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Extract from the Register of European Patents

EP About this file: EP3143042

EP3143042 - IMMUNOGLOBULIN VARIABLE DOMAINS [Right-click to bookmark this link]
Former [2017/12]IMPROVED IMMUNOGLOBULIN VARIABLE DOMAINS
[2019/45]
StatusOpposition rejected
Status updated on  27.09.2024
Database last updated on 09.04.2026
FormerThe patent has been granted
Status updated on  08.05.2020
FormerGrant of patent is intended
Status updated on  04.05.2020
FormerExamination is in progress
Status updated on  24.03.2020
FormerGrant of patent is intended
Status updated on  03.11.2019
FormerExamination is in progress
Status updated on  07.09.2019
FormerGrant of patent is intended
Status updated on  05.04.2019
FormerExamination is in progress
Status updated on  28.12.2017
FormerRequest for examination was made
Status updated on  17.02.2017
FormerThe international publication has been made
Status updated on  21.11.2016
Most recent event   Tooltip27.09.2024Opposition rejectedpublished on 30.10.2024  [2024/44]
Applicant(s)For all designated states
Ablynx N.V.
Technologiepark 21
9052 Ghent-Zwijnaarde / BE
[2017/12]
Inventor(s)01 / BUYSE, Marie-Ange
Burgemeester Edmond Ronsestraat 23
9820 Merelbeke / BE
02 / BOUTTON, Carlo
Rijksweg 115
8710 Wielsbeke / BE
 [2017/12]
Representative(s)Hoffmann Eitle
Patent- und Rechtsanwälte PartmbB
Arabellastraße 30
81925 München / DE
[2017/12]
Application number, filing date15722211.813.05.2015
[2017/12]
WO2015EP60643
Priority number, dateUS201461994552P16.05.2014         Original published format: US 201461994552 P
US201461014015P18.06.2014         Original published format: US 201461014015 P
US201462040167P21.08.2014         Original published format: US 201462040167 P
US201462047560P08.09.2014         Original published format: US 201462047560 P
US201562133600P16.03.2015         Original published format: US 201562133600 P
[2017/12]
Filing languageEN
Procedural languageEN
PublicationType: A2 Application without search report
No.:WO2015173325
Date:19.11.2015
Language:EN
[2015/46]
Type: A2 Application without search report 
No.:EP3143042
Date:22.03.2017
Language:EN
The application published by WIPO in one of the EPO official languages on 19.11.2015 takes the place of the publication of the European patent application.
[2017/12]
Type: B1 Patent specification 
No.:EP3143042
Date:10.06.2020
Language:EN
[2020/24]
Search report(s)International search report - published on:EP18.02.2016
ClassificationIPC:C07K16/00, C07K16/18, C07K16/28
[2017/12]
CPC:
C07K16/00 (EP,CN,IL,KR,RU,US); C07K16/18 (EP,CN,IL,KR,RU,US); A61P37/02 (EP);
C07K16/24 (US); C07K16/241 (EP,US); C07K16/244 (EP,US);
C07K16/28 (EP,US); C07K16/2863 (EP,US); C07K16/2866 (EP,CN,IL,KR,RU,US);
C07K16/2875 (EP,CN,IL,KR,US); C07K16/30 (EP,US); C07K16/32 (EP,US);
C07K16/42 (US); C07K16/4291 (EP,US); C40B40/10 (KR);
C07K2317/22 (EP,US); C07K2317/31 (EP,CN,IL,KR,US); C07K2317/35 (EP,US);
C07K2317/565 (US); C07K2317/567 (EP,CN,IL,KR,US); C07K2317/569 (EP,CN,IL,KR,US);
C07K2317/76 (EP,US); C07K2319/00 (EP,US); C07K2319/31 (EP,US) (-)
Designated contracting statesAL,   AT,   BE,   BG,   CH,   CY,   CZ,   DE,   DK,   EE,   ES,   FI,   FR,   GB,   GR,   HR,   HU,   IE,   IS,   IT,   LI,   LT,   LU,   LV,   MC,   MK,   MT,   NL,   NO,   PL,   PT,   RO,   RS,   SE,   SI,   SK,   SM,   TR [2017/12]
Extension statesBANot yet paid
MENot yet paid
Validation statesMANot yet paid
TitleGerman:VARIABLE IMMUNGLOBULINDOMÄNEN[2019/45]
English:IMMUNOGLOBULIN VARIABLE DOMAINS[2019/45]
French:DOMAINES VARIABLES D'IMMUNOGLOBULINES[2019/45]
Former [2017/12]VERBESSERTE IMMUNGLOBULINVARIABLE DOMÄNEN
Former [2017/12]IMPROVED IMMUNOGLOBULIN VARIABLE DOMAINS
Former [2017/12]DOMAINES VARIABLES D'IMMUNOGLOBULINES AMÉLIORÉS
Entry into regional phase21.11.2016National basic fee paid 
21.11.2016Designation fee(s) paid 
21.11.2016Examination fee paid 
Examination procedure21.03.2016Request for preliminary examination filed
International Preliminary Examining Authority: EP
21.11.2016Examination requested  [2017/12]
21.11.2016Date on which the examining division has become responsible
03.07.2017Amendment by applicant (claims and/or description)
03.01.2018Despatch of a communication from the examining division (Time limit: M06)
12.07.2018Reply to a communication from the examining division
05.04.2019Communication of intention to grant the patent
26.06.2019Observations by third parties
16.08.2019Disapproval of the communication of intention to grant the patent by the applicant or resumption of examination proceedings by the EPO
04.11.2019Communication of intention to grant the patent
13.03.2020Disapproval of the communication of intention to grant the patent by the applicant or resumption of examination proceedings by the EPO
13.03.2020Fee for grant paid
13.03.2020Fee for publishing/printing paid
04.05.2020Information about intention to grant a patent
04.05.2020Receipt of the translation of the claim(s)
Divisional application(s)EP17178990.2  / EP3248986
EP20163286.6  / EP3693386
EP20167969.3  / EP3702369
EP26151158.8
Opposition(s)Opponent(s)01  09.03.2021  11.03.2021  ADMISSIBLE
Icely, Dominic
Impact Intellectual Property LLP
1 Sans Walk
London EC1R 0LT / GB
Opponent's representative
Icely, Dominic Michael
Impact Intellectual Property LLP
1 Sans Walk
London EC1R 0LT / GB
 [2021/48]
Former [2021/45]
Opponent(s)01  09.03.2021  11.03.2021  ADMISSIBLE
Icely, Dominic
Prama House
267 Banbury Road
Oxford
Oxfordshire OX2 7HT / GB
Opponent's representative
Icely, Dominic Michael
Impact Intellectual Property LLP
1 Sans Walk
London EC1R 0LT / GB
Former [2021/15]
Opponent(s)01  09.03.2021  11.03.2021  ADMISSIBLE
Icely, Dominic
Prama House
267 Banbury Road
Oxford
Oxfordshire OX2 7HT / GB
Opponent's representative
Icely, Dominic Michael
The IP Asset Partnership Limited
Prama House
267 Banbury Road
Oxford OX2 7HT / GB
24.03.2021Invitation to proprietor to file observations on the notice of opposition
27.07.2021Reply of patent proprietor to notice(s) of opposition
23.03.2022Date of oral proceedings
14.04.2022Despatch of minutes of oral proceedings
14.04.2022Date of despatch of rejection of opposition
16.09.2024Legal effect of rejection of opposition [2024/44]
Appeal following opposition13.06.2022Appeal received No.  T1503/22
13.06.2022Payment of appeal fee
23.08.2022Statement of grounds filed
16.09.2024Result of appeal procedure: appeal of the opponent withdrawn
Fees paidRenewal fee
18.05.2017Renewal fee patent year 03
22.05.2018Renewal fee patent year 04
23.05.2019Renewal fee patent year 05
31.03.2020Renewal fee patent year 06
Opt-out from the exclusive  Tooltip
competence of the Unified
Patent Court		 See the Register of the Unified Patent Court for opt-out data
Responsibility for the accuracy, completeness or quality of the data displayed under the link provided lies entirely with the Unified Patent Court.
Lapses during opposition  TooltipAL10.06.2020
CY10.06.2020
LV10.06.2020
MC10.06.2020
MK10.06.2020
MT10.06.2020
SM10.06.2020
IS10.10.2020
[2024/41]
Former [2024/22]AL10.06.2020
CY10.06.2020
LV10.06.2020
MC10.06.2020
MK10.06.2020
SM10.06.2020
IS10.10.2020
Former [2023/30]AL10.06.2020
CY10.06.2020
LV10.06.2020
MC10.06.2020
SM10.06.2020
IS10.10.2020
Former [2022/07]AL10.06.2020
LV10.06.2020
MC10.06.2020
SM10.06.2020
IS10.10.2020
Former [2021/13]AL10.06.2020
LV10.06.2020
SM10.06.2020
IS10.10.2020
Former [2021/09]AL10.06.2020
LV10.06.2020
SM10.06.2020
Former [2021/04]AL10.06.2020
LV10.06.2020
Former [2020/51]LV10.06.2020
Cited inInternational search[Y] WO2012175741  (ABLYNX NV et al.) [Y] 1-7,38-42 * the whole document *
 [IY] WO2013024059  (GLAXO GROUP LTD et al.) [I] 1-3,8-72 * the whole document *[Y] 1-7,15-18,23-42,53-57,63-72
 [A] WO2011075861  (ESBATECH ALCON BIOMED RES UNIT et al.) [A] 1-7,38-42 * the whole document *
 [Y] WO2009138494  (ABLYNX NV et al.) [Y] 15-18,23-37,53-57,63-72 * the whole document *
Examination  MUYLDERMANS S ET AL: "Recognition of antigens by single-domain antibody fragments: the superfluous luxury of paired domains", TRENDS IN BIOCHEMICAL SCIE, ELSEVIER, AMSTERDAM, NL, vol. 26, no. 4, 1 April 2001 (2001-04-01), pages 230 - 235, XP004241851, ISSN: 0968-0004, DOI: 10.1016/S0968-0004(01)01790-X [D]

DOI:   http://dx.doi.org/10.1016/S0968-0004(01)01790-X
   SERGE MUYLDERMANS: "Single domain camel antibodies: current status", REVIEWS IN MOLECULAR BIOTECHNOLOGY, vol. 74, no. 4, 1 June 2001 (2001-06-01), NL, pages 277 - 302, XP055277195, ISSN: 1389-0352, DOI: 10.1016/S1389-0352(01)00021-6 [D]

DOI:   http://dx.doi.org/10.1016/S1389-0352(01)00021-6
   STEVEN SHERIFF ET AL: "Redefining the minimal antigen- binding fragment Heavy-chain antibodies", NATURE STRUCT BIOL, vol. 3, 1 January 1996 (1996-01-01), pages 733 - 736, XP055569172 [D]
OppositionWO2012175741
 WO2013024059
 WO2009138494
 WO2011075861
 WO2014004427
 WO2013116296
 WO2013059230
 WO2010019570
 WO2014043509
 WO2006122787
 WO2012175400
   MUYLDERMANS S ET AL.: "Recognition of antigens by single-domain antibody fragments: the superfluous luxury of paired domains", TRENDS IN BIOCHEMICAL SCIE, vol. 26, no. 4, 1 April 2001 (2001-04-01), AMSTERDAM, NL, pages 230 - 235, XP004241851, DOI: 10.1016/S0968-0004(01)01790-X

DOI:   http://dx.doi.org/10.1016/S0968-0004(01)01790-X
   SERGE MUYLDERMANS: "Single domain camel antibodies: current status", REVIEWS IN MOLECULAR BIOTECHNOLOGY, NL, vol. 74, no. 4, 1 June 2001 (2001-06-01), pages 277 - 302, XP055277195, DOI: 10.1016/S1389-0352(01)00021-6

DOI:   http://dx.doi.org/10.1016/S1389-0352(01)00021-6
   STEVEN SHERIFF ET AL.: "Redefining the minimal antigen- binding fragment Heavy-chain antibodies", NATURE STRUCT BIOL, vol. 3, 1 January 1996 (1996-01-01), pages 733 - 736, XP055569172
   STRYER L.: "Biochemistry. 4th ed.", 1995, W.H. FREEMAN & COMPANY, article "Immunoglobulins", pages: 368 - 370, XP055789085
   DATABASE IMGT/LIGM-DB 15 May 1995 (1995-05-15), "Human immunoglobulin heavy chain variable region V3-20 (IGHV@) gene, exons 1-2.", XP055789945, retrieved from IMGT Database accession no. M99657
   MATSUDA ET AL.: "Structure and physical map of 64 variable segments in the 3'0.8-megabase region of the human immunoglobulin heavy-chain locus", NAT. GENET., vol. 3, no. 1, 1993, pages 88 - 94, XP000561270, DOI: 10.1038/ng0193-88

DOI:   http://dx.doi.org/10.1038/ng0193-88
   NIEBA ET AL.: "Disrupting the hydrophobic patches at the antibody variable/ constant domain interface: improved in vivo folding and physical characterization of an engineered scFv fragment", PROTEIN ENGINEERING, vol. 10, no. 4, 1997, pages 435 - 444, XP002249462, DOI: 10.1093/protein/10.4.435

DOI:   http://dx.doi.org/10.1093/protein/10.4.435
   HARMSEN ET AL.: "Llama heavy-chain V regions consist of at least four distinct subfamilies revealing novel sequence features", MOL IMMUNOL., vol. 37, no. 10, 2000, pages 579 - 90, XP002244235, DOI: 10.1016/S0161-5890(00)00081-X

DOI:   http://dx.doi.org/10.1016/S0161-5890(00)00081-X
The EPO accepts no responsibility for the accuracy of data originating from other authorities; in particular, it does not guarantee that it is complete, up to date or fit for specific purposes.