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Extract from the Register of European Patents

EP About this file: EP3122764

EP3122764 - CYCLIC APELIN ANALOGS [Right-click to bookmark this link]
StatusNo opposition filed within time limit
Status updated on  22.11.2019
Database last updated on 02.11.2024
FormerThe patent has been granted
Status updated on  14.12.2018
FormerGrant of patent is intended
Status updated on  09.10.2018
FormerExamination is in progress
Status updated on  09.02.2018
FormerRequest for examination was made
Status updated on  30.12.2016
FormerThe international publication has been made
Status updated on  31.10.2016
Most recent event   Tooltip01.07.2022Lapse of the patent in a contracting state
New state(s): MK		published on 03.08.2022  [2022/31]
Applicant(s)For all designated states
LanthioPep B.V.
Rozenburglaan 13B
9727 DL Groningen / NL
[2017/05]
Inventor(s)01 / RINK, Rick
c/o Rozenburglaan 13B
NL-9727 DL Groningen / NL
 [2017/05]
Representative(s)Spiller, Stephan
MorphoSys AG
Semmelweisstrasse 7
82152 Planegg / DE
[2019/03]
Former [2017/05]Spiller, Stephan
MorphoSys AG
Intellectual Property
Lena-Christ-Strasse 48
82152 Martinsried/Planegg / DE
Application number, filing date15720489.225.03.2015
[2017/05]
WO2015NL50191
Priority number, dateEP2014016153325.03.2014         Original published format: EP 14161533
[2017/05]
Filing languageEN
Procedural languageEN
PublicationType: A1 Application with search report
No.:WO2015147641
Date:01.10.2015
Language:EN
[2015/39]
Type: A1 Application with search report 
No.:EP3122764
Date:01.02.2017
Language:EN
The application published by WIPO in one of the EPO official languages on 01.10.2015 takes the place of the publication of the European patent application.
[2017/05]
Type: B1 Patent specification 
No.:EP3122764
Date:16.01.2019
Language:EN
[2019/03]
Search report(s)International search report - published on:EP01.10.2015
ClassificationIPC:C07K7/08, C07K14/47, C07K7/54
[2017/05]
CPC:
C07K7/08 (EP,KR,RU,US); C07K14/47 (EP,CN,KR,RU,US); C07K7/54 (KR,RU,US);
A61K38/10 (KR); A61K38/12 (KR,RU); A61K38/1709 (KR);
A61P25/00 (EP,RU); A61P25/18 (EP); A61P25/22 (EP);
A61P25/24 (EP); A61P3/00 (EP,RU); A61P7/00 (EP);
A61P9/00 (EP,RU); A61K38/00 (EP,CN,US) (-)
Designated contracting statesAL,   AT,   BE,   BG,   CH,   CY,   CZ,   DE,   DK,   EE,   ES,   FI,   FR,   GB,   GR,   HR,   HU,   IE,   IS,   IT,   LI,   LT,   LU,   LV,   MC,   MK,   MT,   NL,   NO,   PL,   PT,   RO,   RS,   SE,   SI,   SK,   SM,   TR [2017/05]
Extension statesBANot yet paid
MENot yet paid
Validation statesMANot yet paid
TitleGerman:CYCLISCHE APELINANALOGA[2017/05]
English:CYCLIC APELIN ANALOGS[2017/05]
French:ANALOGUES D'APELINE CYCLIQUE[2018/43]
Former [2017/05]ANALOGUES CYCLIQUES DE L'APÉLINE
Entry into regional phase25.10.2016National basic fee paid 
25.10.2016Designation fee(s) paid 
25.10.2016Examination fee paid 
Examination procedure25.10.2016Examination requested  [2017/05]
25.10.2016Date on which the examining division has become responsible
18.05.2017Amendment by applicant (claims and/or description)
19.05.2017Loss of particular rights, legal effect: Claims
23.06.2017Despatch of communication of loss of particular rights: Claims {1}
09.02.2018Despatch of a communication from the examining division (Time limit: M04)
13.06.2018Reply to a communication from the examining division
10.10.2018Communication of intention to grant the patent
04.12.2018Fee for grant paid
04.12.2018Fee for publishing/printing paid
04.12.2018Receipt of the translation of the claim(s)
Opposition(s)17.10.2019No opposition filed within time limit [2019/52]
Fees paidRenewal fee
24.03.2017Renewal fee patent year 03
23.03.2018Renewal fee patent year 04
Opt-out from the exclusive  Tooltip
competence of the Unified
Patent Court		 See the Register of the Unified Patent Court for opt-out data
Responsibility for the accuracy, completeness or quality of the data displayed under the link provided lies entirely with the Unified Patent Court.
Lapses during opposition  TooltipAL16.01.2019
CY16.01.2019
EE16.01.2019
LT16.01.2019
LV16.01.2019
MK16.01.2019
RO16.01.2019
RS16.01.2019
SI16.01.2019
SK16.01.2019
SM16.01.2019
TR16.01.2019
MT25.03.2019
BG16.04.2019
IS16.05.2019
[2022/31]
Former [2021/26]AL16.01.2019
CY16.01.2019
EE16.01.2019
LT16.01.2019
LV16.01.2019
RO16.01.2019
RS16.01.2019
SI16.01.2019
SK16.01.2019
SM16.01.2019
TR16.01.2019
MT25.03.2019
BG16.04.2019
IS16.05.2019
Former [2020/29]AL16.01.2019
EE16.01.2019
LT16.01.2019
LV16.01.2019
RO16.01.2019
RS16.01.2019
SI16.01.2019
SK16.01.2019
SM16.01.2019
TR16.01.2019
MT25.03.2019
BG16.04.2019
IS16.05.2019
Former [2020/17]AL16.01.2019
EE16.01.2019
LT16.01.2019
LV16.01.2019
RO16.01.2019
RS16.01.2019
SI16.01.2019
SK16.01.2019
SM16.01.2019
TR16.01.2019
BG16.04.2019
IS16.05.2019
Former [2020/13]AL16.01.2019
EE16.01.2019
LT16.01.2019
LV16.01.2019
RO16.01.2019
RS16.01.2019
SI16.01.2019
SK16.01.2019
SM16.01.2019
BG16.04.2019
IS16.05.2019
Former [2019/51]AL16.01.2019
EE16.01.2019
LT16.01.2019
LV16.01.2019
RO16.01.2019
RS16.01.2019
SK16.01.2019
SM16.01.2019
BG16.04.2019
IS16.05.2019
Former [2019/49]AL16.01.2019
EE16.01.2019
LT16.01.2019
LV16.01.2019
RO16.01.2019
RS16.01.2019
SK16.01.2019
BG16.04.2019
IS16.05.2019
Former [2019/39]LT16.01.2019
LV16.01.2019
RS16.01.2019
BG16.04.2019
IS16.05.2019
Former [2019/38]LT16.01.2019
BG16.04.2019
Former [2019/33]LT16.01.2019
Cited inInternational search[Y]EP2405008  (LANTHIOPEP BV [NL]) [Y] 1-18 * paragraph [0014]; examples 1-5 *;
 [Y]US2013196899  (ZECRI FREDERIC [US], et al) [Y] 1-14,18 * table 4 *;
 [Y]  - BOSMA TJIBBE ET AL, "Bacterial Display and Screening of Posttranslationally Thioether-Stabilized Peptides", APPLIED AND ENVIRONMENTAL MICROBIOLOGY, AMERICAN SOCIETY FOR MICROBIOLOGY, US, (20111001), vol. 77, no. 19, ISSN 0099-2240, pages 6794 - 6801, XP009153580 [Y] 1-18 * the whole document *
 [Y]  - JURI HAMADA ET AL, "Evaluation of novel cyclic analogues of apelin.", INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE, (20081001), vol. 22, no. 4, ISSN 1107-3756, pages 547 - 552, XP055072884 [Y] 1-14,18 * the whole document *
by applicantWO2012125408
 WO2013111110
 US2013196899
    - O'CARROLL ET AL., J. OF ENDOCRINOLOGY, (2013), vol. 219, pages R13 - R35
    - LEE ET AL., BIOCHEM BIOPHYS RES COMMUN., (2010), vol. 395, pages 185 - 189
    - MA; PEI, J. CELL SCIENCE, (2007), vol. 120, pages 213 - 218
    - ZHOU, N ET AL., APJ. VIROLOGY, (2003), vol. 307, pages 22 - 36
    - LEE, D. K.; GEORGE, S. R.; O'DOWD, B. F., TRENDS IN PHARMACOLOGICAL SCIENCES, (2006), vol. 27, pages 190 - 194
    - HAMADA, J., INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE, (2008), vol. 22, pages 547 - 552
    - HAMADA ET AL., INT. J. OF MOL. MED., (2008), vol. 22, pages 547 - 552
    - ARNISON ET AL., NAT PROD REP, (2013), vol. 30, pages 108 - 160
    - MCAULIFFE ET AL., FEMS MICROBIOL. REV., (2001), vol. 25, pages 285 - 308
    - RINK ET AL., JOURNAL OF PHARMACOLOGICAL AND TOXICOLOGICAL METHODS, (2010), vol. 61, pages 210 - 218
    - BURRAGE ET AL., "Biomimetic synthesis of lantibiotics", CHEM EUR J, (2000), vol. 6, doi:doi:10.1002/(SICI)1521-3765(20000417)6:8<1455::AID-CHEM1455>3.0.CO;2-M, pages 1455 - 1466, XP008062604

DOI:   http://dx.doi.org/10.1002/(SICI)1521-3765(20000417)6:8<1455::AID-CHEM1455>3.0.CO;2-M
    - ZHU ET AL., "Biomimetic studies on the stereoselective lanthionine formation", ORG. BIOMOL. CHEM., (2003), vol. 1, pages 3304 - 3315
    - KNERR ET AL., J. AM. CHEM. SOC., (2012), vol. 134, no. 18, pages 7648 - 7651
    - ZHANG, PLOS, (2013), vol. 8, pages 1 - 11
    - SORLI, DRUG DISCOVERY TODAY, (2006), vol. 11, pages 1100 - 1106
    - KLUSKENS, L.D. ET AL., "Post-translational Modification of Therapeutic Peptides by NisB, the Dehydratase of the Lantibiotic Nisin", BIOCHEMISTRY, (2005), vol. 44, doi:doi:10.1021/bi050805p, pages 12827 - 12834, XP002424516

DOI:   http://dx.doi.org/10.1021/bi050805p
    - KLUSKENS, L.D. ET AL., "Angiotensin-(l-7) with thioether-bridge: an ACE-resistant, potent Ang-(1-7) analogue", J. PHARMACOL. EXPER. THER., (2009), vol. 328, pages 849 - 854
    - RINK, R. ET AL., "NisC, the cyclase of the lantibiotic nisin, can catalyze cyclization of designed non-lantibiotic peptides", BIOCHEMISTRY, (2007), vol. 46, doi:doi:10.1021/BI700106Z, pages 13179 - 13189, XP002546787

DOI:   http://dx.doi.org/10.1021/BI700106Z
    - KLUSKENS LD ET AL., "Post-translational modification of therapeutic peptides by NisB, the dehydratase of the lantibiotic nisin", BIOCHEMISTRY, (2005), vol. 44, doi:doi:10.1021/bi050805p, pages 12827 - 12834, XP002424516

DOI:   http://dx.doi.org/10.1021/bi050805p
    - RINK R ET AL., "Lantibiotic structures as guidelines for the design of peptides that can be modified by lantibiotic enzymes", BIOCHEMISTRY, (2005), vol. 44, doi:doi:10.1021/bi050081h, pages 8873 - 8882, XP002470472

DOI:   http://dx.doi.org/10.1021/bi050081h
    - RINK, BIOCHEMISTRY, (2007), vol. 46, pages 13179 - 13189
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