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Extract from the Register of European Patents

EP About this file: EP3186376

EP3186376 - METHODS FOR INCREASING CAS9-MEDIATED ENGINEERING EFFICIENCY [Right-click to bookmark this link]
StatusNo opposition filed within time limit
Status updated on  24.01.2020
Database last updated on 30.10.2024
FormerThe patent has been granted
Status updated on  15.02.2019
FormerGrant of patent is intended
Status updated on  11.02.2019
FormerExamination is in progress
Status updated on  18.01.2019
FormerGrant of patent is intended
Status updated on  17.12.2018
FormerExamination is in progress
Status updated on  12.01.2018
FormerRequest for examination was made
Status updated on  02.06.2017
FormerThe international publication has been made
Status updated on  25.02.2017
Most recent event   Tooltip01.07.2022Lapse of the patent in a contracting state
New state(s): MK		published on 03.08.2022  [2022/31]
Applicant(s)For all designated states
Caribou Biosciences, Inc.
2929 7th Street
Suite 105
Berkeley, CA 94710 / US
[2018/22]
Former [2017/27]For all designated states
Caribou Biosciences, Inc.
2929 7th Street
Suite 120
Berkeley, CA 94710 / US
Inventor(s)01 / CAMERON, Peter, Sean
2929 7th Street
Suite 120
Berkeley, CA 94710 / US
02 / HAURWITZ, Rachel, E.
2929 7th Street
Suite 120
Berkeley, CA 94710 / US
03 / MAY, Andrew, P.
2929 7th Street
Suite 120
Berkeley, CA 94710 / US
04 / NYE, Christopher, H
2929 7th Street
Suite 120
Berkeley, CA 94710 / US
05 / VAN OVERBEEK, Megan
2929 7th Street
Suite 120
Berkeley, CA 94710 / US
 [2017/27]
Representative(s)Grund, Martin
Grund Intellectual Property Group
Patentanwälte und Solicitor PartG mbB
Steinsdorfstraße 2
80538 München / DE
[N/P]
Former [2017/27]Grund, Martin
Grund Intellectual Property Group
Patentanwalt und Solicitor PartG mbB
Postfach 44 05 16
80754 München / DE
Application number, filing date15763698.626.08.2015
[2017/27]
WO2015US47046
Priority number, dateUS201462042358P27.08.2014         Original published format: US 201462042358 P
US201462047495P08.09.2014         Original published format: US 201462047495 P
[2017/27]
Filing languageEN
Procedural languageEN
PublicationType: A1 Application with search report
No.:WO2016033246
Date:03.03.2016
Language:EN
[2016/09]
Type: A1 Application with search report 
No.:EP3186376
Date:05.07.2017
Language:EN
The application published by WIPO in one of the EPO official languages on 03.03.2016 takes the place of the publication of the European patent application.
[2017/27]
Type: B1 Patent specification 
No.:EP3186376
Date:20.03.2019
Language:EN
[2019/12]
Search report(s)International search report - published on:EP03.03.2016
ClassificationIPC:C12N15/11, C12N15/10
[2018/51]
CPC:
C12N9/22 (EP,GB,IL,US); C12N15/907 (IL,US); C12N15/11 (GB);
A61K48/00 (GB); C12N15/09 (GB); C12N15/102 (EP,GB,IL,US);
C12N15/111 (EP,GB,IL,US); C12Y301/30 (EP,GB,IL,US); C12N2310/10 (EP,IL,US);
C12N2310/20 (EP,US) (-)
Former IPC [2017/27]C12N15/11, C12N15/09
Designated contracting statesAL,   AT,   BE,   BG,   CH,   CY,   CZ,   DE,   DK,   EE,   ES,   FI,   FR,   GB,   GR,   HR,   HU,   IE,   IS,   IT,   LI,   LT,   LU,   LV,   MC,   MK,   MT,   NL,   NO,   PL,   PT,   RO,   RS,   SE,   SI,   SK,   SM,   TR [2017/27]
Extension statesBANot yet paid
MENot yet paid
Validation statesMANot yet paid
TitleGerman:VERFAHREN ZUR ERHÖHUNG DER CAS9-VERMITTELTEN MANIPULATIONSEFFIZIENZ[2017/27]
English:METHODS FOR INCREASING CAS9-MEDIATED ENGINEERING EFFICIENCY[2017/27]
French:PROCÉDÉS POUR AUGMENTER L'EFFICACITÉ DE L'INGÉNIERIE MÉDIÉE PAR CAS9[2017/27]
Entry into regional phase24.02.2017National basic fee paid 
24.02.2017Designation fee(s) paid 
24.02.2017Examination fee paid 
Examination procedure24.02.2017Examination requested  [2017/27]
24.02.2017Date on which the examining division has become responsible
06.10.2017Amendment by applicant (claims and/or description)
16.01.2018Despatch of a communication from the examining division (Time limit: M04)
23.05.2018Reply to a communication from the examining division
21.06.2018Despatch of a communication from the examining division (Time limit: M04)
05.10.2018Reply to a communication from the examining division
18.12.2018Communication of intention to grant the patent
15.01.2019Disapproval of the communication of intention to grant the patent by the applicant or resumption of examination proceedings by the EPO
15.01.2019Fee for grant paid
15.01.2019Fee for publishing/printing paid
11.02.2019Information about intention to grant a patent
11.02.2019Receipt of the translation of the claim(s)
Opposition(s)02.01.2020No opposition filed within time limit [2020/09]
Fees paidRenewal fee
28.08.2017Renewal fee patent year 03
27.08.2018Renewal fee patent year 04
Opt-out from the exclusive  Tooltip
competence of the Unified
Patent Court		 See the Register of the Unified Patent Court for opt-out data
Responsibility for the accuracy, completeness or quality of the data displayed under the link provided lies entirely with the Unified Patent Court.
Lapses during opposition  TooltipHU26.08.2015
AL20.03.2019
AT20.03.2019
CY20.03.2019
CZ20.03.2019
EE20.03.2019
FI20.03.2019
HR20.03.2019
LT20.03.2019
LV20.03.2019
MC20.03.2019
MK20.03.2019
MT20.03.2019
PL20.03.2019
RO20.03.2019
RS20.03.2019
SI20.03.2019
SK20.03.2019
SM20.03.2019
TR20.03.2019
BG20.06.2019
GR21.06.2019
IS20.07.2019
PT20.07.2019
LU26.08.2019
BE31.08.2019
[2022/31]
Former [2021/34]HU26.08.2015
AL20.03.2019
AT20.03.2019
CY20.03.2019
CZ20.03.2019
EE20.03.2019
FI20.03.2019
HR20.03.2019
LT20.03.2019
LV20.03.2019
MC20.03.2019
MT20.03.2019
PL20.03.2019
RO20.03.2019
RS20.03.2019
SI20.03.2019
SK20.03.2019
SM20.03.2019
TR20.03.2019
BG20.06.2019
GR21.06.2019
IS20.07.2019
PT20.07.2019
LU26.08.2019
BE31.08.2019
Former [2021/33]HU26.08.2015
AL20.03.2019
AT20.03.2019
CY20.03.2019
CZ20.03.2019
EE20.03.2019
FI20.03.2019
HR20.03.2019
LT20.03.2019
LV20.03.2019
MC20.03.2019
PL20.03.2019
RO20.03.2019
RS20.03.2019
SI20.03.2019
SK20.03.2019
SM20.03.2019
TR20.03.2019
BG20.06.2019
GR21.06.2019
IS20.07.2019
PT20.07.2019
LU26.08.2019
BE31.08.2019
Former [2021/26]AL20.03.2019
AT20.03.2019
CY20.03.2019
CZ20.03.2019
EE20.03.2019
FI20.03.2019
HR20.03.2019
LT20.03.2019
LV20.03.2019
MC20.03.2019
PL20.03.2019
RO20.03.2019
RS20.03.2019
SI20.03.2019
SK20.03.2019
SM20.03.2019
TR20.03.2019
BG20.06.2019
GR21.06.2019
IS20.07.2019
PT20.07.2019
LU26.08.2019
BE31.08.2019
Former [2020/38]AL20.03.2019
AT20.03.2019
CZ20.03.2019
EE20.03.2019
FI20.03.2019
HR20.03.2019
LT20.03.2019
LV20.03.2019
MC20.03.2019
PL20.03.2019
RO20.03.2019
RS20.03.2019
SI20.03.2019
SK20.03.2019
SM20.03.2019
TR20.03.2019
BG20.06.2019
GR21.06.2019
IS20.07.2019
PT20.07.2019
LU26.08.2019
BE31.08.2019
Former [2020/25]AL20.03.2019
AT20.03.2019
CZ20.03.2019
EE20.03.2019
FI20.03.2019
HR20.03.2019
LT20.03.2019
LV20.03.2019
MC20.03.2019
PL20.03.2019
RO20.03.2019
RS20.03.2019
SI20.03.2019
SK20.03.2019
SM20.03.2019
TR20.03.2019
BG20.06.2019
GR21.06.2019
IS20.07.2019
PT20.07.2019
LU26.08.2019
Former [2020/17]AL20.03.2019
AT20.03.2019
CZ20.03.2019
EE20.03.2019
FI20.03.2019
HR20.03.2019
LT20.03.2019
LV20.03.2019
PL20.03.2019
RO20.03.2019
RS20.03.2019
SI20.03.2019
SK20.03.2019
SM20.03.2019
TR20.03.2019
BG20.06.2019
GR21.06.2019
IS20.07.2019
PT20.07.2019
Former [2020/13]AL20.03.2019
AT20.03.2019
CZ20.03.2019
EE20.03.2019
FI20.03.2019
HR20.03.2019
LT20.03.2019
LV20.03.2019
PL20.03.2019
RO20.03.2019
RS20.03.2019
SI20.03.2019
SK20.03.2019
SM20.03.2019
BG20.06.2019
GR21.06.2019
IS20.07.2019
PT20.07.2019
Former [2020/04]AL20.03.2019
AT20.03.2019
CZ20.03.2019
EE20.03.2019
FI20.03.2019
HR20.03.2019
LT20.03.2019
LV20.03.2019
PL20.03.2019
RO20.03.2019
RS20.03.2019
SK20.03.2019
SM20.03.2019
BG20.06.2019
GR21.06.2019
IS20.07.2019
PT20.07.2019
Former [2020/03]AL20.03.2019
AT20.03.2019
CZ20.03.2019
EE20.03.2019
FI20.03.2019
HR20.03.2019
LT20.03.2019
LV20.03.2019
PL20.03.2019
RO20.03.2019
RS20.03.2019
SK20.03.2019
SM20.03.2019
BG20.06.2019
GR21.06.2019
PT20.07.2019
Former [2019/52]AL20.03.2019
CZ20.03.2019
EE20.03.2019
FI20.03.2019
HR20.03.2019
LT20.03.2019
LV20.03.2019
PL20.03.2019
RO20.03.2019
RS20.03.2019
SK20.03.2019
SM20.03.2019
BG20.06.2019
GR21.06.2019
PT20.07.2019
Former [2019/51]AL20.03.2019
CZ20.03.2019
EE20.03.2019
FI20.03.2019
HR20.03.2019
LT20.03.2019
LV20.03.2019
RO20.03.2019
RS20.03.2019
SK20.03.2019
SM20.03.2019
BG20.06.2019
GR21.06.2019
PT20.07.2019
Former [2019/49]AL20.03.2019
CZ20.03.2019
EE20.03.2019
FI20.03.2019
HR20.03.2019
LT20.03.2019
LV20.03.2019
RO20.03.2019
RS20.03.2019
SK20.03.2019
BG20.06.2019
GR21.06.2019
PT20.07.2019
Former [2019/48]FI20.03.2019
HR20.03.2019
LT20.03.2019
LV20.03.2019
RS20.03.2019
BG20.06.2019
GR21.06.2019
PT20.07.2019
Former [2019/39]FI20.03.2019
HR20.03.2019
LT20.03.2019
LV20.03.2019
RS20.03.2019
BG20.06.2019
GR21.06.2019
Former [2019/38]FI20.03.2019
LT20.03.2019
BG20.06.2019
GR21.06.2019
Former [2019/37]FI20.03.2019
LT20.03.2019
GR21.06.2019
Former [2019/33]FI20.03.2019
LT20.03.2019
Cited inInternational search[IA]WO2014065596  (TOOLGEN INC [KR]) [I] 44-68 * figures 17-19; example 7 * [A] 1-25;
 [IA]WO2014093622  (BROAD INST INC [US], et al) [I] 44-68 * the whole document * [A] 1-25;
 [IA]  - L. CONG ET AL, "Multiplex Genome Engineering Using CRISPR/Cas Systems", SCIENCE, (20130103), vol. 339, no. 6121, doi:10.1126/science.1231143, ISSN 0036-8075, pages 819 - 823, XP055102030 [I] 44-68 * figure 4 * [A] 1-25

DOI:   http://dx.doi.org/10.1126/science.1231143
 [IA]  - JOHN P GUILINGER ET AL, "Fusion of catalytically inactive Cas9 to FokI nuclease improves the specificity of genome modification", NATURE BIOTECHNOLOGY, US, (20140425), vol. 32, no. 6, doi:10.1038/nbt.2909, ISSN 1087-0156, pages 577 - 582, XP055157221 [I] 44-68 * the whole document * [A] 1-25

DOI:   http://dx.doi.org/10.1038/nbt.2909
 [A]  - LEI S. QI ET AL, "Repurposing CRISPR as an RNA-Guided Platform for Sequence-Specific Control of Gene Expression", CELL, (20130228), vol. 152, no. 5, doi:10.1016/j.cell.2013.02.022, ISSN 0092-8674, pages 1173 - 1183, XP055068548 [A] 1-25,44-68 * the whole document *

DOI:   http://dx.doi.org/10.1016/j.cell.2013.02.022
 [A]  - SHENGDAR Q TSAI ET AL, "Dimeric CRISPR RNA-guided FokI nucleases for highly specific genome editing", NATURE BIOTECHNOLOGY, (20140425), vol. 32, no. 6, doi:10.1038/nbt.2908, ISSN 1087-0156, pages 569 - 576, XP055178523 [A] 1-25,44-68 * the whole document *

DOI:   http://dx.doi.org/10.1038/nbt.2908
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