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Extract from the Register of European Patents

EP About this file: EP3154968

EP3154968 - OXIDATIVE DEAROMATIZATION OF BERBINES [Right-click to bookmark this link]
StatusNo opposition filed within time limit
Status updated on  11.06.2021
Database last updated on 05.10.2024
FormerThe patent has been granted
Status updated on  03.07.2020
FormerGrant of patent is intended
Status updated on  02.01.2020
FormerRequest for examination was made
Status updated on  20.03.2017
FormerThe international publication has been made
Status updated on  06.01.2017
Most recent event   Tooltip06.09.2024Lapse of the patent in a contracting state
New state(s): MT		published on 09.10.2024 [2024/41]
Applicant(s)For all designated states
SpecGx LLC
385 Marshall Avenue
Webster Groves, Missouri 63119 / US
[2018/28]
Former [2018/16]For all designated states
SpecGx, LLC
385 Marshall Avenue
Webster Groves, Missouri 63119 / US
Former [2017/16]For all designated states
Mallinckrodt LLC
675 McDonnell Boulevard
Hazelwood, MO 63042 / US
Inventor(s)01 / GROTE, Christopher W.
c/o Mallinckrodt LLC
675 McDonnell Blvd.
Hazelwood, Missouri 63042 / US
 [2017/16]
Representative(s)Jones, Nicholas Andrew
Withers & Rogers LLP
2 London Bridge
London SE1 9RA / GB
[N/P]
Former [2017/16]Jones, Nicholas Andrew
Withers & Rogers LLP
4 More London Riverside
London, SE1 2AU / GB
Application number, filing date15806033.511.06.2015
[2017/16]
WO2015US35300
Priority number, dateUS201462010648P11.06.2014         Original published format: US 201462010648 P
[2017/16]
Filing languageEN
Procedural languageEN
PublicationType: A1 Application with search report
No.:WO2015191837
Date:17.12.2015
Language:EN
[2015/50]
Type: A1 Application with search report 
No.:EP3154968
Date:19.04.2017
Language:EN
The application published by WIPO in one of the EPO official languages on 17.12.2015 takes the place of the publication of the European patent application.
[2017/16]
Type: B1 Patent specification 
No.:EP3154968
Date:05.08.2020
Language:EN
[2020/32]
Search report(s)International search report - published on:US17.12.2015
(Supplementary) European search report - dispatched on:EP10.01.2018
ClassificationIPC:C07D455/03, C07D217/20, C07D221/18
[2017/16]
CPC:
C07D471/04 (EP,US); A61P35/00 (EP)
Designated contracting statesAL,   AT,   BE,   BG,   CH,   CY,   CZ,   DE,   DK,   EE,   ES,   FI,   FR,   GB,   GR,   HR,   HU,   IE,   IS,   IT,   LI,   LT,   LU,   LV,   MC,   MK,   MT,   NL,   NO,   PL,   PT,   RO,   RS,   SE,   SI,   SK,   SM,   TR [2017/16]
Extension statesBANot yet paid
MENot yet paid
Validation statesMANot yet paid
TitleGerman:OXIDATIVE ENTAROMATISIERUNG VON BERBINEN[2017/16]
English:OXIDATIVE DEAROMATIZATION OF BERBINES[2017/16]
French:DÉSAROMATISATION OXYDATIVE DE BERBINES[2017/16]
Entry into regional phase05.01.2017National basic fee paid 
05.01.2017Search fee paid 
05.01.2017Designation fee(s) paid 
05.01.2017Examination fee paid 
Examination procedure06.01.2017Examination requested  [2017/16]
06.01.2017Date on which the examining division has become responsible
27.07.2018Amendment by applicant (claims and/or description)
03.01.2020Communication of intention to grant the patent
20.03.2020Fee for grant paid
20.03.2020Fee for publishing/printing paid
20.03.2020Receipt of the translation of the claim(s)
Opposition(s)07.05.2021No opposition filed within time limit [2021/28]
Fees paidRenewal fee
27.06.2017Renewal fee patent year 03
27.06.2018Renewal fee patent year 04
27.06.2019Renewal fee patent year 05
29.06.2020Renewal fee patent year 06
Opt-out from the exclusive  Tooltip
competence of the Unified
Patent Court		 See the Register of the Unified Patent Court for opt-out data
Responsibility for the accuracy, completeness or quality of the data displayed under the link provided lies entirely with the Unified Patent Court.
Lapses during opposition  TooltipHU11.06.2015
AL05.08.2020
AT05.08.2020
CY05.08.2020
CZ05.08.2020
DK05.08.2020
EE05.08.2020
FI05.08.2020
HR05.08.2020
LT05.08.2020
LV05.08.2020
MC05.08.2020
MK05.08.2020
MT05.08.2020
NL05.08.2020
RO05.08.2020
RS05.08.2020
SE05.08.2020
SI05.08.2020
SK05.08.2020
SM05.08.2020
BG05.11.2020
NO05.11.2020
GR06.11.2020
IS05.12.2020
PT07.12.2020
[2024/41]
Former [2024/22]HU11.06.2015
AL05.08.2020
AT05.08.2020
CY05.08.2020
CZ05.08.2020
DK05.08.2020
EE05.08.2020
FI05.08.2020
HR05.08.2020
LT05.08.2020
LV05.08.2020
MC05.08.2020
MK05.08.2020
NL05.08.2020
RO05.08.2020
RS05.08.2020
SE05.08.2020
SI05.08.2020
SK05.08.2020
SM05.08.2020
BG05.11.2020
NO05.11.2020
GR06.11.2020
IS05.12.2020
PT07.12.2020
Former [2023/30]HU11.06.2015
AL05.08.2020
AT05.08.2020
CY05.08.2020
CZ05.08.2020
DK05.08.2020
EE05.08.2020
FI05.08.2020
HR05.08.2020
LT05.08.2020
LV05.08.2020
MC05.08.2020
NL05.08.2020
RO05.08.2020
RS05.08.2020
SE05.08.2020
SI05.08.2020
SK05.08.2020
SM05.08.2020
BG05.11.2020
NO05.11.2020
GR06.11.2020
IS05.12.2020
PT07.12.2020
Former [2023/29]HU11.06.2015
AL05.08.2020
AT05.08.2020
CZ05.08.2020
DK05.08.2020
EE05.08.2020
FI05.08.2020
HR05.08.2020
LT05.08.2020
LV05.08.2020
MC05.08.2020
NL05.08.2020
RO05.08.2020
RS05.08.2020
SE05.08.2020
SI05.08.2020
SK05.08.2020
SM05.08.2020
BG05.11.2020
NO05.11.2020
GR06.11.2020
IS05.12.2020
PT07.12.2020
Former [2022/08]AL05.08.2020
AT05.08.2020
CZ05.08.2020
DK05.08.2020
EE05.08.2020
FI05.08.2020
HR05.08.2020
LT05.08.2020
LV05.08.2020
MC05.08.2020
NL05.08.2020
RO05.08.2020
RS05.08.2020
SE05.08.2020
SI05.08.2020
SK05.08.2020
SM05.08.2020
BG05.11.2020
NO05.11.2020
GR06.11.2020
IS05.12.2020
PT07.12.2020
Former [2021/36]AL05.08.2020
AT05.08.2020
CZ05.08.2020
DK05.08.2020
EE05.08.2020
FI05.08.2020
HR05.08.2020
LT05.08.2020
LV05.08.2020
NL05.08.2020
RO05.08.2020
RS05.08.2020
SE05.08.2020
SI05.08.2020
SK05.08.2020
SM05.08.2020
BG05.11.2020
NO05.11.2020
GR06.11.2020
IS05.12.2020
PT07.12.2020
Former [2021/28]AL05.08.2020
AT05.08.2020
CZ05.08.2020
DK05.08.2020
EE05.08.2020
FI05.08.2020
HR05.08.2020
LT05.08.2020
LV05.08.2020
NL05.08.2020
RO05.08.2020
RS05.08.2020
SE05.08.2020
SK05.08.2020
SM05.08.2020
BG05.11.2020
NO05.11.2020
GR06.11.2020
IS05.12.2020
PT07.12.2020
Former [2021/25]AL05.08.2020
AT05.08.2020
CZ05.08.2020
DK05.08.2020
EE05.08.2020
FI05.08.2020
HR05.08.2020
LT05.08.2020
LV05.08.2020
NL05.08.2020
RO05.08.2020
RS05.08.2020
SE05.08.2020
SM05.08.2020
BG05.11.2020
NO05.11.2020
GR06.11.2020
IS05.12.2020
PT07.12.2020
Former [2021/23]AT05.08.2020
CZ05.08.2020
DK05.08.2020
EE05.08.2020
FI05.08.2020
HR05.08.2020
LT05.08.2020
LV05.08.2020
NL05.08.2020
RO05.08.2020
RS05.08.2020
SE05.08.2020
SM05.08.2020
BG05.11.2020
NO05.11.2020
GR06.11.2020
IS05.12.2020
PT07.12.2020
Former [2021/22]AT05.08.2020
CZ05.08.2020
DK05.08.2020
EE05.08.2020
FI05.08.2020
HR05.08.2020
LT05.08.2020
LV05.08.2020
NL05.08.2020
RO05.08.2020
RS05.08.2020
SE05.08.2020
BG05.11.2020
NO05.11.2020
GR06.11.2020
IS05.12.2020
PT07.12.2020
Former [2021/20]AT05.08.2020
DK05.08.2020
FI05.08.2020
HR05.08.2020
LT05.08.2020
LV05.08.2020
NL05.08.2020
RS05.08.2020
SE05.08.2020
BG05.11.2020
NO05.11.2020
GR06.11.2020
IS05.12.2020
PT07.12.2020
Former [2021/12]AT05.08.2020
FI05.08.2020
HR05.08.2020
LT05.08.2020
LV05.08.2020
NL05.08.2020
RS05.08.2020
SE05.08.2020
BG05.11.2020
NO05.11.2020
GR06.11.2020
IS05.12.2020
PT07.12.2020
Former [2021/10]AT05.08.2020
FI05.08.2020
HR05.08.2020
LT05.08.2020
LV05.08.2020
RS05.08.2020
SE05.08.2020
BG05.11.2020
NO05.11.2020
GR06.11.2020
IS05.12.2020
PT07.12.2020
Former [2021/09]AT05.08.2020
FI05.08.2020
LT05.08.2020
SE05.08.2020
BG05.11.2020
NO05.11.2020
GR06.11.2020
PT07.12.2020
Former [2021/08]FI05.08.2020
LT05.08.2020
SE05.08.2020
BG05.11.2020
NO05.11.2020
PT07.12.2020
Former [2021/07]FI05.08.2020
LT05.08.2020
NO05.11.2020
Documents cited:Search[A]WO2007094548  (KOREA RES INST OF BIOSCIENCE [KR], et al) [A] 1-15 * paragraph [0002]; claim 1; tables 1,2 *;
 [A]  - LO CHIH-YU ET AL, "Synthesis and anticancer activity of a novel series of 9-O-substituted berberine derivatives: A lipophilic substitute role", BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, (20121101), vol. 23, no. 1, doi:10.1016/J.BMCL.2012.10.098, ISSN 0960-894X, pages 305 - 309, XP028961570 [A] 1-15 * paragraph [0002]; table 1; compound 2 *

DOI:   http://dx.doi.org/10.1016/j.bmcl.2012.10.098
 [A]  - SILVIA SPINOZZI ET AL, "Berberine and Its Metabolites: Relationship between Physicochemical Properties and Plasma Levels after Administration to Human Subjects", JOURNAL OF NATURAL PRODUCTS., US, (20140425), vol. 77, no. 4, doi:10.1021/np400607k, ISSN 0163-3864, pages 766 - 772, XP055415871 [A] 1-15 * page 766, column 1; compounds 2,2a *

DOI:   http://dx.doi.org/10.1021/np400607k
 [X]  - HIROYUKI MIZUTA ET AL, "Smiles rearrangement in isoquinolinium salts.", CHEMICAL AND PHARMACEUTICAL BULLETIN, JP, (19870101), vol. 35, no. 6, doi:10.1248/cpb.35.2238, ISSN 0009-2363, pages 2238 - 2242, XP055415886 [X] 1 * compound 6 *

DOI:   http://dx.doi.org/10.1248/cpb.35.2238
International search[A]US4033966  (SAWA YOSHIO) [A] 1-4, 5/1-4, 6-9, 10/6-9, 13/10/6-9 * ; entire document *;
 [Y]US2010056789  (WANG PETER X [US], et al) [Y] 1-4, 5/1-4, 6-9, 10/6-9, 13/10/6-9 * ; paragraphs [0005], [0007]-[0011], [0087], [0130]-[0131] *;
 [Y]US2012308589  (YAO ZHUJUN [CN], et al) [Y] 1-4, 5/1-4, 6-9, 10/6-9, 13/10/6-9 * ; abstract; paragraphs [0001], [0012], [0036] *;
 [A]US2013064825  (CHAN JOYCE CHI YEE [US], et al) [A] 1-4, 5/1-4, 6-9, 10/6-9, 13/10/6-9* ; entire document *
The EPO accepts no responsibility for the accuracy of data originating from other authorities; in particular, it does not guarantee that it is complete, up to date or fit for specific purposes.