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Extract from the Register of European Patents

EP About this file: EP3114128

EP3114128 - NOVEL 6-FUSED HETEROARYLDIHYDROPYRIMIDINES FOR THE TREATMENT AND PROPHYLAXIS OF HEPATITIS B VIRUS INFECTION [Right-click to bookmark this link]
StatusNo opposition filed within time limit
Status updated on  08.11.2019
Database last updated on 08.04.2026
FormerThe patent has been granted
Status updated on  30.11.2018
FormerGrant of patent is intended
Status updated on  20.08.2018
FormerExamination is in progress
Status updated on  30.06.2018
FormerGrant of patent is intended
Status updated on  14.03.2018
FormerExamination is in progress
Status updated on  10.11.2017
FormerRequest for examination was made
Status updated on  09.12.2016
Most recent event   Tooltip01.07.2022Lapse of the patent in a contracting state
New state(s): MK		published on 03.08.2022  [2022/31]
Applicant(s)For all designated states
F. Hoffmann-La Roche AG
Grenzacherstrasse 124
4070 Basel / CH
[2017/02]
Inventor(s)01 / GUO, Lei
Building No. 5
Lane 720 Cailun Road
Shanghai 201203 / CN
02 / HU, Taishan
Building No. 5
Lane 720 Cailun Road
Shanghai 201203 / CN
03 / KOU, Buyu
Building No. 5
Lane 720 Cailun Road
Shanghai 201203 / CN
04 / LIN, Xianfeng
Building No. 5
Lane 720 Cailun Road
Shanghai 201203 / CN
05 / SHEN, Hong
Building No. 5
Lane 720 Cailun Road
Shanghai 201203 / CN
06 / SHI, Houguang
Building No. 5
Lane 720 Cailun Road
Shanghai 201203 / CN
07 / YAN, Shixiang
Building No. 5
Lane 720 Cailun Road
Shanghai 201203 / CN
08 / ZHANG, Weixing
Building No. 5
Lane 720 Cailun Road
Shanghai 201203 / CN
09 / ZHANG, Zhisen
Building No. 5
Lane 720 Cailun Road
Shanghai 201203 / CN
10 / ZHOU, Mingwei
Building No. 5
Lane 720 Cailun Road
Shanghai 201203 / CN
11 / ZHU, Wei
Building No. 5
Lane 720 Cailun Road
Shanghai 201203 / CN
 [2017/02]
Representative(s)Halbig, Dirk
F. Hoffmann-La Roche AG
Patent Department
Grenzacherstrasse 124
4070 Basel / CH
[2017/02]
Application number, filing date15710127.004.03.2015
[2017/02]
WO2015EP54454
Priority number, dateWO2014CN7306807.03.2014         Original published format: PCT/CN2014/073068
WO2014CN8302725.07.2014         Original published format: PCT/CN2014/083027
WO2015CN7089516.01.2015         Original published format: PCT/CN2015/070895
[2017/02]
Filing languageEN
Procedural languageEN
PublicationType: A1 Application with search report
No.:WO2015132276
Date:11.09.2015
Language:EN
[2015/36]
Type: A1 Application with search report 
No.:EP3114128
Date:11.01.2017
Language:EN
The application published by WIPO in one of the EPO official languages on 11.09.2015 takes the place of the publication of the European patent application.
[2017/02]
Type: B1 Patent specification 
No.:EP3114128
Date:02.01.2019
Language:EN
[2019/01]
Search report(s)International search report - published on:EP11.09.2015
ClassificationIPC:C07D487/04, A61K31/4985, C07D498/04, C07D513/04, A61P31/12
[2017/02]
CPC:
C07D471/04 (EP,CN,KR,US); C07D487/04 (EP,CN,IL,KR,US); C07D498/04 (EP,CN,IL,KR,US);
A61K31/4985 (EP,IL,KR,US); A61K31/506 (KR); A61K31/517 (EP,KR,US);
A61K31/519 (EP,KR,US); A61P31/00 (EP); A61P31/12 (EP,IL);
A61P31/20 (EP); A61P43/00 (EP); C07D417/04 (KR);
C07D513/04 (EP,CN,IL,KR,US) (-)
Designated contracting statesAL,   AT,   BE,   BG,   CH,   CY,   CZ,   DE,   DK,   EE,   ES,   FI,   FR,   GB,   GR,   HR,   HU,   IE,   IS,   IT,   LI,   LT,   LU,   LV,   MC,   MK,   MT,   NL,   NO,   PL,   PT,   RO,   RS,   SE,   SI,   SK,   SM,   TR [2017/02]
Extension statesBANot yet paid
MENot yet paid
Validation statesMA07.10.2016
TitleGerman:NEUARTIGE 6-KONDENSIERTE HETEROARYLDIHYDROPYRIMIDINE ZUR BEHANDLUNG UND PROPHYLAXE VON HEPATITIS-B-VIRUS-INFEKTION[2017/02]
English:NOVEL 6-FUSED HETEROARYLDIHYDROPYRIMIDINES FOR THE TREATMENT AND PROPHYLAXIS OF HEPATITIS B VIRUS INFECTION[2017/02]
French:NOUVELLES HÉTEROARYLDIHYDROPYRIMIDINES CONDENSÉES EN POSITION 6 POUR LE TRAITEMENT ET LA PROPHYLAXIE D'UNE INFECTION À VIRUS DE L'HÉPATITE B[2017/02]
Entry into regional phase07.10.2016National basic fee paid 
07.10.2016Designation fee(s) paid 
07.10.2016Examination fee paid 
Examination procedure09.08.2016Date on which the examining division has become responsible
07.10.2016Examination requested  [2017/02]
19.01.2017Amendment by applicant (claims and/or description)
08.11.2017Despatch of a communication from the examining division (Time limit: M04)
15.12.2017Reply to a communication from the examining division
15.03.2018Communication of intention to grant the patent
26.06.2018Disapproval of the communication of intention to grant the patent by the applicant or resumption of examination proceedings by the EPO
21.08.2018Communication of intention to grant the patent
20.11.2018Fee for grant paid
20.11.2018Fee for publishing/printing paid
20.11.2018Receipt of the translation of the claim(s)
Opposition(s)03.10.2019No opposition filed within time limit [2019/50]
Fees paidRenewal fee
07.03.2017Renewal fee patent year 03
08.03.2018Renewal fee patent year 04
Opt-out from the exclusive  Tooltip
competence of the Unified
Patent Court		 See the Register of the Unified Patent Court for opt-out data
Responsibility for the accuracy, completeness or quality of the data displayed under the link provided lies entirely with the Unified Patent Court.
Lapses during opposition  TooltipAL02.01.2019
CY02.01.2019
EE02.01.2019
LV02.01.2019
MC02.01.2019
MK02.01.2019
SM02.01.2019
LU04.03.2019
MT04.03.2019
IS02.05.2019
[2022/31]
Former [2021/26]AL02.01.2019
CY02.01.2019
EE02.01.2019
LV02.01.2019
MC02.01.2019
SM02.01.2019
LU04.03.2019
MT04.03.2019
IS02.05.2019
Former [2020/29]AL02.01.2019
EE02.01.2019
LV02.01.2019
MC02.01.2019
SM02.01.2019
LU04.03.2019
MT04.03.2019
IS02.05.2019
Former [2019/52]AL02.01.2019
EE02.01.2019
LV02.01.2019
MC02.01.2019
SM02.01.2019
LU04.03.2019
IS02.05.2019
Former [2019/49]AL02.01.2019
EE02.01.2019
LV02.01.2019
MC02.01.2019
IS02.05.2019
Former [2019/46]LV02.01.2019
MC02.01.2019
IS02.05.2019
Former [2019/39]LV02.01.2019
IS02.05.2019
Cited inInternational search[AP] WO2014184328  (HOFFMANN LA ROCHE et al.) [AP] 1-28 * example - *
 [A] WO2014029193  (SUNSHINE LAKE PHARMA CO LTD et al.) [A] 1-28 * example - *
 [I] DE10013126  (BAYER AG et al.) [I] 1-28 * example - *
by applicantWO2012019426
 WO2008090115
 WO2009103176
 WO2010023480
 WO2009067547
 WO2005085462
 US2007072934
   YINGXIAN ZHU
   FELD J. ET AL., ANTIVIRAL RESEARCH, 2007, pages 168 - 177
   DERES K. ET AL., SCIENCE, 2003, pages 893
   BREZILLON N ET AL., PLOS ONE, 2011, pages E25096
   ZLOTNICK A. ET AL., J. VIROL., 2002, pages 4848 - 4854
   BASTIN R.J. ET AL., ORGANIC PROCESS RESEARCH & DEVELOPMENT, vol. 4, 2000, pages 427 - 435
   ANSEL, H. ET AL.: "Pharmaceutical Dosage Forms and Drug Delivery Systems", 1995, pages: 196,1456 - 1457
   ANSEL, HOWARD C. ET AL.: "Ansel's Pharmaceutical Dosage Forms and Drug Delivery Systems", 2004, LIPPINCOTT, WILLIAMS & WILKINS
   GENNARO, ALFONSO R. ET AL.: "Remington: The Science and Practice of Pharmacy", 2000, LIPPINCOTT, WILLIAMS & WILKINS
   ROWE, RAYMOND C.: "Handbook of Pharmaceutical Excipients", 2005, PHARMACEUTICAL PRESS
   GAO H.; RENSLO A. R., J. ORG. CHEM., vol. 72, 2007, pages 8591 - 8592
   MERTIN A. ET AL., SYNLETT, vol. 2, 1991, pages 87 - 9
   GRYGORENKO O. O. ET AL., SYNTHETIC COMMUNICATIONS, vol. 41, 2011, pages 1644 - 1649
   SANDSTROEM A. ET AL., BIOORGANIC & MEDICINAL CHEMISTRY, vol. 16, no. 10, 2008, pages 5590 - 5605
   ALLAN, ROBIN D.; FONG, JOYCE, AUSTRALIAN JOURNAL OF CHEMISTRY, vol. 39, no. 6, 1986, pages 855 - 64
   SELLES ET AL., PROC. NATL. ACAD. SCI. USA, vol. 84, 1987, pages 1005 - 1009
   H GUO ET AL., JOURNAL OF VIROLOGY, vol. 81, 2007, pages 12472 - 12484
The EPO accepts no responsibility for the accuracy of data originating from other authorities; in particular, it does not guarantee that it is complete, up to date or fit for specific purposes.