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Extract from the Register of European Patents

EP About this file: EP3165603

EP3165603 - PANCREATIC ENDOCRINE CELLS, METHOD FOR PRODUCING SAME, AND TRANSDIFFERENTIATION AGENT [Right-click to bookmark this link]
StatusNo opposition filed within time limit
Status updated on  24.07.2020
Database last updated on 20.09.2024
FormerThe patent has been granted
Status updated on  16.08.2019
FormerGrant of patent is intended
Status updated on  28.04.2019
FormerExamination is in progress
Status updated on  23.11.2018
FormerRequest for examination was made
Status updated on  07.04.2017
FormerThe international publication has been made
Status updated on  27.01.2017
Most recent event   Tooltip08.07.2022Lapse of the patent in a contracting state
New state(s): MK		published on 10.08.2022  [2022/32]
Applicant(s)For all designated states
Juntendo Educational Foundation
2-1-1, Hongo
Bunkyo-ku
Tokyo 113-8421 / JP
[2019/12]
Former [2017/19]For all designated states
Saitama Medical University
38, Morohongo Moroyama-machi
Iruma-gun, Saitama 350-0495 / JP
Inventor(s)01 / MATSUMOTO, Masahito
c/o Saitama Medical University
Morohongo
38 Moroyama-machi
Iruma-gun Saitama 350-0495 / JP
02 / OKAZAKI, Yasushi
c/o Saitama Medical University
Morohongo
38 Moroyama-machi
Iruma-gun Saitama 350-0495 / JP
03 / SUGAHARA, Izumi
c/o Saitama Medical University
Morohongo
38 Moroyama-machi
Iruma-gun Saitama 350-0495 / JP
 [2017/19]
Representative(s)Graf von Stosch, Andreas, et al
Graf von Stosch
Patentanwaltsgesellschaft mbH
Prinzregentenstraße 22
80538 München / DE
[2017/19]
Application number, filing date15815940.003.07.2015
[2017/19]
WO2015JP69296
Priority number, dateJP2014013771903.07.2014         Original published format: JP 2014137719
[2017/19]
Filing languageJA
Procedural languageEN
PublicationType: A1 Application with search report
No.:WO2016002937
Date:07.01.2016
Language:JA
[2016/01]
Type: A1 Application with search report 
No.:EP3165603
Date:10.05.2017
Language:EN
[2017/19]
Type: B1 Patent specification 
No.:EP3165603
Date:18.09.2019
Language:EN
[2019/38]
Search report(s)International search report - published on:JP07.01.2016
(Supplementary) European search report - dispatched on:EP13.12.2017
ClassificationIPC:C12N5/10, C12N15/09
[2017/19]
CPC:
C12N5/0676 (EP,US); C12N2501/60 (EP,US); C12N2506/02 (EP,US);
C12N2506/1307 (EP,US); C12N2506/14 (EP,US); C12N2506/25 (EP,US);
C12N2506/30 (EP,US); C12N2510/00 (EP,US); C12N2799/06 (EP,US) (-)
Designated contracting statesAL,   AT,   BE,   BG,   CH,   CY,   CZ,   DE,   DK,   EE,   ES,   FI,   FR,   GB,   GR,   HR,   HU,   IE,   IS,   IT,   LI,   LT,   LU,   LV,   MC,   MK,   MT,   NL,   NO,   PL,   PT,   RO,   RS,   SE,   SI,   SK,   SM,   TR [2017/19]
Extension statesBANot yet paid
MENot yet paid
Validation statesMANot yet paid
TitleGerman:ENDOKRINE PANKREASZELLEN, VERFAHREN ZUR HERSTELLUNG DAVON UND TRANSDIFFERENZIERUNGSMITTEL[2017/19]
English:PANCREATIC ENDOCRINE CELLS, METHOD FOR PRODUCING SAME, AND TRANSDIFFERENTIATION AGENT[2017/19]
French:CELLULES ENDOCRINES PANCRÉATIQUES, PROCÉDÉ DE PRODUCTION DE CELLES-CI ET AGENT DE TRANSDIFFÉRENCIATION[2017/19]
Entry into regional phase20.01.2017Translation filed 
20.01.2017National basic fee paid 
20.01.2017Search fee paid 
20.01.2017Designation fee(s) paid 
20.01.2017Examination fee paid 
Examination procedure28.10.2015Request for preliminary examination filed
International Preliminary Examining Authority: JP
20.01.2017Examination requested  [2017/19]
20.01.2017Date on which the examining division has become responsible
15.06.2018Amendment by applicant (claims and/or description)
22.11.2018Despatch of a communication from the examining division (Time limit: M04)
21.01.2019Reply to a communication from the examining division
29.04.2019Communication of intention to grant the patent
08.08.2019Fee for grant paid
08.08.2019Fee for publishing/printing paid
08.08.2019Receipt of the translation of the claim(s)
Opposition(s)19.06.2020No opposition filed within time limit [2020/35]
Fees paidRenewal fee
22.05.2017Renewal fee patent year 03
10.07.2018Renewal fee patent year 04
12.06.2019Renewal fee patent year 05
Opt-out from the exclusive  Tooltip
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Responsibility for the accuracy, completeness or quality of the data displayed under the link provided lies entirely with the Unified Patent Court.
Lapses during opposition  TooltipHU03.07.2015
AL18.09.2019
AT18.09.2019
CY18.09.2019
CZ18.09.2019
DK18.09.2019
EE18.09.2019
ES18.09.2019
FI18.09.2019
HR18.09.2019
IT18.09.2019
LT18.09.2019
LV18.09.2019
MC18.09.2019
MK18.09.2019
MT18.09.2019
NL18.09.2019
PL18.09.2019
RO18.09.2019
RS18.09.2019
SE18.09.2019
SI18.09.2019
SK18.09.2019
SM18.09.2019
TR18.09.2019
BG18.12.2019
NO18.12.2019
GR19.12.2019
IS19.01.2020
PT20.01.2020
[2022/32]
Former [2022/27]HU03.07.2015
AL18.09.2019
AT18.09.2019
CY18.09.2019
CZ18.09.2019
DK18.09.2019
EE18.09.2019
ES18.09.2019
FI18.09.2019
HR18.09.2019
IT18.09.2019
LT18.09.2019
LV18.09.2019
MC18.09.2019
MT18.09.2019
NL18.09.2019
PL18.09.2019
RO18.09.2019
RS18.09.2019
SE18.09.2019
SI18.09.2019
SK18.09.2019
SM18.09.2019
TR18.09.2019
BG18.12.2019
NO18.12.2019
GR19.12.2019
IS19.01.2020
PT20.01.2020
Former [2021/15]AL18.09.2019
AT18.09.2019
CZ18.09.2019
DK18.09.2019
EE18.09.2019
ES18.09.2019
FI18.09.2019
HR18.09.2019
IT18.09.2019
LT18.09.2019
LV18.09.2019
MC18.09.2019
NL18.09.2019
PL18.09.2019
RO18.09.2019
RS18.09.2019
SE18.09.2019
SI18.09.2019
SK18.09.2019
SM18.09.2019
BG18.12.2019
NO18.12.2019
GR19.12.2019
IS19.01.2020
PT20.01.2020
Former [2020/37]AL18.09.2019
AT18.09.2019
CZ18.09.2019
DK18.09.2019
EE18.09.2019
ES18.09.2019
FI18.09.2019
HR18.09.2019
IT18.09.2019
LT18.09.2019
LV18.09.2019
NL18.09.2019
PL18.09.2019
RO18.09.2019
RS18.09.2019
SE18.09.2019
SI18.09.2019
SK18.09.2019
SM18.09.2019
BG18.12.2019
NO18.12.2019
GR19.12.2019
IS19.01.2020
PT20.01.2020
Former [2020/36]AL18.09.2019
AT18.09.2019
CZ18.09.2019
DK18.09.2019
EE18.09.2019
ES18.09.2019
FI18.09.2019
HR18.09.2019
IT18.09.2019
LT18.09.2019
LV18.09.2019
NL18.09.2019
PL18.09.2019
RO18.09.2019
RS18.09.2019
SE18.09.2019
SK18.09.2019
SM18.09.2019
BG18.12.2019
NO18.12.2019
GR19.12.2019
IS19.01.2020
PT20.01.2020
Former [2020/27]AL18.09.2019
AT18.09.2019
CZ18.09.2019
EE18.09.2019
ES18.09.2019
FI18.09.2019
HR18.09.2019
IT18.09.2019
LT18.09.2019
LV18.09.2019
NL18.09.2019
PL18.09.2019
RO18.09.2019
RS18.09.2019
SE18.09.2019
SK18.09.2019
SM18.09.2019
BG18.12.2019
NO18.12.2019
GR19.12.2019
PT20.01.2020
IS24.02.2020
Former [2020/25]AL18.09.2019
AT18.09.2019
CZ18.09.2019
EE18.09.2019
ES18.09.2019
FI18.09.2019
HR18.09.2019
IT18.09.2019
LT18.09.2019
LV18.09.2019
NL18.09.2019
PL18.09.2019
RO18.09.2019
RS18.09.2019
SE18.09.2019
SK18.09.2019
BG18.12.2019
NO18.12.2019
GR19.12.2019
PT20.01.2020
IS24.02.2020
Former [2020/24]AL18.09.2019
AT18.09.2019
EE18.09.2019
ES18.09.2019
FI18.09.2019
HR18.09.2019
IT18.09.2019
LT18.09.2019
LV18.09.2019
NL18.09.2019
PL18.09.2019
RO18.09.2019
RS18.09.2019
SE18.09.2019
BG18.12.2019
NO18.12.2019
GR19.12.2019
PT20.01.2020
IS24.02.2020
Former [2020/23]AL18.09.2019
AT18.09.2019
EE18.09.2019
ES18.09.2019
FI18.09.2019
HR18.09.2019
IT18.09.2019
LT18.09.2019
LV18.09.2019
NL18.09.2019
PL18.09.2019
RO18.09.2019
RS18.09.2019
SE18.09.2019
BG18.12.2019
NO18.12.2019
GR19.12.2019
PT20.01.2020
Former [2020/22]AL18.09.2019
EE18.09.2019
FI18.09.2019
HR18.09.2019
LT18.09.2019
LV18.09.2019
NL18.09.2019
RS18.09.2019
SE18.09.2019
BG18.12.2019
NO18.12.2019
GR19.12.2019
PT20.01.2020
Former [2020/20]AL18.09.2019
FI18.09.2019
HR18.09.2019
LT18.09.2019
LV18.09.2019
NL18.09.2019
RS18.09.2019
SE18.09.2019
BG18.12.2019
NO18.12.2019
GR19.12.2019
Former [2020/15]AL18.09.2019
FI18.09.2019
HR18.09.2019
LT18.09.2019
LV18.09.2019
RS18.09.2019
SE18.09.2019
BG18.12.2019
NO18.12.2019
GR19.12.2019
Former [2020/12]FI18.09.2019
HR18.09.2019
LT18.09.2019
LV18.09.2019
RS18.09.2019
SE18.09.2019
BG18.12.2019
NO18.12.2019
GR19.12.2019
Former [2020/10]FI18.09.2019
LT18.09.2019
SE18.09.2019
BG18.12.2019
NO18.12.2019
Former [2020/09]FI18.09.2019
LT18.09.2019
NO18.12.2019
Former [2020/08]LT18.09.2019
NO18.12.2019
Documents cited:Search[Y]WO03078636  (UNIV BATH [GB], et al) [Y] 1-12 * abstract * * page 13, lines 5-11 *;
 [Y]US2009280096  (KUBO ATSUSHI [JP], et al) [Y] 1-12 * abstract *;
 [Y]US2011112015  (JULIER CECILE [FR], et al) [Y] 1-12 * abstract *;
 [Y]US2013029423  (YAMANAKA SHINYA [JP], et al) [Y] 1-12 * abstract *;
 [Y]  - AKINCI E ET AL, "Reprogramming of pancreatic exocrine cells towards a beta (beta) cell character using Pdx1, Ngn3 and MafA", BIOCHEMICAL JOURNAL, PORTLAND PRESS LTD, GB, (20120315), vol. 442, no. Part 3, doi:10.1042/BJ20111678, ISSN 0264-6021, pages 539 - 550, XP002725446 [Y] 1-12 * figures 1A, 4A *

DOI:   http://dx.doi.org/10.1042/BJ20111678
 [Y]  - MOMOKO MAEKAWA ET AL, "Direct reprogramming of somatic cells is promoted by maternal transcription factor Glis1", NATURE, (20110609), vol. 474, no. 7350, doi:10.1038/nature10106, ISSN 0028-0836, pages 225 - 229, XP055034083 [Y] 1-12 * abstract *

DOI:   http://dx.doi.org/10.1038/nature10106
 [A]  - MFOPOU JOSUÉ KUNJOM ET AL, "Recent advances and prospects in the differentiation of pancreatic cells from human embryonic stem cells", DIAB, AMERICAN DIABETES ASSOCIATION, US, (20100901), vol. 59, no. 9, doi:10.2337/DB10-0439, ISSN 0012-1797, pages 2094 - 2101, XP009138606 [A] 1-12 * figure 1 *

DOI:   http://dx.doi.org/10.2337/db10-0439
 [T]  - DAVID W. SCOVILLE ET AL, "GLIS1-3: emerging roles in reprogramming, stem and progenitor cell differentiation and maintenance", STEM CELL INVESTIGATION, (20170927), vol. 4, no. 9, doi:10.21037/sci.2017.09.01, pages 80 - 80, XP055431048 [T] * figure 1 *

DOI:   http://dx.doi.org/10.21037/sci.2017.09.01
International search[YA]  - KANG H.S. et al., "Transcription factor Glis3, a novel critical player in the regulation of pancreatic P- cell development and insulin gene expression", Mol. Cell . Biol., (20091200), vol. 29, no. 24, ISSN 0270-7306, pages 6366 - 6379, XP055062862 [Y] 1-2, 4-9, 11-12 * , particularly, abstract, fig. 10 * [A] 3, 10

DOI:   http://dx.doi.org/10.1128/MCB.01259-09
 [YA]  - KIM Y.S. et al., "Glis3 regulates neurogenin 3 expression in pancreatic p-cells and interacts with its activator", Hnf6, Mol. Cells, (20120800), vol. 34, no. 2, ISSN 1016-8478, pages 193 - 200, XP055250727 [Y] 1-2, 4-9, 11-12 * , particularly, abstract * [A] 3, 10

DOI:   http://dx.doi.org/10.1007/s10059-012-0109-z
 [YA]  - YANG Y. et al., "The Krueppel-like zinc finger protein GLIS3 transactivates neurogenin 3 for proper fetal pancreatic islet differentiation in mice", Diabetologia, (20111000), vol. 54, no. 10, ISSN 1432-0428, pages 2595 - 2605, XP019948984 [Y] 1-2, 4-9, 11-12 * , particularly, abstract * [A] 3, 10

DOI:   http://dx.doi.org/10.1007/s00125-011-2255-9
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