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Extract from the Register of European Patents

EP About this file: EP3147358

EP3147358 - METHOD FOR MONOMERIZING MATRIX METALLOPROTEINASE-7 (MMP-7) AGGREGATE [Right-click to bookmark this link]
StatusExamination is in progress
Status updated on  02.08.2019
Database last updated on 14.09.2024
FormerRequest for examination was made
Status updated on  24.02.2017
FormerThe international publication has been made
Status updated on  16.12.2016
Most recent event   Tooltip24.05.2024New entry: Renewal fee paid 
Applicant(s)For all designated states
KM Biologics Co., Ltd.
1-6-1 Okubo
Kita-ku
Kumamoto-shi
Kumamoto 860-8568 / JP
[2018/46]
Former [2017/13]For all designated states
The Chemo-Sero-Therapeutic Research Institute
1-6-1 Okubo
Kita-ku
Kumamoto-shi
Kumamoto 860-8568 / JP
Inventor(s)01 / NAKATAKE, Hiroshi
c/o THE CHEMO-SERO-THERAPEUTIC RESEARCH INSTITUTE
KIKUCHI RESEARCH CENTER
1314-1 Kyokushi Kawabe
Kikuchi-shi Kumamoto 869-1298 / JP
02 / HIRASHIMA, Masaki
c/o THE CHEMO-SERO-THERAPEUTIC RESEARCH INSTITUTE
KIKUCHI RESEARCH CENTER
1314-1 Kyokushi Kawabe
Kikuchi-shi Kumamoto 869-1298 / JP
03 / TAKEO, Hideki
c/o THE CHEMO-SERO-THERAPEUTIC
RESEARCH INSTITUTE
1-6-1 Okubo
Kita-ku
Kumamoto-shi Kumamoto 860-8568 / JP
04 / MATSUYAMA, Reiko
c/o THE CHEMO-SERO-THERAPEUTIC
RESEARCH INSTITUTE
KIKUCHI RESEARCH CENTER
1314-1 Kyokushi Kawabe
Kikuchi-shi Kumamoto 869-1298 / JP
05 / MORIKAWA, Wataru
c/o THE CHEMO-SERO-THERAPEUTIC
RESEARCH INSTITUTE
KIKUCHI RESEARCH CENTER
1314-1 Kyokushi Kawabe
Kikuchi-shi Kumamoto 869-1298 / JP
 [2017/13]
Representative(s)Vossius & Partner Patentanwälte Rechtsanwälte mbB
Siebertstrasse 3
81675 München / DE
[2017/13]
Application number, filing date15795955.220.05.2015
[2017/13]
WO2015JP64451
Priority number, dateJP2014010545221.05.2014         Original published format: JP 2014105452
[2017/13]
Filing languageJA
Procedural languageEN
PublicationType: A1 Application with search report
No.:WO2015178414
Date:26.11.2015
Language:JA
[2015/47]
Type: A1 Application with search report 
No.:EP3147358
Date:29.03.2017
Language:EN
[2017/13]
Search report(s)International search report - published on:JP26.11.2015
(Supplementary) European search report - dispatched on:EP07.11.2017
ClassificationIPC:C12N9/64, A61K38/46, A61K47/02, A61K47/10, A61K47/16, A61K47/26, A61P19/00, A61P25/00, C12N9/96, A61K38/48, C12N15/52
[2017/49]
CPC:
C12N9/96 (EP,KR,RU,US); C12N9/64 (EP,KR,US); A61K38/46 (EP,KR,US);
A61K38/4886 (EP,RU,US); A61K47/02 (EP,KR,RU,US); A61K47/10 (EP,KR,US);
A61K47/16 (EP,KR,US); A61K47/26 (EP,KR,US); A61P19/00 (EP,RU);
A61P19/04 (EP); A61P25/00 (EP); C12N15/52 (EP,US);
C12N9/6491 (EP,RU,US); C12Y304/24023 (EP,RU,US) (-)
Former IPC [2017/13]C12N9/64, A61K38/46, A61K47/02, A61K47/10, A61K47/16, A61K47/26, A61P19/00, A61P25/00, C12N9/96
Designated contracting statesAL,   AT,   BE,   BG,   CH,   CY,   CZ,   DE,   DK,   EE,   ES,   FI,   FR,   GB,   GR,   HR,   HU,   IE,   IS,   IT,   LI,   LT,   LU,   LV,   MC,   MK,   MT,   NL,   NO,   PL,   PT,   RO,   RS,   SE,   SI,   SK,   SM,   TR [2017/13]
TitleGerman:VERFAHREN ZUR MONOMERISIERUNG EINES MATRIXMETALLOPROTEINASE-7-AGGREGATS (MMP-7)[2017/13]
English:METHOD FOR MONOMERIZING MATRIX METALLOPROTEINASE-7 (MMP-7) AGGREGATE[2017/13]
French:PROCÉDÉ DE MONOMÉRISATION D'UN AGRÉGAT DE MÉTALLOPROTÉINASE-7 MATRICIELLE (MMP -7)[2017/13]
Entry into regional phase16.12.2016Translation filed 
16.12.2016National basic fee paid 
16.12.2016Search fee paid 
16.12.2016Designation fee(s) paid 
16.12.2016Examination fee paid 
Examination procedure16.12.2016Examination requested  [2017/13]
16.12.2016Date on which the examining division has become responsible
28.05.2018Amendment by applicant (claims and/or description)
06.08.2019Despatch of a communication from the examining division (Time limit: M04)
05.12.2019Reply to a communication from the examining division
08.07.2021Despatch of a communication from the examining division (Time limit: M06)
18.01.2022Reply to a communication from the examining division
22.01.2024Despatch of a communication from the examining division (Time limit: M04)
22.04.2024Reply to a communication from the examining division
Fees paidRenewal fee
23.05.2017Renewal fee patent year 03
23.05.2018Renewal fee patent year 04
22.05.2019Renewal fee patent year 05
31.03.2020Renewal fee patent year 06
21.05.2021Renewal fee patent year 07
30.03.2022Renewal fee patent year 08
30.03.2023Renewal fee patent year 09
23.05.2024Renewal fee patent year 10
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Documents cited:Search[XI]US6194189  (SENIOR ROBERT M [US]) [X] 1-10,17,19,20 * column 6, line 25 - line 44 * [I] 11-16,18,21,22;
 [XI]  - YU W-H ET AL, "Heparan sulfate proteoglycans as extracellular docking molecules for matrilysin (matrix metalloproteinase 7)", JOURNAL OF BIOLOGICAL CHEMISTRY, AMERICAN SOCIETY FOR BIOCHEMISTRY AND MOLECULAR BIOLOGY, US, (20000211), vol. 275, no. 6, doi:10.1074/JBC.275.6.4183, ISSN 0021-9258, pages 4183 - 4191, XP002310584 [X] 1-3,8,10,17,19,20 * abstract * * page 4184, column r, paragraph 3 * * page 4185, column r, paragraph 3 * [I] 4-7,9,11-16,18,21,22

DOI:   http://dx.doi.org/10.1074/jbc.275.6.4183
International search[A]JPH10276774  (TOYO BOSEKI) [A] 1-46 * , claims; paragraph [0006] (Family: none) *;
 [A]JP2000344672  (MEIJI MILK PROD CO LTD, et al) [A] 1-46 * , paragraph [0028] (Family: none) *;
 [A]JP2005006509  (ARKRAY INC) [A] 1-46 * , paragraph [0027] (Family: none) *;
 [A]JP2005528109  (Astex Technology Ltd.) [A] 1-46 * , paragraph [0020] & US 2004/0243319 A1 & WO 2003/102192 A1 & EP 1509608 A2 *;
 [YA]JP2008206491  (TOYO BOSEKI) [Y] 1, 2, 4, 7-14, 16-27, 29-37, 39-46 * , claims (Family: none) * [A] 3, 5, 6, 15, 28, 38;
 [YA]JP2009517086  (Biomatrica, Inc.) [Y] 1, 2, 4, 7-14, 16-27, 29-37, 39-46 * , claims; paragraph [0043] & US 2006/0099567 A1 & WO 2005/113147 A2 & EP 1951868 A2 * [A] 3, 5, 6, 15, 28, 38;
 [YA]WO2010047347  (CHEMO SERO THERAPEUT RES INST [JP], et al) [Y] 1, 2, 4, 7-14, 16-27, 29-37, 39-46 * , examples 4, 5 & US 2011/0262998 A1 & EP 2363469 A1 * [A] 3, 5, 6, 15, 28, 38;
 [YA]WO2012167271  (BAXTER INT [US], et al) [Y] 1, 2, 4, 7-14, 16-27, 29-37, 39-46 * , claims & JP 2014-519506 A & US 2012/0329128 A1 & EP 2714087 A2 * [A] 3, 5, 6, 15, 28, 38;
 [YA]JP2013518893  (Biomarin Pharmaceutical Inc.) [Y] 1, 2, 4, 7-14, 16-27, 29-37, 39-46 * , claims; paragraph [0162] & US 2013/0039898 A1 & WO 2011/097335 A2 & EP 2531209 A1 * [A] 3, 5, 6, 15, 28, 38;
 [XYA]  - LOPEZ DE TURISO J et al., "Expression and purification of human matrilysin produced in baculovirus-infected insect cells", J. Biotechnol., (19960000), vol. 46, no. 3, ISSN 0168-1656, pages 235 - 241, XP004036792 [X] 1, 2, 4, 7-13, 22, 23 [Y] 14, 16-21, 24-27, 29-37, 39-46 [A] 3, 5, 6, 15, 28, 38

DOI:   http://dx.doi.org/10.1016/0168-1656(96)00002-8
 [YA]  - HARO H, "Translational research of herniated discs: current status of diagnosis and treatment", J. Orthop. Sci., (20140700), vol. 19, no. 4, ISSN 0949-2658, pages 515 - 520, XP055238066 [Y] 1, 2, 4, 7-14, 16-27, 29-37, 39-46 [A] 3, 5, 6, 15, 28, 38

DOI:   http://dx.doi.org/10.1007/s00776-014-0571-x
 [YA]  - OU L et al., "The expression and refolding of isotopically labeled recombinant Matrilysin for NMR studies", Protein Expr. Purif., (20060000), vol. 47, no. 2, ISSN 1046-5928, pages 367 - 373, XP024908753 [Y] 1, 2, 4, 7-14, 16-27, 29-37, 39-46 [A] 3, 5, 6, 15, 28, 38

DOI:   http://dx.doi.org/10.1016/j.pep.2006.01.016
 [YA]  - KANNAN R et al., "Purification of active matrix metalloproteinase catalytic domains and its use for screening of specific stromelysin-3 inhibitors", Protein Expr. Purif., (19990000), vol. 16, no. 1, ISSN 1046-5928, pages 76 - 83, XP004441684 [Y] 1, 2, 4, 7-14, 16-27, 29-37, 39-46 [A] 3, 5, 6, 15, 28, 38

DOI:   http://dx.doi.org/10.1006/prep.1999.1068
 [YA]  - BROWNER MF et al., "Matrilysin-inhibitor complexes: common themes among metalloproteases", Biochemistry, (19950000), vol. 34, no. 20, pages 6602 - 6610, XP000983457 [Y] 26, 27, 29-37, 39-46 [A] 1-25, 28, 38

DOI:   http://dx.doi.org/10.1021/bi00020a004
 [A]  - BARNETT J et al., "Production, purification, and characterization of human matrilysin (PUMP) from recombinant Chinese hamster ovary cells", Protein Expr. Purif., (19940000), vol. 5, no. 1, ISSN 1046-5928, pages 27 - 36, XP024799933 [A] 1-46

DOI:   http://dx.doi.org/10.1006/prep.1994.1004
 [A]  - KIHIRA Y et al., "Production of recombinant human matrix metalloproteinase 7 (Matrilysin) with potential role in tumor invasion by refolding from Escherichia coli inclusion bodies and development of sandwich ELISA of MMP-7", Urol. Oncol., (19960000), vol. 2, no. 1, pages 20 - 26, XP055238069 [A] 1-46
 [A]  - ZHOU JH et al., "Autoantibodies against MMP-7 as a novel diagnostic biomarker in esophageal squamous cell carcinoma", World J. Gastroenterol., (20110000), vol. 17, no. 10, ISSN 1007-9327, pages 1373 - 1378, XP055238070 [A] 1-46

DOI:   http://dx.doi.org/10.3748/wjg.v17.i10.1373
 [A]  - INOUYE K et al., "States of tryptophyl residues and stability of recombinant human matrix metalloproteinase 7 (matrilysin) as examined by fluorescence", J. Biochem., (20000000), vol. 128, no. 3, pages 363 - 369, XP055238071 [A] 1-46
 [A]  - SAMUKANGE V et al., "Effects of heparin and cholesterol sulfate on the activity and stability of human matrix metalloproteinase 7", Bioscience, biotechnology, and biochemistry, (20140000), vol. 78, no. 1, ISSN 0916-8451, pages 41 - 48, XP055238072 [A] 1-46

DOI:   http://dx.doi.org/10.1080/09168451.2014.878213
 [A]  - CRABBE T et al., "Biochemical characterization of matrilysin. Activation conforms to the stepwise mechanisms proposed for other matrix metalloproteinases", Biochemistry, (19920000), vol. 31, no. 36, pages 8500 - 8507, XP055238073 [A] 1-46
 [A]  - ONEDA H et al., "Refolding and recovery of recombinant human matrix metalloproteinase 7 (matrilysin) from inclusion bodies expressed by Escherichia coli", J. Biochem., (19990000), vol. 126, no. 5, ISSN 0021-924x, pages 905 - 911, XP055238074 [A] 1-46

DOI:   http://dx.doi.org/10.1093/oxfordjournals.jbchem.a022533
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