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Extract from the Register of European Patents

EP About this file: EP3098316

EP3098316 - HUMAN-DERIVED INSECT-RESISTANT GENE AND ANTI-CRY1B TOXIN IDIOTYPE SINGLE-CHAIN ANTIBODY ENCODED THEREBY AND APPLICATION THEREOF [Right-click to bookmark this link]
StatusNo opposition filed within time limit
Status updated on  24.07.2020
Database last updated on 28.03.2026
FormerThe patent has been granted
Status updated on  16.08.2019
FormerGrant of patent is intended
Status updated on  15.05.2019
FormerExamination is in progress
Status updated on  02.03.2018
Most recent event   Tooltip08.07.2022Lapse of the patent in a contracting state
New state(s): MK		published on 10.08.2022  [2022/32]
Applicant(s)For all designated states
Jiangsu Academy of Agricultural Sciences
Institute of Food Safety and Monitoring Technology
No.50 Zhongling Road
Xuanwu
Nanjing, Jiangsu 210014 / CN
[2016/48]
Inventor(s)01 / LIU, Xianjin
Jiangsu Academy of Agricultural Sciences
Institute of Food Safety and Monitoring Technology
No.50 Zhongling Road
Xuanwu
Nanjing Jiangsu 210014 / CN
02 / XU, Chongxin
Jiangsu Academy of Agricultural Sciences
Institute of Food Safety and Monitoring Technology
No.50 Zhongling Road
Xuanwu
Nanjing Jiangsu 210014 / CN
03 / ZHANG, Xiao
Jiangsu Academy of Agricultural Sciences
Institute of Food Safety and Monitoring Technology
No.50 Zhongling Road
Xuanwu
Nanjing Jiangsu 210014 / CN
04 / LIU, Yuan
Jiangsu Academy of Agricultural Sciences
Institute of Food Safety and Monitoring Technology
No.50 Zhongling Road
Xuanwu
Nanjing Jiangsu 210014 / CN
05 / XIE, Yajing
Jiangsu Academy of Agricultural Sciences
Institute of Food Safety and Monitoring Technology
No.50 Zhongling Road
Xuanwu
Nanjing Jiangsu 210014 / CN
06 / ZHANG, Cunzheng
Jiangsu Academy of Agricultural Sciences
Institute of Food Safety and Monitoring Technology
No.50 Zhongling Road
Xuanwu
Nanjing Jiangsu 210014 / CN
07 / YU, Xiangyang
Jiangsu Academy of Agricultural Sciences
Institute of Food Safety and Monitoring Technology
No.50 Zhongling Road
Xuanwu
Nanjing Jiangsu 210014 / CN
08 / WANG, Donglan
Jiangsu Academy of Agricultural Sciences
Institute of Food Safety and Monitoring Technology
No.50 Zhongling Road
Xuanwu
Nanjing Jiangsu 210014 / CN
 [2016/48]
Representative(s)Rippel, Hans Christoph, et al
Patentanwälte
Isenbruck Bösl Hörschler PartG mbB
Eastsite One
Seckenheimer Landstrasse 4
68163 Mannheim / DE
[2019/38]
Former [2016/48]Rippel, Hans Christoph, et al
Isenbruck Bösl Hörschler LLP Eastsite One Seckenheimer Landstrasse 4
68163 Mannheim / DE
Application number, filing date15739989.009.01.2015
[2016/48]
WO2015CN70421
Priority number, dateCN2014103717526.01.2014         Original published format: CN201410037175
[2016/48]
Filing languageZH
Procedural languageEN
PublicationType: A1 Application with search report
No.:WO2015109952
Date:30.07.2015
Language:ZH
[2015/30]
Type: A1 Application with search report 
No.:EP3098316
Date:30.11.2016
Language:EN
[2016/48]
Type: A9 Corrected patent application 
No.:EP3098316
Date:28.06.2017
[2017/26]
Type: B1 Patent specification 
No.:EP3098316
Date:18.09.2019
Language:EN
[2019/38]
Search report(s)International search report - published on:CN30.07.2015
(Supplementary) European search report - dispatched on:EP19.05.2017
ClassificationIPC:C07K16/42, A01N63/02, C12N15/70
[2019/23]
CPC:
C07K16/4233 (EP,US); A01N47/44 (BR); A01N63/50 (EP,US);
C07K16/12 (BR,US); C07K16/1278 (US); C12N15/70 (EP,BR,US);
C07K2317/24 (EP,US); C07K2317/622 (EP,US) (-)
Former IPC [2017/25]C12N15/13, C12N15/70, C07K16/12, A01N47/44, A01P7/04, A01N63/02
Former IPC [2016/48]C12N15/13, C12N15/70, C07K16/12, A01N47/44, A01P7/04
Designated contracting statesAL,   AT,   BE,   BG,   CH,   CY,   CZ,   DE,   DK,   EE,   ES,   FI,   FR,   GB,   GR,   HR,   HU,   IE,   IS,   IT,   LI,   LT,   LU,   LV,   MC,   MK,   MT,   NL,   NO,   PL,   PT,   RO,   RS,   SE,   SI,   SK,   SM,   TR [2016/48]
Extension statesBANot yet paid
MENot yet paid
TitleGerman:VOM MENSCHEN ABGELEITETES INSEKTENRESISTENTES GEN UND DADURCH CODIERTER IDIOTYPISCHER ANTI-CRY1B-TOXIN-EINZELKETTENANTIKÖRPER UND ANWENDUNG DAVON[2016/48]
English:HUMAN-DERIVED INSECT-RESISTANT GENE AND ANTI-CRY1B TOXIN IDIOTYPE SINGLE-CHAIN ANTIBODY ENCODED THEREBY AND APPLICATION THEREOF[2016/48]
French:GÈNE DE RÉSISTANCE AUX INSECTES ANTHROPIQUE ET ANTICORPS À CHAÎNE UNIQUE À IDIOTYPE ANTI-TOXINE CRY1B AINSI CODÉ ET LEUR APPLICATION[2016/48]
Entry into regional phase25.05.2016Translation filed 
25.05.2016National basic fee paid 
25.05.2016Search fee paid 
25.05.2016Designation fee(s) paid 
25.05.2016Examination fee paid 
Examination procedure25.05.2016Examination requested  [2016/48]
08.12.2017Amendment by applicant (claims and/or description)
05.03.2018Despatch of a communication from the examining division (Time limit: M04)
05.07.2018Reply to a communication from the examining division
05.11.2018Despatch of a communication from the examining division (Time limit: M02)
15.01.2019Reply to a communication from the examining division
16.05.2019Communication of intention to grant the patent
06.08.2019Fee for grant paid
06.08.2019Fee for publishing/printing paid
06.08.2019Receipt of the translation of the claim(s)
Opposition(s)19.06.2020No opposition filed within time limit [2020/35]
Fees paidRenewal fee
29.11.2016Renewal fee patent year 03
24.01.2018Renewal fee patent year 04
24.12.2018Renewal fee patent year 05
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Patent Court		 See the Register of the Unified Patent Court for opt-out data
Responsibility for the accuracy, completeness or quality of the data displayed under the link provided lies entirely with the Unified Patent Court.
Lapses during opposition  TooltipHU09.01.2015
AL18.09.2019
AT18.09.2019
CY18.09.2019
CZ18.09.2019
DK18.09.2019
EE18.09.2019
ES18.09.2019
FI18.09.2019
HR18.09.2019
IT18.09.2019
LT18.09.2019
LV18.09.2019
MC18.09.2019
MK18.09.2019
MT18.09.2019
PL18.09.2019
RO18.09.2019
RS18.09.2019
SE18.09.2019
SI18.09.2019
SK18.09.2019
SM18.09.2019
TR18.09.2019
BG18.12.2019
NO18.12.2019
GR19.12.2019
IE09.01.2020
LU09.01.2020
IS19.01.2020
PT20.01.2020
BE31.01.2020
CH31.01.2020
LI31.01.2020
[2022/32]
Former [2022/27]HU09.01.2015
AL18.09.2019
AT18.09.2019
CY18.09.2019
CZ18.09.2019
DK18.09.2019
EE18.09.2019
ES18.09.2019
FI18.09.2019
HR18.09.2019
IT18.09.2019
LT18.09.2019
LV18.09.2019
MC18.09.2019
MT18.09.2019
PL18.09.2019
RO18.09.2019
RS18.09.2019
SE18.09.2019
SI18.09.2019
SK18.09.2019
SM18.09.2019
TR18.09.2019
BG18.12.2019
NO18.12.2019
GR19.12.2019
IE09.01.2020
LU09.01.2020
IS19.01.2020
PT20.01.2020
BE31.01.2020
CH31.01.2020
LI31.01.2020
Former [2021/08]AL18.09.2019
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IT18.09.2019
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MC18.09.2019
PL18.09.2019
RO18.09.2019
RS18.09.2019
SE18.09.2019
SI18.09.2019
SK18.09.2019
SM18.09.2019
BG18.12.2019
NO18.12.2019
GR19.12.2019
IE09.01.2020
LU09.01.2020
IS19.01.2020
PT20.01.2020
BE31.01.2020
CH31.01.2020
LI31.01.2020
Former [2020/51]AL18.09.2019
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EE18.09.2019
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IT18.09.2019
LT18.09.2019
LV18.09.2019
MC18.09.2019
PL18.09.2019
RO18.09.2019
RS18.09.2019
SE18.09.2019
SI18.09.2019
SK18.09.2019
SM18.09.2019
BG18.12.2019
NO18.12.2019
GR19.12.2019
LU09.01.2020
IS19.01.2020
PT20.01.2020
BE31.01.2020
CH31.01.2020
LI31.01.2020
Former [2020/46]AL18.09.2019
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MC18.09.2019
PL18.09.2019
RO18.09.2019
RS18.09.2019
SE18.09.2019
SI18.09.2019
SK18.09.2019
SM18.09.2019
BG18.12.2019
NO18.12.2019
GR19.12.2019
LU09.01.2020
IS19.01.2020
PT20.01.2020
Former [2020/39]AL18.09.2019
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EE18.09.2019
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SI18.09.2019
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BG18.12.2019
NO18.12.2019
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PT20.01.2020
Former [2020/37]AL18.09.2019
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EE18.09.2019
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FI18.09.2019
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IT18.09.2019
LT18.09.2019
LV18.09.2019
PL18.09.2019
RO18.09.2019
RS18.09.2019
SE18.09.2019
SI18.09.2019
SK18.09.2019
SM18.09.2019
BG18.12.2019
NO18.12.2019
GR19.12.2019
IS19.01.2020
PT20.01.2020
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BG18.12.2019
NO18.12.2019
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PT20.01.2020
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BG18.12.2019
NO18.12.2019
GR19.12.2019
PT20.01.2020
IS24.02.2020
Former [2020/25]AL18.09.2019
AT18.09.2019
CZ18.09.2019
EE18.09.2019
ES18.09.2019
FI18.09.2019
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LT18.09.2019
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PL18.09.2019
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RS18.09.2019
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BG18.12.2019
NO18.12.2019
GR19.12.2019
PT20.01.2020
IS24.02.2020
Former [2020/24]AL18.09.2019
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FI18.09.2019
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PL18.09.2019
RO18.09.2019
RS18.09.2019
SE18.09.2019
BG18.12.2019
NO18.12.2019
GR19.12.2019
PT20.01.2020
IS24.02.2020
Former [2020/23]AL18.09.2019
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FI18.09.2019
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PL18.09.2019
RO18.09.2019
RS18.09.2019
SE18.09.2019
BG18.12.2019
NO18.12.2019
GR19.12.2019
PT20.01.2020
Former [2020/22]AL18.09.2019
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LT18.09.2019
LV18.09.2019
RS18.09.2019
SE18.09.2019
BG18.12.2019
NO18.12.2019
GR19.12.2019
PT20.01.2020
Former [2020/15]AL18.09.2019
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LV18.09.2019
RS18.09.2019
SE18.09.2019
BG18.12.2019
NO18.12.2019
GR19.12.2019
Former [2020/11]FI18.09.2019
HR18.09.2019
LT18.09.2019
LV18.09.2019
RS18.09.2019
SE18.09.2019
BG18.12.2019
NO18.12.2019
GR19.12.2019
Former [2020/10]FI18.09.2019
LT18.09.2019
SE18.09.2019
BG18.12.2019
NO18.12.2019
Former [2020/09]FI18.09.2019
LT18.09.2019
NO18.12.2019
Former [2020/08]LT18.09.2019
NO18.12.2019
Documents cited:Search[Y] EP0526397  (CIBA GEIGY AG et al.) [Y] 1-5 * page 5, line 35 - page 6, line 21; claims 9-15 *
 [Y]   XU CHONGXIN ET AL: "Eecretory expression and characterization of humanized anti-Cry1B scFv antibody in Escherichia coli", JOURNAL OF NANJING AGRICULTURAL UNIVERSITY, 1 January 2013 (2013-01-01), pages 47 - 52, XP055215181, Retrieved from the Internet [retrieved on 20150922] [Y] 1-5 * abstract *
 [Y]   XIAO ZHANG ET AL: "Rapid isolation of single-chain antibodies from a human synthetic phage display library for detection of(Bt) Cry1B toxin", ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY, ACADEMIC PRESS, SAN DIEGO, CA, US, vol. 81, 21 April 2012 (2012-04-21), pages 84 - 90, XP028429815, ISSN: 0147-6513, [retrieved on 20120508], DOI: 10.1016/J.ECOENV.2012.04.021 [Y] 1-5 * abstract * * page 84, column 2, lines 3-17 * * page 85, column 1, lines 21-23 *

DOI:   http://dx.doi.org/10.1016/j.ecoenv.2012.04.021
 [Y]   ENAMUL KABIR M ET AL: "Peptide derived from anti-idiotypic single-chain antibody is a potent antifungal agent compared to its parent fungicide HM-1 killer toxin peptide", APPLIED MICROBIOLOGY AND BIOTECHNOLOGY, SPRINGER, BERLIN, DE, vol. 92, no. 6, 21 June 2011 (2011-06-21), pages 1151 - 1160, XP019983751, ISSN: 1432-0614, DOI: 10.1007/S00253-011-3412-2 [Y] 1-5 * abstract *

DOI:   http://dx.doi.org/10.1007/s00253-011-3412-2
International search[XP] CN103773775  (JIANGSU ACAD AGRICULTURAL SCI et al.) [XP]
 [XP] CN103773774  (JIANGSU ACAD AGRICULTURAL SCI et al.) [XP]
 [XP] CN103773776  (JIANGSU ACAD AGRICULTURAL SCI et al.) [XP]
 [A]   XIAO ZHANG ET AL.: "RApidi solation of single-chain antibodies from a human synthetic phage display library for detection of bacillus thuringiensis (Bt) CrylBtoxin", ECOTOXICILOGY AND ENVIRONMENTAL SAFETY, 23 May 2012 (2012-05-23), pages 84 - 90, XP028429815 [A]

DOI:   http://dx.doi.org/10.1016/j.ecoenv.2012.04.021
 [A]   M ENAMUL KABIR ET AL.: "An improved phage-display panning method to produce an HM-1 killer toxin anti-idiotypic antibody", BMC BIOTECHNOLOGY, vol. 9, 14 December 2009 (2009-12-14), XP055215223 [A]

DOI:   http://dx.doi.org/10.1186/1472-6750-9-99
 [A]   PASCALE ODDOU ET AL.: "Immunologically unrelated Heliothis sp. and Spodoptera sp. midgut membrane-proteins bind Bacillus thuringiensis CryIA(b) delta-endotoxin", EUR. J. BIOCHEM., vol. 212, no. 1, 15 February 1993 (1993-02-15), pages 145 - 150, XP055215225 [A]

DOI:   http://dx.doi.org/10.1111/j.1432-1033.1993.tb17644.x
 [A]   HUANG, KUIYING ET AL.: "Advances in Research on Anti-idiotypic Antibody", GUANGXI JOURNAL OF LIGHT INDUSTRY, 30 April 2009 (2009-04-30), pages 9 - 11, XP008184127 [A]
ExaminationWO2007107302
by applicant  WANG MIN ET AL.: "Diversity of Rhizospheric Microorganisms and Bacterial Physiological Groups of Transgenic Bt Maize", CHINESE JOURNAL OF ECOLOGY, 2010
   LIU LING ET AL.: "Influence of Transgenic Bt Maize on Bacterial Quantity and Diversity of Soil", JOURNAL OF ECOLOGY AND RURAL ENVIRONMENT, 2011
   VAZQUEZ-PADRON ET AL.: "CrylAc protoxin from Bacillus thuringiensis sp. kurstaki HD73 binds to surface proteins in the mouse small intestine", BIOCHEM BIOPHYS RES COMMUN, 2000
The EPO accepts no responsibility for the accuracy of data originating from other authorities; in particular, it does not guarantee that it is complete, up to date or fit for specific purposes.