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EP3194438
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EP About this file: EP3194438
| EP3194438 - ANTIBODIES BINDING TO BMP4, AND USES THEREOF [Right-click to bookmark this link] | Status | The patent has been granted Status updated on 01.03.2024 Database last updated on 20.07.2024 | |
| Former | Grant of patent is intended Status updated on 05.11.2023 | ||
| Former | Examination is in progress Status updated on 07.09.2018 | ||
| Former | Request for examination was made Status updated on 23.06.2017 | ||
| Former | The international publication has been made Status updated on 18.04.2017 | Most recent event Tooltip | 01.03.2024 | (Expected) grant | published on 03.04.2024 [2024/14] | Applicant(s) | For all designated states Upadia Holding BV Kweekduinweg 12 2051 EL Overveen / NL | [2024/14] |
| Former [2021/35] | For all designated states Upadia Holding BV Kweekduinweg 12 2051 EL Overveen / NL | ||
| Former [2017/30] | For all designated states Academisch Medisch Centrum Bureau Kennistransfer AMC TKs0-136 (De Rode Luifel) Meibergdreef 9 AMC 1105 AZ Amsterdam / NL | Inventor(s) | 01 /
KRISHNADATH, Kausilia Krishnawatie Kweekduinweg 12 NL-2051 EL Overveen / NL | 02 /
CALPE, Silvia IXA office AMC Meibergdreef 9 NL-1105 AZ Amsterdam / NL | [2017/30] | Representative(s) | De Vries & Metman, et al Overschiestraat 180 1062 XK Amsterdam / NL | [2024/14] |
| Former [2017/30] | de Pauw, Elmar Sebastian David, et al Bureau Kennistransfer AMC TKs0-136 (De Rode Luifel) Meibergdreef 9 1105 AZ Amsterdam / NL | Application number, filing date | 15763610.1 | 16.09.2015 | [2017/30] | WO2015EP71270 | Priority number, date | WO2014NL50632 | 16.09.2014 Original published format: PCT/NL2014/050632 | [2017/30] | Filing language | EN | Procedural language | EN | Publication | Type: | A1 Application with search report | No.: | WO2016042050 | Date: | 24.03.2016 | Language: | EN | [2016/12] | Type: | A1 Application with search report | No.: | EP3194438 | Date: | 26.07.2017 | Language: | EN | The application published by WIPO in one of the EPO official languages on 24.03.2016 takes the place of the publication of the European patent application. | [2017/30] | Type: | B1 Patent specification | No.: | EP3194438 | Date: | 03.04.2024 | Language: | EN | [2024/14] | Search report(s) | International search report - published on: | EP | 24.03.2016 | Classification | IPC: | C07K16/22, A61K39/395 | [2017/30] | CPC: |
C07K16/22 (EP,US);
A61K33/243 (EP,US);
A61K35/00 (US);
A61P13/12 (EP);
A61P17/14 (EP);
A61P19/02 (EP);
A61P19/08 (EP);
A61P21/00 (EP);
A61P27/16 (EP);
A61P3/10 (EP);
A61P35/00 (EP);
A61P37/04 (EP);
A61P9/00 (EP);
A61P9/10 (EP);
A61P9/12 (EP);
C07K2317/22 (EP,US);
C07K2317/31 (EP,US);
C07K2317/33 (EP,US);
C07K2317/34 (EP,US);
C07K2317/35 (EP,US);
C07K2317/569 (EP,US);
| Designated contracting states | AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LI, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR [2017/30]
| Extension states | BA | Not yet paid | ME | Not yet paid | Validation states | MA | Not yet paid | Title | German: | AN BMP4 BINDENDE ANTIKÖRPER UND VERWENDUNGEN DAVON | [2017/30] | English: | ANTIBODIES BINDING TO BMP4, AND USES THEREOF | [2017/30] | French: | ANTICORPS DE LIAISON À BMP4, ET LEURS UTILISATIONS | [2017/30] | Entry into regional phase | 18.04.2017 | National basic fee paid | 18.04.2017 | Designation fee(s) paid | 18.04.2017 | Examination fee paid | Examination procedure | 16.04.2017 | Date on which the examining division has become responsible | 18.04.2017 | Examination requested [2017/30] | 08.11.2017 | Amendment by applicant (claims and/or description) | 10.09.2018 | Despatch of a communication from the examining division (Time limit: M04) | 18.04.2019 | Reply to a communication from the examining division | 07.04.2020 | Despatch of a communication from the examining division (Time limit: M06) | 10.11.2020 | Despatch of communication that the application is deemed to be withdrawn, reason: reply to the communication from the examining division not received in time | 13.01.2021 | Reply to a communication from the examining division | 19.01.2023 | Cancellation of oral proceeding that was planned for 20.01.2023 | 20.01.2023 | Date of oral proceedings (cancelled) | 22.06.2023 | Despatch of a communication from the examining division (Time limit: M01) | 05.07.2023 | Reply to a communication from the examining division | 06.11.2023 | Communication of intention to grant the patent | 21.02.2024 | Fee for grant paid | 21.02.2024 | Fee for publishing/printing paid | 21.02.2024 | Receipt of the translation of the claim(s) | Request for further processing for: | The application is deemed to be withdrawn due to failure to reply to the examination report | 13.01.2021 | Request for further processing filed | 13.01.2021 | Full payment received (date of receipt of payment) Request granted | 04.02.2021 | Decision despatched | The application is deemed to be withdrawn due to failure to reply to the examination report | 18.04.2019 | Request for further processing filed | 18.04.2019 | Full payment received (date of receipt of payment) Request granted | 06.05.2019 | Decision despatched | Fees paid | Renewal fee | 02.10.2017 | Renewal fee patent year 03 | 01.10.2018 | Renewal fee patent year 04 | 30.09.2019 | Renewal fee patent year 05 | 31.03.2021 | Renewal fee patent year 06 | 29.09.2021 | Renewal fee patent year 07 | 29.09.2022 | Renewal fee patent year 08 | 27.11.2023 | Renewal fee patent year 09 | Penalty fee | Additional fee for renewal fee | 30.09.2020 | 06 M06 Fee paid on 31.03.2021 | 30.09.2023 | 09 M06 Fee paid on 27.11.2023 |
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| Responsibility for the accuracy, completeness or quality of the data displayed under the link provided lies entirely with the Unified Patent Court. | Cited in | International search | [XYI]WO2008030611 (MEDAREX INC [US], et al) [X] 11-14 * p.104, §2; Antibodies 8B3 and 7D6 bind BMP2/4 epitope corresponding to residues 87-101; with high affinity (Table1); blocking binding, Example 7. * [Y] 1,4-9,31-33 [I] 1,4-9,11-23,30-40; | [IY]EP2047862 (CHUGAI PHARMACEUTICAL CO LTD [JP]) [I] 1,4-9,11-23,30-40 * paragraph [0017] - paragraph [0020]; example 2 *[Y] 1,4-9,31-33; | [XAYI] - A. BHATTACHERJEE ET AL, "Bone Morphogenetic Protein 4 Mediates Estrogen-Regulated Sensory Axon Plasticity in the Adult Female Reproductive Tract", JOURNAL OF NEUROSCIENCE, (20130116), vol. 33, no. 3, doi:10.1523/JNEUROSCI.1704-12.2013, ISSN 0270-6474, pages 1050 - 1061, XP055178314 [X] 11-14 * figure 4 * [A] 1,4-9 [Y] 31-33 [I] 11-23,30-40 DOI: http://dx.doi.org/10.1523/JNEUROSCI.1704-12.2013 | [XAYI] - KWAK YOUNG-DON ET AL, "Secreted type of amyloid precursor protein induces glial differentiation by stimulating the BMP/Smad signaling pathway", BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, (20140413), vol. 447, no. 3, doi:10.1016/J.BBRC.2014.03.139, ISSN 0006-291X, pages 394 - 399, XP028655267 [X] 11-14 * Section 3.3 * [A] 1,4-9 [Y] 31-33 [I] 11-23,30-40 DOI: http://dx.doi.org/10.1016/j.bbrc.2014.03.139 | [AP] - SATISH KHURANA ET AL, "SMAD Signaling Regulates CXCL12 Expression in the Bone Marrow Niche, Affecting Homing and Mobilization of Hematopoietic Progenitors", STEM CELLS, (20141114), vol. 32, no. 11, doi:10.1002/stem.1794, ISSN 1066-5099, pages 3012 - 3022, XP055178311 [AP] 1,4-9 * p.3'16, col.2, first full para. * DOI: http://dx.doi.org/10.1002/stem.1794 | [A] - WEBER FRANZ E ET AL, "Deletion mutants of BMP folding variants act as BMP antagonists and are efficient inhibitors for heterotopic ossification", JOURNAL OF BONE AND MINERAL RESEARCH, BLACKWELL SCIENCE, INC, (20031201), vol. 18, no. 12, doi:10.1359/JBMR.2003.18.12.2142, ISSN 0884-0431, pages 2142 - 2151, XP002469933 [A] 1,4-9 * the whole document * DOI: http://dx.doi.org/10.1359/jbmr.2003.18.12.2142 | [Y] - DENG H ET AL, "Overexpression of bone morphogenetic protein 4 enhances the invasiveness of Smad4-deficient human colorectal cancer cells", CANCER LETTERS, NEW YORK, NY, US, vol. 281, no. 2, doi:10.1016/J.CANLET.2009.02.046, ISSN 0304-3835, (20090828), pages 220 - 231, (20090324), XP026194484 [Y] 1,4-9,31-33 * The whole document, in particular, p.228, col.1, §1 * DOI: http://dx.doi.org/10.1016/j.canlet.2009.02.046 | [Y] - PHILIP W. VOORNEVELD ET AL, "Loss of SMAD4 Alters BMP Signaling to Promote Colorectal Cancer Cell Metastasis via Activation of Rho and ROCK", GASTROENTEROLOGY, PHILADELPHIA, PA, (20140701), vol. 147, no. 1, doi:10.1053/j.gastro.2014.03.052, ISSN 0016-5085, pages 196 - 208.e13, XP055227478 [Y] 1,4-9,31-33 * the whole document * DOI: http://dx.doi.org/10.1053/j.gastro.2014.03.052 |