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Extract from the Register of European Patents

EP About this file: EP3160503

EP3160503 - INHIBITION OF SEROTONIN EXPRESSION IN GUT ENTEROENDOCRINE CELLS RESULTS IN CONVERSION TO INSULIN-POSITIVE CELLS [Right-click to bookmark this link]
StatusNo opposition filed within time limit
Status updated on  24.12.2021
Database last updated on 02.11.2024
FormerThe patent has been granted
Status updated on  15.01.2021
FormerGrant of patent is intended
Status updated on  07.10.2020
FormerExamination is in progress
Status updated on  18.09.2020
FormerGrant of patent is intended
Status updated on  05.05.2020
FormerExamination is in progress
Status updated on  16.11.2018
FormerRequest for examination was made
Status updated on  31.03.2017
FormerThe international publication has been made
Status updated on  27.01.2017
Most recent event   Tooltip06.09.2024Lapse of the patent in a contracting state
New state(s): MT		published on 09.10.2024  [2024/41]
Applicant(s)For all designated states
The Trustees of Columbia University in the City of New York
412 Low Memorial Library
535 West 116th Street
New York, NY 10027 / US
[2021/07]
Former [2017/18]For all designated states
The Trustees of Columbia University in the City of New York
412 Low Memorial Library 535 West 116th Street
New York, New York 10027 / US
Inventor(s)01 / ACCILI, Domenico
80 Chambers St. 15A
New York, New York 10007 / US
02 / BOUCHI, Ryotaro
National Center for Global Health and Medicine
Department of Diabetes, Endoncrinology and
Metabolism, Center Hospital
Division of Clinical Information Research Diabetes and Metabolism Information Center Research Institute 1-21-1 Toyama, Shinjuku, Tokyo 162-8655 / JP
 [2020/22]
Former [2017/28]01 / ACCILI, Domenico
80 Chambers St. 15A
New York, New York 10007 / US
02 / BOUCHI, Ryotaro
National Center for Global Health and Medicine
Department of Diabetes, Endoncrinology and
Metabolism, Center Hospital
Division of Clinical Information Research Diabetes and Metabolism Information Center Research Institute 1-21-1 Toyame, Shinjuku, Tokyo 162-8655 / JP
Former [2017/18]01 / ACCILI, Domenico
80 Chambers St. 15A
New York, New York 10007 / US
02 / BOUCHI, Ryotaro
2-19-12 Hyakunincho
Shinjuku-ku Tokyo 169-0073 / JP
Representative(s)Chapman, Paul Gilmour, et al
Marks & Clerk LLP
40 Torphichen Street
Edinburgh EH3 8JB / GB
[2021/07]
Former [2017/18]Chapman, Paul Gilmour
Marks & Clerk LLP
Atholl Exchange
6 Canning Street
Edinburgh EH3 8EG / GB
Application number, filing date15811242.526.06.2015
[2017/18]
WO2015US38186
Priority number, dateUS201462017405P26.06.2014         Original published format: US 201462017405 P
[2017/18]
Filing languageEN
Procedural languageEN
PublicationType: A1 Application with search report
No.:WO2015200901
Date:30.12.2015
Language:EN
[2015/52]
Type: A1 Application with search report 
No.:EP3160503
Date:03.05.2017
Language:EN
The application published by WIPO in one of the EPO official languages on 30.12.2015 takes the place of the publication of the European patent application.
[2017/18]
Type: B1 Patent specification 
No.:EP3160503
Date:17.02.2021
Language:EN
[2021/07]
Search report(s)International search report - published on:US30.12.2015
(Supplementary) European search report - dispatched on:EP04.01.2018
ClassificationIPC:A61K31/7088, A61P3/10, C12N5/071, C12N15/113, A61K38/28
[2020/13]
CPC:
C12N15/113 (EP,US); C12N5/0679 (US); A61K31/7088 (EP);
A61K31/713 (EP); A61K35/38 (US); A61K38/28 (EP,US);
A61K45/06 (EP); A61L27/3687 (US); A61L27/3813 (US);
A61L27/383 (US); A61L27/3882 (US); A61P3/10 (EP);
C07K14/62 (US); C07K16/40 (US); C12N15/1137 (EP,US);
C12N5/0676 (EP); C12Y114/16004 (EP,US); C12Y401/01028 (EP,US);
A61L2430/22 (US); C12N2310/11 (EP,US); C12N2310/12 (EP,US);
C12N2310/14 (EP,US); C12N2310/531 (EP,US); C12N2501/60 (EP);
C12N2501/65 (EP); C12N2501/825 (EP); C12N2506/23 (US);
C12N2506/45 (EP); C12N2510/00 (EP) (-)
Former IPC [2018/04]A61K39/395, C12N15/113, A61P3/10, A61K38/28, A61L27/36
Former IPC [2017/18]A61K39/395, C12N15/113
Designated contracting statesAL,   AT,   BE,   BG,   CH,   CY,   CZ,   DE,   DK,   EE,   ES,   FI,   FR,   GB,   GR,   HR,   HU,   IE,   IS,   IT,   LI,   LT,   LU,   LV,   MC,   MK,   MT,   NL,   NO,   PL,   PT,   RO,   RS,   SE,   SI,   SK,   SM,   TR [2017/18]
Extension statesBANot yet paid
MENot yet paid
Validation statesMANot yet paid
TitleGerman:HEMMUNG DER SEROTONINEXPRESSION IN ENTEROENDOKRINEN DARMZELLENERGEBNISSEN BEI DER UMWANDLUNG IN INSULINPOSITIVE ZELLEN[2017/18]
English:INHIBITION OF SEROTONIN EXPRESSION IN GUT ENTEROENDOCRINE CELLS RESULTS IN CONVERSION TO INSULIN-POSITIVE CELLS[2017/18]
French:L'INHIBITION DE L'EXPRESSION DE LA SÉROTONINE DANS DES CELLULES ENTÉROENDOCRINES INTESTINALES PROVOQUE LEUR CONVERSION EN CELLULES POSITIVES POUR L'INSULINE[2017/18]
Entry into regional phase26.01.2017National basic fee paid 
26.01.2017Search fee paid 
26.01.2017Designation fee(s) paid 
26.01.2017Examination fee paid 
Examination procedure26.01.2017Examination requested  [2017/18]
26.01.2017Date on which the examining division has become responsible
02.08.2018Amendment by applicant (claims and/or description)
15.11.2018Despatch of a communication from the examining division (Time limit: M04)
22.03.2019Reply to a communication from the examining division
02.05.2019Despatch of a communication from the examining division (Time limit: M06)
08.11.2019Reply to a communication from the examining division
06.05.2020Communication of intention to grant the patent
15.09.2020Disapproval of the communication of intention to grant the patent by the applicant or resumption of examination proceedings by the EPO
15.09.2020Fee for grant paid
15.09.2020Fee for publishing/printing paid
08.10.2020Communication of intention to grant the patent
07.01.2021Receipt of the translation of the claim(s)
Opposition(s)18.11.2021No opposition filed within time limit [2022/04]
Fees paidRenewal fee
16.06.2017Renewal fee patent year 03
25.06.2018Renewal fee patent year 04
28.06.2019Renewal fee patent year 05
15.06.2020Renewal fee patent year 06
Opt-out from the exclusive  Tooltip
competence of the Unified
Patent Court		 See the Register of the Unified Patent Court for opt-out data
Responsibility for the accuracy, completeness or quality of the data displayed under the link provided lies entirely with the Unified Patent Court.
Lapses during opposition  TooltipHU26.06.2015
AL17.02.2021
AT17.02.2021
CY17.02.2021
CZ17.02.2021
DK17.02.2021
EE17.02.2021
ES17.02.2021
FI17.02.2021
HR17.02.2021
IT17.02.2021
LT17.02.2021
LV17.02.2021
MC17.02.2021
MK17.02.2021
MT17.02.2021
NL17.02.2021
PL17.02.2021
RO17.02.2021
RS17.02.2021
SE17.02.2021
SI17.02.2021
SK17.02.2021
SM17.02.2021
BG17.05.2021
NO17.05.2021
GR18.05.2021
IS17.06.2021
PT17.06.2021
IE26.06.2021
LU26.06.2021
BE30.06.2021
CH30.06.2021
LI30.06.2021
[2024/41]
Former [2024/22]HU26.06.2015
AL17.02.2021
AT17.02.2021
CY17.02.2021
CZ17.02.2021
DK17.02.2021
EE17.02.2021
ES17.02.2021
FI17.02.2021
HR17.02.2021
IT17.02.2021
LT17.02.2021
LV17.02.2021
MC17.02.2021
MK17.02.2021
NL17.02.2021
PL17.02.2021
RO17.02.2021
RS17.02.2021
SE17.02.2021
SI17.02.2021
SK17.02.2021
SM17.02.2021
BG17.05.2021
NO17.05.2021
GR18.05.2021
IS17.06.2021
PT17.06.2021
IE26.06.2021
LU26.06.2021
BE30.06.2021
CH30.06.2021
LI30.06.2021
Former [2023/33]HU26.06.2015
AL17.02.2021
AT17.02.2021
CY17.02.2021
CZ17.02.2021
DK17.02.2021
EE17.02.2021
ES17.02.2021
FI17.02.2021
HR17.02.2021
IT17.02.2021
LT17.02.2021
LV17.02.2021
MC17.02.2021
NL17.02.2021
PL17.02.2021
RO17.02.2021
RS17.02.2021
SE17.02.2021
SI17.02.2021
SK17.02.2021
SM17.02.2021
BG17.05.2021
NO17.05.2021
GR18.05.2021
IS17.06.2021
PT17.06.2021
IE26.06.2021
LU26.06.2021
BE30.06.2021
CH30.06.2021
LI30.06.2021
Former [2023/30]HU26.06.2015
AL17.02.2021
AT17.02.2021
CY17.02.2021
CZ17.02.2021
DK17.02.2021
EE17.02.2021
ES17.02.2021
FI17.02.2021
HR17.02.2021
IT17.02.2021
LT17.02.2021
LV17.02.2021
MC17.02.2021
NL17.02.2021
PL17.02.2021
RO17.02.2021
RS17.02.2021
SE17.02.2021
SI17.02.2021
SM17.02.2021
BG17.05.2021
NO17.05.2021
GR18.05.2021
IS17.06.2021
PT17.06.2021
IE26.06.2021
LU26.06.2021
BE30.06.2021
CH30.06.2021
LI30.06.2021
Former [2023/29]HU26.06.2015
AL17.02.2021
AT17.02.2021
CZ17.02.2021
DK17.02.2021
EE17.02.2021
ES17.02.2021
FI17.02.2021
HR17.02.2021
IT17.02.2021
LT17.02.2021
LV17.02.2021
MC17.02.2021
NL17.02.2021
PL17.02.2021
RO17.02.2021
RS17.02.2021
SE17.02.2021
SI17.02.2021
SM17.02.2021
BG17.05.2021
NO17.05.2021
GR18.05.2021
IS17.06.2021
PT17.06.2021
IE26.06.2021
LU26.06.2021
BE30.06.2021
CH30.06.2021
LI30.06.2021
Former [2022/34]AL17.02.2021
AT17.02.2021
CZ17.02.2021
DK17.02.2021
EE17.02.2021
ES17.02.2021
FI17.02.2021
HR17.02.2021
IT17.02.2021
LT17.02.2021
LV17.02.2021
MC17.02.2021
NL17.02.2021
PL17.02.2021
RO17.02.2021
RS17.02.2021
SE17.02.2021
SI17.02.2021
SM17.02.2021
BG17.05.2021
NO17.05.2021
GR18.05.2021
IS17.06.2021
PT17.06.2021
IE26.06.2021
LU26.06.2021
BE30.06.2021
CH30.06.2021
LI30.06.2021
Former [2022/23]AL17.02.2021
AT17.02.2021
CZ17.02.2021
DK17.02.2021
EE17.02.2021
ES17.02.2021
FI17.02.2021
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IT17.02.2021
LT17.02.2021
LV17.02.2021
MC17.02.2021
NL17.02.2021
PL17.02.2021
RO17.02.2021
RS17.02.2021
SE17.02.2021
SI17.02.2021
SM17.02.2021
BG17.05.2021
NO17.05.2021
GR18.05.2021
IS17.06.2021
PT17.06.2021
IE26.06.2021
LU26.06.2021
CH30.06.2021
LI30.06.2021
Former [2022/21]AL17.02.2021
AT17.02.2021
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DK17.02.2021
EE17.02.2021
ES17.02.2021
FI17.02.2021
HR17.02.2021
LT17.02.2021
LV17.02.2021
MC17.02.2021
NL17.02.2021
PL17.02.2021
RO17.02.2021
RS17.02.2021
SE17.02.2021
SI17.02.2021
SM17.02.2021
BG17.05.2021
NO17.05.2021
GR18.05.2021
PT17.06.2021
IE26.06.2021
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CH30.06.2021
LI30.06.2021
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EE17.02.2021
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MC17.02.2021
NL17.02.2021
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RO17.02.2021
RS17.02.2021
SE17.02.2021
SM17.02.2021
BG17.05.2021
NO17.05.2021
GR18.05.2021
PT17.06.2021
Former [2022/07]AL17.02.2021
AT17.02.2021
CZ17.02.2021
DK17.02.2021
EE17.02.2021
ES17.02.2021
FI17.02.2021
HR17.02.2021
LT17.02.2021
LV17.02.2021
MC17.02.2021
NL17.02.2021
PL17.02.2021
RO17.02.2021
RS17.02.2021
SE17.02.2021
SM17.02.2021
BG17.05.2021
NO17.05.2021
GR18.05.2021
IS17.06.2021
PT17.06.2021
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CZ17.02.2021
DK17.02.2021
EE17.02.2021
ES17.02.2021
FI17.02.2021
HR17.02.2021
LT17.02.2021
LV17.02.2021
NL17.02.2021
PL17.02.2021
RO17.02.2021
RS17.02.2021
SE17.02.2021
SM17.02.2021
BG17.05.2021
NO17.05.2021
GR18.05.2021
IS17.06.2021
PT17.06.2021
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CZ17.02.2021
DK17.02.2021
EE17.02.2021
FI17.02.2021
HR17.02.2021
LT17.02.2021
LV17.02.2021
NL17.02.2021
PL17.02.2021
RO17.02.2021
RS17.02.2021
SE17.02.2021
SM17.02.2021
BG17.05.2021
NO17.05.2021
GR18.05.2021
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NO17.05.2021
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RS17.02.2021
SE17.02.2021
SM17.02.2021
BG17.05.2021
NO17.05.2021
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