| EP3177726 - GENOME EDITING FOR THE TREATMENT OF HUNTINGTON'S DISEASE [Right-click to bookmark this link] | |||
| Former [2017/24] | GENOME EDITING FOR THE TREATMENT OF HUNTINGTON's DISEASE | ||
| [2020/36] | Status | No opposition filed within time limit Status updated on 03.12.2021 Database last updated on 26.03.2026 | |
| Former | The patent has been granted Status updated on 25.12.2020 | ||
| Former | Grant of patent is intended Status updated on 07.09.2020 | ||
| Former | Examination is in progress Status updated on 18.05.2018 | ||
| Former | Request for examination was made Status updated on 12.05.2017 | ||
| Former | The international publication has been made Status updated on 14.02.2017 | Most recent event Tooltip | 19.12.2025 | Lapse of the patent in a contracting state New state(s): TR | published on 21.01.2026 [2026/04] | Applicant(s) | For all designated states Centre Hospitalier Universitaire Vaudois (CHUV) Rue du Bugnon 21 1011 Lausanne / CH | [2017/24] | Inventor(s) | 01 /
DEGLON, Nicole Chemin des Biolles 13A CH-1521 Curtilles / CH | 02 /
MERIENNE, Nicolas Rue du Village 42 CH-1081 Montpreveyres / CH | [2017/24] | Representative(s) | KATZAROV S.A. Geneva Business Center 12 Avenue des Morgines 1213 Petit-Lancy / CH | [N/P] |
| Former [2021/04] | KATZAROV S.A. European Patent Attorneys 12, Avenue des Morgines 1213 Petit-Lancy / CH | ||
| Former [2017/24] | KATZAROV S.A. European Patent Attorneys 19, rue des Epinettes 1227 Genève / CH | Application number, filing date | 15760097.4 | 04.08.2015 | [2017/24] | WO2015EP67986 | Priority number, date | EP20140179767 | 04.08.2014 Original published format: EP 14179767 | [2017/24] | Filing language | EN | Procedural language | EN | Publication | Type: | A1 Application with search report | No.: | WO2016020399 | Date: | 11.02.2016 | Language: | EN | [2016/06] | Type: | A1 Application with search report | No.: | EP3177726 | Date: | 14.06.2017 | Language: | EN | The application published by WIPO in one of the EPO official languages on 11.02.2016 takes the place of the publication of the European patent application. | [2017/24] | Type: | B1 Patent specification | No.: | EP3177726 | Date: | 27.01.2021 | Language: | EN | [2021/04] | Search report(s) | International search report - published on: | EP | 11.02.2016 | Classification | IPC: | C12N15/86, C12N9/52, A61K48/00, A61P25/00 | [2020/36] | CPC: |
A61K48/005 (EP,US);
A61K38/1709 (EP,US);
A61K38/465 (EP,US);
A61K48/00 (EP,US);
C12N15/11 (US);
C12N15/86 (EP,US);
C12N9/52 (EP,US);
C12N2310/20 (US);
C12N2310/3513 (US);
C12N2740/16043 (EP,US);
C12N2750/14143 (EP,US);
C12N2799/04 (EP,US);
C12N2799/06 (EP,US)
(-)
|
| Former IPC [2017/24] | C12N15/86, C12N9/52, A61K48/00 | Designated contracting states | AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LI, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR [2017/24] | Extension states | BA | Not yet paid | ME | Not yet paid | Validation states | MA | Not yet paid | Title | German: | GEMONEDITIERUNG ZUR BEHANDLUNG VON MORBUS HUNTINGTON | [2020/36] | English: | GENOME EDITING FOR THE TREATMENT OF HUNTINGTON'S DISEASE | [2020/36] | French: | ÉDITION DE GÉNOME POUR LE TRAITEMENT DE LA MALADIE DE HUNTINGTON | [2020/36] |
| Former [2017/24] | GENOMÄNDERUNG ZUR BEHANDLUNG VON MORBUS HUNTINGTON | ||
| Former [2017/24] | GENOME EDITING FOR THE TREATMENT OF HUNTINGTON's DISEASE | ||
| Former [2017/24] | ÉDITION DU GÉNOME À DES FINS DE TRAITEMENT DE LA MALADIE DE HUNTINGTON | Entry into regional phase | 14.02.2017 | National basic fee paid | 14.02.2017 | Designation fee(s) paid | 14.02.2017 | Examination fee paid | Examination procedure | 14.02.2017 | Examination requested [2017/24] | 14.02.2017 | Date on which the examining division has become responsible | 23.08.2017 | Amendment by applicant (claims and/or description) | 22.05.2018 | Despatch of a communication from the examining division (Time limit: M04) | 13.09.2018 | Reply to a communication from the examining division | 20.02.2019 | Despatch of a communication from the examining division (Time limit: M06) | 19.08.2019 | Reply to a communication from the examining division | 25.11.2019 | Despatch of a communication from the examining division (Time limit: M04) | 10.03.2020 | Reply to a communication from the examining division | 29.06.2020 | Despatch of a communication from the examining division (Time limit: M02) | 22.07.2020 | Reply to a communication from the examining division | 08.09.2020 | Communication of intention to grant the patent | 16.12.2020 | Fee for grant paid | 16.12.2020 | Fee for publishing/printing paid | 16.12.2020 | Receipt of the translation of the claim(s) | Opposition(s) | 28.10.2021 | No opposition filed within time limit [2022/01] | Fees paid | Renewal fee | 08.08.2017 | Renewal fee patent year 03 | 25.06.2018 | Renewal fee patent year 04 | 22.08.2019 | Renewal fee patent year 05 | 25.08.2020 | Renewal fee patent year 06 |
| Opt-out from the exclusive Tooltip competence of the Unified Patent Court | See the Register of the Unified Patent Court for opt-out data | ||
| Responsibility for the accuracy, completeness or quality of the data displayed under the link provided lies entirely with the Unified Patent Court. | Lapses during opposition Tooltip | HU | 04.08.2015 | AL | 27.01.2021 | AT | 27.01.2021 | CY | 27.01.2021 | CZ | 27.01.2021 | DK | 27.01.2021 | EE | 27.01.2021 | ES | 27.01.2021 | FI | 27.01.2021 | HR | 27.01.2021 | IT | 27.01.2021 | LT | 27.01.2021 | LV | 27.01.2021 | MC | 27.01.2021 | MK | 27.01.2021 | MT | 27.01.2021 | NL | 27.01.2021 | PL | 27.01.2021 | RO | 27.01.2021 | RS | 27.01.2021 | SE | 27.01.2021 | SI | 27.01.2021 | SK | 27.01.2021 | SM | 27.01.2021 | TR | 27.01.2021 | BG | 27.04.2021 | NO | 27.04.2021 | GR | 28.04.2021 | IS | 27.05.2021 | PT | 27.05.2021 | GB | 04.08.2021 | IE | 04.08.2021 | LU | 04.08.2021 | BE | 31.08.2021 | CH | 31.08.2021 | FR | 31.08.2021 | LI | 31.08.2021 | [2026/04] |
| Former [2024/41] | HU | 04.08.2015 | |
| AL | 27.01.2021 | ||
| AT | 27.01.2021 | ||
| CY | 27.01.2021 | ||
| CZ | 27.01.2021 | ||
| DK | 27.01.2021 | ||
| EE | 27.01.2021 | ||
| ES | 27.01.2021 | ||
| FI | 27.01.2021 | ||
| HR | 27.01.2021 | ||
| IT | 27.01.2021 | ||
| LT | 27.01.2021 | ||
| LV | 27.01.2021 | ||
| MC | 27.01.2021 | ||
| MK | 27.01.2021 | ||
| MT | 27.01.2021 | ||
| NL | 27.01.2021 | ||
| PL | 27.01.2021 | ||
| RO | 27.01.2021 | ||
| RS | 27.01.2021 | ||
| SE | 27.01.2021 | ||
| SI | 27.01.2021 | ||
| SK | 27.01.2021 | ||
| SM | 27.01.2021 | ||
| BG | 27.04.2021 | ||
| NO | 27.04.2021 | ||
| GR | 28.04.2021 | ||
| IS | 27.05.2021 | ||
| PT | 27.05.2021 | ||
| GB | 04.08.2021 | ||
| IE | 04.08.2021 | ||
| LU | 04.08.2021 | ||
| BE | 31.08.2021 | ||
| CH | 31.08.2021 | ||
| FR | 31.08.2021 | ||
| LI | 31.08.2021 | ||
| Former [2024/22] | HU | 04.08.2015 | |
| AL | 27.01.2021 | ||
| AT | 27.01.2021 | ||
| CY | 27.01.2021 | ||
| CZ | 27.01.2021 | ||
| DK | 27.01.2021 | ||
| EE | 27.01.2021 | ||
| ES | 27.01.2021 | ||
| FI | 27.01.2021 | ||
| HR | 27.01.2021 | ||
| IT | 27.01.2021 | ||
| LT | 27.01.2021 | ||
| LV | 27.01.2021 | ||
| MC | 27.01.2021 | ||
| MK | 27.01.2021 | ||
| NL | 27.01.2021 | ||
| PL | 27.01.2021 | ||
| RO | 27.01.2021 | ||
| RS | 27.01.2021 | ||
| SE | 27.01.2021 | ||
| SI | 27.01.2021 | ||
| SK | 27.01.2021 | ||
| SM | 27.01.2021 | ||
| BG | 27.04.2021 | ||
| NO | 27.04.2021 | ||
| GR | 28.04.2021 | ||
| IS | 27.05.2021 | ||
| PT | 27.05.2021 | ||
| GB | 04.08.2021 | ||
| IE | 04.08.2021 | ||
| LU | 04.08.2021 | ||
| BE | 31.08.2021 | ||
| CH | 31.08.2021 | ||
| FR | 31.08.2021 | ||
| LI | 31.08.2021 | ||
| Former [2023/30] | HU | 04.08.2015 | |
| AL | 27.01.2021 | ||
| AT | 27.01.2021 | ||
| CY | 27.01.2021 | ||
| CZ | 27.01.2021 | ||
| DK | 27.01.2021 | ||
| EE | 27.01.2021 | ||
| ES | 27.01.2021 | ||
| FI | 27.01.2021 | ||
| HR | 27.01.2021 | ||
| IT | 27.01.2021 | ||
| LT | 27.01.2021 | ||
| LV | 27.01.2021 | ||
| MC | 27.01.2021 | ||
| NL | 27.01.2021 | ||
| PL | 27.01.2021 | ||
| RO | 27.01.2021 | ||
| RS | 27.01.2021 | ||
| SE | 27.01.2021 | ||
| SI | 27.01.2021 | ||
| SK | 27.01.2021 | ||
| SM | 27.01.2021 | ||
| BG | 27.04.2021 | ||
| NO | 27.04.2021 | ||
| GR | 28.04.2021 | ||
| IS | 27.05.2021 | ||
| PT | 27.05.2021 | ||
| GB | 04.08.2021 | ||
| IE | 04.08.2021 | ||
| LU | 04.08.2021 | ||
| BE | 31.08.2021 | ||
| CH | 31.08.2021 | ||
| FR | 31.08.2021 | ||
| LI | 31.08.2021 | ||
| Former [2023/27] | HU | 04.08.2015 | |
| AL | 27.01.2021 | ||
| AT | 27.01.2021 | ||
| CZ | 27.01.2021 | ||
| DK | 27.01.2021 | ||
| EE | 27.01.2021 | ||
| ES | 27.01.2021 | ||
| FI | 27.01.2021 | ||
| HR | 27.01.2021 | ||
| IT | 27.01.2021 | ||
| LT | 27.01.2021 | ||
| LV | 27.01.2021 | ||
| MC | 27.01.2021 | ||
| NL | 27.01.2021 | ||
| PL | 27.01.2021 | ||
| RO | 27.01.2021 | ||
| RS | 27.01.2021 | ||
| SE | 27.01.2021 | ||
| SI | 27.01.2021 | ||
| SK | 27.01.2021 | ||
| SM | 27.01.2021 | ||
| BG | 27.04.2021 | ||
| NO | 27.04.2021 | ||
| GR | 28.04.2021 | ||
| IS | 27.05.2021 | ||
| PT | 27.05.2021 | ||
| GB | 04.08.2021 | ||
| IE | 04.08.2021 | ||
| LU | 04.08.2021 | ||
| BE | 31.08.2021 | ||
| CH | 31.08.2021 | ||
| FR | 31.08.2021 | ||
| LI | 31.08.2021 | ||
| Former [2022/35] | AL | 27.01.2021 | |
| AT | 27.01.2021 | ||
| CZ | 27.01.2021 | ||
| DK | 27.01.2021 | ||
| EE | 27.01.2021 | ||
| ES | 27.01.2021 | ||
| FI | 27.01.2021 | ||
| HR | 27.01.2021 | ||
| IT | 27.01.2021 | ||
| LT | 27.01.2021 | ||
| LV | 27.01.2021 | ||
| MC | 27.01.2021 | ||
| NL | 27.01.2021 | ||
| PL | 27.01.2021 | ||
| RO | 27.01.2021 | ||
| RS | 27.01.2021 | ||
| SE | 27.01.2021 | ||
| SI | 27.01.2021 | ||
| SK | 27.01.2021 | ||
| SM | 27.01.2021 | ||
| BG | 27.04.2021 | ||
| NO | 27.04.2021 | ||
| GR | 28.04.2021 | ||
| IS | 27.05.2021 | ||
| PT | 27.05.2021 | ||
| GB | 04.08.2021 | ||
| IE | 04.08.2021 | ||
| LU | 04.08.2021 | ||
| BE | 31.08.2021 | ||
| CH | 31.08.2021 | ||
| FR | 31.08.2021 | ||
| LI | 31.08.2021 | ||
| Former [2022/34] | AL | 27.01.2021 | |
| AT | 27.01.2021 | ||
| CZ | 27.01.2021 | ||
| DK | 27.01.2021 | ||
| EE | 27.01.2021 | ||
| ES | 27.01.2021 | ||
| FI | 27.01.2021 | ||
| HR | 27.01.2021 | ||
| IT | 27.01.2021 | ||
| LT | 27.01.2021 | ||
| LV | 27.01.2021 | ||
| MC | 27.01.2021 | ||
| NL | 27.01.2021 | ||
| PL | 27.01.2021 | ||
| RO | 27.01.2021 | ||
| RS | 27.01.2021 | ||
| SE | 27.01.2021 | ||
| SI | 27.01.2021 | ||
| SK | 27.01.2021 | ||
| SM | 27.01.2021 | ||
| BG | 27.04.2021 | ||
| NO | 27.04.2021 | ||
| GR | 28.04.2021 | ||
| IS | 27.05.2021 | ||
| PT | 27.05.2021 | ||
| LU | 04.08.2021 | ||
| BE | 31.08.2021 | ||
| CH | 31.08.2021 | ||
| FR | 31.08.2021 | ||
| LI | 31.08.2021 | ||
| Former [2022/23] | AL | 27.01.2021 | |
| AT | 27.01.2021 | ||
| CZ | 27.01.2021 | ||
| DK | 27.01.2021 | ||
| EE | 27.01.2021 | ||
| ES | 27.01.2021 | ||
| FI | 27.01.2021 | ||
| HR | 27.01.2021 | ||
| IT | 27.01.2021 | ||
| LT | 27.01.2021 | ||
| LV | 27.01.2021 | ||
| MC | 27.01.2021 | ||
| NL | 27.01.2021 | ||
| PL | 27.01.2021 | ||
| RO | 27.01.2021 | ||
| RS | 27.01.2021 | ||
| SE | 27.01.2021 | ||
| SI | 27.01.2021 | ||
| SK | 27.01.2021 | ||
| SM | 27.01.2021 | ||
| BG | 27.04.2021 | ||
| NO | 27.04.2021 | ||
| GR | 28.04.2021 | ||
| IS | 27.05.2021 | ||
| PT | 27.05.2021 | ||
| LU | 04.08.2021 | ||
| CH | 31.08.2021 | ||
| LI | 31.08.2021 | ||
| Former [2022/21] | AL | 27.01.2021 | |
| AT | 27.01.2021 | ||
| CZ | 27.01.2021 | ||
| DK | 27.01.2021 | ||
| EE | 27.01.2021 | ||
| ES | 27.01.2021 | ||
| FI | 27.01.2021 | ||
| HR | 27.01.2021 | ||
| LT | 27.01.2021 | ||
| LV | 27.01.2021 | ||
| MC | 27.01.2021 | ||
| NL | 27.01.2021 | ||
| PL | 27.01.2021 | ||
| RO | 27.01.2021 | ||
| RS | 27.01.2021 | ||
| SE | 27.01.2021 | ||
| SI | 27.01.2021 | ||
| SK | 27.01.2021 | ||
| SM | 27.01.2021 | ||
| BG | 27.04.2021 | ||
| NO | 27.04.2021 | ||
| GR | 28.04.2021 | ||
| PT | 27.05.2021 | ||
| CH | 31.08.2021 | ||
| LI | 31.08.2021 | ||
| Former [2022/18] | AL | 27.01.2021 | |
| AT | 27.01.2021 | ||
| CZ | 27.01.2021 | ||
| DK | 27.01.2021 | ||
| EE | 27.01.2021 | ||
| ES | 27.01.2021 | ||
| FI | 27.01.2021 | ||
| HR | 27.01.2021 | ||
| LT | 27.01.2021 | ||
| LV | 27.01.2021 | ||
| MC | 27.01.2021 | ||
| NL | 27.01.2021 | ||
| PL | 27.01.2021 | ||
| RO | 27.01.2021 | ||
| RS | 27.01.2021 | ||
| SE | 27.01.2021 | ||
| SI | 27.01.2021 | ||
| SK | 27.01.2021 | ||
| SM | 27.01.2021 | ||
| BG | 27.04.2021 | ||
| NO | 27.04.2021 | ||
| GR | 28.04.2021 | ||
| PT | 27.05.2021 | ||
| Former [2022/13] | AL | 27.01.2021 | |
| AT | 27.01.2021 | ||
| CZ | 27.01.2021 | ||
| DK | 27.01.2021 | ||
| EE | 27.01.2021 | ||
| ES | 27.01.2021 | ||
| FI | 27.01.2021 | ||
| HR | 27.01.2021 | ||
| LT | 27.01.2021 | ||
| LV | 27.01.2021 | ||
| NL | 27.01.2021 | ||
| PL | 27.01.2021 | ||
| RO | 27.01.2021 | ||
| RS | 27.01.2021 | ||
| SE | 27.01.2021 | ||
| SI | 27.01.2021 | ||
| SK | 27.01.2021 | ||
| SM | 27.01.2021 | ||
| BG | 27.04.2021 | ||
| NO | 27.04.2021 | ||
| GR | 28.04.2021 | ||
| PT | 27.05.2021 | ||
| Former [2022/10] | AL | 27.01.2021 | |
| AT | 27.01.2021 | ||
| CZ | 27.01.2021 | ||
| DK | 27.01.2021 | ||
| EE | 27.01.2021 | ||
| ES | 27.01.2021 | ||
| FI | 27.01.2021 | ||
| HR | 27.01.2021 | ||
| LT | 27.01.2021 | ||
| LV | 27.01.2021 | ||
| NL | 27.01.2021 | ||
| PL | 27.01.2021 | ||
| RO | 27.01.2021 | ||
| RS | 27.01.2021 | ||
| SE | 27.01.2021 | ||
| SK | 27.01.2021 | ||
| SM | 27.01.2021 | ||
| BG | 27.04.2021 | ||
| NO | 27.04.2021 | ||
| GR | 28.04.2021 | ||
| PT | 27.05.2021 | ||
| Former [2022/08] | AL | 27.01.2021 | |
| AT | 27.01.2021 | ||
| CZ | 27.01.2021 | ||
| DK | 27.01.2021 | ||
| EE | 27.01.2021 | ||
| ES | 27.01.2021 | ||
| FI | 27.01.2021 | ||
| HR | 27.01.2021 | ||
| LT | 27.01.2021 | ||
| LV | 27.01.2021 | ||
| NL | 27.01.2021 | ||
| PL | 27.01.2021 | ||
| RO | 27.01.2021 | ||
| RS | 27.01.2021 | ||
| SE | 27.01.2021 | ||
| SK | 27.01.2021 | ||
| SM | 27.01.2021 | ||
| BG | 27.04.2021 | ||
| NO | 27.04.2021 | ||
| GR | 28.04.2021 | ||
| IS | 27.05.2021 | ||
| PT | 27.05.2021 | ||
| Former [2022/07] | AL | 27.01.2021 | |
| AT | 27.01.2021 | ||
| CZ | 27.01.2021 | ||
| DK | 27.01.2021 | ||
| EE | 27.01.2021 | ||
| FI | 27.01.2021 | ||
| HR | 27.01.2021 | ||
| LT | 27.01.2021 | ||
| LV | 27.01.2021 | ||
| NL | 27.01.2021 | ||
| PL | 27.01.2021 | ||
| RO | 27.01.2021 | ||
| RS | 27.01.2021 | ||
| SE | 27.01.2021 | ||
| SK | 27.01.2021 | ||
| SM | 27.01.2021 | ||
| BG | 27.04.2021 | ||
| NO | 27.04.2021 | ||
| GR | 28.04.2021 | ||
| IS | 27.05.2021 | ||
| PT | 27.05.2021 | ||
| Former [2021/50] | AT | 27.01.2021 | |
| CZ | 27.01.2021 | ||
| DK | 27.01.2021 | ||
| EE | 27.01.2021 | ||
| FI | 27.01.2021 | ||
| HR | 27.01.2021 | ||
| LT | 27.01.2021 | ||
| LV | 27.01.2021 | ||
| NL | 27.01.2021 | ||
| PL | 27.01.2021 | ||
| RO | 27.01.2021 | ||
| RS | 27.01.2021 | ||
| SE | 27.01.2021 | ||
| SK | 27.01.2021 | ||
| SM | 27.01.2021 | ||
| BG | 27.04.2021 | ||
| NO | 27.04.2021 | ||
| GR | 28.04.2021 | ||
| IS | 27.05.2021 | ||
| PT | 27.05.2021 | ||
| Former [2021/49] | AT | 27.01.2021 | |
| CZ | 27.01.2021 | ||
| DK | 27.01.2021 | ||
| EE | 27.01.2021 | ||
| FI | 27.01.2021 | ||
| HR | 27.01.2021 | ||
| LT | 27.01.2021 | ||
| LV | 27.01.2021 | ||
| NL | 27.01.2021 | ||
| PL | 27.01.2021 | ||
| RS | 27.01.2021 | ||
| SE | 27.01.2021 | ||
| SM | 27.01.2021 | ||
| BG | 27.04.2021 | ||
| NO | 27.04.2021 | ||
| GR | 28.04.2021 | ||
| IS | 27.05.2021 | ||
| PT | 27.05.2021 | ||
| Former [2021/48] | AT | 27.01.2021 | |
| CZ | 27.01.2021 | ||
| EE | 27.01.2021 | ||
| FI | 27.01.2021 | ||
| HR | 27.01.2021 | ||
| LT | 27.01.2021 | ||
| LV | 27.01.2021 | ||
| NL | 27.01.2021 | ||
| PL | 27.01.2021 | ||
| RS | 27.01.2021 | ||
| SE | 27.01.2021 | ||
| SM | 27.01.2021 | ||
| BG | 27.04.2021 | ||
| NO | 27.04.2021 | ||
| GR | 28.04.2021 | ||
| IS | 27.05.2021 | ||
| PT | 27.05.2021 | ||
| Former [2021/46] | AT | 27.01.2021 | |
| FI | 27.01.2021 | ||
| HR | 27.01.2021 | ||
| LT | 27.01.2021 | ||
| LV | 27.01.2021 | ||
| NL | 27.01.2021 | ||
| PL | 27.01.2021 | ||
| RS | 27.01.2021 | ||
| SE | 27.01.2021 | ||
| SM | 27.01.2021 | ||
| BG | 27.04.2021 | ||
| NO | 27.04.2021 | ||
| GR | 28.04.2021 | ||
| IS | 27.05.2021 | ||
| PT | 27.05.2021 | ||
| Former [2021/42] | AT | 27.01.2021 | |
| FI | 27.01.2021 | ||
| HR | 27.01.2021 | ||
| LT | 27.01.2021 | ||
| LV | 27.01.2021 | ||
| NL | 27.01.2021 | ||
| PL | 27.01.2021 | ||
| RS | 27.01.2021 | ||
| SE | 27.01.2021 | ||
| BG | 27.04.2021 | ||
| NO | 27.04.2021 | ||
| GR | 28.04.2021 | ||
| IS | 27.05.2021 | ||
| PT | 27.05.2021 | ||
| Former [2021/39] | AT | 27.01.2021 | |
| FI | 27.01.2021 | ||
| HR | 27.01.2021 | ||
| LT | 27.01.2021 | ||
| LV | 27.01.2021 | ||
| NL | 27.01.2021 | ||
| PL | 27.01.2021 | ||
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| PT | 27.05.2021 | Cited in | International search | [A] WO2013130824 (SANGAMO BIOSCIENCES INC et al.) | [A] WO2014093701 (BROAD INST INC et al.) | [A] M. GARRIGA-CANUT ET AL: "Synthetic zinc finger repressors reduce mutant huntingtin expression in the brain of R6/2 mice", PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES, vol. 109, no. 45, 10 October 2012 (2012-10-10), pages E3136 - E3145, XP055161220, ISSN: 0027-8424, DOI: 10.1073/pnas.1206506109 DOI: http://dx.doi.org/10.1073/pnas.1206506109 | [A] CONG LE ET AL: "In Vivo Genome Engineering With AAV Vector Carrying CRISPR-Cas9 System", MOLECULAR THERAPY, vol. 22, no. Suppl. 1, May 2014 (2014-05-01), & 17TH ANNUAL MEETING OF THE AMERICAN-SOCIETY-OF-GENE-AND-CELL-THERAPY (ASGCT); WASHINGTON, DC, USA; MAY 21 -24, 2014, pages S214, XP002734380 | [T] A. FISZER ET AL: "Oligonucleotide-based strategies to combat polyglutamine diseases", NUCLEIC ACIDS RESEARCH, vol. 42, no. 11, 21 May 2014 (2014-05-21), pages 6787 - 6810, XP055161218, ISSN: 0305-1048, DOI: 10.1093/nar/gku385 DOI: http://dx.doi.org/10.1093/nar/gku385 | [T] SAMUEL H. STERNBERG ET AL: "DNA interrogation by the CRISPR RNA-guided endonuclease Cas9", NATURE, vol. 507, no. 7490, 29 January 2014 (2014-01-29), pages 62 - 67, XP055161285, ISSN: 0028-0836, DOI: 10.1038/nature13011 DOI: http://dx.doi.org/10.1038/nature13011 | [T] MICHELE SIMONATO ET AL: "Progress in gene therapy for neurological disorders", NATURE REVIEWS NEUROLOGY, vol. 9, no. 5, 23 April 2013 (2013-04-23), pages 277 - 291, XP055161287, ISSN: 1759-4758, DOI: 10.1038/nrneurol.2013.56 DOI: http://dx.doi.org/10.1038/nrneurol.2013.56 | [T] C. ZUCCATO ET AL: "Molecular Mechanisms and Potential Therapeutical Targets in Huntington's Disease", PHYSIOLOGICAL REVIEWS, vol. 90, no. 3, 1 July 2010 (2010-07-01), pages 905 - 981, XP055161189, ISSN: 0031-9333, DOI: 10.1152/physrev.00041.2009 DOI: http://dx.doi.org/10.1152/physrev.00041.2009 | Examination | NICOLAS MERIENNE ET AL: "The Self-Inactivating KamiCas9 System for the Editing of CNS Disease Genes", CELL REPORTS, vol. 20, no. 12, 1 September 2017 (2017-09-01), US, pages 2980 - 2991, XP055548036, ISSN: 2211-1247, DOI: 10.1016/j.celrep.2017.08.075 [DP] DOI: http://dx.doi.org/10.1016/j.celrep.2017.08.075 | ZOGHBI H Y ET AL: "Glutamine repeats and neurodegeneration", ANNUAL REVIEW OF NEUROSCIENCE, ANNUAL REVIEWS INC., PALO ALTO, CA, US, vol. 23, 1 January 2000 (2000-01-01), pages 217 - 247, XP002443799, ISSN: 0147-006X, DOI: 10.1146/ANNUREV.NEURO.23.1.217 DOI: http://dx.doi.org/10.1146/annurev.neuro.23.1.217 | by applicant | WO2013130824 | WO2014093701 | SMITH; WATERMAN, ADVANCES IN APPLIED MATHEMATICS, vol. 2, 1981, pages 482 - 489 | W.R. PEARSON, METHODS IN ENZYMOLOGY, vol. 183, 1990, pages 63 - 98 | VONSATTEL JP; DIFIGLIA M: "Huntington disease", J NEUROPATH EXP NEUROL, vol. 57, 1998, pages 369 - 384 | ZUCCATO C; VALENZA M; CATTANEO E: "Molecular mechanisms and potential therapeutical targets in Huntington's disease", PHYSIOL REV, vol. 90, no. 3, 2010, pages 905 - 981 | ROSS CA; TABRIZI SJ: "Huntington's disease: from molecular pathogenesis to clinical treatment", LANCET NEURL, vol. 10, no. 1, 2011, pages 83 - 98 | FISZER A; KRZYZOSIAK WJ: "Oligonucleotide-based strategies to combat polyglutamine diseases", NUCLEIC ACIDS RES, vol. 42, no. 11, 2014, pages 6787 - 6810 | DROUET V ET AL.: "Sustained effects of nonallele-specific Huntingtin silencing", ANN NEUROL, vol. 65, no. 3, 2009, pages 276 - 285 | DROUET V ET AL.: "Allele-specific silencing of mutant huntingtin in rodent brain and human stem cells", PLOS ONE, vol. 9, no. 6, 2014, pages E99341 | GARRIGA-CANUT M ET AL.: "Synthetic zinc finger repressors reduce mutant huntingtin expression in the brain of R6/2 mice", PROC NATL ACAD SCI USA, vol. 109, no. 45, 2012, pages E3136 - 3145 | CONG L ET AL.: "Multiplex genome engineering using CRISPR/Cas systems", SCIENCE, vol. 339, no. 6121, 2013, pages 819 - 823 | JINEK M ET AL.: "RNA-programmed genome editing in human cells", ELIFE, vol. 2, 2013, pages E00471 | STERNBERG SH; REDDING S; JINEK M; GREENE EC; DOUDNA JA: "DNA interrogation by the CRISPR RNA-guided endonuclease Cas9", NATURE, vol. 507, no. 7490, 2014, pages 62 - 67 | MERIENNE N; LE DOUCE J; FAIVRE E; DEGLON N; BONVENTO G: "Efficient gene delivery and selective transduction of astrocytes in the mammalian brain using viral vectors", FRONT CELL NEUROSCI, vol. 7, 2013, pages 106 | SIMONATO M ET AL.: "Progress in gene therapy for neurological disorders", NAT REV NEUROL, vol. 9, no. 5, 2013, pages 277 - 291 | CARTIER N ET AL.: "Hematopoietic stem cell gene therapy with a lentiviral vector in X-linked adrenoleukodystrophy", SCIENCE, vol. 326, no. 5954, 2009, pages 818 - 823 | PALFI S ET AL.: "Long-term safety and tolerability of ProSavin, a lentiviral vector-based gene therapy for Parkinson's disease: a dose escalation, open-label, phase 1/2 trial", LANCET, vol. 383, no. 9923, 2014, pages 1138 - 1146 | WEINBERG MS; SAMULSKI RJ; MCCOWN TJ: "Adeno-associated virus (AAV) gene therapy for neurological disease", NEUROPHARMACOLOGY, vol. 69, 2013, pages 82 - 88 | NALDINI L ET AL.: "In vivo gene delivery and stable transduction of nondividing cells by a lentiviral vector", SCIENCE, vol. 272, no. 5259, 1996, pages 263 - 267 | MALI P ET AL.: "RNA-guided human genome engineering via Cas9", SCIENCE, vol. 339, no. 6121, 2013, pages 823 - 826 | JINEK M ET AL.: "A programmable dual-RNA-guided DNA endonuclease in adaptive bacterial immunity", SCIENCE, vol. 337, no. 6096, 2012, pages 816 - 821 | HIRANO M ET AL.: "Highly efficient retrograde gene transfer into motor neurons by a lentiviral vector pseudotyped with fusion glycoprotein", PLOS ONE, vol. 8, no. 9, 2013, pages E75896 | CASTLE MJ; GERSHENSON ZT; GILES AR; HOLZBAUR EL; WOLFE JH: "Adeno-Associated Virus Serotypes 1, 8, and 9 Share Conserved Mechanisms for Anterograde and Retrograde Axonal Transport", HUM GENE THER, vol. 25, no. 8, 2014, pages 705 - 720 | GRIMM D ET AL.: "In vitro and in vivo gene therapy vector evolution via multispecies interbreeding and retargeting of adeno-associated viruses", J VIROL, vol. 82, no. 12, 2008, pages 5887 - 5911 | MELO SP ET AL.: "Somatic Correction of Junctional Epidermolysis Bullosa by a Highly Recombinogenic AAV Variant", MOL THER, vol. 22, no. 4, 2014, pages 725 - 733 | DEGLON N ET AL.: "Self-inactivating lentiviral vectors with enhanced transgene expression as potential gene transfer system in Parkinson's disease", HUM GENE THER, vol. 11, no. 1, 2000, pages 179 - 190 | HOTTINGER AF; AZZOUZ M; DEGLON N; AEBISCHER P; ZURN AD: "Complete and long-term rescue oflesioned adult motoneurons by lentiviral-mediated expression of glial cell line-derived neurotrophic factor in the facial nucleus", J NEUROSC, vol. 20, no. 15, 2000, pages 5587 - 5593 | DULL T ET AL.: "A third-generation lentivirus vector with a conditional packaging system", J VIROL, vol. 72, no. 11, 1998, pages 8463 - 8471 | LOW K; AEBISCHER P; SCHNEIDER BL: "Direct and retrograde transduction of nigral neurons with AAV6, 8, and 9 and intraneuronal persistence of viral particles", HUM GENE THER, vol. 24, no. 6, 2013, pages 613 - 629 | DRINKUT A; TERESHCHENKO Y; SCHULZ JB; BAHR M; KUGLER S: "Efficient gene therapy for Parkinson's disease using astrocytes as hosts for localized neurotrophic factor delivery", MOL THER, vol. 20, no. 3, 2012, pages 534 - 543 | AURNHAMMER C ET AL.: "Universal real-time PCR for the detection and quantification of adeno-associated virus serotype 2-derived inverted terminal repeat sequences", HUM GENE THER METHODS, vol. 23, no. 1, 2012, pages 18 - 28 | DUJARDIN S ET AL.: "Ectosomes: a new mechanism for non-exosomal secretion of tau protein", PLOS ONE, vol. 9, no. 6, 2014, pages EL00760 | QIU P ET AL.: "Mutation detection using Surveyor nuclease", BIOTECHNIQUES, vol. 36, no. 4, 2004, pages 702 - 707 | RAN FA ET AL.: "Genome engineering using the CRISPR-Cas9 system", NAT PROTOC, vol. 8, no. 11, 2013, pages 2281 - 2308 |