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Extract from the Register of European Patents

EP About this file: EP3233882

EP3233882 - FLUORINATED CYCLIC DINUCLEOTIDES FOR CYTOKINE INDUCTION [Right-click to bookmark this link]
Former [2017/43]CYCLIC DINUCLEOTIDES FOR CYTOKINE INDUCTION
[2019/25]
StatusNo opposition filed within time limit
Status updated on  04.09.2020
Database last updated on 14.09.2024
FormerThe patent has been granted
Status updated on  27.09.2019
FormerGrant of patent is intended
Status updated on  13.06.2019
FormerExamination is in progress
Status updated on  15.06.2018
FormerRequest for examination was made
Status updated on  22.09.2017
FormerThe international publication has been made
Status updated on  16.06.2017
Most recent event   Tooltip08.07.2022Lapse of the patent in a contracting state
New state(s): MK		published on 10.08.2022  [2022/32]
Applicant(s)For all designated states
Kayla Therapeutics
77 avenue de Toulouse
31240 L'Union / FR
[2019/07]
Former [2017/43]For all designated states
Invivogen
5 rue Jean Rodier
ZI de Montaudran
31400 Toulouse / FR
Inventor(s)01 / VERNEJOUL, Fabienne
Rés. Jardin Royal II, Appart 90D
1 Chemin du Marin
31100 Toulouse / FR
02 / TIRABY, Gérard
39 Chemin des Côtes de Pech David, Villa 41
31400 Toulouse / FR
03 / LIOUX, Thierry
1 rue Raoul Follereau
Cyprié Village
31130 Balma / FR
 [2017/43]
Representative(s)Plasseraud IP
104 Rue de Richelieu
CS92104
75080 Paris Cedex 02 / FR
[N/P]
Former [2017/43]Cabinet Plasseraud
66, rue de la Chaussée d'Antin
75440 Paris Cedex 09 / FR
Application number, filing date15762583.109.09.2015
[2017/43]
WO2015EP70635
Priority number, dateEP2014030705416.12.2014         Original published format: EP 14307054
[2017/43]
Filing languageEN
Procedural languageEN
PublicationType: A1 Application with search report
No.:WO2016096174
Date:23.06.2016
Language:EN
[2016/25]
Type: A1 Application with search report 
No.:EP3233882
Date:25.10.2017
Language:EN
The application published by WIPO in one of the EPO official languages on 23.06.2016 takes the place of the publication of the European patent application.
[2017/43]
Type: B1 Patent specification 
No.:EP3233882
Date:30.10.2019
Language:EN
[2019/44]
Search report(s)International search report - published on:EP23.06.2016
ClassificationIPC:C07H21/04, A61K31/7084, A61P37/00
[2019/25]
CPC:
C07H21/04 (EP,CN,US); A61K31/7084 (EP,US); A61P31/04 (EP);
A61P31/12 (EP); A61P35/00 (EP); A61P37/00 (EP);
C07H21/00 (US); C07H21/02 (US) (-)
C-Set:
A61K31/7084, A61K2300/00 (EP,US)
Former IPC [2017/43]C07H21/00, A61K31/7084, A61P37/00
Designated contracting statesAL,   AT,   BE,   BG,   CH,   CY,   CZ,   DE,   DK,   EE,   ES,   FI,   FR,   GB,   GR,   HR,   HU,   IE,   IS,   IT,   LI,   LT,   LU,   LV,   MC,   MK,   MT,   NL,   NO,   PL,   PT,   RO,   RS,   SE,   SI,   SK,   SM,   TR [2017/43]
Extension statesBANot yet paid
MENot yet paid
Validation statesMANot yet paid
TitleGerman:FLUORINIERTE CYCLISCHE DINUKLEOTIDE ZUR CYTOKININDUKTION[2019/25]
English:FLUORINATED CYCLIC DINUCLEOTIDES FOR CYTOKINE INDUCTION[2019/25]
French:DINUCLÉOTIDES CYCLIQUES FLUORÉS POUR L'INDUCTION DE LA CYTOKINE[2019/25]
Former [2017/43]CYCLISCHE DINUKLEOTIDE ZUR CYTOKININDUKTION
Former [2017/43]CYCLIC DINUCLEOTIDES FOR CYTOKINE INDUCTION
Former [2017/43]DINUCLÉOTIDES CYCLIQUES POUR L'INDUCTION DE CYTOKINES
Entry into regional phase16.06.2017National basic fee paid 
16.06.2017Designation fee(s) paid 
16.06.2017Examination fee paid 
Examination procedure16.06.2017Examination requested  [2017/43]
16.06.2017Date on which the examining division has become responsible
20.11.2017Amendment by applicant (claims and/or description)
14.06.2018Despatch of a communication from the examining division (Time limit: M04)
23.10.2018Reply to a communication from the examining division
08.02.2019Despatch of a communication from the examining division (Time limit: M04)
06.05.2019Reply to a communication from the examining division
14.06.2019Communication of intention to grant the patent
13.09.2019Fee for grant paid
13.09.2019Fee for publishing/printing paid
13.09.2019Receipt of the translation of the claim(s)
Divisional application(s)EP19174902.7  / EP3546473
Opposition(s)31.07.2020No opposition filed within time limit [2020/41]
Fees paidRenewal fee
21.07.2017Renewal fee patent year 03
16.07.2018Renewal fee patent year 04
18.09.2019Renewal fee patent year 05
Opt-out from the exclusive  Tooltip
competence of the Unified
Patent Court		 See the Register of the Unified Patent Court for opt-out data
Responsibility for the accuracy, completeness or quality of the data displayed under the link provided lies entirely with the Unified Patent Court.
Lapses during opposition  TooltipHU09.09.2015
AL30.10.2019
CY30.10.2019
CZ30.10.2019
EE30.10.2019
HR30.10.2019
LT30.10.2019
LV30.10.2019
MC30.10.2019
MK30.10.2019
MT30.10.2019
RO30.10.2019
RS30.10.2019
SI30.10.2019
SK30.10.2019
SM30.10.2019
TR30.10.2019
BG30.01.2020
GR31.01.2020
IS29.02.2020
[2022/32]
Former [2022/28]HU09.09.2015
AL30.10.2019
CY30.10.2019
CZ30.10.2019
EE30.10.2019
HR30.10.2019
LT30.10.2019
LV30.10.2019
MC30.10.2019
MT30.10.2019
RO30.10.2019
RS30.10.2019
SI30.10.2019
SK30.10.2019
SM30.10.2019
TR30.10.2019
BG30.01.2020
GR31.01.2020
IS29.02.2020
Former [2022/27]HU09.09.2015
AL30.10.2019
CY30.10.2019
CZ30.10.2019
EE30.10.2019
HR30.10.2019
LT30.10.2019
LV30.10.2019
MT30.10.2019
RO30.10.2019
RS30.10.2019
SI30.10.2019
SK30.10.2019
SM30.10.2019
TR30.10.2019
BG30.01.2020
GR31.01.2020
IS29.02.2020
Former [2020/51]AL30.10.2019
CZ30.10.2019
EE30.10.2019
HR30.10.2019
LT30.10.2019
LV30.10.2019
RO30.10.2019
RS30.10.2019
SI30.10.2019
SK30.10.2019
SM30.10.2019
BG30.01.2020
GR31.01.2020
IS29.02.2020
Former [2020/37]AL30.10.2019
CZ30.10.2019
EE30.10.2019
HR30.10.2019
LT30.10.2019
LV30.10.2019
RO30.10.2019
RS30.10.2019
SK30.10.2019
SM30.10.2019
BG30.01.2020
GR31.01.2020
IS29.02.2020
Former [2020/35]AL30.10.2019
CZ30.10.2019
HR30.10.2019
LT30.10.2019
LV30.10.2019
RO30.10.2019
RS30.10.2019
BG30.01.2020
GR31.01.2020
IS29.02.2020
Former [2020/32]AL30.10.2019
HR30.10.2019
LT30.10.2019
LV30.10.2019
RS30.10.2019
BG30.01.2020
GR31.01.2020
IS29.02.2020
Former [2020/26]HR30.10.2019
LT30.10.2019
LV30.10.2019
RS30.10.2019
BG30.01.2020
GR31.01.2020
IS29.02.2020
Former [2020/24]LT30.10.2019
LV30.10.2019
BG30.01.2020
GR31.01.2020
IS29.02.2020
Former [2020/22]LT30.10.2019
BG30.01.2020
Cited inInternational search[A]WO2014179335  (SLOAN KETTERING INST CANCER [US], et al) [A] 1-12 * the whole document * * page 37, paragraphs 99-100 * * page 2, paragraph 0003 * * page 82, paragraphs 0218-0220; claim - * * figure S7B *;
 [AD]WO2014189805  (AURO BIOTECH INC [US], et al) [AD] 1-12 * abstract * * page 3, paragraph 9; claim - * * page 12, paragraph 66 * * page 19, paragraph 89 * * claim - *;
 [A]  - TAKAFUMI TEZUKA ET AL, "Synthesis of 2'-Modified Cyclic Bis(3'-5')diadenylic Acids (c-di-AMPs) and Their Promotion of Cell Division in a Freshwater Green Alga", CHEMISTRY LETTERS, (20121208), vol. 41, no. 12, doi:10.1246/cl.2012.1723, ISSN 0366-7022, pages 1723 - 1725, XP055172477 [A] 1-12 * the whole document * *Page 1723; Chart 1; compound 1c*

DOI:   http://dx.doi.org/10.1246/cl.2012.1723
 [AD]  - CARLY A. SHANAHAN ET AL, "Identification of c-di-GMP Derivatives Resistant to an EAL Domain Phosphodiesterase", BIOCHEMISTRY, (20130115), vol. 52, no. 2, doi:10.1021/bi301510v, ISSN 0006-2960, pages 365 - 377, XP055172476 [AD] 1-12 * abstract * * page 369; figure 3; compounds c-di-2'F-GMP * * "Enzymatic Hydrolysis of Analogues containing ribose modifications"; page 370, column left, paragraph last - column right, paragraph first *

DOI:   http://dx.doi.org/10.1021/bi301510v
 [A]  - BENJAMIN T. ROEMBKE ET AL, "A cyclic dinucleotide containing 2-aminopurine is a general fluorescent sensor for c-di-GMP and 3',3'-cGAMP", MOLECULAR BIOSYSTEMS, (20140328), vol. 10, no. 6, doi:10.1039/c3mb70518h, ISSN 1742-206X, page 1568, XP055172186 [A] 1-12 * abstract * * page 1569; figure 1; compound 1 *

DOI:   http://dx.doi.org/10.1039/c3mb70518h
 [AD]  - LINGYIN LI ET AL, "Hydrolysis of 2'3'-cGAMP by ENPP1 and design of nonhydrolyzable analogs", NATURE CHEMICAL BIOLOGY, (20141026), vol. 10, no. 12, doi:10.1038/nchembio.1661, ISSN 1552-4450, pages 1043 - 1048, XP055172172 [AD] 1-12 * abstract * * page 1043, column left; figure 4; compounds 4-6 *

DOI:   http://dx.doi.org/10.1038/nchembio.1661
by applicantUS2014066436
 US2014205653
 US2014329889
 WO2014189805
 US2015056224
 WO2015077354
    - ABLASSER, A.; GOLDECK, M.; CAVLAR, T.; DEIMLING, T.; WITTE, G.; ROHL, I.; HOMUNG, V., "cGAS produces a 2'-5'-linked cyclic dinucleotide second messenger that activates STING", NATURE, (2013), vol. 498, no. 7454, pages 380 - 384
    - CHEN, H.; SUN, H.; YOU, F.; SUN, W.; ZHOU, X.; CHEN, L.; JIANG, Z., "Activation of STAT6 by STING is critical for antiviral innate immunity", CELL, (2011), vol. 147, no. 2, pages 436 - 446
    - DANILCHANKA, 0.; MEKALANOS, J. J., "Cyclic dinucleotides and the innate immune response", CELL, (2013), vol. 154, no. 5, pages 962 - 970
    - DINER, E. J.; BURDETTE, D. L.; WILSON, S. C.; MONROE, K. M.; KELLENBERGER, C. A.; HYODO, M.; VANCE, R. E., "The innate immune DNA sensor cGAS produces a noncanonical cyclic dinucleotide that activates human STING", CELL REP, (2013), vol. 3, no. 5, pages 1355 - 1361
    - DUBENSKY, T. W., JR.; KANNE, D. B.; LEONG, M. L., "Rationale, progress and development of vaccines utilizing STING-activating cyclic dinucleotide adjuvants", THERADV VACCINES, (2013), vol. 1, no. 4, pages 131 - 143
    - FENSTERL, V.; WHITE, C. L.; YAMASHITA, M.; SEN, G. C., "Novel characteristics of the function and induction of murine p56 family proteins", J VIROL, (2008), vol. 82, no. 22, pages 11045 - 11053
    - GOMELSKY, M., "cAMP, c-di-GMP, c-di-AMP and now cGMP: bacteria use them all!", MOL MICROBIOL, (2011), vol. 79, no. 3, pages 562 - 565
    - HECKER, S. J.; ERION, M. D., "Prodrugs of phosphates and phosphonates", J MED CHEM, (2008), vol. 51, no. 8, pages 2328 - 2345
    - HERDEWIJNA, P. V. A. A. A. K. L., "Synthesis of Nucleosides Fluorinated in the Sugar Moiety. The Application of Diethylaminosulfur Trifluoride to the Synthesis of Fluorinated Nucleosides", NUCLEOSIDES AND NUCLEOTIDES, (1989), vol. 8, no. 1, pages 65 - 96
    - JONES, R. B., N., "Nucleotide prodrugs", ANTIVIRAL RESEARCH, (1995), vol. 27, no. 1-2, pages 1 - 17
    - LI, L.; YIN, Q.; KUSS, P.; MALIGA, Z.; MILLAN, J. L.; WU, H.; MITCHISON, T. J., "Hydrolysis of 2'3'-cGAMP by ENPP1 and design of nonhydrolyzable analogs", NAT CHEM BIOL, (2014), vol. 10, no. 12, pages 1043 - 1048
    - RAUTIO, J.; KUMPULAINEN, H.; HEIMBACH, T.; OLIYAI, R.; OH, D.; JARVINEN, T.; SAVOLAINEN, J., "Prodrugs: design and clinical applications", NAT REV DRUG DISCOV, (2008), vol. 7, no. 3, pages 255 - 270
    - ROSS, B. S. S., R.H.; SPRANKLE, K.G.; VASQUEZ, G., "An Efficient and Scalable Synthesis of Arabinosylguanine and 2'-Deoxy-2'-Fluoro-guanosine", NUCLEOSIDES AND NUCLEOTIDES, (1997), vol. 16, no. 7-9, pages 1645 - 1647
    - SHANAHAN, C. A.; GAFFNEY, B. L.; JONES, R. A.; STROBEL, S. A., "Identification of c-di-GMP derivatives resistant to an EAL domain phosphodiesterase", BIOCHEMISTRY, (2013), vol. 52, no. 2, pages 365 - 377
    - SIMM, R.; MORR, M.; KADER, A.; NIMTZ, M.; ROMLING, U., "GGDEF and EAL domains inversely regulate cyclic di-GMP levels and transition from sessility to motility", MOL MICROBIOL, (2004), vol. 53, no. 4, pages 1123 - 1134
    - THOMAS, H. J.; TIWARIA, K.N.; CLAYTONA, S.J.; SECRIST J.A.; MONTGOMERY J.A, "Synthesis and Biologic Activity of Purine 2'-Deoxy-2'-fluoro-ribonucleosides", NUCLEOSIDES AND NUCLEOTIDES, (1994), vol. 13, no. 1-3, pages 309 - 323
    - ZHANG, X.; SHI, H.; WU, J.; ZHANG, X.; SUN, L.; CHEN, C.; CHEN, Z. J., "Cyclic GMP-AMP containing mixed phosphodiester linkages is an endogenous high-affinity ligand for STING", MOL CELL, (2013), vol. 51, no. 2, pages 226 - 235
The EPO accepts no responsibility for the accuracy of data originating from other authorities; in particular, it does not guarantee that it is complete, up to date or fit for specific purposes.