO2011091304  (GENENTECH INC [US], et al) [X] 1-3,5-16 * the whole document * * page 16, line 19 - page 18, line 13; sequence 3 * * page 17, line 10 * * page 22, line 32 - page 23, line 12 * * page 29, line 27 * * page 30, line 3 - page 32, line 5 * * page 53, lines 3-25 * * page 57, line 7 - page 70, line 33 * * page 16, line 34 * [Y] 1-16;
 [Y]WO2013041238  (SYGNIS BIOSCIENCE GMBH & CO KG [DE], et al) [Y] 1-16 * the whole document * * page 61, line 31 - page 66, line 16 *;
 [Y]  - GONZALEZ ANA MARIA ET AL, "Targeting choroid plexus epithelia and ventricular ependyma for drug delivery to the central nervous system", BMC NEUROSCIENCE, BIOMED CENTRAL, LONDON, GB, (20110107), vol. 12, no. 1, doi:10.1186/1471-2202-12-4, ISSN 1471-2202, page 4, XP021086692 [Y] 1-16 * the whole document *

DOI:   http://dx.doi.org/10.1186/1471-2202-12-4
 [YD]  - PASQUALINI R ET AL, "Aminopeptidase N is a receptor for tumor-homing peptides and a target for inhibiting angiogenesis", CANCER RESEARCH, AMERICAN ASSOCIATION FOR CANCER RESEARCH, US, (20000201), vol. 60, ISSN 0008-5472, pages 722 - 727, XP002189748 [YD] 1-16 * the whole document *
 [Y]  - MATHEW W. SMITH ET AL, "Peptide sequences mediating tropism to intact blood-brain barrier: An in vivo biodistribution study using phage display", PEPTIDES, AMSTERDAM, NL, (20121101), vol. 38, no. 1, doi:10.1016/j.peptides.2012.06.019, ISSN 0196-9781, pages 172 - 180, XP055182690 [Y] 1-16 * the whole document *

DOI:   http://dx.doi.org/10.1016/j.peptides.2012.06.019
 [XY]  - Alexandre Bastit ET AL, "Novasep Presentation", (20100102), URL: http://biotuesday.fr/files/2010/09/novasep.pdf, (20150626), XP055198553 [X] 1-3,5-7,12-16 * the whole document * [Y] 1-16
 [XY]  - Christophe Rousselle ET AL, "Enhanced Delivery of Doxorubicin into the Brain via a Peptide-Vector-Mediated Strategy: Saturation Kinetics and Specificity", Journal of Pharmacology and Experimental Therapeutics, UNITED STATES, (20010101), page 124, URL: http://jpet.aspetjournals.org/content/296/1/124.abstract, (20150626), XP055198653 [X] 1-3,5-7,12-16 * the whole document * [Y] 1-16
The EPO accepts no responsibility for the accuracy of data originating from other authorities; in particular, it does not guarantee that it is complete, up to date or fit for specific purposes.