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Extract from the Register of European Patents

EP About this file: EP3201353

EP3201353 - A METHOD OF IDENTIFYING OR PRODUCING AN APTAMER [Right-click to bookmark this link]
StatusNo opposition filed within time limit
Status updated on  30.10.2020
Database last updated on 17.09.2024
FormerThe patent has been granted
Status updated on  22.11.2019
FormerGrant of patent is intended
Status updated on  21.07.2019
FormerExamination is in progress
Status updated on  26.01.2018
FormerRequest for examination was made
Status updated on  07.07.2017
FormerThe international publication has been made
Status updated on  07.04.2017
Most recent event   Tooltip08.07.2022Lapse of the patent in a contracting state
New state(s): MK		published on 10.08.2022  [2022/32]
Applicant(s)For all designated states
Rheinische Friedrich-Wilhelms-Universität Bonn
Regina-Pacis-Weg 3
53113 Bonn / DE
[2017/32]
Inventor(s)01 / MAYER, Guenter
Martin-Legros-Str. 59
53123 Bonn / DE
02 / TOLLE, Fabian
8 Showground Close
CB2 9AA, Cambridge / GB
 [2017/42]
Former [2017/32]01 / MAYER, Guenter
Martin-Legros-Str. 59
53123 Bonn / DE
02 / TOLLE, Fabian
Hermann-Wandersleb-Ring 8
53121 Bonn / DE
Representative(s)Michalski Hüttermann & Partner Patentanwälte mbB
Kaistraße 16A
40221 Düsseldorf / DE
[N/P]
Former [2017/32]Michalski Hüttermann & Partner Patentanwälte mbB
Speditionstraße 21
40221 Düsseldorf / DE
Application number, filing date15777645.130.09.2015
[2017/32]
WO2015EP72566
Priority number, dateUS201462058703P02.10.2014         Original published format: US 201462058703 P
[2017/32]
Filing languageEN
Procedural languageEN
PublicationType: A1 Application with search report
No.:WO2016050850
Date:07.04.2016
Language:EN
[2016/14]
Type: A1 Application with search report 
No.:EP3201353
Date:09.08.2017
Language:EN
The application published by WIPO in one of the EPO official languages on 07.04.2016 takes the place of the publication of the European patent application.
[2017/32]
Type: B1 Patent specification 
No.:EP3201353
Date:25.12.2019
Language:EN
[2019/52]
Search report(s)International search report - published on:EP07.04.2016
ClassificationIPC:C12Q1/6811, C12N15/10, C12N15/11
[2019/32]
CPC:
C12N15/1048 (EP,US); C12N15/111 (EP,US); C12N15/115 (US);
C12Q1/6811 (EP,US); C12N2310/16 (EP,US); C12N2320/11 (EP,US)
C-Set:
C12N15/1048, C12Q2525/117, C12Q2525/205, C12Q2541/101 (US,EP);
C12Q1/6811, C12Q2525/117, C12Q2525/205, C12Q2541/101 (EP,US)
Former IPC [2017/32]C12Q1/68, C12N15/10, C12N15/115
Designated contracting statesAL,   AT,   BE,   BG,   CH,   CY,   CZ,   DE,   DK,   EE,   ES,   FI,   FR,   GB,   GR,   HR,   HU,   IE,   IS,   IT,   LI,   LT,   LU,   LV,   MC,   MK,   MT,   NL,   NO,   PL,   PT,   RO,   RS,   SE,   SI,   SK,   SM,   TR [2017/32]
Extension statesBANot yet paid
MENot yet paid
Validation statesMANot yet paid
TitleGerman:VERFAHREN ZUR IDENTIFIZIERUNG ODER HERSTELLUNG EINES APTAMERS[2017/32]
English:A METHOD OF IDENTIFYING OR PRODUCING AN APTAMER[2017/32]
French:PROCÉDÉ D'IDENTIFICATION OU DE PRODUCTION D'UN APTAMÈRE[2017/32]
Entry into regional phase02.05.2017National basic fee paid 
02.05.2017Designation fee(s) paid 
02.05.2017Examination fee paid 
Examination procedure02.05.2017Examination requested  [2017/32]
02.05.2017Date on which the examining division has become responsible
17.11.2017Amendment by applicant (claims and/or description)
29.01.2018Despatch of a communication from the examining division (Time limit: M06)
31.07.2018Reply to a communication from the examining division
15.01.2019Despatch of a communication from the examining division (Time limit: M04)
10.05.2019Reply to a communication from the examining division
22.07.2019Communication of intention to grant the patent
14.11.2019Fee for grant paid
14.11.2019Fee for publishing/printing paid
14.11.2019Receipt of the translation of the claim(s)
Opposition(s)28.09.2020No opposition filed within time limit [2020/49]
Fees paidRenewal fee
30.11.2017Renewal fee patent year 03
29.10.2018Renewal fee patent year 04
26.09.2019Renewal fee patent year 05
Penalty fee
Additional fee for renewal fee
30.09.201703   M06   Fee paid on   30.11.2017
30.09.201804   M06   Fee paid on   29.10.2018
Opt-out from the exclusive  Tooltip
competence of the Unified
Patent Court		 See the Register of the Unified Patent Court for opt-out data
Responsibility for the accuracy, completeness or quality of the data displayed under the link provided lies entirely with the Unified Patent Court.
Lapses during opposition  TooltipHU30.09.2015
AL25.12.2019
AT25.12.2019
CY25.12.2019
CZ25.12.2019
DK25.12.2019
EE25.12.2019
FI25.12.2019
HR25.12.2019
LT25.12.2019
LV25.12.2019
MC25.12.2019
MK25.12.2019
MT25.12.2019
NL25.12.2019
PL25.12.2019
RO25.12.2019
RS25.12.2019
SE25.12.2019
SI25.12.2019
SK25.12.2019
SM25.12.2019
TR25.12.2019
BG25.03.2020
NO25.03.2020
GR26.03.2020
IS25.04.2020
PT20.05.2020
[2022/32]
Former [2022/27]HU30.09.2015
AL25.12.2019
AT25.12.2019
CY25.12.2019
CZ25.12.2019
DK25.12.2019
EE25.12.2019
FI25.12.2019
HR25.12.2019
LT25.12.2019
LV25.12.2019
MC25.12.2019
MT25.12.2019
NL25.12.2019
PL25.12.2019
RO25.12.2019
RS25.12.2019
SE25.12.2019
SI25.12.2019
SK25.12.2019
SM25.12.2019
TR25.12.2019
BG25.03.2020
NO25.03.2020
GR26.03.2020
IS25.04.2020
PT20.05.2020
Former [2021/23]AL25.12.2019
AT25.12.2019
CZ25.12.2019
DK25.12.2019
EE25.12.2019
FI25.12.2019
HR25.12.2019
LT25.12.2019
LV25.12.2019
MC25.12.2019
NL25.12.2019
PL25.12.2019
RO25.12.2019
RS25.12.2019
SE25.12.2019
SI25.12.2019
SK25.12.2019
SM25.12.2019
BG25.03.2020
NO25.03.2020
GR26.03.2020
IS25.04.2020
PT20.05.2020
Former [2021/11]AL25.12.2019
AT25.12.2019
CZ25.12.2019
DK25.12.2019
EE25.12.2019
FI25.12.2019
HR25.12.2019
LT25.12.2019
LV25.12.2019
NL25.12.2019
PL25.12.2019
RO25.12.2019
RS25.12.2019
SE25.12.2019
SI25.12.2019
SK25.12.2019
SM25.12.2019
BG25.03.2020
NO25.03.2020
GR26.03.2020
IS25.04.2020
PT20.05.2020
Former [2020/51]AL25.12.2019
CZ25.12.2019
DK25.12.2019
EE25.12.2019
FI25.12.2019
HR25.12.2019
LT25.12.2019
LV25.12.2019
NL25.12.2019
RO25.12.2019
RS25.12.2019
SE25.12.2019
SI25.12.2019
SK25.12.2019
SM25.12.2019
BG25.03.2020
NO25.03.2020
GR26.03.2020
IS25.04.2020
PT20.05.2020
Former [2020/47]AL25.12.2019
CZ25.12.2019
DK25.12.2019
EE25.12.2019
FI25.12.2019
HR25.12.2019
LT25.12.2019
LV25.12.2019
NL25.12.2019
RO25.12.2019
RS25.12.2019
SE25.12.2019
SK25.12.2019
SM25.12.2019
BG25.03.2020
NO25.03.2020
GR26.03.2020
IS25.04.2020
PT20.05.2020
Former [2020/40]AL25.12.2019
CZ25.12.2019
EE25.12.2019
FI25.12.2019
HR25.12.2019
LT25.12.2019
LV25.12.2019
NL25.12.2019
RO25.12.2019
RS25.12.2019
SE25.12.2019
SK25.12.2019
SM25.12.2019
BG25.03.2020
NO25.03.2020
GR26.03.2020
IS25.04.2020
PT20.05.2020
Former [2020/37]AL25.12.2019
CZ25.12.2019
EE25.12.2019
FI25.12.2019
HR25.12.2019
LT25.12.2019
LV25.12.2019
NL25.12.2019
RO25.12.2019
RS25.12.2019
SE25.12.2019
SK25.12.2019
SM25.12.2019
BG25.03.2020
NO25.03.2020
GR26.03.2020
PT20.05.2020
Former [2020/36]AL25.12.2019
CZ25.12.2019
EE25.12.2019
FI25.12.2019
HR25.12.2019
LT25.12.2019
LV25.12.2019
NL25.12.2019
RO25.12.2019
RS25.12.2019
SE25.12.2019
BG25.03.2020
NO25.03.2020
GR26.03.2020
PT20.05.2020
Former [2020/35]AL25.12.2019
CZ25.12.2019
FI25.12.2019
HR25.12.2019
LT25.12.2019
LV25.12.2019
NL25.12.2019
RO25.12.2019
RS25.12.2019
SE25.12.2019
BG25.03.2020
NO25.03.2020
GR26.03.2020
Former [2020/32]AL25.12.2019
FI25.12.2019
HR25.12.2019
LT25.12.2019
LV25.12.2019
NL25.12.2019
RS25.12.2019
SE25.12.2019
BG25.03.2020
NO25.03.2020
GR26.03.2020
Former [2020/25]FI25.12.2019
HR25.12.2019
LT25.12.2019
LV25.12.2019
RS25.12.2019
SE25.12.2019
BG25.03.2020
NO25.03.2020
GR26.03.2020
Former [2020/23]FI25.12.2019
LT25.12.2019
LV25.12.2019
SE25.12.2019
BG25.03.2020
NO25.03.2020
GR26.03.2020
Former [2020/22]FI25.12.2019
LT25.12.2019
SE25.12.2019
BG25.03.2020
NO25.03.2020
Former [2020/21]NO25.03.2020
Cited inInternational search[Y]WO2009012410  (SOMALOGIC INC [US], et al) [Y] 1-15 * claim 1 * * the whole document *;
 [XY]US2011210017  (LAI REBECCA Y [US], et al) [X] 10,12 * example 3 * [Y] 11,13-15;
 [YA]US2012115752  (ZICHI DOMINIC [US], et al) [Y] 14,15 * paragraph [0128] * [A] 1-13;
 [Y]US2014100120  (GORENSTEIN DAVID G [US], et al) [Y] 1-15 * figure 9; example 3 *;
 [XPY]WO2015049356  (TOLLE FABIAN [DE], et al) [XP] 1-13 * claims 1-8 * * the whole document * [Y] 14,15;
 [XY]  - YUNFENG CHENG ET AL, "Design, Synthesis, and Polymerase-Catalyzed Incorporation of Click-Modified Boronic Acid-TTP Analogues", CHEMISTRY - AN ASIAN JOURNAL, (20111004), vol. 6, no. 10, doi:10.1002/asia.201100229, ISSN 1861-4728, pages 2747 - 2752, XP055160640 [X] 10,12 * page 2748, column 1, paragraph 2 - page 2750, column 1, paragraph 2; figures 2,4 * [Y] 1-9,11,13-15

DOI:   http://dx.doi.org/10.1002/asia.201100229
 [XY]  - SAMRA OBEID ET AL, "Interactions of non-polar and "Click-able" nucleotides in the confines of a DNA polymerase active site", CHEMICAL COMMUNICATIONS, (20120101), vol. 48, no. 67, doi:10.1039/c2cc34181f, ISSN 1359-7345, page 8320, XP055160951 [X] 10,12 * page 8320 - page 8321; figure 1 * [Y] 11,13-15

DOI:   http://dx.doi.org/10.1039/c2cc34181f
 [XY]  - GRAMLICH PHILIPP M E ET AL, "Postsynthetic DNA modification through the copper-catalyzed azide-alkyne cycloaddition reaction", ANGEWANDTE CHEMIE INTERNATIONAL EDITION, WILEY - V C H VERLAG GMBH & CO. KGAA, DE, vol. 47, no. 44, doi:10.1002/ANIE.200802077, ISSN 1433-7851, (20081020), pages 8350 - 8358, (20080922), XP009120328 [X] 10,12 * Scheme 6; page 8355, column 2, paragraph 7 * [Y] 11,13-15

DOI:   http://dx.doi.org/10.1002/anie.200802077
 [XYI]  - PHILIPP M E GRAMLICH ET AL, "Click?Click?Click: Single to Triple Modification of DNA", ANGEWANDTE CHEMIE INTERNATIONAL EDITION, WILEY - V C H VERLAG GMBH & CO. KGAA, DE, vol. 47, no. 18, doi:10.1002/ANIE.200705664, ISSN 1433-7851, (20080101), pages 3442 - 3444, (20080328), XP007916867 [X] 10,11 * the whole document * [Y] 13-15 [I] 12

DOI:   http://dx.doi.org/10.1002/anie.200705664
 [Y]  - KEEFE A D ET AL, "SELEX with modified nucleotides", CURRENT OPINION IN CHEMICAL BIOLOGY, CURRENT BIOLOGY LTD, LONDON, GB, vol. 12, no. 4, doi:10.1016/J.CBPA.2008.06.028, ISSN 1367-5931, (20080801), pages 448 - 456, (20080721), XP024528065 [Y] 1-15 * page 452, column 2, paragraph 2 - page 454, column 1, paragraph 1; figures 1, 2a,3 *

DOI:   http://dx.doi.org/10.1016/j.cbpa.2008.06.028
 [Y]  - MAYER G ET AL, "From selection to caged aptamers: Identification of light-dependent ssDNA aptamers targeting cytohesin", BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, PERGAMON, AMSTERDAM, NL, vol. 19, no. 23, doi:10.1016/J.BMCL.2009.10.032, ISSN 0960-894X, (20091201), pages 6561 - 6564, (20091014), XP026736055 [Y] 7,11 * the whole document *

DOI:   http://dx.doi.org/10.1016/j.bmcl.2009.10.032
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DOI:   http://dx.doi.org/10.1002/anie.201202134
 [Y]  - FABIAN TOLLE ET AL, "Dressed for success - applying chemistry to modulate aptamer functionality", CHEMICAL SCIENCE, (20130101), vol. 4, no. 1, doi:10.1039/c2sc21510a, ISSN 2041-6520, page 60, XP055160479 [Y] 1-15 * pages 61,63,64; figures 4B,5 * * the whole document *

DOI:   http://dx.doi.org/10.1039/C2SC21510A
 [Y]  - VARATHARASA THIVIYANATHAN ET AL, "Aptamers and the next generation of diagnostic reagents", PROTEOMICS - CLINICAL APPLICATIONS, (20121215), vol. 6, no. 11-12, doi:10.1002/prca.201200042, ISSN 1862-8346, pages 563 - 573, XP055160488 [Y] 1-15 * page 565, column 2, paragraph 2 *

DOI:   http://dx.doi.org/10.1002/prca.201200042
 [Y]  - LATHAM J A ET AL, "The application of a modified nucleotide in aptamer selection : novel thrombin aptamers containing 5-(1-pentynyl)-2'-deoxyuridine", NUCLEIC ACIDS RESEARCH, OXFORD UNIVERSITY PRESS, GB, (19940101), vol. 22, no. 14, ISSN 0305-1048, pages 2817 - 2822, XP002176163 [Y] 1-9 * page 2818, column 1, paragraph 2 - column 2, paragraph 1; figure 1 *
 [Y]  - MOHAMMAD MEHEDI MASUD ET AL, "Sialyllactose-binding modified DNA aptamer bearing additional functionality by SELEX", BIOORGANIC & MEDICINAL CHEMISTRY, (20040301), vol. 12, no. 5, doi:10.1016/j.bmc.2003.12.009, ISSN 0968-0896, pages 1111 - 1120, XP055160822 [Y] 1-9 * page 1112 - page 1113; figure 13 *

DOI:   http://dx.doi.org/10.1016/j.bmc.2003.12.009
 [A]  - KOLB H C ET AL, "The growing impact of click chemistry on drug discovery", DRUG DISCOVERY TODAY, ELSEVIER, RAHWAY, NJ, US, (20031215), vol. 8, no. 24, doi:10.1016/S1359-6446(03)02933-7, ISSN 1359-6446, pages 1128 - 1137, XP002377521 [A] 1-15 * figure 1 *

DOI:   http://dx.doi.org/10.1016/S1359-6446(03)02933-7
The EPO accepts no responsibility for the accuracy of data originating from other authorities; in particular, it does not guarantee that it is complete, up to date or fit for specific purposes.