EP3131944 - VITAMIN E-BASED NANOCARRIERS FOR DRUG DELIVERY AND METHODS OF MAKING AND USING THE SAME [Right-click to bookmark this link] | Status | No opposition filed within time limit Status updated on 11.10.2019 Database last updated on 24.08.2024 | |
Former | The patent has been granted Status updated on 02.11.2018 | ||
Former | Grant of patent is intended Status updated on 19.06.2018 | ||
Former | Examination is in progress Status updated on 10.11.2017 | ||
Former | Request for examination was made Status updated on 20.01.2017 | ||
Former | The international publication has been made Status updated on 31.10.2016 | Most recent event Tooltip | 01.07.2022 | Lapse of the patent in a contracting state New state(s): MK | published on 03.08.2022 [2022/31] | Applicant(s) | For all designated states The Corporation OF Mercer University 1400 Coleman Avenue Macon, GA 31207 / US | [2017/08] | Inventor(s) | 01 /
TAN, Chalet 1270 Saint Andrews Drive Bogart, GA 30622 / US | 02 /
FAN, Wei 10012 Kansas Plaza Omaha, NE 68134 / US | [2017/08] | Representative(s) | Weickmann & Weickmann PartmbB Postfach 860 820 81635 München / DE | [2017/08] | Application number, filing date | 15721401.6 | 17.04.2015 | [2017/08] | WO2015US26535 | Priority number, date | US201461980786P | 17.04.2014 Original published format: US 201461980786 P | [2017/08] | Filing language | EN | Procedural language | EN | Publication | Type: | A1 Application with search report | No.: | WO2015161295 | Date: | 22.10.2015 | Language: | EN | [2015/42] | Type: | A1 Application with search report | No.: | EP3131944 | Date: | 22.02.2017 | Language: | EN | The application published by WIPO in one of the EPO official languages on 22.10.2015 takes the place of the publication of the European patent application. | [2017/08] | Type: | B1 Patent specification | No.: | EP3131944 | Date: | 05.12.2018 | Language: | EN | [2018/49] | Search report(s) | International search report - published on: | EP | 22.10.2015 | Classification | IPC: | A61K9/00, C08G65/332, A61K47/10, A61K47/22, A61K9/10, A61K47/34, A61K9/107, A61K31/337, A61K31/713, C08G65/331, C08G65/333, C08G65/334, C12N15/113, A61K31/727 | [2018/26] | CPC: |
A61K47/10 (EP,US);
C08G65/3318 (US);
A61K31/337 (US);
A61K31/713 (US);
A61K31/727 (US);
A61K47/22 (EP,US);
A61K47/34 (US);
A61K9/0019 (EP,US);
A61K9/10 (EP,US);
A61K9/1075 (US);
C08G65/3322 (EP,US);
C08G65/33306 (US);
C08G65/334 (US);
C12N15/113 (US);
C08G2650/04 (US);
C08G2650/20 (US);
C08G2650/38 (US);
C12N2310/141 (US);
|
Former IPC [2017/08] | C08G65/332, A61K47/10, A61K47/22 | Designated contracting states | AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LI, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR [2017/08] | Extension states | BA | Not yet paid | ME | Not yet paid | Validation states | MA | Not yet paid | Title | German: | NANOTRÄGER AUF VITAMIN-E-BASIS ZUR ARZNEIMITTELVERABREICHUNG UND VERFAHREN ZUR HERSTELLUNG DAVON | [2018/26] | English: | VITAMIN E-BASED NANOCARRIERS FOR DRUG DELIVERY AND METHODS OF MAKING AND USING THE SAME | [2017/08] | French: | NANOVÉHICULES À BASE DE VITAMINE E POUR L'ADMINISTRATION DE MÉDICAMENTS ET LEURS PROCÉDÉS DE FABRICATION | [2018/26] |
Former [2017/08] | VITAMIN-E-BASIERTE NANOTRÄGER ZUR WIRKSTOFFFREISETZUNG UND VERFAHREN ZUR HERSTELLUNG UND VERWENDUNG DAVON | ||
Former [2017/08] | NANOVECTEURS À BASE DE VITAMINE E POUR L'ADMINISTRATION DE MÉDICAMENTS, ET LEURS PROCÉDÉS DE FABRICATION ET D'UTILISATION | Entry into regional phase | 17.10.2016 | National basic fee paid | 17.10.2016 | Designation fee(s) paid | 17.10.2016 | Examination fee paid | Examination procedure | 17.10.2016 | Examination requested [2017/08] | 17.10.2016 | Date on which the examining division has become responsible | 04.04.2017 | Amendment by applicant (claims and/or description) | 14.11.2017 | Despatch of a communication from the examining division (Time limit: M04) | 12.03.2018 | Reply to a communication from the examining division | 20.06.2018 | Communication of intention to grant the patent | 18.10.2018 | Fee for grant paid | 18.10.2018 | Fee for publishing/printing paid | 18.10.2018 | Receipt of the translation of the claim(s) | Opposition(s) | 06.09.2019 | No opposition filed within time limit [2019/46] | Fees paid | Renewal fee | 31.01.2017 | Renewal fee patent year 03 | 28.03.2018 | Renewal fee patent year 04 |
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Responsibility for the accuracy, completeness or quality of the data displayed under the link provided lies entirely with the Unified Patent Court. | Lapses during opposition Tooltip | HU | 17.04.2015 | AL | 05.12.2018 | AT | 05.12.2018 | CY | 05.12.2018 | CZ | 05.12.2018 | DK | 05.12.2018 | EE | 05.12.2018 | ES | 05.12.2018 | FI | 05.12.2018 | HR | 05.12.2018 | IT | 05.12.2018 | LT | 05.12.2018 | LV | 05.12.2018 | MC | 05.12.2018 | MK | 05.12.2018 | MT | 05.12.2018 | PL | 05.12.2018 | RO | 05.12.2018 | RS | 05.12.2018 | SE | 05.12.2018 | SI | 05.12.2018 | SK | 05.12.2018 | SM | 05.12.2018 | TR | 05.12.2018 | BG | 05.03.2019 | NO | 05.03.2019 | GR | 06.03.2019 | IS | 05.04.2019 | PT | 05.04.2019 | IE | 17.04.2019 | LU | 17.04.2019 | BE | 30.04.2019 | CH | 30.04.2019 | LI | 30.04.2019 | [2022/31] |
Former [2021/34] | HU | 17.04.2015 | |
AL | 05.12.2018 | ||
AT | 05.12.2018 | ||
CY | 05.12.2018 | ||
CZ | 05.12.2018 | ||
DK | 05.12.2018 | ||
EE | 05.12.2018 | ||
ES | 05.12.2018 | ||
FI | 05.12.2018 | ||
HR | 05.12.2018 | ||
IT | 05.12.2018 | ||
LT | 05.12.2018 | ||
LV | 05.12.2018 | ||
MC | 05.12.2018 | ||
MT | 05.12.2018 | ||
PL | 05.12.2018 | ||
RO | 05.12.2018 | ||
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SM | 05.12.2018 | ||
TR | 05.12.2018 | ||
BG | 05.03.2019 | ||
NO | 05.03.2019 | ||
GR | 06.03.2019 | ||
IS | 05.04.2019 | ||
PT | 05.04.2019 | ||
IE | 17.04.2019 | ||
LU | 17.04.2019 | ||
BE | 30.04.2019 | ||
CH | 30.04.2019 | ||
LI | 30.04.2019 | ||
Former [2021/32] | HU | 17.04.2015 | |
AL | 05.12.2018 | ||
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CY | 05.12.2018 | ||
CZ | 05.12.2018 | ||
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EE | 05.12.2018 | ||
ES | 05.12.2018 | ||
FI | 05.12.2018 | ||
HR | 05.12.2018 | ||
IT | 05.12.2018 | ||
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MC | 05.12.2018 | ||
PL | 05.12.2018 | ||
RO | 05.12.2018 | ||
RS | 05.12.2018 | ||
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SI | 05.12.2018 | ||
SK | 05.12.2018 | ||
SM | 05.12.2018 | ||
TR | 05.12.2018 | ||
BG | 05.03.2019 | ||
NO | 05.03.2019 | ||
GR | 06.03.2019 | ||
IS | 05.04.2019 | ||
PT | 05.04.2019 | ||
IE | 17.04.2019 | ||
LU | 17.04.2019 | ||
BE | 30.04.2019 | ||
CH | 30.04.2019 | ||
LI | 30.04.2019 | ||
Former [2021/26] | AL | 05.12.2018 | |
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CY | 05.12.2018 | ||
CZ | 05.12.2018 | ||
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ES | 05.12.2018 | ||
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MC | 05.12.2018 | ||
PL | 05.12.2018 | ||
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RS | 05.12.2018 | ||
SE | 05.12.2018 | ||
SI | 05.12.2018 | ||
SK | 05.12.2018 | ||
SM | 05.12.2018 | ||
TR | 05.12.2018 | ||
BG | 05.03.2019 | ||
NO | 05.03.2019 | ||
GR | 06.03.2019 | ||
IS | 05.04.2019 | ||
PT | 05.04.2019 | ||
IE | 17.04.2019 | ||
LU | 17.04.2019 | ||
BE | 30.04.2019 | ||
CH | 30.04.2019 | ||
LI | 30.04.2019 | ||
Former [2020/21] | AL | 05.12.2018 | |
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LV | 05.12.2018 | ||
MC | 05.12.2018 | ||
PL | 05.12.2018 | ||
RO | 05.12.2018 | ||
RS | 05.12.2018 | ||
SE | 05.12.2018 | ||
SI | 05.12.2018 | ||
SK | 05.12.2018 | ||
SM | 05.12.2018 | ||
TR | 05.12.2018 | ||
BG | 05.03.2019 | ||
NO | 05.03.2019 | ||
GR | 06.03.2019 | ||
IS | 05.04.2019 | ||
PT | 05.04.2019 | ||
IE | 17.04.2019 | ||
LU | 17.04.2019 | ||
BE | 30.04.2019 | ||
CH | 30.04.2019 | ||
LI | 30.04.2019 | ||
Former [2020/17] | AL | 05.12.2018 | |
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MC | 05.12.2018 | ||
PL | 05.12.2018 | ||
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RS | 05.12.2018 | ||
SE | 05.12.2018 | ||
SI | 05.12.2018 | ||
SK | 05.12.2018 | ||
SM | 05.12.2018 | ||
TR | 05.12.2018 | ||
BG | 05.03.2019 | ||
NO | 05.03.2019 | ||
GR | 06.03.2019 | ||
IS | 05.04.2019 | ||
PT | 05.04.2019 | ||
LU | 17.04.2019 | ||
BE | 30.04.2019 | ||
CH | 30.04.2019 | ||
LI | 30.04.2019 | ||
Former [2020/11] | AL | 05.12.2018 | |
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CZ | 05.12.2018 | ||
DK | 05.12.2018 | ||
EE | 05.12.2018 | ||
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IT | 05.12.2018 | ||
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MC | 05.12.2018 | ||
PL | 05.12.2018 | ||
RO | 05.12.2018 | ||
RS | 05.12.2018 | ||
SE | 05.12.2018 | ||
SI | 05.12.2018 | ||
SK | 05.12.2018 | ||
SM | 05.12.2018 | ||
BG | 05.03.2019 | ||
NO | 05.03.2019 | ||
GR | 06.03.2019 | ||
IS | 05.04.2019 | ||
PT | 05.04.2019 | ||
LU | 17.04.2019 | ||
BE | 30.04.2019 | ||
CH | 30.04.2019 | ||
LI | 30.04.2019 | ||
Former [2020/04] | AL | 05.12.2018 | |
AT | 05.12.2018 | ||
CZ | 05.12.2018 | ||
DK | 05.12.2018 | ||
EE | 05.12.2018 | ||
ES | 05.12.2018 | ||
FI | 05.12.2018 | ||
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LT | 05.12.2018 | ||
LV | 05.12.2018 | ||
MC | 05.12.2018 | ||
PL | 05.12.2018 | ||
RO | 05.12.2018 | ||
RS | 05.12.2018 | ||
SE | 05.12.2018 | ||
SI | 05.12.2018 | ||
SK | 05.12.2018 | ||
SM | 05.12.2018 | ||
BG | 05.03.2019 | ||
NO | 05.03.2019 | ||
GR | 06.03.2019 | ||
IS | 05.04.2019 | ||
PT | 05.04.2019 | ||
LU | 17.04.2019 | ||
Former [2020/02] | AL | 05.12.2018 | |
AT | 05.12.2018 | ||
CZ | 05.12.2018 | ||
DK | 05.12.2018 | ||
EE | 05.12.2018 | ||
ES | 05.12.2018 | ||
FI | 05.12.2018 | ||
HR | 05.12.2018 | ||
IT | 05.12.2018 | ||
LT | 05.12.2018 | ||
LV | 05.12.2018 | ||
MC | 05.12.2018 | ||
PL | 05.12.2018 | ||
RO | 05.12.2018 | ||
RS | 05.12.2018 | ||
SE | 05.12.2018 | ||
SI | 05.12.2018 | ||
SK | 05.12.2018 | ||
SM | 05.12.2018 | ||
BG | 05.03.2019 | ||
NO | 05.03.2019 | ||
GR | 06.03.2019 | ||
IS | 05.04.2019 | ||
PT | 05.04.2019 | ||
Former [2019/50] | AL | 05.12.2018 | |
AT | 05.12.2018 | ||
CZ | 05.12.2018 | ||
DK | 05.12.2018 | ||
EE | 05.12.2018 | ||
ES | 05.12.2018 | ||
FI | 05.12.2018 | ||
HR | 05.12.2018 | ||
IT | 05.12.2018 | ||
LT | 05.12.2018 | ||
LV | 05.12.2018 | ||
PL | 05.12.2018 | ||
RO | 05.12.2018 | ||
RS | 05.12.2018 | ||
SE | 05.12.2018 | ||
SI | 05.12.2018 | ||
SK | 05.12.2018 | ||
SM | 05.12.2018 | ||
BG | 05.03.2019 | ||
NO | 05.03.2019 | ||
GR | 06.03.2019 | ||
IS | 05.04.2019 | ||
PT | 05.04.2019 | ||
Former [2019/48] | AL | 05.12.2018 | |
AT | 05.12.2018 | ||
CZ | 05.12.2018 | ||
DK | 05.12.2018 | ||
EE | 05.12.2018 | ||
ES | 05.12.2018 | ||
FI | 05.12.2018 | ||
HR | 05.12.2018 | ||
IT | 05.12.2018 | ||
LT | 05.12.2018 | ||
LV | 05.12.2018 | ||
PL | 05.12.2018 | ||
RO | 05.12.2018 | ||
RS | 05.12.2018 | ||
SE | 05.12.2018 | ||
SK | 05.12.2018 | ||
SM | 05.12.2018 | ||
BG | 05.03.2019 | ||
NO | 05.03.2019 | ||
GR | 06.03.2019 | ||
IS | 05.04.2019 | ||
PT | 05.04.2019 | ||
Former [2019/39] | AL | 05.12.2018 | |
AT | 05.12.2018 | ||
CZ | 05.12.2018 | ||
EE | 05.12.2018 | ||
ES | 05.12.2018 | ||
FI | 05.12.2018 | ||
HR | 05.12.2018 | ||
IT | 05.12.2018 | ||
LT | 05.12.2018 | ||
LV | 05.12.2018 | ||
PL | 05.12.2018 | ||
RO | 05.12.2018 | ||
RS | 05.12.2018 | ||
SE | 05.12.2018 | ||
SK | 05.12.2018 | ||
SM | 05.12.2018 | ||
BG | 05.03.2019 | ||
NO | 05.03.2019 | ||
GR | 06.03.2019 | ||
IS | 05.04.2019 | ||
PT | 05.04.2019 | ||
Former [2019/37] | AL | 05.12.2018 | |
AT | 05.12.2018 | ||
CZ | 05.12.2018 | ||
EE | 05.12.2018 | ||
ES | 05.12.2018 | ||
FI | 05.12.2018 | ||
HR | 05.12.2018 | ||
IT | 05.12.2018 | ||
LT | 05.12.2018 | ||
LV | 05.12.2018 | ||
PL | 05.12.2018 | ||
RO | 05.12.2018 | ||
RS | 05.12.2018 | ||
SE | 05.12.2018 | ||
SM | 05.12.2018 | ||
BG | 05.03.2019 | ||
NO | 05.03.2019 | ||
GR | 06.03.2019 | ||
PT | 05.04.2019 | ||
Former [2019/35] | AL | 05.12.2018 | |
AT | 05.12.2018 | ||
CZ | 05.12.2018 | ||
ES | 05.12.2018 | ||
FI | 05.12.2018 | ||
HR | 05.12.2018 | ||
IT | 05.12.2018 | ||
LT | 05.12.2018 | ||
LV | 05.12.2018 | ||
PL | 05.12.2018 | ||
RS | 05.12.2018 | ||
SE | 05.12.2018 | ||
BG | 05.03.2019 | ||
NO | 05.03.2019 | ||
GR | 06.03.2019 | ||
PT | 05.04.2019 | ||
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AT | 05.12.2018 | ||
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FI | 05.12.2018 | ||
HR | 05.12.2018 | ||
IT | 05.12.2018 | ||
LT | 05.12.2018 | ||
LV | 05.12.2018 | ||
RS | 05.12.2018 | ||
SE | 05.12.2018 | ||
BG | 05.03.2019 | ||
NO | 05.03.2019 | ||
GR | 06.03.2019 | ||
PT | 05.04.2019 | ||
Former [2019/33] | AL | 05.12.2018 | |
AT | 05.12.2018 | ||
ES | 05.12.2018 | ||
FI | 05.12.2018 | ||
HR | 05.12.2018 | ||
LT | 05.12.2018 | ||
LV | 05.12.2018 | ||
RS | 05.12.2018 | ||
SE | 05.12.2018 | ||
BG | 05.03.2019 | ||
NO | 05.03.2019 | ||
GR | 06.03.2019 | ||
PT | 05.04.2019 | ||
Former [2019/26] | AL | 05.12.2018 | |
AT | 05.12.2018 | ||
ES | 05.12.2018 | ||
FI | 05.12.2018 | ||
HR | 05.12.2018 | ||
LT | 05.12.2018 | ||
LV | 05.12.2018 | ||
RS | 05.12.2018 | ||
SE | 05.12.2018 | ||
BG | 05.03.2019 | ||
NO | 05.03.2019 | ||
GR | 06.03.2019 | ||
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ES | 05.12.2018 | ||
FI | 05.12.2018 | ||
HR | 05.12.2018 | ||
LT | 05.12.2018 | ||
LV | 05.12.2018 | ||
RS | 05.12.2018 | ||
SE | 05.12.2018 | ||
BG | 05.03.2019 | ||
NO | 05.03.2019 | ||
GR | 06.03.2019 | ||
Former [2019/24] | AT | 05.12.2018 | |
ES | 05.12.2018 | ||
FI | 05.12.2018 | ||
HR | 05.12.2018 | ||
LT | 05.12.2018 | ||
LV | 05.12.2018 | ||
SE | 05.12.2018 | ||
BG | 05.03.2019 | ||
NO | 05.03.2019 | ||
GR | 06.03.2019 | ||
Former [2019/23] | AT | 05.12.2018 | |
ES | 05.12.2018 | ||
FI | 05.12.2018 | ||
HR | 05.12.2018 | ||
LT | 05.12.2018 | ||
LV | 05.12.2018 | ||
BG | 05.03.2019 | ||
NO | 05.03.2019 | ||
Former [2019/22] | FI | 05.12.2018 | |
LT | 05.12.2018 | ||
BG | 05.03.2019 | ||
NO | 05.03.2019 | ||
Former [2019/21] | FI | 05.12.2018 | |
LT | 05.12.2018 | ||
NO | 05.03.2019 | ||
Former [2019/20] | LT | 05.12.2018 | |
NO | 05.03.2019 | Cited in | International search | [A]EP1891962 (IND TECH RES INST [TW]) [A] 1-89 * claims 1-24 * * tables 1-6 ** examples 1-3 *; | [A]US2008187568 (SAWHNEY AMARPREET S [US]) [A] 1-89 * claims 1-21 * * examples 1-10 *; | [XA] - JIANQIN LU ET AL, "Design and Characterization of PEG-Derivatized Vitamin E as a Nanomicellar Formulation for Delivery of Paclitaxel", MOLECULAR PHARMACEUTICS, (20130805), vol. 10, no. 8, doi:10.1021/mp300729y, ISSN 1543-8384, pages 2880 - 2890, XP055196703 [X] 2,6-8,34-40,59-63 * figures 1,2 * * page 2886, column 2, line 24 - line 31 * * Experimental Section;; table 1 * [A] 1,3-5,9-33,41-58,65-89 DOI: http://dx.doi.org/10.1021/mp300729y | [A] - A. D. JENKINS et. al, "GLOSSARY OF BASIC TERMS IN POLYMER SCIENCE", Pure & Appl. Chem., vol. 68, no. 12, (19961212), pages 2287 - 2311, URL: http://pac.iupac.org/publications/pac/pdf/1996/pdf/6812x2287.pdf, (20150618), XP055196796 [A] 2 * example 1.59 * | [A] - JUNTAO LUO ET AL, "Well-Defined, Size-Tunable, Multifunctional Micelles for Efficient Paclitaxel Delivery for Cancer Treatment", BIOCONJUGATE CHEMISTRY, (20100721), vol. 21, no. 7, doi:10.1021/bc1000033, ISSN 1043-1802, pages 1216 - 1224, XP055196709 [A] 1-88 * abstract * * figure 1 * DOI: http://dx.doi.org/10.1021/bc1000033 | by applicant | - LAWSON KA; ANDERSON K; MENCHACA M; ATKINSON J; SUN L; KNIGHT V ET AL., "Novel Vitamin E analogue decreases syngeneic mouse mammary tumor burden and reduces lung metastasis", MOL CANCER THER, (2003), vol. 2, pages 437 - 44 | - KATRAGADDA U; FAN W; WANG Y; TENG Q; TAN C, "Combined delivery of paclitaxel and tanespimycin via micellar nanocarriers: pharmacokinetics, efficacy and metabolomic analysis", PLOS ONE, (2013), no. 8, page E58619 |