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Extract from the Register of European Patents

EP About this file: EP3158054

EP3158054 - GENETICALLY MODIFIED BACTERIA AND METHODS FOR GENETIC MODIFICATION OF BACTERIA [Right-click to bookmark this link]
StatusNo opposition filed within time limit
Status updated on  26.12.2025
Database last updated on 08.04.2026
FormerThe patent has been granted
Status updated on  17.01.2025
FormerGrant of patent is intended
Status updated on  28.10.2024
FormerExamination is in progress
Status updated on  30.04.2021
FormerRequest for examination was made
Status updated on  24.03.2017
FormerThe international publication has been made
Status updated on  17.01.2017
Most recent event   Tooltip20.02.2026Lapse of the patent in a contracting state
New state(s): LU		published on 25.03.2026  [2026/13]
Applicant(s)For all designated states
Crown Laboratories, Inc.
349 Lafe Cox Drive
Johnson City, TN 37604 / US
[2019/47]
Former [2017/17]For all designated states
Xycrobe Therapeutics Inc.
3210 Merrfield Row
San Diego, California 92121 / US
Inventor(s)01 / HITCHCOCK, Thomas
1873 Robinson Avenue
San Diego, California 92103 / US
02 / RHEE, Mun Su
Apt 118
8775 Costa Verde Blvd.
San Diego, California 92122 / US
 [2017/17]
Representative(s)Vossius & Partner Patentanwälte Rechtsanwälte mbB
Siebertstrasse 3
81675 München / DE
[2017/17]
Application number, filing date15809700.617.06.2015
[2017/17]
WO2015US36306
Priority number, dateUS201462013159P17.06.2014         Original published format: US 201462013159 P
[2017/17]
Filing languageEN
Procedural languageEN
PublicationType: A1 Application with search report
No.:WO2015195845
Date:23.12.2015
Language:EN
[2015/51]
Type: A1 Application with search report 
No.:EP3158054
Date:26.04.2017
Language:EN
The application published by WIPO in one of the EPO official languages on 23.12.2015 takes the place of the publication of the European patent application.
[2017/17]
Type: B1 Patent specification 
No.:EP3158054
Date:19.02.2025
Language:EN
[2025/08]
Search report(s)International search report - published on:IL23.12.2015
(Supplementary) European search report - dispatched on:EP16.10.2017
ClassificationIPC:C12N1/21, A61K35/74, A61K38/18, A61K38/19, A61P17/10
[2017/17]
CPC:
C12N15/746 (EP,US); A61P17/00 (EP); A61P17/06 (EP);
A61P17/08 (EP); A61P17/10 (EP); C07K14/475 (EP,US);
C07K14/715 (EP,US); A61K48/0025 (EP,US) (-)
Designated contracting statesAL,   AT,   BE,   BG,   CH,   CY,   CZ,   DE,   DK,   EE,   ES,   FI,   FR,   GB,   GR,   HR,   HU,   IE,   IS,   IT,   LI,   LT,   LU,   LV,   MC,   MK,   MT,   NL,   NO,   PL,   PT,   RO,   RS,   SE,   SI,   SK,   SM,   TR [2017/17]
Extension statesBANot yet paid
MENot yet paid
Validation statesMANot yet paid
TitleGerman:GENTECHNISCH MODIFIZIERTE BAKTERIEN UND VERFAHREN ZUR GENETISCHEN MODIFIKATION VON BAKTERIEN[2017/17]
English:GENETICALLY MODIFIED BACTERIA AND METHODS FOR GENETIC MODIFICATION OF BACTERIA[2017/17]
French:BACTÉRIES GÉNÉTIQUEMENT MODIFIÉES ET PROCÉDÉS DE MODIFICATION GÉNÉTIQUE DE BACTÉRIES[2017/17]
Entry into regional phase17.01.2017National basic fee paid 
17.01.2017Search fee paid 
17.01.2017Designation fee(s) paid 
17.01.2017Examination fee paid 
Examination procedure17.01.2017Examination requested  [2017/17]
17.01.2017Date on which the examining division has become responsible
16.05.2018Amendment by applicant (claims and/or description)
04.05.2021Despatch of a communication from the examining division (Time limit: M04)
10.09.2021Reply to a communication from the examining division
17.10.2022Despatch of a communication from the examining division (Time limit: M04)
15.12.2022Reply to a communication from the examining division
10.05.2023Despatch of a communication from the examining division (Time limit: M04)
18.07.2023Reply to a communication from the examining division
19.04.2024Despatch of a communication from the examining division (Time limit: M04)
23.05.2024Reply to a communication from the examining division
29.10.2024Communication of intention to grant the patent
14.01.2025Fee for grant paid
14.01.2025Fee for publishing/printing paid
14.01.2025Receipt of the translation of the claim(s)
Opposition(s)20.11.2025No opposition filed within time limit [2026/05]
Fees paidRenewal fee
26.06.2017Renewal fee patent year 03
25.06.2018Renewal fee patent year 04
10.07.2019Renewal fee patent year 05
29.06.2020Renewal fee patent year 06
28.06.2021Renewal fee patent year 07
27.06.2022Renewal fee patent year 08
27.06.2023Renewal fee patent year 09
27.06.2024Renewal fee patent year 10
Penalty fee
Additional fee for renewal fee
30.06.201905   M06   Fee paid on   10.07.2019
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Responsibility for the accuracy, completeness or quality of the data displayed under the link provided lies entirely with the Unified Patent Court.
Lapses during opposition  TooltipBG19.02.2025
EE19.02.2025
FI19.02.2025
HR19.02.2025
LV19.02.2025
MC19.02.2025
RO19.02.2025
SE19.02.2025
SM19.02.2025
NO19.05.2025
RS19.05.2025
GR20.05.2025
LU17.06.2025
IS19.06.2025
PT20.06.2025
[2026/13]
Former [2026/11]BG19.02.2025
EE19.02.2025
FI19.02.2025
HR19.02.2025
LV19.02.2025
MC19.02.2025
RO19.02.2025
SE19.02.2025
SM19.02.2025
NO19.05.2025
RS19.05.2025
GR20.05.2025
IS19.06.2025
PT20.06.2025
Former [2025/49]BG19.02.2025
EE19.02.2025
FI19.02.2025
HR19.02.2025
LV19.02.2025
RO19.02.2025
SE19.02.2025
SM19.02.2025
NO19.05.2025
RS19.05.2025
GR20.05.2025
IS19.06.2025
PT20.06.2025
Former [2025/48]BG19.02.2025
EE19.02.2025
FI19.02.2025
HR19.02.2025
LV19.02.2025
SE19.02.2025
SM19.02.2025
NO19.05.2025
RS19.05.2025
GR20.05.2025
IS19.06.2025
PT20.06.2025
Former [2025/46]BG19.02.2025
FI19.02.2025
HR19.02.2025
LV19.02.2025
SE19.02.2025
SM19.02.2025
NO19.05.2025
RS19.05.2025
GR20.05.2025
IS19.06.2025
PT20.06.2025
Former [2025/42]BG19.02.2025
FI19.02.2025
HR19.02.2025
LV19.02.2025
SE19.02.2025
NO19.05.2025
RS19.05.2025
GR20.05.2025
IS19.06.2025
PT20.06.2025
Former [2025/35]BG19.02.2025
FI19.02.2025
HR19.02.2025
LV19.02.2025
NO19.05.2025
RS19.05.2025
GR20.05.2025
IS19.06.2025
PT20.06.2025
Former [2025/34]FI19.02.2025
HR19.02.2025
LV19.02.2025
NO19.05.2025
RS19.05.2025
IS19.06.2025
PT20.06.2025
Former [2025/33]FI19.02.2025
RS19.05.2025
Documents cited:Search[X] WO2010061226  (PLANT BIOSCIENCE LTD et al.) [X] 1,2,4,7,12,14 * claims 1-26 *
 [IY] EP0965641  (NESTLE SA et al.) [I] 8 * claims 1-10 example 2 *[Y] 1-18
 [X] WO2011060488  (MURRAY GOULBURN COOP CO LTD et al.) [X] 1,2,5,14 * claims 1-14 *
 [IY]   SORENSEN M ET AL: "Mutagenesis of Propionibacterium acnes and analysis of two CAMP factor knock-out mutants", JOURNAL OF MICROBIOLOGICAL METHODS, ELSEVIER, AMSTERDAM, NL, vol. 83, no. 2, 1 November 2010 (2010-11-01), pages 211 - 216, XP027417387, ISSN: 0167-7012, [retrieved on 20101013] [I] 9-11 * the whole document * [Y] 1-18
International search[XY] WO2010061226  (PLANT BIOSCIENCE LTD et al.) [X] 1, 2, 15-21, 26, 35, 41, 42 * claims 1-26 claims 1-26 *[Y] 3-14, 22-25, 27-34, 36-40, 43-52
 [XY] WO2011060488  (MURRAY GOULBURN COOP CO LTD et al.) [X] 1, 2, 22, 41, 42 * claims 1-14 claims 1-14 *[Y] 3-21, 23-40, 43-49
 [Y] WO9967356  (GIST BROCADES BV et al.) [Y] 1-22, 27, 28 * claims 1-25, pages 10-12 *
 [Y] EP0965641  (NESTLE SA et al.) [Y] 26-29, 37, 38, 48 * claims 1-10, example 2, figures 1-5 *
 [Y]   SORENSEN, M. ET AL.: "Mutagenesis of Propionibacterium acnes and analysis of two CAMP factor knock-out mutants.", JOURNAL OF MICROBIOLOGICAL METHODS, vol. 83, no. 2, 31 December 2010 (2010-12-31), pages 211 - 216, XP027417387 [Y] 1-23, 30-34 * whole document, especially abstract *
 [Y]   ASADULLAH, K. ET AL.: "IL -10 is a key cytokine in psoriasis. Proof of principle by IL -10 therapy: a new therapeutic approach.", JOURNAL OF CLINICAL INVESTIGATION, vol. 101, no. 4, 4 February 1998 (1998-02-04), pages 783, XP055396338 [Y] 50-52 * whole document, especially abstract *

DOI:   http://dx.doi.org/10.1172/JCI1476
Examination  HELENE FALENTIN ET AL: "The Complete Genome of Propionibacterium freudenreichii CIRM-BIA1T, a Hardy Actinobacterium with Food and Probiotic Applications", PLOS ONE, vol. 5, no. 7, 1 January 2010 (2010-01-01), pages e11748, XP055013560, ISSN: 1932-6203, DOI: 10.1371/journal.pone.0011748

DOI:   http://dx.doi.org/10.1371/journal.pone.0011748
   LUCAS P PARIZZI ET AL: "The genome sequence of Propionibacterium acidipropionici provides insights into its biotechnological and industrial potential", BMC GENOMICS, BIOMED CENTRAL, vol. 13, no. 1, 19 October 2012 (2012-10-19), pages 562, XP021134721, ISSN: 1471-2164, DOI: 10.1186/1471-2164-13-562 [I] 9-11 * the whole document * [Y] 1-18

DOI:   http://dx.doi.org/10.1186/1471-2164-13-562
by applicant  ROVNER AJ ET AL., NATURE, vol. 518, no. 7537, 2015, pages 89 - 93 [Y] 3-14, 22-25, 27-34, 36-40, 43-52
   FITZ-GIBBON, S. ET AL., INVEST. DERMATOL., vol. 133, no. 9, 2013, pages 2152 - 60 [Y] 3-21, 23-40, 43-49
   LOMHOLT HBKILIAN M., PLOS ONE, vol. 5, no. 8, 2010, pages e12277
   MCDOWELL A ET AL., MICROBIOLOGY, vol. 157, 2011, pages 1990 - 2003 [Y] 1-23, 30-34 * whole document, especially abstract *
   BRU**GGEMANN H ET AL., PLOS ONE, vol. 7, no. 3, 2012, pages e34171
   HORVATHBARRANGOU, SCIENCE, vol. 327, 2010, pages 167 - 70 [Y] 50-52 * whole document, especially abstract *
   MAKAROVA ET AL., NAT REV MICROBIOL, vol. 9, 2011, pages 467 - 77
   "Remington's Pharmaceutical Sciences", 1990, MACK PUBLISHING CO.
   "Remington: The Science and Practice of Pharmacy", 2003, MACK PUBLISHING CO.
   "The Merck Index", 1996, MERCK PUBLISHING GROUP
   "Pharmaceutical Principles of Solid Dosage Forms", 1993, TECHNONIC PUBLISHING CO., INC.
   ANSELSOKLOSA: "Pharmaceutical Calculations", 2001, LIPPINCOTT WILLIAMS & WILKINS
   POZNANSKY ET AL.: "Drug Delivery Systems", 1980, pages: 253 - 315
   SORENSEN M, M. T.: "Mutagenesis of Propionibacterium acnes and analysis of two CAMP factor knock-out mutants", J MICROBIOL METHODS, 2010, pages 211 - 216, XP027417387
   RHEE MSMORITZ BEXIE GGLAVINA DEL RIO TDALIN ETICE HBRUCE DGOODWIN LCHERTKOV OBRETTIN T: "Complete Genome Sequence of a thermotolerant sporogenic lactic acid bacterium, Bacillus coagulans strain", STANDARDS IN GENOMIC SCIENCES, vol. 5, 2011, pages 331 - 340, XP055552287, DOI: 10.4056/sigs.2365342

DOI:   http://dx.doi.org/10.4056/sigs.2365342
   RHEE MSKIM JWQIAN YLINGRAM LOSHANMUGAM KT: "Development of plasmid vector and electroporation condition for gene transfer in sporogenic lactic acid bacterium, Bacillus coagulans", PLASMID, vol. 58, 2007, pages 13 - 22, XP022106897, DOI: 10.1016/j.plasmid.2006.11.006

DOI:   http://dx.doi.org/10.1016/j.plasmid.2006.11.006
   CHEONG DELEE HISO JS: "Optimization of electrotransformation conditions for Propionibacterium acnes", J MICROBIOL METHODS, vol. 72, no. 1, 2008, pages 38 - 41, XP022404756, DOI: 10.1016/j.mimet.2007.10.013

DOI:   http://dx.doi.org/10.1016/j.mimet.2007.10.013
   RHEE MSWEI LSAWHNEY NRICE JD.ST. JOHN FHURLBERT, JCPRESTON, JF: "Engineering the xylan utilization system in Bacillus subtilis for production of acidic xylooligosaccharides", APPL. ENVIRON. MICROBIOL., vol. 80, no. 3, 2014, pages 917 - 927
The EPO accepts no responsibility for the accuracy of data originating from other authorities; in particular, it does not guarantee that it is complete, up to date or fit for specific purposes.