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EP About this file: EP3229800

EP3229800 - USE OF PAN FGFR INHIBITORS AND METHOD OF IDENTIFYING PATIENTS WITH CANCER ELIGIBLE FOR TREATMENT WITH A PAN FGFR INHIBITOR [Right-click to bookmark this link]
StatusThe application has been withdrawn
Status updated on  22.01.2021
Database last updated on 02.09.2024
FormerExamination is in progress
Status updated on  15.03.2019
FormerRequest for examination was made
Status updated on  15.09.2017
FormerThe international publication has been made
Status updated on  26.05.2017
Most recent event   Tooltip22.01.2021Change: Date of cancellation oral proceedings 
22.01.2021New entry: Date of cancellation oral proceedings 
22.01.2021Withdrawal of applicationpublished on 24.02.2021  [2021/08]
Applicant(s)For all designated states
Bayer Pharma Aktiengesellschaft
Müller Strasse 178
13353 Berlin / DE
[2017/42]
Inventor(s)01 / ELLINGHAUS, Peter
Auf der Obstwiese 3
49324 Melle / DE
02 / HEROULT, Melanie
Ulenberg Str. 3d
40223 Düsseldorf / DE
 [2017/42]
Representative(s)BIP Patents
c/o Bayer Intellectual Property GmbH
Alfred-Nobel-Straße 50
40789 Monheim am Rhein / DE
[N/P]
Former [2017/42]BIP Patents
c/o Bayer Intellectual Property GmbH
Alfred-Nobel-Straße 10
40789 Monheim am Rhein / DE
Application number, filing date15805493.208.12.2015
[2017/42]
WO2015EP78919
Priority number, dateEP2014019740011.12.2014         Original published format: EP 14197400
[2017/42]
Filing languageEN
Procedural languageEN
PublicationType: A2 Application without search report
No.:WO2016091849
Date:16.06.2016
Language:EN
[2016/24]
Type: A2 Application without search report 
No.:EP3229800
Date:18.10.2017
Language:EN
The application published by WIPO in one of the EPO official languages on 16.06.2016 takes the place of the publication of the European patent application.
[2017/42]
Search report(s)International search report - published on:EP28.07.2016
(Supplementary) European search report - dispatched on:EP19.03.2019
ClassificationIPC:A61K31/4184, A61K31/4965, A61K31/498, A61K31/506, A61K31/53, A61P35/00
[2017/42]
CPC:
A61K31/53 (EP,CN,IL,KR,US); A61K45/00 (CN,IL); A61K31/4184 (EP,CN,IL,KR,US);
A61K31/496 (EP,CN,IL,US); A61K31/4965 (EP,IL,KR,US); A61K31/498 (EP,CN,IL,KR,US);
A61K31/506 (EP,CN,IL,KR,US); A61P35/00 (EP,IL,US); C12Q1/6886 (IL,US);
C12Q2600/106 (IL,US) (-)
Designated contracting statesAL,   AT,   BE,   BG,   CH,   CY,   CZ,   DE,   DK,   EE,   ES,   FI,   FR,   GB,   GR,   HR,   HU,   IE,   IS,   IT,   LI,   LT,   LU,   LV,   MC,   MK,   MT,   NL,   NO,   PL,   PT,   RO,   RS,   SE,   SI,   SK,   SM,   TR [2017/42]
Extension statesBA11.07.2017
ME11.07.2017
TitleGerman:VERWENDUNG VON PAN-FGFR-INHIBITOREN UND VERFAHREN ZUR IDENTIFIZIERUNG VON PATIENTEN MIT KREBS, DIE ZUR BEHANDLUNG MIT EINEM PAN-FGFR-INHIBITOREN IN FRAGE KOMMEN[2017/42]
English:USE OF PAN FGFR INHIBITORS AND METHOD OF IDENTIFYING PATIENTS WITH CANCER ELIGIBLE FOR TREATMENT WITH A PAN FGFR INHIBITOR[2017/42]
French:UTILISATION D'INHIBITEURS CIBLANT TOUS LES FGFR ET PROCÉDÉ D'IDENTIFICATION DE PATIENTS SOUFFRANT D'UN CANCER ÉLIGIBLES POUR UN TRAITEMENT AVEC UN INHIBITEUR CIBLANT TOUS LES FGFR[2017/42]
Entry into regional phase11.07.2017National basic fee paid 
11.07.2017Designation fee(s) paid 
11.07.2017Examination fee paid 
Examination procedure30.06.2017Date on which the examining division has become responsible
11.07.2017Examination requested  [2017/42]
22.01.2018Amendment by applicant (claims and/or description)
19.03.2019Despatch of a communication from the examining division to which search results under Rule 164(2) EPC are annexed (Time limit: M06) [2019/16]
19.03.2019Despatch of a communication from the examining division (Time limit: M06)
27.09.2019Reply to a communication from the examining division
19.01.2021Application withdrawn by applicant  [2021/08]
19.01.2021Cancellation of oral proceeding that was planned for 15.03.2021
15.03.2021Date of oral proceedings (cancelled)
Fees paidRenewal fee
12.12.2017Renewal fee patent year 03
12.12.2018Renewal fee patent year 04
13.12.2019Renewal fee patent year 05
14.12.2020Renewal fee patent year 06
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Cited inInternational search[XI]WO2011128701  (IMP INNOVATIONS LTD [GB], et al) [X] 1,30,31 * claims 1, 20 * [I] 2-5,17-19,25-29;
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 [XI]  - NILS C LEHNEN ET AL, "Fibroblast growth factor receptor 1 gene amplification in pancreatic ductal adenocarcinoma", HISTOPATHOLOGY., GB, (20130628), vol. 63, no. 2, doi:10.1111/his.12115, ISSN 0309-0167, pages 157 - 166, XP055246591 [X] 1,2,17,18,26,30,31 * figure 4 * [I] 3-5,19,25,27-29

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 [XDI]  - M. W. WYNES ET AL, "FGFR1 mRNA and Protein Expression, not Gene Copy Number, Predict FGFR TKI Sensitivity across All Lung Cancer Histologies", CLINICAL CANCER RESEARCH, US, (20140615), vol. 20, no. 12, doi:10.1158/1078-0432.CCR-13-3060, ISSN 1078-0432, pages 3299 - 3309, XP055246497 [XD] 1,2,18,30,31 * page 3302, paragraph l - page 3303 * [I] 1,3-5,19,25-29

DOI:   http://dx.doi.org/10.1158/1078-0432.CCR-13-3060
 [XDI]  - M. E. MARSHALL ET AL, "Fibroblast Growth Factor Receptors Are Components of Autocrine Signaling Networks in Head and Neck Squamous Cell Carcinoma Cells", CLINICAL CANCER RESEARCH, (20110614), vol. 17, no. 15, doi:10.1158/1078-0432.CCR-11-0050, ISSN 1078-0432, pages 5016 - 5025, XP055180409 [XD] 1-5,18,19,30,31 * figure 1c * * page 5020, column 1 * [I] 17,25-29

DOI:   http://dx.doi.org/10.1158/1078-0432.CCR-11-0050
 [X]  - R. GYANCHANDANI ET AL, "A Proangiogenic Signature Is Revealed in FGF-Mediated Bevacizumab-Resistant Head and Neck Squamous Cell Carcinoma", MOLECULAR CANCER RESEARCH, US, (20131003), vol. 11, no. 12, doi:10.1158/1541-7786.MCR-13-0358, ISSN 1541-7786, pages 1585 - 1596, XP055246944 [X] 1-5,18,19,30,31 * page 1592, column 1 *

DOI:   http://dx.doi.org/10.1158/1541-7786.MCR-13-0358
 [A]  - P T NGUYEN ET AL, "The FGFR1 inhibitor PD173074 induces mesenchymal-epithelial transition through the transcription factor AP-1", BRITISH JOURNAL OF CANCER, GB, (20130917), vol. 109, no. 8, doi:10.1038/bjc.2013.550, ISSN 0007-0920, pages 2248 - 2258, XP055247675 [A] 1-5,17-19,25-31 * figure 5 *

DOI:   http://dx.doi.org/10.1038/bjc.2013.550
ExaminationEP2695950
 WO2016105503
    - JÖRG HÄNZE ET AL, "Epithelial mesenchymal transition status is associated with anti-cancer responses towards receptor tyrosine-kinase inhibition by dovitinib in human bladder cancer cells", BMC CANCER, BIOMED CENTRAL, LONDON, GB, (20131211), vol. 13, no. 1, doi:10.1186/1471-2407-13-589, ISSN 1471-2407, page 589, XP021171013

DOI:   http://dx.doi.org/10.1186/1471-2407-13-589
    - TIEWEI CHENG ET AL, "Fibroblast Growth Factor Receptors-1 and -3 Play Distinct Roles in the Regulation of Bladder Cancer Growth and Metastasis: Implications for Therapeutic Targeting", PLOS ONE, (20130226), vol. 8, no. 2, doi:10.1371/journal.pone.0057284, page e57284, XP055554959

DOI:   http://dx.doi.org/10.1371/journal.pone.0057284
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DOI:   http://dx.doi.org/10.1002/cam4.262
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DOI:   http://dx.doi.org/10.1517/13543784.2014.966900
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The EPO accepts no responsibility for the accuracy of data originating from other authorities; in particular, it does not guarantee that it is complete, up to date or fit for specific purposes.