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EP3169710
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EP Citations: EP3169710
| Cited in | International search | Type: | Patent literature | Publication No.: | WO2009026558
[XD] (AMGEN INC et al.) | Type: | Patent literature | Publication No.: | WO2013166448
[Y] (AMGEN INC et al.) | Type: | Patent literature | Publication No.: | WO02072636
[Y] (ALTUS BIOLOGICS INC et al.) | Type: | Non-patent literature | Publication information: | [A] YANG M X ET AL: "Crystalline monoclonal antibodies for subcutaneous delivery", PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES, NATIONAL ACADEMY OF SCIENCES, US, vol. 100, no. 12, 10 June 2003 (2003-06-10), pages 6934 - 6939, XP002307180, ISSN: 0027-8424, DOI: 10.1073/PNAS.1131899100 | DOI: | http://dx.doi.org/10.1073/pnas.1131899100 | Type: | Non-patent literature | Publication information: | [A] BASU S K ET AL: "PROTEIN CRYSTALS FOR THE DELIVERY OF BIOPHARMACEUTICALS", EXPERT OPINION ON BIOLOGICAL THERAPY, INFORMA HEALTHCARE, ASHLEY, LONDON; GB, vol. 4, no. 3, 1 March 2004 (2004-03-01), pages 301 - 317, XP009040451, ISSN: 1471-2598, DOI: 10.1517/EOBT.4.3.301.27331 | DOI: | http://dx.doi.org/10.1517/eobt.4.3.301.27331 | Type: | Non-patent literature | Publication information: | [A] LIANG H ET AL: "Proprotein convertase substilisin/kexin type 9 antagonism reduces low-density lipoprotein cholesterol in statin-treated hypercholesterolemic nonhuman primates", JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS, AMERICAN SOCIETY FOR PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS, US, vol. 340, no. 2, 1 February 2012 (2012-02-01), pages 228 - 236, XP009166142, ISSN: 0022-3565 | DOI: | http://dx.doi.org/10.1124/jpet.111.187419 | Type: | Non-patent literature | Publication information: | [A] YAN G NI ET AL: "A PCSK9-binding antibody that structurally mimics the EGF(A) domain of LDL-receptor reduces LDL cholesterol in vivo", JOURNAL OF LIPID RESEARCH, AMERICAN SOCIETY FOR BIOCHEMISTRY AND MOLECULAR BIOLOGY, INC, US, vol. 52, no. 1, 1 January 2011 (2011-01-01), pages 78 - 86, XP002686538, ISSN: 0022-2275, [retrieved on 20101019], DOI: 10.1194/JLR.M011445 | DOI: | http://dx.doi.org/10.1194/jlr.m011445 | Cited in | Examination | Type: | Non-patent literature | Publication information: | EGOR TRILISKY ET AL: "Crystallization and liquid-liquid phase separation of monoclonal antibodies and fc-fusion proteins: Screening results", BIOTECHNOLOGY PROGRESS, vol. 27, no. 4, 8 July 2011 (2011-07-08), pages 1054 - 1067, XP055213554, ISSN: 8756-7938, DOI: 10.1002/btpr.621 | DOI: | http://dx.doi.org/10.1002/btpr.621 | Type: | Non-patent literature | Publication information: | YUGUO ZANG ET AL: "Towards Protein Crystallization as a Process Step in Downstream Processing of Therapeutic Antibodies: Screening and Optimization at Microbatch Scale", PLOS ONE, vol. 6, no. 9, 22 September 2011 (2011-09-22), pages e25282, XP055606728, DOI: 10.1371/journal.pone.0025282 | DOI: | http://dx.doi.org/10.1371/journal.pone.0025282 | Cited in | by applicant | Type: | Patent literature | Publication No.: | US8030457
| Type: | Patent literature | Publication No.: | US6036978
| Type: | Patent literature | Publication No.: | US6083534
| Type: | Patent literature | Publication No.: | US6020004
| Type: | Patent literature | Publication No.: | US6432449
| Type: | Patent literature | Publication No.: | US6541033
| Type: | Patent literature | Publication No.: | US6451346
| Type: | Patent literature | Publication No.: | US6245740
| Type: | Patent literature | Publication No.: | US6541606
| Type: | Non-patent literature | Publication information: | YANG, M.X.; SHENOY, B.; DISTTLER, M.; PATEL, R.; MCGRATH, M.; PECHENOV, S.; MARGOLIN, A.L.: "Crystalline monoclonal antibodies for subcutaneous delivery", PNAS, vol. 100, 2003, pages 6934 - 6939 | Type: | Non-patent literature | Publication information: | SHIRE, S.J.; ZAHRA, S.; LIU, J.: "Challenges in the development of high concentration formulations", J. PHARM. SCI., vol. 93, 2004, pages 1390 - 1402, XP009108986, DOI: doi:10.1002/jps.20079 | DOI: | http://dx.doi.org/10.1002/jps.20079 | Type: | Non-patent literature | Publication information: | JENKINS, T. W.: "Three solutions of the protein solubility problem", PROTEIN SCIENCE, vol. 7, 1998, pages 376 - 382 | Type: | Non-patent literature | Publication information: | DREUTH, J.; HAAS, C.: "Protein crystals and their stability", J. CRYSTAL GROWTH, vol. 122, 1992, pages 107 - 109, XP024438148, DOI: doi:10.1016/0022-0248(92)90233-9 | DOI: | http://dx.doi.org/10.1016/0022-0248(92)90233-9 | Type: | Non-patent literature | Publication information: | BASU, S. K.; GOVARDHAN, C. P.; JUNG, C. W.; MARGOLIN, A. L.: "Protein crystals for the delivery of biopharmaceuticals", EXPERT OPIN. BIOL. THERA, vol. 4, 2004, pages 301 - 317, XP009040451, DOI: doi:10.1517/eobt.4.3.301.27331 | DOI: | http://dx.doi.org/10.1517/eobt.4.3.301.27331 | Type: | Non-patent literature | Publication information: | PECHENOV, S.; SHENOY, B.; YANG, M. X.; BASU, S.; MARGOLIN, A. L.: "Injectable controlled release formulations incorporating protein crystals", JOURNAL OF CONTROLLED RELEASE, vol. 96, 2004, pages 149 - 158, XP004500740, DOI: doi:10.1016/j.jconrel.2004.01.019 | DOI: | http://dx.doi.org/10.1016/j.jconrel.2004.01.019 | Type: | Non-patent literature | Publication information: | HAGEDORN H. C.; JENSEN, B. N.; KRARUP, N. B.; WODSTRUP, 1.: "Protamine insulinate", J. AM. MED. ASSN., vol. 106, 1936, pages 177 - 180 | Type: | Non-patent literature | Publication information: | JOHNSON, 1. S.: "The trials and tribulations of producing the first genetically engineered drug", NAT. REV. DRUG. DISCOVERY, vol. 2, 2003, pages 747 - 751 | Type: | Non-patent literature | Publication information: | JEN, A.; MERKLE, H.P.: "Diamonds in the rough: Protein crystals from a formulation perspective", PHARM. RES., vol. 18, 2001, pages 1483 - 1488, XP002307178, DOI: doi:10.1023/A:1013057825942 | DOI: | http://dx.doi.org/10.1023/A:1013057825942 | Type: | Non-patent literature | Publication information: | COSTET ET AL.: "Hepatic PCSK9 Expression is Regulated by Nutritional Status via Insulin and Sterol Regulatory Element-binding Protein 1C", J. BIOL. CHEM., vol. 281, 2006, pages 6211 - 6218 | Type: | Non-patent literature | Publication information: | PAUL, W.,: "Fundamental Immunology, 2nd ed.", 1989, RAVEN PRESS, article "Ch. 7" | Type: | Non-patent literature | Publication information: | KABAT ET AL.: "Sequences of Proteins of Immunological Interest, 5th Ed.", 1991, NATIONAL INSTITUTES OF HEALTH | Type: | Non-patent literature | Publication information: | SHIELDS ET AL., J. BIOL. CHEM., vol. 276, no. 9, 2001, pages 6591 - 6604 | Type: | Non-patent literature | Publication information: | GREENFIELD ET AL., CANCER RESEARCH, vol. 50, 1990, pages 6600 - 6607 | Type: | Non-patent literature | Publication information: | ARNON ET AL., ADV. EXP. MED. BIOL., vol. 303, 1991, pages 79 - 90 | Type: | Non-patent literature | Publication information: | KISELEVA ET AL., MOL. BIOL. (USSR, vol. 25, 1991, pages 508 - 514 | Type: | Non-patent literature | Publication information: | MCPHERSON, METHODS ENZYMOL, vol. 114, 1985, pages 112 - 120 | Type: | Non-patent literature | Publication information: | MCPHERSON; GILLILAND, J CRYSTAL GROWTH, vol. 90, 1988, pages 51 - 59 | Type: | Non-patent literature | Publication information: | BERNSTEIN ET AL., J MOL BIOL, vol. 112, 1977, pages 535 - 542 | Type: | Non-patent literature | Publication information: | C. S. BARRETT: "Structure of Metals, 2nd ed.,", 1952, MCGRAW-HILL, pages: L | Type: | Non-patent literature | Publication information: | BASU ET AL., EXPERT OPIN. BIOL. THERA, vol. 4, 2004, pages 301 - 317 | Type: | Non-patent literature | Publication information: | "Remington's Pharmaceutical Sciences, 16 Ed.,", 1980, MACK PUBLISHING COMPANY | Type: | Non-patent literature | Publication information: | "Handbook of Pharmaceutical Excipients", AMERICAN PHARMACEUTICAL ASSOCIATION | Type: | Non-patent literature | Publication information: | AKERS, J PHARM SCI, vol. 91, 2002, pages 2283 - 2300 | Type: | Non-patent literature | Publication information: | KIM, C.: "Controlled Release Dosage Form Design", 2000, TECHONOMIC PUBLISHING CO. | Type: | Non-patent literature | Publication information: | "Remington's Pharmaceutical Sciences, 18th Ed.", 1990, MACK PUBLISHING CO., pages: 1435 - 1712 |