blank Quick help
blank Maintenance news

Scheduled maintenance

Regular maintenance outages:
between 05.00 and 05.15 hrs CET (Monday to Sunday).

Other outages
Availability

2022.02.11

More...
blank News flashes

Italy joins the Federated Register

Click here for more information on the Federated Register.

2025-06-12

More...
blank Related links

Release notes
European Patent Register Assistant
European Patent Register User Manual
European Patent Register – pocket guide
FAQ - European Patent Register
Federated Register (Flyer)
Global Dossier (Flyer)
Register events
Deep link coverage
Federated Register content
The Patent Information Tour
Fair use charter

Extract from the Register of European Patents

EP About this file: EP3122871

EP3122871 - EXTRACELLULAR MATRIX GRAFTS LOADED WITH EXOGENOUS FACTORS [Right-click to bookmark this link]
StatusNo opposition filed within time limit
Status updated on  09.07.2021
Database last updated on 08.04.2026
FormerThe patent has been granted
Status updated on  31.07.2020
FormerGrant of patent is intended
Status updated on  26.03.2020
FormerExamination is in progress
Status updated on  13.07.2018
FormerRequest for examination was made
Status updated on  30.12.2016
FormerThe international publication has been made
Status updated on  04.11.2016
Most recent event   Tooltip06.09.2024Lapse of the patent in a contracting state
New state(s): MT		published on 09.10.2024  [2024/41]
Applicant(s)For all designated states
Cook Biotech Incorporated
1425 Innovation Place
West Lafayette, IN 47906 / US
[2017/05]
Inventor(s)01 / HILES, Michael, C.
4326 South 900 East
Lafayette, IN 47905 / US
02 / RYAN, Christopher, T.
5101 N. Kenwood Avenue
Indianapolis, IN 46208 / US
 [2017/05]
Representative(s)Stafford, Jonathan Alan Lewis, et al
Marks & Clerk LLP
1 New York Street
Manchester M1 4HD / GB
[2020/36]
Former [2017/05]Atkinson, Peter Birch
Marks & Clerk LLP
1 New York Street
Manchester M1 4HD / GB
Application number, filing date15769922.425.03.2015
[2017/05]
WO2015US22569
Priority number, dateUS201461970344P25.03.2014         Original published format: US 201461970344 P
US201461971504P27.03.2014         Original published format: US 201461971504 P
[2017/05]
Filing languageEN
Procedural languageEN
PublicationType: A1 Application with search report
No.:WO2015148723
Date:01.10.2015
Language:EN
[2015/39]
Type: A1 Application with search report 
No.:EP3122871
Date:01.02.2017
Language:EN
The application published by WIPO in one of the EPO official languages on 01.10.2015 takes the place of the publication of the European patent application.
[2017/05]
Type: B1 Patent specification 
No.:EP3122871
Date:02.09.2020
Language:EN
[2020/36]
Search report(s)International search report - published on:KR01.10.2015
(Supplementary) European search report - dispatched on:EP22.09.2017
ClassificationIPC:C12N5/02, C12N5/078, C07K14/745, C07K14/52, C07K14/54, C07K14/555, C07K14/78, A61L27/38, A61L27/54
[2017/05]
CPC:
A61L27/3616 (EP,US); A61L27/225 (US); A61L27/227 (US);
A61L27/24 (US); A61L27/3633 (EP,US); A61L27/54 (EP,US);
C12N5/0644 (EP,US); A61L2300/414 (EP,US); C12N2533/54 (EP,US) (-)
Designated contracting statesAL,   AT,   BE,   BG,   CH,   CY,   CZ,   DE,   DK,   EE,   ES,   FI,   FR,   GB,   GR,   HR,   HU,   IE,   IS,   IT,   LI,   LT,   LU,   LV,   MC,   MK,   MT,   NL,   NO,   PL,   PT,   RO,   RS,   SE,   SI,   SK,   SM,   TR [2017/05]
Extension statesBANot yet paid
MENot yet paid
Validation statesMANot yet paid
TitleGerman:EXTRAZELLULÄRE MATRIXGRAFTS MIT EXOGENEN FAKTOREN[2017/05]
English:EXTRACELLULAR MATRIX GRAFTS LOADED WITH EXOGENOUS FACTORS[2017/05]
French:GREFFONS DE MATRICE EXTRACELLULAIRE CHARGÉS AVEC DES FACTEURS EXOGÈNES[2017/05]
Entry into regional phase05.10.2016National basic fee paid 
05.10.2016Search fee paid 
05.10.2016Designation fee(s) paid 
05.10.2016Examination fee paid 
Examination procedure05.10.2016Examination requested  [2017/05]
05.10.2016Date on which the examining division has become responsible
19.04.2018Amendment by applicant (claims and/or description)
17.07.2018Despatch of a communication from the examining division (Time limit: M06)
25.02.2019Despatch of communication that the application is deemed to be withdrawn, reason: reply to the communication from the examining division not received in time
07.05.2019Reply to a communication from the examining division
18.09.2019Despatch of a communication from the examining division (Time limit: M02)
26.11.2019Reply to a communication from the examining division
27.03.2020Communication of intention to grant the patent
23.07.2020Fee for grant paid
23.07.2020Fee for publishing/printing paid
23.07.2020Receipt of the translation of the claim(s)
Opposition(s)03.06.2021No opposition filed within time limit [2021/32]
Request for further processing for:The application is deemed to be withdrawn due to failure to reply to the examination report
07.05.2019Request for further processing filed
07.05.2019Full payment received (date of receipt of payment)
Request granted
20.05.2019Decision despatched
Fees paidRenewal fee
10.03.2017Renewal fee patent year 03
13.03.2018Renewal fee patent year 04
13.03.2019Renewal fee patent year 05
12.03.2020Renewal fee patent year 06
Opt-out from the exclusive  Tooltip
competence of the Unified
Patent Court		 See the Register of the Unified Patent Court for opt-out data
Responsibility for the accuracy, completeness or quality of the data displayed under the link provided lies entirely with the Unified Patent Court.
Lapses during opposition  TooltipHU25.03.2015
AL02.09.2020
AT02.09.2020
CY02.09.2020
CZ02.09.2020
DK02.09.2020
EE02.09.2020
ES02.09.2020
FI02.09.2020
HR02.09.2020
IT02.09.2020
LT02.09.2020
LV02.09.2020
MC02.09.2020
MK02.09.2020
MT02.09.2020
NL02.09.2020
PL02.09.2020
RO02.09.2020
RS02.09.2020
SE02.09.2020
SI02.09.2020
SK02.09.2020
SM02.09.2020
TR02.09.2020
BG02.12.2020
NO02.12.2020
GR03.12.2020
IS02.01.2021
PT04.01.2021
LU25.03.2021
BE31.03.2021
CH31.03.2021
FR31.03.2021
LI31.03.2021
[2024/41]
Former [2024/29]HU25.03.2015
AL02.09.2020
AT02.09.2020
CY02.09.2020
CZ02.09.2020
DK02.09.2020
EE02.09.2020
ES02.09.2020
FI02.09.2020
HR02.09.2020
IT02.09.2020
LT02.09.2020
LV02.09.2020
MC02.09.2020
MK02.09.2020
NL02.09.2020
PL02.09.2020
RO02.09.2020
RS02.09.2020
SE02.09.2020
SI02.09.2020
SK02.09.2020
SM02.09.2020
TR02.09.2020
BG02.12.2020
NO02.12.2020
GR03.12.2020
IS02.01.2021
PT04.01.2021
LU25.03.2021
BE31.03.2021
CH31.03.2021
FR31.03.2021
LI31.03.2021
Former [2024/22]HU25.03.2015
AL02.09.2020
AT02.09.2020
CY02.09.2020
CZ02.09.2020
DK02.09.2020
EE02.09.2020
ES02.09.2020
FI02.09.2020
HR02.09.2020
IT02.09.2020
LT02.09.2020
LV02.09.2020
MC02.09.2020
MK02.09.2020
NL02.09.2020
PL02.09.2020
RO02.09.2020
RS02.09.2020
SE02.09.2020
SI02.09.2020
SK02.09.2020
SM02.09.2020
BG02.12.2020
NO02.12.2020
GR03.12.2020
IS02.01.2021
PT04.01.2021
LU25.03.2021
BE31.03.2021
CH31.03.2021
FR31.03.2021
LI31.03.2021
Former [2023/30]HU25.03.2015
AL02.09.2020
AT02.09.2020
CY02.09.2020
CZ02.09.2020
DK02.09.2020
EE02.09.2020
ES02.09.2020
FI02.09.2020
HR02.09.2020
IT02.09.2020
LT02.09.2020
LV02.09.2020
MC02.09.2020
NL02.09.2020
PL02.09.2020
RO02.09.2020
RS02.09.2020
SE02.09.2020
SI02.09.2020
SK02.09.2020
SM02.09.2020
BG02.12.2020
NO02.12.2020
GR03.12.2020
IS02.01.2021
PT04.01.2021
LU25.03.2021
BE31.03.2021
CH31.03.2021
FR31.03.2021
LI31.03.2021
Former [2023/27]HU25.03.2015
AL02.09.2020
AT02.09.2020
CZ02.09.2020
DK02.09.2020
EE02.09.2020
ES02.09.2020
FI02.09.2020
HR02.09.2020
IT02.09.2020
LT02.09.2020
LV02.09.2020
MC02.09.2020
NL02.09.2020
PL02.09.2020
RO02.09.2020
RS02.09.2020
SE02.09.2020
SI02.09.2020
SK02.09.2020
SM02.09.2020
BG02.12.2020
NO02.12.2020
GR03.12.2020
IS02.01.2021
PT04.01.2021
LU25.03.2021
BE31.03.2021
CH31.03.2021
FR31.03.2021
LI31.03.2021
Former [2022/34]AL02.09.2020
AT02.09.2020
CZ02.09.2020
DK02.09.2020
EE02.09.2020
ES02.09.2020
FI02.09.2020
HR02.09.2020
IT02.09.2020
LT02.09.2020
LV02.09.2020
MC02.09.2020
NL02.09.2020
PL02.09.2020
RO02.09.2020
RS02.09.2020
SE02.09.2020
SI02.09.2020
SK02.09.2020
SM02.09.2020
BG02.12.2020
NO02.12.2020
GR03.12.2020
IS02.01.2021
PT04.01.2021
LU25.03.2021
BE31.03.2021
CH31.03.2021
FR31.03.2021
LI31.03.2021
Former [2022/11]AL02.09.2020
AT02.09.2020
CZ02.09.2020
DK02.09.2020
EE02.09.2020
ES02.09.2020
FI02.09.2020
HR02.09.2020
IT02.09.2020
LT02.09.2020
LV02.09.2020
MC02.09.2020
NL02.09.2020
PL02.09.2020
RO02.09.2020
RS02.09.2020
SE02.09.2020
SI02.09.2020
SK02.09.2020
SM02.09.2020
BG02.12.2020
NO02.12.2020
GR03.12.2020
IS02.01.2021
PT04.01.2021
LU25.03.2021
CH31.03.2021
FR31.03.2021
LI31.03.2021
Former [2022/08]AL02.09.2020
AT02.09.2020
CZ02.09.2020
DK02.09.2020
EE02.09.2020
ES02.09.2020
FI02.09.2020
HR02.09.2020
IT02.09.2020
LT02.09.2020
LV02.09.2020
MC02.09.2020
NL02.09.2020
PL02.09.2020
RO02.09.2020
RS02.09.2020
SE02.09.2020
SI02.09.2020
SK02.09.2020
SM02.09.2020
BG02.12.2020
NO02.12.2020
GR03.12.2020
IS02.01.2021
PT04.01.2021
LU25.03.2021
FR31.03.2021
Former [2021/48]AL02.09.2020
AT02.09.2020
CZ02.09.2020
DK02.09.2020
EE02.09.2020
ES02.09.2020
FI02.09.2020
HR02.09.2020
IT02.09.2020
LT02.09.2020
LV02.09.2020
MC02.09.2020
NL02.09.2020
PL02.09.2020
RO02.09.2020
RS02.09.2020
SE02.09.2020
SI02.09.2020
SK02.09.2020
SM02.09.2020
BG02.12.2020
NO02.12.2020
GR03.12.2020
IS02.01.2021
PT04.01.2021
Former [2021/45]AL02.09.2020
AT02.09.2020
CZ02.09.2020
DK02.09.2020
EE02.09.2020
ES02.09.2020
FI02.09.2020
HR02.09.2020
LT02.09.2020
LV02.09.2020
MC02.09.2020
NL02.09.2020
PL02.09.2020
RO02.09.2020
RS02.09.2020
SE02.09.2020
SI02.09.2020
SK02.09.2020
SM02.09.2020
BG02.12.2020
NO02.12.2020
GR03.12.2020
IS02.01.2021
PT04.01.2021
Former [2021/37]AL02.09.2020
AT02.09.2020
CZ02.09.2020
DK02.09.2020
EE02.09.2020
ES02.09.2020
FI02.09.2020
HR02.09.2020
LT02.09.2020
LV02.09.2020
NL02.09.2020
PL02.09.2020
RO02.09.2020
RS02.09.2020
SE02.09.2020
SI02.09.2020
SK02.09.2020
SM02.09.2020
BG02.12.2020
NO02.12.2020
GR03.12.2020
IS02.01.2021
PT04.01.2021
Former [2021/36]AL02.09.2020
AT02.09.2020
CZ02.09.2020
EE02.09.2020
ES02.09.2020
FI02.09.2020
HR02.09.2020
LT02.09.2020
LV02.09.2020
NL02.09.2020
PL02.09.2020
RO02.09.2020
RS02.09.2020
SE02.09.2020
SI02.09.2020
SK02.09.2020
SM02.09.2020
BG02.12.2020
NO02.12.2020
GR03.12.2020
IS02.01.2021
PT04.01.2021
Former [2021/28]AL02.09.2020
AT02.09.2020
CZ02.09.2020
EE02.09.2020
ES02.09.2020
FI02.09.2020
HR02.09.2020
LT02.09.2020
LV02.09.2020
NL02.09.2020
PL02.09.2020
RO02.09.2020
RS02.09.2020
SE02.09.2020
SK02.09.2020
SM02.09.2020
BG02.12.2020
NO02.12.2020
GR03.12.2020
IS02.01.2021
PT04.01.2021
Former [2021/25]AL02.09.2020
AT02.09.2020
CZ02.09.2020
EE02.09.2020
ES02.09.2020
FI02.09.2020
HR02.09.2020
LT02.09.2020
LV02.09.2020
NL02.09.2020
PL02.09.2020
RO02.09.2020
RS02.09.2020
SE02.09.2020
SM02.09.2020
BG02.12.2020
NO02.12.2020
GR03.12.2020
IS02.01.2021
PT04.01.2021
Former [2021/24]AT02.09.2020
CZ02.09.2020
EE02.09.2020
FI02.09.2020
HR02.09.2020
LT02.09.2020
LV02.09.2020
NL02.09.2020
PL02.09.2020
RO02.09.2020
RS02.09.2020
SE02.09.2020
SM02.09.2020
BG02.12.2020
NO02.12.2020
GR03.12.2020
PT04.01.2021
Former [2021/23]CZ02.09.2020
EE02.09.2020
FI02.09.2020
HR02.09.2020
LT02.09.2020
LV02.09.2020
NL02.09.2020
PL02.09.2020
RO02.09.2020
RS02.09.2020
SE02.09.2020
SM02.09.2020
BG02.12.2020
NO02.12.2020
GR03.12.2020
PT04.01.2021
Former [2021/22]CZ02.09.2020
EE02.09.2020
FI02.09.2020
HR02.09.2020
LT02.09.2020
LV02.09.2020
NL02.09.2020
PL02.09.2020
RO02.09.2020
RS02.09.2020
SE02.09.2020
BG02.12.2020
NO02.12.2020
GR03.12.2020
PT04.01.2021
Former [2021/21]FI02.09.2020
HR02.09.2020
LT02.09.2020
LV02.09.2020
NL02.09.2020
PL02.09.2020
RS02.09.2020
SE02.09.2020
BG02.12.2020
NO02.12.2020
GR03.12.2020
PT04.01.2021
Former [2021/18]FI02.09.2020
HR02.09.2020
LT02.09.2020
LV02.09.2020
NL02.09.2020
PL02.09.2020
RS02.09.2020
SE02.09.2020
BG02.12.2020
NO02.12.2020
GR03.12.2020
Former [2021/10]FI02.09.2020
HR02.09.2020
LT02.09.2020
LV02.09.2020
PL02.09.2020
RS02.09.2020
SE02.09.2020
BG02.12.2020
NO02.12.2020
GR03.12.2020
Former [2021/09]FI02.09.2020
LT02.09.2020
SE02.09.2020
BG02.12.2020
NO02.12.2020
GR03.12.2020
Former [2021/08]FI02.09.2020
LT02.09.2020
SE02.09.2020
BG02.12.2020
NO02.12.2020
Former [2021/07]FI02.09.2020
LT02.09.2020
NO02.12.2020
Documents cited:Search[X] WO2007011644  (CORMATRIX CARDIOVASCULAR INC et al.) [X] 1-4,21,22 * claims 1,4,8,10,11 *
 [X] WO9500632  (AMGEN INC et al.) [X] 1-4 * claims 1,11,13,16,18 *
International search[Y] US2008299171  (HILES MICHAEL C et al.) [Y] 1-59, 93-96 * See abstract; claims 1-38; and paragraphs [0007]-[0009], [0015], [0012]-[0013], [0021]-[0024], [0028], [0031], [0038]-[0039], [0041], [0047], [0054]. *
 [A] US2008274184  (HUNT JAMES B et al.) [A] 1-59, 93-96 * See abstract; claims 1-20; paragraphs [0015]-[0016], [0039]-[0079], [0114]-[0154]; and figures 1-2. *
 [Y]   CHEN, FA-MING ET AL.: "Toward delivery of multiple growth factors in tissue engineering", BIOMATERIALS, vol. 31, no. Issue 24, 2010, pages 6279 - 6308, XP027474530 [Y] 1-59, 93-96 * See abstract; pages 6279-6281, 6291, 6298, 6300, 6304; and figure 10. *

DOI:   http://dx.doi.org/10.1016/j.biomaterials.2010.04.053
 [A]   HEMEDA, HATIM ET AL.: "Heparin concentration is critical for cell culture with human platelet lysate.", CYTOTHERAPY, vol. 15, no. Issue 9, 2013, pages 1174 - 1181, XP055227968 [A] 1-59, 93-96 * See abstract; pages 1174-1175, 1177-1180; and figures 1-2. *

DOI:   http://dx.doi.org/10.1016/j.jcyt.2013.05.006
 [A]   FEKETE, NATALIE ET AL.: "Platelet lysate from whole blood-derived pooled platelet concentrates and apheresis-derived platelet concentrates for the isolation and expansion of human bone marrow mesenchymal stromal cells: production process, content and identification of active components", CYTOTHERAPY, vol. 14, no. Issue 5, 2012, pages 540 - 554, XP055178087 [A] 1-59, 93-96 * See abstract; pages 541-551; figures 1-6; and tables I-III. *

DOI:   http://dx.doi.org/10.3109/14653249.2012.655420
 [PA]   TAYLOR, C. G. ET AL.: "Comparison of human platelet lysate and fetal bovine serum for optimal culture conditions of neonatal and adult mesenchymal stem cells", CYTOTHERAPY, vol. 16, no. Issue 4, April 2014 (2014-04-01), pages S84 - S85, XP055358824 [PA] 1-59, 93-96 * , Poster No. 291 See the whole document. *

DOI:   http://dx.doi.org/10.1016/j.jcyt.2014.01.308
by applicantWO2007011644
 US2008299171
 US6206931
 US8192763
The EPO accepts no responsibility for the accuracy of data originating from other authorities; in particular, it does not guarantee that it is complete, up to date or fit for specific purposes.