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Extract from the Register of European Patents

EP Citations: EP3204376

Cited inInternational search
Type:Patent literature
Publication No.:CN103435606  [X]
 (UNIV CHINA PHARMA et al.) [X] 1,14-21 * compounds 4, 5 *
Type:Patent literature
Publication No.:WO2013155341  [X]
 (UNIV GEORGETOWN et al.) [X] 1,4,14-21 * claim -; table 2 *
Type:Patent literature
Publication No.:WO2012078519  [X]
 (NUMERATE INC et al.) [X] 1,14-21 * scheme of [0074] and compounds 21-27 of table 1;; claim - *
Type:Patent literature
Publication No.:WO2010083505  [X]
 (UNIV PENNSYLVANIA et al.) [X] 1,14-21 * claim -; compounds S10, S13 *
Type:Patent literature
Publication No.:WO2006113864  [A]
 (XENON PHARMACEUTICALS INC et al.) [A] 1-21 * overlap;; claim - *
Type:Non-patent literature
Publication information:[X]   NAGLE, AMRITA A. ET AL: "3-(2-Oxoethylidene)indolin-2-one Derivatives Activate Nrf2 and Inhibit NF-.kappa.B: Potential Candidates for Chemoprevention", CHEMMEDCHEM, vol. 9, no. 8, 2014, pages 1763 - 1774, XP002751371, DOI: 10.1002/CMDC.201402038 [X] 1,3 * compounds B1-B18 *
DOI: http://dx.doi.org/10.1002/CMDC.201402038
Type:Non-patent literature
Publication information:[X]   YU, JIN-SHENG ET AL: "Highly efficient "on water" catalyst-free nucleophilic addition reactions using difluoroenoxysilanes: Dramatic fluorine effects", ANGEWANDTE CHEMIE, INTERNATIONAL EDITION, vol. 53, no. 36, 2014, pages 9512 - 9516, XP002751372, DOI: 10.1002/ANIE.201404432 [X] 1 * compounds 6a-6f *
DOI: http://dx.doi.org/10.1002/ANIE.201404432
Type:Non-patent literature
Publication information:[X]   ZHONG, FANGRUI ET AL: "Molecular sieve mediated decarboxylative Mannich and aldol reactions of .beta.-ketoacids", TETRAHEDRON LETTERS, vol. 54, no. 32, 2013, pages 4333 - 4336, XP002751373, DOI: 10.1016/J.TETLET.2013.06.030 [X] 1 * compounds 1,6-14 *
DOI: http://dx.doi.org/10.1016/J.TETLET.2013.06.030
Type:Non-patent literature
Publication information:[X]   LU, YU ET AL: "Synthesis of planar chiral [2.2]paracyclophane-based amino thioureas and their application in asymmetric aldol reactions of ketones with isatins", TETRAHEDRON: ASYMMETRY, vol. 24, no. 18, 2013, pages 1082 - 1088, XP002751374, DOI: 10.1016/J.TETASY.2013.07.023 [X] 1 * compounds 9-12 *
DOI: http://dx.doi.org/10.1016/J.TETASY.2013.07.023
Type:Non-patent literature
Publication information:[X]   SAIDALIMU, IBRAYIM ET AL: "Highly enantioselective construction of 3-hydroxy oxindoles through a decarboxylative aldol addition of trifluoromethyl .alpha.-fluorinated gem-diols to N-benzyl isatins", ANGEWANDTE CHEMIE, INTERNATIONAL EDITION, vol. 52, no. 21, 2013, pages 5566 - 5570, XP002751375, DOI: 10.1002/ANIE.201301443 [X] 1 * Scheme 2, 1rst compound; table 2: compounds 3aj, 3ak *
DOI: http://dx.doi.org/10.1002/ANIE.201301443
Type:Non-patent literature
Publication information:[X]   LIU, YUN-LIN ET AL: "Organocatalytic asymmetric synthesis of 3-difluoroalkyl 3-hydroxyoxindoles", CHEMICAL COMMUNICATIONS CAMBRIDGE, vol. 48, 2012, pages 1919 - 1921, XP002751376, DOI: 10.1039/C2CC17140F [X] 1 * compounds 4,8a-8g,8j-8p *
DOI: http://dx.doi.org/10.1039/C2CC17140F
Type:Non-patent literature
Publication information:[X]   RICHTER, LARS ET AL: "Diazepam-bound GABAA receptor models identify new benzodiazepine binding-site ligands", NATURE CHEMICAL BIOLOGY, vol. 8, no. 5, 2012, pages 455 - 464, XP002751377, DOI: 10.1038/NCHEMBIO.917 [X] 1 * table 2; compounds 15, 15f, 15g *
DOI: http://dx.doi.org/10.1038/NCHEMBIO.917
Type:Non-patent literature
Publication information:[X]   BYLER, KENDALL G. ET AL: "Identification of benzoylisoquinolines as potential anti-Chagas agents", BIOORGANIC & MEDICINAL CHEMISTRY, vol. 20, no. 8, 2012, pages 2587 - 2594, XP002751378, DOI: 10.1016/J.BMC.2012.02.046 [X] 1 * table 3; compound CHEMBL259139 *
DOI: http://dx.doi.org/10.1016/J.BMC.2012.02.046
Type:Non-patent literature
Publication information:[X]   ALLU, SURESH ET AL: "Enantioselective organocatalytic aldol reaction of unactivated ketones with isatins", TETRAHEDRON LETTERS, vol. 52, no. 32, 2011, pages 4080 - 4083, XP002751379, DOI: 10.1016/J.TETLET.2011.05.013 [X] 1 * compounds 4a-4j, 4o *
DOI: http://dx.doi.org/10.1016/J.TETLET.2011.05.013
Type:Non-patent literature
Publication information:[X]   KLOECK, CORNELIUS ET AL: "Acylideneoxoindoles: A new class of reversible inhibitors of human transglutaminase 2", BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, vol. 21, no. 9, 2011, pages 2692 - 2696, XP002751380, DOI: 10.1016/J.BMCL.2010.12.037 [X] 1 * intermediate (b-->c) for compounds 20-25 *
DOI: http://dx.doi.org/10.1016/J.BMCL.2010.12.037
Type:Non-patent literature
Publication information:[X]   GUO, QUNSHENG ET AL: "Quinidine thiourea-catalyzed aldol reaction of unactivated ketones: highly enantioselective synthesis of 3-alkyl-3-hydroxyindolin-2-ones", ANGEWANDTE CHEMIE, INTERNATIONAL EDITION, vol. 49, no. 49, 2010, pages 9460 - 9464, XP002751381, DOI: 10.1002/ANIE.201004161 [X] 1 * table 2; compounds 12.7-12.12, 12r *
DOI: http://dx.doi.org/10.1002/ANIE.201004161
Type:Non-patent literature
Publication information:[X]   BECERRA, DIANA ET AL: "Hydrogen-bonding patterns in 3-alkyl-3-hydroxyindolin-2-ones", ACTA CRYSTALLOGRAPHICA, SECTION C: CRYSTAL STRUCTURE COMMUNICATIONS, vol. 66, no. 2, 2010, pages o79 - o86, XP002751382, DOI: 10.1107/S0108270110001058 [X] 1 * compounds (I)-(VI) *
DOI: http://dx.doi.org/10.1107/S0108270110001058
Type:Non-patent literature
Publication information:[X]   ERKIZAN, HAYRIYE V. ET AL: "A small molecule blocking oncogenic protein EWS-FLI1 interaction with RNA helicase A inhibits growth of Ewing's sarcoma", NATURE MEDICINE, vol. 15, no. 7, 2009, pages 750 - 757, XP002751383, DOI: 10.1038/NM.1983 [X] 1,14-21 * figure 3; compounds NSC635473, YK-4-279 *
DOI: http://dx.doi.org/10.1038/NM.1983
Type:Non-patent literature
Publication information:[X]   CHEN, WEN-BING ET AL: "Catalyst-free aldol condensation of ketones and isatins under mild reaction conditions in DMF with molecular sieves 4 .ANG. as additive", GREEN CHEMISTRY, vol. 11, no. 9, 2009, pages 1465 - 1476, XP002751384, DOI: 10.1039/B906684E [X] 1 * compounds 3a-3k,3q-3z,3a' *
DOI: http://dx.doi.org/10.1039/B906684E
Type:Non-patent literature
Publication information:[X]   SEGURA-CABRERA, ALDO ET AL: "Structure-based prediction of Mycobacterium tuberculosis shikimate kinase inhibitors by high-throughput virtual screening", BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, vol. 18, no. 11, 2008, pages 3152 - 3157, XP002751385, DOI: 10.1016/J.BMCL.2008.05.003 [X] 1 * Chem. Abs. RNs 404842-60-0, 442567-97-7 *
DOI: http://dx.doi.org/10.1016/J.BMCL.2008.05.003
Type:Non-patent literature
Publication information:[X]   MACAEV, F. Z. ET AL: "Synthesis and structure of new oxoindoles", CHEMISTRY OF HETEROCYCLIC COMPOUNDS, vol. 43, no. 3, 2007, pages 298 - 305, XP002751386, DOI: 10.1007/S10593-007-0045-6 [X] 1 * compounds 8-15,18 *
DOI: http://dx.doi.org/10.1007/S10593-007-0045-6
Type:Non-patent literature
Publication information:[X]   LOPEZ-ALVARADO, PILAR ET AL: "New diastereoselective synthesis of 3-alkylidene-1-methyloxindoles", SYNTHESIS, vol. 1, 2002, pages 104 - 110, XP002751387, DOI: 10.1055/S-2002-19299 [X] 1 * compounds 2-15 *
DOI: http://dx.doi.org/10.1055/S-2002-19299
Type:Non-patent literature
Publication information:[X]   EL-GENDY, ADEL A. ET AL: "Synthesis and antimicrobial activity of some new 2-indolinone derived oximes and spiro-isoxazolines", ARCHIVES OF PHARMACAL RESEARCH, vol. 23, no. 4, 2000, pages 310 - 314, XP002751388, DOI: 10.1007/BF02975439 [X] 1 * table I; compounds 9-20 *
DOI: http://dx.doi.org/10.1007/BF02975439
Type:Non-patent literature
Publication information:[X]   GRIGG, RONALD ET AL: "Silver acetate catalyzed cycloadditions of isocyanoacetates", TETRAHEDRON, vol. 55, no. 7, 1999, pages 2025 - 2044, XP002751389, DOI: 10.1016/S0040-4020(98)01216-2 [X] 1 * Chem. Abs. RN 222420-93-1 *
DOI: http://dx.doi.org/10.1016/S0040-4020(98)01216-2
Type:Non-patent literature
Publication information:[X]   JOSHI, KRISHNA C. ET AL: "Studies in spiroheterocycles. Part XXVIII. Investigation of the reaction of 3-(aroylmethylene)indolin-2-ones with thiosemicarbazide and synthesis of spiro[3H-indole-3,4'(3'H)-pyrimidin]-2(1H)-ones", HETEROCYCLES, vol. 31, no. 3, 1990, pages 473 - 477, XP008178197, ISSN: 0385-5414 [X] 1 * compound IIIa *
DOI: http://dx.doi.org/10.3987/COM-89-5133
Type:Non-patent literature
Publication information:[X]   JOSHI, KRISHNA C. ET AL: "Investigation of the reaction of 1,3-dihydro-3-(2-phenyl-2-oxoethylidene)indol-2(H)-ones with 3-amino-1-phenyl-2-pyrazolin-5-one", INDIAN JOURNAL OF CHEMISTRY, SECTION B: ORGANIC CHEMISTRY INCLUDING MEDICINAL CHEMISTRY, vol. 29B, no. 10, 1990, pages 933 - 936, XP008178196 [X] 1 * intermediates to prepare compounds I *
Type:Non-patent literature
Publication information:[X]   JOSHI, KRISHNA C. ET AL: "Synthesis and antibacterial activity of some novel fluorine containing spiro[3H-indole-3,3'-[3H]-pyrazol]-2(1H)-one derivatives", JOURNAL OF THE INDIAN CHEMICAL SOCIETY, vol. 67, no. 9, 1990, pages 753 - 756, XP008178194 [X] 1 * compounds (1) *
Type:Non-patent literature
Publication information:[X]   JOSHI, K. C. ET AL: "Studies in spiro heterocycles. Part 4: investigation of the reactions of fluorinated 3-aroylmethyleneindol-2-ones with hydrazine and phenylhydrazine and synthesis of spiro [indole-3,3'-pyrazol]-2-ones", PHARMAZIE, vol. 40, no. 1, 1985, pages 21 - 22, XP008178195 [X] 1 * compounds 3 *
Type:Non-patent literature
Publication information:[X]   BAYOUMY- B E ET AL: "Studies on Spiroheterocyclic Nitrogen Compounds. Part 1: Synthesis of Some New Spiro Pyrazolines, Isoxazolines and Pyrimidinethiones Containing Benzanilide Moiety", JOURNAL OF THE INDIAN CHEMICAL SOCIETY, THE INDIAN CHEMICAL SOCIETY, CALCUTTA; IN, vol. LXI, 1 June 1984 (1984-06-01), pages 520 - 522, XP008175382, ISSN: 0019-4522 [X] 1 * compounds 2a-d *
Type:Non-patent literature
Publication information:[X]   PAJOUHESH, HOSSEIN ET AL: "Potential anticonvulsants. VI: Condensation of isatins with cyclohexanone and other cyclic ketones", JOURNAL OF PHARMACEUTICAL SCIENCES, vol. 72, no. 3, 1983, pages 318 - 321, XP002751390, DOI: 10.1002/JPS.2600720330 [X] 1 * compounds of table IV *
DOI: http://dx.doi.org/10.1002/JPS.2600720330
Type:Non-patent literature
Publication information:[X]   POPP, F. D. ET AL: "Synthesis of 3-hydroxy-3-phenacyloxindole analogs", JOURNAL OF PHARMACEUTICAL SCIENCES, vol. 68, no. 4, 1979, pages 519 - 520, XP002751391, DOI: 10.1002/JPS.2600680437 [X] 1,4 * table I; compounds 1,2,4,5,7-13 *
DOI: http://dx.doi.org/10.1002/JPS.2600680437
Type:Non-patent literature
Publication information:[X]   KOBAYASHI, GORO ET AL: "Studies on Indole derivatives. I. Synthesis of 3-phenyl-9H-pyridazino-[3,4-b]indole derivatives", CHEMICAL & PHARMACEUTICAL BULLETIN, vol. 12, no. 10, 1964, pages 1120 - 1135, XP002751392, DOI: 10.1248/CPB.12.1129 [X] 1 * compounds of table I *
DOI: http://dx.doi.org/10.1248/CPB.12.1129
Type:Non-patent literature
Publication information:[X]   PIETRA, SILVIO ET AL: "The stereochemistry of propiophenone addition to isatin", GAZZETTA CHIMICA ITALIANA, vol. 92, no. XII, 1962, pages 1422 - 1431, XP008178198 [X] 1 * compounds IA, IB and compounds of scheme I *
Type:Non-patent literature
Publication information:[X]   LUTZ R E ET AL: "ACID-CATALYZED REARRANGEMENTS OF THE .GAMMA.-(METHYLANILINO)LACTONE OF CIS-.BETA.-(P-BROMOBENZOYL)-.BETA.-METHYLACRYLIC ACID, AND OF TRANS-.BETA.-(P-BROMOBENZOYL)ACRYLIC METHYLANILIDE, TO OXINDOLES", THE JOURNAL OF ORGANIC CHEMISTRY, AMERICAN CHEMICAL SOCIETY, US, vol. 25, 1 February 1960 (1960-02-01), pages 193 - 196, XP002393294, ISSN: 0022-3263, DOI: 10.1021/JO01072A010 [X] 1 * compounds V(a), V(b) *
DOI: http://dx.doi.org/10.1021/jo01072a010