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Extract from the Register of European Patents

EP About this file: EP3152295

EP3152295 - A NOVEL AND EFFICIENT METHOD FOR REPROGRAMMING IMMORTALIZED LYMPHOBLASTOID CELL LINES TO INDUCED PLURIPOTENT STEM CELLS [Right-click to bookmark this link]
StatusNo opposition filed within time limit
Status updated on  04.06.2021
Database last updated on 15.07.2024
FormerThe patent has been granted
Status updated on  26.06.2020
FormerGrant of patent is intended
Status updated on  09.01.2020
FormerExamination is in progress
Status updated on  14.09.2018
FormerRequest for examination was made
Status updated on  10.03.2017
FormerThe international publication has been made
Status updated on  23.12.2016
Most recent event   Tooltip14.06.2024Lapse of the patent in a contracting state
New state(s): TR		published on 17.07.2024 [2024/29]
Applicant(s)For all designated states
Cedars-Sinai Medical Center
8700 Beverly Boulevard
Los Angeles, CA 90048 / US
[2017/15]
Inventor(s)01 / SAREEN, Dhruv
19375 Crystal Ridge Lane
Porter Ranch, California 91326 / US
02 / ORNELAS, Loren A.
2883 Round Drive
Los Angeles, California 90032 / US
03 / BARRETT, Robert
1320 North Hayworth Avenue
Apt. 4
Los Angeles, California 90046 / US
 [2017/15]
Representative(s)HGF
HGF Limited
1 City Walk
Leeds LS11 9DX / GB
[N/P]
Former [2020/31]HGF
1 City Walk
Leeds LS11 9DX / GB
Former [2017/15]HGF Limited
4th Floor
Merchant Exchange
17-19 Whitworth Street West
Manchester M1 5WG / GB
Application number, filing date15802756.505.06.2015
[2017/15]
WO2015US34532
Priority number, dateUS201462008198P05.06.2014         Original published format: US 201462008198 P
[2017/15]
Filing languageEN
Procedural languageEN
PublicationType: A1 Application with search report
No.:WO2015188131
Date:10.12.2015
Language:EN
[2015/49]
Type: A1 Application with search report 
No.:EP3152295
Date:12.04.2017
Language:EN
The application published by WIPO in one of the EPO official languages on 10.12.2015 takes the place of the publication of the European patent application.
[2017/15]
Type: B1 Patent specification 
No.:EP3152295
Date:29.07.2020
Language:EN
[2020/31]
Search report(s)International search report - published on:US10.12.2015
(Supplementary) European search report - dispatched on:EP13.10.2017
ClassificationIPC:C12N5/00, C12N15/00, A01N63/00, C12N5/074, A61K35/17, C12N15/86, A61K35/12
[2017/41]
CPC:
C12N5/0696 (EP,US); A61K35/17 (EP,US); C12N15/00 (US);
C12N15/86 (US); A61K2035/124 (US); C12N2501/115 (EP,US);
C12N2501/15 (EP,US); C12N2501/16 (EP,US); C12N2501/235 (EP,US);
C12N2501/48 (EP,US); C12N2501/602 (EP,US); C12N2501/603 (EP,US);
C12N2501/604 (EP,US); C12N2501/606 (EP,US); C12N2501/608 (EP,US);
C12N2501/727 (EP,US); C12N2501/999 (US); C12N2506/11 (EP,US) (-)
Former IPC [2017/15]C12N5/00, C12N15/00, A01N63/00
Designated contracting statesAL,   AT,   BE,   BG,   CH,   CY,   CZ,   DE,   DK,   EE,   ES,   FI,   FR,   GB,   GR,   HR,   HU,   IE,   IS,   IT,   LI,   LT,   LU,   LV,   MC,   MK,   MT,   NL,   NO,   PL,   PT,   RO,   RS,   SE,   SI,   SK,   SM,   TR [2017/15]
Extension statesBANot yet paid
MENot yet paid
Validation statesMANot yet paid
TitleGerman:NEUARTIGES UND EFFIZIENTES VERFAHREN ZUR UMPROGRAMMIERUNG IMMORTALISIERTER LYMPHOBLASTOIDER ZELLLINIEN ZU INDUZIERTEN PLURIPOTENTEN STAMMZELLEN[2017/15]
English:A NOVEL AND EFFICIENT METHOD FOR REPROGRAMMING IMMORTALIZED LYMPHOBLASTOID CELL LINES TO INDUCED PLURIPOTENT STEM CELLS[2017/15]
French:PROCÉDÉ NOUVEAU ET EFFICACE POUR REPROGRAMMER DES LIGNÉES CELLULAIRES LYMPHOBLASTOÏDES IMMORTALISÉES EN CELLULES SOUCHES PLURIPOTENTES INDUITES[2017/15]
Entry into regional phase22.12.2016National basic fee paid 
22.12.2016Search fee paid 
22.12.2016Designation fee(s) paid 
22.12.2016Examination fee paid 
Examination procedure22.12.2016Examination requested  [2017/15]
22.12.2016Date on which the examining division has become responsible
20.04.2018Amendment by applicant (claims and/or description)
17.09.2018Despatch of a communication from the examining division (Time limit: M04)
14.01.2019Reply to a communication from the examining division
10.01.2020Communication of intention to grant the patent
11.05.2020Fee for grant paid
11.05.2020Fee for publishing/printing paid
11.05.2020Receipt of the translation of the claim(s)
Divisional application(s)EP20187881.6  / EP3786285
Opposition(s)30.04.2021No opposition filed within time limit [2021/27]
Fees paidRenewal fee
27.06.2017Renewal fee patent year 03
27.06.2018Renewal fee patent year 04
27.06.2019Renewal fee patent year 05
22.06.2020Renewal fee patent year 06
Opt-out from the exclusive  Tooltip
competence of the Unified
Patent Court		 See the Register of the Unified Patent Court for opt-out data
Responsibility for the accuracy, completeness or quality of the data displayed under the link provided lies entirely with the Unified Patent Court.
Lapses during opposition  TooltipHU05.06.2015
AL29.07.2020
AT29.07.2020
CY29.07.2020
CZ29.07.2020
DK29.07.2020
EE29.07.2020
ES29.07.2020
FI29.07.2020
HR29.07.2020
IT29.07.2020
LT29.07.2020
LV29.07.2020
MC29.07.2020
MK29.07.2020
PL29.07.2020
RO29.07.2020
RS29.07.2020
SE29.07.2020
SI29.07.2020
SK29.07.2020
SM29.07.2020
TR29.07.2020
BG29.10.2020
NO29.10.2020
GR30.10.2020
IS29.11.2020
PT30.11.2020
[2024/29]
Former [2024/22]HU05.06.2015
AL29.07.2020
AT29.07.2020
CY29.07.2020
CZ29.07.2020
DK29.07.2020
EE29.07.2020
ES29.07.2020
FI29.07.2020
HR29.07.2020
IT29.07.2020
LT29.07.2020
LV29.07.2020
MC29.07.2020
MK29.07.2020
PL29.07.2020
RO29.07.2020
RS29.07.2020
SE29.07.2020
SI29.07.2020
SK29.07.2020
SM29.07.2020
BG29.10.2020
NO29.10.2020
GR30.10.2020
IS29.11.2020
PT30.11.2020
Former [2023/30]HU05.06.2015
AL29.07.2020
AT29.07.2020
CY29.07.2020
CZ29.07.2020
DK29.07.2020
EE29.07.2020
ES29.07.2020
FI29.07.2020
HR29.07.2020
IT29.07.2020
LT29.07.2020
LV29.07.2020
MC29.07.2020
PL29.07.2020
RO29.07.2020
RS29.07.2020
SE29.07.2020
SI29.07.2020
SK29.07.2020
SM29.07.2020
BG29.10.2020
NO29.10.2020
GR30.10.2020
IS29.11.2020
PT30.11.2020
Former [2023/29]HU05.06.2015
AL29.07.2020
AT29.07.2020
CZ29.07.2020
DK29.07.2020
EE29.07.2020
ES29.07.2020
FI29.07.2020
HR29.07.2020
IT29.07.2020
LT29.07.2020
LV29.07.2020
MC29.07.2020
PL29.07.2020
RO29.07.2020
RS29.07.2020
SE29.07.2020
SI29.07.2020
SK29.07.2020
SM29.07.2020
BG29.10.2020
NO29.10.2020
GR30.10.2020
IS29.11.2020
PT30.11.2020
Former [2022/08]AL29.07.2020
AT29.07.2020
CZ29.07.2020
DK29.07.2020
EE29.07.2020
ES29.07.2020
FI29.07.2020
HR29.07.2020
IT29.07.2020
LT29.07.2020
LV29.07.2020
MC29.07.2020
PL29.07.2020
RO29.07.2020
RS29.07.2020
SE29.07.2020
SI29.07.2020
SK29.07.2020
SM29.07.2020
BG29.10.2020
NO29.10.2020
GR30.10.2020
IS29.11.2020
PT30.11.2020
Former [2021/36]AL29.07.2020
AT29.07.2020
CZ29.07.2020
DK29.07.2020
EE29.07.2020
ES29.07.2020
FI29.07.2020
HR29.07.2020
IT29.07.2020
LT29.07.2020
LV29.07.2020
PL29.07.2020
RO29.07.2020
RS29.07.2020
SE29.07.2020
SI29.07.2020
SK29.07.2020
SM29.07.2020
BG29.10.2020
NO29.10.2020
GR30.10.2020
IS29.11.2020
PT30.11.2020
Former [2021/28]AL29.07.2020
AT29.07.2020
CZ29.07.2020
DK29.07.2020
EE29.07.2020
ES29.07.2020
FI29.07.2020
HR29.07.2020
IT29.07.2020
LT29.07.2020
LV29.07.2020
PL29.07.2020
RO29.07.2020
RS29.07.2020
SE29.07.2020
SK29.07.2020
SM29.07.2020
BG29.10.2020
NO29.10.2020
GR30.10.2020
IS29.11.2020
PT30.11.2020
Former [2021/25]AL29.07.2020
AT29.07.2020
CZ29.07.2020
DK29.07.2020
EE29.07.2020
ES29.07.2020
FI29.07.2020
HR29.07.2020
IT29.07.2020
LT29.07.2020
LV29.07.2020
PL29.07.2020
RO29.07.2020
RS29.07.2020
SE29.07.2020
SM29.07.2020
BG29.10.2020
NO29.10.2020
GR30.10.2020
IS29.11.2020
PT30.11.2020
Former [2021/22]AT29.07.2020
CZ29.07.2020
DK29.07.2020
EE29.07.2020
ES29.07.2020
FI29.07.2020
HR29.07.2020
IT29.07.2020
LT29.07.2020
LV29.07.2020
PL29.07.2020
RO29.07.2020
RS29.07.2020
SE29.07.2020
SM29.07.2020
BG29.10.2020
NO29.10.2020
GR30.10.2020
IS29.11.2020
PT30.11.2020
Former [2021/20]AT29.07.2020
DK29.07.2020
ES29.07.2020
FI29.07.2020
HR29.07.2020
IT29.07.2020
LT29.07.2020
LV29.07.2020
PL29.07.2020
RS29.07.2020
SE29.07.2020
BG29.10.2020
NO29.10.2020
GR30.10.2020
IS29.11.2020
PT30.11.2020
Former [2021/10]AT29.07.2020
ES29.07.2020
FI29.07.2020
HR29.07.2020
LT29.07.2020
LV29.07.2020
PL29.07.2020
RS29.07.2020
SE29.07.2020
BG29.10.2020
NO29.10.2020
GR30.10.2020
IS29.11.2020
PT30.11.2020
Former [2021/09]AT29.07.2020
ES29.07.2020
FI29.07.2020
LT29.07.2020
SE29.07.2020
BG29.10.2020
NO29.10.2020
GR30.10.2020
PT30.11.2020
Former [2021/08]ES29.07.2020
FI29.07.2020
LT29.07.2020
SE29.07.2020
BG29.10.2020
NO29.10.2020
PT30.11.2020
Former [2021/07]FI29.07.2020
LT29.07.2020
NO29.10.2020
Documents cited:Search[X]WO2011159684  (CELLULAR DYNAMICS INT INC [US], et al) [X] 1-15 * paragraphs [0059] , [0079]; claims 1-20 *;
 [Y]  - S. M. CHOI ET AL, "Reprogramming of EBV-immortalized B-lymphocyte cell lines into induced pluripotent stem cells", BLOOD, (20110531), vol. 118, no. 7, doi:10.1182/blood-2011-03-340620, ISSN 0006-4971, pages 1801 - 1805, XP055083381 [Y] 1-15 * page 1802, paragraph last; figure 1 *

DOI:   http://dx.doi.org/10.1182/blood-2011-03-340620
 [Y]  - ZHAOHUI YE ET AL, "Hematopoietic cells as sources for patient-specific iPSCs and disease modeling", CELL CYCLE, (20110901), vol. 10, no. 17, doi:10.4161/cc.10.17.17180, ISSN 1538-4101, pages 2840 - 2844, XP055092521 [Y] 1-15 * page 2841, column 1, paragraph 2; table 1 *

DOI:   http://dx.doi.org/10.4161/cc.10.17.17180
 [Y]  - D. RAJESH ET AL, "Human lymphoblastoid B-cell lines reprogrammed to EBV-free induced pluripotent stem cells", BLOOD, (20110627), vol. 118, no. 7, doi:10.1182/blood-2011-01-332064, ISSN 0006-4971, pages 1797 - 1800, XP055083379 [Y] 1-15 * figure 1 *

DOI:   http://dx.doi.org/10.1182/blood-2011-01-332064
 [T]  - ROBERT BARRETT ET AL, "Reliable Generation of Induced Pluripotent Stem Cells From Human Lymphoblastoid Cell Lines : Reliable iPSC Generation From LCLs", STEM CELLS TRANSLATIONAL MEDICINE : SCTM, Durham, (20141008), vol. 3, no. 12, doi:10.5966/sctm.2014-0121, ISSN 2157-6564, pages 1429 - 1434, XP055403729 [T] 1-15

DOI:   http://dx.doi.org/10.5966/sctm.2014-0121
International search[XY]US2012009676  (MACK AMANDA [US]) [X] 14, 6-13, 17, 19-20, 22 * para abstract, [0010], [0012], [0023], [0026], [0039], [0057], [0061], [0090], [0091], [0100], [0111], [0112]. [0198], [0299] * [Y] 5, 14-16, 18, 21;
 [Y]US2012196360  (OKITA KEISUKE [JP], et al) [Y] 5, 18 * para [0008], [0072], [0102], [0154] *;
 [Y]US8257941  (SAKURADA KAZUHIRO [JP], et al) [Y] 14-16 * col 1, In 45-49, col, 2, In 51-58, Table 3 *;
 [Y]WO2013062140  (UNIV KYOTO [JP]) [Y] 21* abstract, pg 37, In 2-35 -pg 38,In 1-2 *
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