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Extract from the Register of European Patents

EP About this file: EP3126451

EP3126451 - AZETIDINE-SUBSTITUTED FLUORESCENT COMPOUNDS [Right-click to bookmark this link]
StatusNo opposition filed within time limit
Status updated on  16.07.2021
Database last updated on 03.04.2025
FormerThe patent has been granted
Status updated on  07.08.2020
FormerGrant of patent is intended
Status updated on  08.04.2020
FormerExamination is in progress
Status updated on  18.02.2020
FormerGrant of patent is intended
Status updated on  13.10.2019
FormerExamination is in progress
Status updated on  27.02.2019
FormerRequest for examination was made
Status updated on  06.01.2017
FormerThe international publication has been made
Status updated on  23.11.2016
Most recent event   Tooltip06.09.2024Lapse of the patent in a contracting state
New state(s): MT		published on 09.10.2024  [2024/41]
Applicant(s)For all designated states
Howard Hughes Medical Institute
4000 Jones Bridge Road
Chevy Chase, Maryland 20815-6789 / US
[2017/06]
Inventor(s)01 / LAVIS, Luke, D.
4000 Jones Bridge Road
Chevy Chase, MD 20815-6789 / US
02 / GRIMM, Jonathan, B.
4000 Jones Bridge Road
Chevy Chase, MD 20815-6789 / US
03 / CHEN, Jiji
4000 Jones Bridge Road
Chevy Chase, MD 20815-6789 / US
04 / LIONETTE, Timothee
4000 Jones Bridge Road
Chevy Chase MD 20815-6789 / US
05 / ZHANG, Zhengjian
4000 Jones Bridge Road
Chevy Chase MD 20815-6789 / US
06 / REVYAKIN, Audrey
4000 Jones Bridge Road
Chevy Chase, MD 20815-6789 / US
07 / SLAUGHTER, Joel
4000 Jones Bridge Road
Chevy Chase, MD 20815-6789 / US
 [2017/06]
Representative(s)Greaves Brewster LLP
Copa House
Station Road
Cheddar, Somerset BS27 3AH / GB
[2020/37]
Former [2017/06]Wallis, Naomi Rachel, et al
Greaves Brewster LLP
Copa House
Station Road
Cheddar BS27 3AH / GB
Application number, filing date15774408.701.04.2015
[2017/06]
WO2015US23953
Priority number, dateUS201461973795P01.04.2014         Original published format: US 201461973795 P
US201461991109P09.05.2014         Original published format: US 201461991109 P
[2017/06]
Filing languageEN
Procedural languageEN
PublicationType: A1 Application with search report
No.:WO2015153813
Date:08.10.2015
Language:EN
[2015/40]
Type: A1 Application with search report 
No.:EP3126451
Date:08.02.2017
Language:EN
The application published by WIPO in one of the EPO official languages on 08.10.2015 takes the place of the publication of the European patent application.
[2017/06]
Type: B1 Patent specification 
No.:EP3126451
Date:09.09.2020
Language:EN
[2020/37]
Search report(s)International search report - published on:US08.10.2015
(Supplementary) European search report - dispatched on:EP23.08.2017
ClassificationIPC:C09B57/02, C07D311/06, A61K31/37, A61K31/397, C09B57/14, C07D405/04, C07D413/04
[2017/38]
CPC:
G01N33/52 (EP,US); C07D205/06 (EP,US); C07D401/14 (EP,US);
C07D403/14 (EP,US); C07D405/04 (EP,US); C07D405/14 (EP,US);
C07D413/14 (EP,US); C07D473/18 (EP,US); C07D493/10 (EP,US);
C07D519/00 (EP,US); C07F7/0812 (EP,US); C09B1/16 (US);
C09B11/02 (US); C09B11/24 (EP,US); C09B11/28 (EP,US);
C09B15/00 (EP,US); C09B19/00 (EP,US); C09B21/00 (EP,US);
C09B57/02 (EP,US); C09B69/008 (EP,US); C09K11/06 (EP,US);
G01N33/582 (US); C09K2211/1029 (US); C09K2211/1044 (US);
C09K2211/1096 (US) (-)
Former IPC [2017/06]C09B57/02, C07D311/06, A61K31/37, A61K31/397
Designated contracting statesAL,   AT,   BE,   BG,   CH,   CY,   CZ,   DE,   DK,   EE,   ES,   FI,   FR,   GB,   GR,   HR,   HU,   IE,   IS,   IT,   LI,   LT,   LU,   LV,   MC,   MK,   MT,   NL,   NO,   PL,   PT,   RO,   RS,   SE,   SI,   SK,   SM,   TR [2017/06]
Extension statesBANot yet paid
MENot yet paid
Validation statesMANot yet paid
TitleGerman:AZETIDIN-SUBSTITUIERTE FLUORESZIERENDE VERBINDUNGEN[2017/06]
English:AZETIDINE-SUBSTITUTED FLUORESCENT COMPOUNDS[2017/06]
French:COMPOSÉS FLUORESCENTS À SUBSTITUTION AZÉTIDINE[2017/06]
Entry into regional phase31.10.2016National basic fee paid 
31.10.2016Search fee paid 
31.10.2016Designation fee(s) paid 
31.10.2016Examination fee paid 
Examination procedure25.10.2016Date on which the examining division has become responsible
31.10.2016Examination requested  [2017/06]
02.03.2018Amendment by applicant (claims and/or description)
04.03.2019Despatch of a communication from the examining division (Time limit: M04)
27.06.2019Reply to a communication from the examining division
14.10.2019Communication of intention to grant the patent
14.02.2020Disapproval of the communication of intention to grant the patent by the applicant or resumption of examination proceedings by the EPO
09.04.2020Communication of intention to grant the patent
24.06.2020Receipt of the translation of the claim(s)
30.07.2020Fee for grant paid
30.07.2020Fee for publishing/printing paid
Opposition(s)10.06.2021No opposition filed within time limit [2021/33]
Fees paidRenewal fee
27.04.2017Renewal fee patent year 03
27.04.2018Renewal fee patent year 04
29.04.2019Renewal fee patent year 05
27.04.2020Renewal fee patent year 06
Opt-out from the exclusive  Tooltip
competence of the Unified
Patent Court		 See the Register of the Unified Patent Court for opt-out data
Responsibility for the accuracy, completeness or quality of the data displayed under the link provided lies entirely with the Unified Patent Court.
Lapses during opposition  TooltipHU01.04.2015
AL09.09.2020
AT09.09.2020
CY09.09.2020
CZ09.09.2020
DK09.09.2020
EE09.09.2020
ES09.09.2020
FI09.09.2020
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LT09.09.2020
LV09.09.2020
MC09.09.2020
MK09.09.2020
MT09.09.2020
NL09.09.2020
PL09.09.2020
RO09.09.2020
RS09.09.2020
SE09.09.2020
SI09.09.2020
SK09.09.2020
SM09.09.2020
TR09.09.2020
BG09.12.2020
NO09.12.2020
GR10.12.2020
IS09.01.2021
PT11.01.2021
IE01.04.2021
LU01.04.2021
BE30.04.2021
CH30.04.2021
LI30.04.2021
[2024/41]
Former [2024/29]HU01.04.2015
AL09.09.2020
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TR09.09.2020
BG09.12.2020
NO09.12.2020
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IS09.01.2021
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BE30.04.2021
CH30.04.2021
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Former [2024/22]HU01.04.2015
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BG09.12.2020
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IS09.01.2021
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BE30.04.2021
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IS09.01.2021
PT11.01.2021
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BE30.04.2021
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PT11.01.2021
IE01.04.2021
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BE30.04.2021
CH30.04.2021
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PT11.01.2021
IE01.04.2021
LU01.04.2021
CH30.04.2021
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BG09.12.2020
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PT11.01.2021
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LU01.04.2021
CH30.04.2021
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SI09.09.2020
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NO09.12.2020
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Former [2022/04]AL09.09.2020
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SI09.09.2020
SK09.09.2020
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SE09.09.2020
SI09.09.2020
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LT09.09.2020
LV09.09.2020
NL09.09.2020
PL09.09.2020
RO09.09.2020
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SI09.09.2020
SK09.09.2020
SM09.09.2020
BG09.12.2020
NO09.12.2020
GR10.12.2020
IS09.01.2021
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LV09.09.2020
NL09.09.2020
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SM09.09.2020
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NO09.12.2020
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Documents cited:Search[X]EP0395244  (WYETH JOHN & BROTHER LTD [GB]) [X] 1,2,6,8 * see examples 50 and 51 *;
 [X]GB2247887  (WYETH JOHN & BROTHER LTD [GB]) [X] 1,2,6,8 * see example 1 to 4 *;
 [X]US5164385  (CLIFFE IAN A [GB], et al) [X] 1,2,6,8 * see examples 1 to 4 *;
 [X]US5194439  (CLIFFE IAN A [US], et al) [X] 1,2,6,8 * see example 50 *;
 [X]US5555861  (MAYR BERTOLD DR ING [DE], et al) [X] 1-3,6,8 * see e.g. examples 1-4, 8-12, 14-17, 19, 20, 22, 23, 25, 26, 28, 29, 31-34 and several compounds of examples 36 *;
 [X]WO2004087687  (PHARMACIA CORP [US], et al) [X] 1,2,6,8 * see example 8j *;
 [X]WO2007105053  (PFIZER PROD INC [US], et al) [X] 1,2,6,8 * see e.g. the azetidine derivatives on p. 67, 8, 9, 14, 21 and 29 and the first compound on p. 68 *;
 [X]WO2007133637  (RENOVIS INC [US], et al) [X] 1,2,6,8 * see example 25B) *;
 [A]WO2010149190  (MAX PLANCK GES ZUR [DE], et al) [A] 1-15 * see substituents of the rhodamine derivatives according to claim 1 and their use as fluorescent dyes *;
 [X]WO2012045196  (ABBOTT LAB [US], et al) [X] 1,2,6 * see example 90 *;
 [X]WO2013010974  (EADS EUROP AERONAUTIC DEFENCE [FR], et al) [X] 1,2,6,8 * see compounds 619, 943, 944, 963 and 966 on p. 327, 344 and 345 *;
 [X]WO2013090929  (GILEAD SCIENCES INC [US]) [X] 1,2,6,8 * see compound 2 in the preparation of example 42 on p. 76 *;
 [X]  - BERNHARD WITULSKI ET AL, "Palladium-Catalyzed N-Arylation Reactions with Aziridine and Azetidine", SYNTHESIS, STUTTGART, DE., (20070101), vol. 2007, no. 2, doi:10.1055/s-2006-958947, ISSN 0039-7881, pages 243 - 250, XP055398459 [X] 1,2,6,8 * see compound 5c in table 3 *

DOI:   http://dx.doi.org/10.1055/s-2006-958947
 [X]  - CLIFFE I A ET AL, "7-amino-5,6,7,8-tetrahydroquinolines. Preparation from 5,6-dihydroquinoline and nitrogen nucleophiles", TETRAHEDRON LETTERS, ELSEVIER, AMSTERDAM, NL, vol. 32, no. 46, doi:10.1016/S0040-4039(00)93604-9, ISSN 0040-4039, (19911111), pages 6789 - 6792, (19911111), XP028085580 [X] 1,2,6,8 * see entry 3h in table 1 *

DOI:   http://dx.doi.org/10.1016/S0040-4039(00)93604-9
 [X]  - White, "The effect of RPR 102341 on theophylline metabolism and phenacetin O-deethylase activity in human liver microsomes", (19970101), URL: https://rd.springer.com/content/pdf/10.1023/A:1012163919636.pdf, (20170816), XP055399066 [X] 1-3,6,8 * see compound RPR 102341 *
 [IP]  - JONATHAN B GRIMM ET AL, "A general method to improve fluorophores for live-cell and single-molecule microscopy", NATURE METHODS, (20150119), vol. 12, no. 3, doi:10.1038/nmeth.3256, ISSN 1548-7091, pages 244 - 250, XP055397561 [IP] 4-6,9-15 * see the whole document published online 19th January 2015 *

DOI:   http://dx.doi.org/10.1038/nmeth.3256
International search[Y]US5164385  (CLIFFE IAN A [GB], et al) [Y] 1, 7-8, 14, 16-17 * col 1, In 8-29; col 2, ln 52-55; col 3, In 14-25; col 4, ln 48-50, Example 1; col 5, ln 6-8, Example 2 *;
 [A]US2009163482  (MCHARDY STANTON FURST [US], et al) [A] 1, 7-8, 14, 16-17 * pg 19, col 2, Example 272, Example 276 *;
 [A]US8212056  (KWONG FUK YEE [CN], et al) [A] 1, 7-8, 14, 16-17* col 9-10, Table 3, entry 9 *;
 [Y]  - PUBCHEM, (20121130), Database accession no. 69026937, XP055229252 [Y] 1, 7-8, 14, 16-17 * , Fig *
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