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Extract from the Register of European Patents

EP About this file: EP3197457

EP3197457 - 4'-VINYL SUBSTITUTED NUCLEOSIDE DERIVATIVES AS INHIBITORS OF RESPIRATORY SYNCYTIAL VIRUS RNA REPLICATION [Right-click to bookmark this link]
StatusNo opposition filed within time limit
Status updated on  15.09.2023
Database last updated on 31.08.2024
FormerThe patent has been granted
Status updated on  07.10.2022
FormerGrant of patent is intended
Status updated on  11.05.2022
FormerExamination is in progress
Status updated on  24.07.2020
FormerRequest for examination was made
Status updated on  04.07.2017
FormerThe international publication has been made
Status updated on  26.04.2017
Most recent event   Tooltip07.06.2024Lapse of the patent in a contracting state
New state(s): MC		published on 10.07.2024  [2024/28]
Applicant(s)For all designated states
Riboscience LLC
3901 Laguna Avenue
Palo Alto, CA 94306 / US
[2017/31]
Inventor(s)01 / SMITH, Mark
333 Harrison Street 363
San Francisco, California 94105 / US
02 / KLUMPP, Klaus G.
611 Winston Lane
West Chester, Pennsylvania 19382 / US
 [2017/31]
Representative(s)Vossius & Partner Patentanwälte Rechtsanwälte mbB
Siebertstrasse 3
81675 München / DE
[2017/31]
Application number, filing date15844391.125.09.2015
[2017/31]
WO2015US52144
Priority number, dateUS201462055704P26.09.2014         Original published format: US 201462055704 P
[2017/31]
Filing languageEN
Procedural languageEN
PublicationType: A1 Application with search report
No.:WO2016049415
Date:31.03.2016
Language:EN
[2016/13]
Type: A1 Application with search report 
No.:EP3197457
Date:02.08.2017
Language:EN
The application published by WIPO in one of the EPO official languages on 31.03.2016 takes the place of the publication of the European patent application.
[2017/31]
Type: B1 Patent specification 
No.:EP3197457
Date:09.11.2022
Language:EN
[2022/45]
Search report(s)International search report - published on:US31.03.2016
(Supplementary) European search report - dispatched on:EP04.07.2018
ClassificationIPC:C07H19/067, C07H19/10, C07H19/11, C07H19/167, C07H19/20, C07H19/213, A61K31/708, A61K31/7072, A61K31/7068, A61K31/7076, A61P31/14
[2018/31]
CPC:
C07H19/10 (EP,IL,KR,US); C07H19/067 (EP,IL,KR,US); A61P31/14 (EP,US);
C07H19/11 (EP,IL,US); C07H19/167 (EP,IL,KR,US); C07H19/20 (EP,IL,KR,US);
C07H19/207 (IL,KR,US); C07H19/213 (EP,IL,KR,US) (-)
Former IPC [2017/31]A61K31/52, A61K31/708
Designated contracting statesAL,   AT,   BE,   BG,   CH,   CY,   CZ,   DE,   DK,   EE,   ES,   FI,   FR,   GB,   GR,   HR,   HU,   IE,   IS,   IT,   LI,   LT,   LU,   LV,   MC,   MK,   MT,   NL,   NO,   PL,   PT,   RO,   RS,   SE,   SI,   SK,   SM,   TR [2017/31]
Extension statesBANot yet paid
MENot yet paid
Validation statesMANot yet paid
TitleGerman:4'-VINYLSUBSTITUIERTE NUKLEOSIDDERIVATE ALS HEMMER DER RNA-REPLIKATION DES RESPIRATORISCHEN SYNZYTIAL-VIRUS[2017/31]
English:4'-VINYL SUBSTITUTED NUCLEOSIDE DERIVATIVES AS INHIBITORS OF RESPIRATORY SYNCYTIAL VIRUS RNA REPLICATION[2017/31]
French:DÉRIVÉS DE NUCLÉOSIDE 4'-VINYLE SUBSTITUÉS UTILES EN TANT QU'INHIBITEURS DE LA RÉPLICATION DUE L'ARN DU VIRUS RESPIRATOIRE SYNCYTIAL[2017/31]
Entry into regional phase26.04.2017National basic fee paid 
26.04.2017Search fee paid 
26.04.2017Designation fee(s) paid 
26.04.2017Examination fee paid 
Examination procedure26.04.2017Examination requested  [2017/31]
26.04.2017Date on which the examining division has become responsible
09.01.2018Despatch of communication of loss of particular rights: Claims {1}
30.01.2019Amendment by applicant (claims and/or description)
23.07.2020Despatch of a communication from the examining division (Time limit: M02)
02.10.2020Reply to a communication from the examining division
12.05.2022Communication of intention to grant the patent
22.09.2022Fee for grant paid
22.09.2022Fee for publishing/printing paid
22.09.2022Receipt of the translation of the claim(s)
Opposition(s)10.08.2023No opposition filed within time limit [2023/42]
Request for further processing for:Loss of rights: Claims
13.02.2018Request for further processing filed
13.02.2018Full payment received (date of receipt of payment)
Fees paidRenewal fee
22.09.2017Renewal fee patent year 03
26.09.2018Renewal fee patent year 04
13.09.2019Renewal fee patent year 05
14.09.2020Renewal fee patent year 06
15.09.2021Renewal fee patent year 07
11.08.2022Renewal fee patent year 08
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Responsibility for the accuracy, completeness or quality of the data displayed under the link provided lies entirely with the Unified Patent Court.
Lapses during opposition  TooltipAL09.11.2022
AT09.11.2022
CZ09.11.2022
DK09.11.2022
EE09.11.2022
ES09.11.2022
FI09.11.2022
HR09.11.2022
LT09.11.2022
LV09.11.2022
MC09.11.2022
NL09.11.2022
PL09.11.2022
RO09.11.2022
RS09.11.2022
SE09.11.2022
SI09.11.2022
SK09.11.2022
SM09.11.2022
NO09.02.2023
GR10.02.2023
IS09.03.2023
PT09.03.2023
[2024/28]
Former [2023/51]AL09.11.2022
AT09.11.2022
CZ09.11.2022
DK09.11.2022
EE09.11.2022
ES09.11.2022
FI09.11.2022
HR09.11.2022
LT09.11.2022
LV09.11.2022
NL09.11.2022
PL09.11.2022
RO09.11.2022
RS09.11.2022
SE09.11.2022
SI09.11.2022
SK09.11.2022
SM09.11.2022
NO09.02.2023
GR10.02.2023
IS09.03.2023
PT09.03.2023
Former [2023/38]AL09.11.2022
AT09.11.2022
CZ09.11.2022
DK09.11.2022
EE09.11.2022
ES09.11.2022
FI09.11.2022
HR09.11.2022
LT09.11.2022
LV09.11.2022
NL09.11.2022
PL09.11.2022
RO09.11.2022
RS09.11.2022
SE09.11.2022
SK09.11.2022
SM09.11.2022
NO09.02.2023
GR10.02.2023
IS09.03.2023
PT09.03.2023
Former [2023/37]AL09.11.2022
AT09.11.2022
CZ09.11.2022
DK09.11.2022
EE09.11.2022
ES09.11.2022
FI09.11.2022
HR09.11.2022
LT09.11.2022
LV09.11.2022
NL09.11.2022
PL09.11.2022
RO09.11.2022
RS09.11.2022
SE09.11.2022
SM09.11.2022
NO09.02.2023
GR10.02.2023
IS09.03.2023
PT09.03.2023
Former [2023/35]AT09.11.2022
CZ09.11.2022
DK09.11.2022
EE09.11.2022
ES09.11.2022
FI09.11.2022
HR09.11.2022
LT09.11.2022
LV09.11.2022
NL09.11.2022
PL09.11.2022
RO09.11.2022
RS09.11.2022
SE09.11.2022
SM09.11.2022
NO09.02.2023
GR10.02.2023
IS09.03.2023
PT09.03.2023
Former [2023/34]AT09.11.2022
DK09.11.2022
EE09.11.2022
ES09.11.2022
FI09.11.2022
HR09.11.2022
LT09.11.2022
LV09.11.2022
NL09.11.2022
PL09.11.2022
RS09.11.2022
SE09.11.2022
SM09.11.2022
NO09.02.2023
GR10.02.2023
IS09.03.2023
PT09.03.2023
Former [2023/33]AT09.11.2022
DK09.11.2022
ES09.11.2022
FI09.11.2022
HR09.11.2022
LT09.11.2022
LV09.11.2022
NL09.11.2022
PL09.11.2022
RS09.11.2022
SE09.11.2022
SM09.11.2022
NO09.02.2023
GR10.02.2023
IS09.03.2023
PT09.03.2023
Former [2023/29]AT09.11.2022
ES09.11.2022
FI09.11.2022
HR09.11.2022
LT09.11.2022
LV09.11.2022
NL09.11.2022
PL09.11.2022
RS09.11.2022
SE09.11.2022
NO09.02.2023
GR10.02.2023
IS09.03.2023
PT09.03.2023
Former [2023/26]AT09.11.2022
ES09.11.2022
FI09.11.2022
HR09.11.2022
LT09.11.2022
LV09.11.2022
PL09.11.2022
RS09.11.2022
SE09.11.2022
NO09.02.2023
GR10.02.2023
IS09.03.2023
PT09.03.2023
Former [2023/24]AT09.11.2022
ES09.11.2022
FI09.11.2022
HR09.11.2022
LT09.11.2022
LV09.11.2022
SE09.11.2022
NO09.02.2023
GR10.02.2023
PT09.03.2023
Former [2023/23]AT09.11.2022
ES09.11.2022
FI09.11.2022
LT09.11.2022
LV09.11.2022
SE09.11.2022
NO09.02.2023
GR10.02.2023
PT09.03.2023
Former [2023/22]AT09.11.2022
ES09.11.2022
FI09.11.2022
LT09.11.2022
SE09.11.2022
NO09.02.2023
PT09.03.2023
Former [2023/20]LT09.11.2022
NO09.02.2023
Documents cited:Search[IA]WO9816184  (ICN PHARMACEUTICALS [US], et al) [I] 1-5,16,18,19 * Claims, in particular claims 1, 8, 9 and 10; Page 11 lines 13-14; Examples * [A] 6-15,17,20;
 [IA]WO0203997  (ICN PHARMACEUTICALS [US], et al) [I] 1-5,8,10,11,13,16-20 * Claims, in particular claims 1 and 10-21; page 14 lines 1-16; examples * [A] 6,7,9,12,14,15;
 [XAI]US2004167096  (CHENG YUNG-CHI [US], et al) [X] 1-15,18,19 * Claims, in particular claims 1, 22, 26 and 27; 4'vinyl-thymidine in figure 1; paragraph [13] and Tables 1, 2a, 3a and 3b * [A] 16 [I] 17,20;
 [A]WO2013096679  (ALIOS BIOPHARMA INC [US]) [A] 1-20 * Claims and examples *;
 [XPA]WO2015054465  (ALIOS BIOPHARMA INC [US]) [XP] 1-16,19 * Claims and compound 303 in example 180 *[A] 17,18,20;
 [E]WO2015200219  (ALIOS BIOPHARMA INC [US]) [E] 1-16,19 * Claims, in particular claims 1 and 99, and compound 303 in example 180 *;
 [XA]  - NOMURA M ET AL, "NUCLEOSIDES AND NUCLEOTIDES. 185. SYNTHESIS AND BIOLOGICAL ACTIVITIES OF 4'ALPHA-C-BRANCHED-CHAIN SUGAR PYRIMIDINE NUCLEOSIDES", JOURNAL OF MEDICINAL CHEMISTRY, AMERICAN CHEMICAL SOCIETY, (19990101), vol. 42, no. 15, doi:10.1021/JM990050I, ISSN 0022-2623, pages 2901 - 2908, XP000915083 [X] 1,3-5,14,19 * Compound 19 in scheme 1 and page 2905 and HCl salt thereof * [A] 2,6-13,15-18,20

DOI:   http://dx.doi.org/10.1021/jm990050i
 [XA]  - KODAMA E-I ET AL, "4'-ETHYNYL NUCLEOSIDE ANALOGS: POTENT INHIBITORS OF MULTIDRUG-RESISTANT HUMAN IMMUNODEFICIENCY VIRUS VARIANTS IN VITRO", ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, AMERICAN SOCIETY FOR MICROBIOLOGY, US, (20010501), vol. 45, no. 5, doi:10.1128/AAC.45.5.1539-1546.2001, ISSN 0066-4804, pages 1539 - 1546, XP001127402 [X] 1,3-5,19 * 4'-vinyl-thymidine in table * [A] 2,6-18,20

DOI:   http://dx.doi.org/10.1128/AAC.45.5.1539-1546.2001
 [XA]  - SMITH ET AL, "Design, synthesis, and antiviral properties of 4'-substituted ribonucleosides as inhibitors of hepatitis C virus replication: The discovery of R1479", BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, PERGAMON, AMSTERDAM, NL, (20070403), vol. 17, no. 9, doi:10.1016/J.BMCL.2007.02.004, ISSN 0960-894X, pages 2570 - 2576, XP022015347 [X] 1-5,14,15,19 * Compound 21 in scheme 3 and compound 32 in scheme 5 * [A] 6-13,16-18,20

DOI:   http://dx.doi.org/10.1016/j.bmcl.2007.02.004
 [XA]  - KIRCHHOFF C ET AL, "Dinucleotides of 4'-C-vinyl- and 5'-C-allylthymidine as substrates for ring-closing metathesis reactions", TETRAHEDRON LET, ELSEVIER, AMSTERDAM, NL, (20030818), vol. 44, no. 34, doi:10.1016/S0040-4039(03)01584-3, ISSN 0040-4039, pages 6475 - 6478, XP004442779 [X] 1,3-5 * Deprotected intermediate between (4) and (7) * [A] 2,6-20

DOI:   http://dx.doi.org/10.1016/S0040-4039(03)01584-3
International search[XY]US2003236216  (DEVOS RENE ROBERT [GB], et al) [X] 1-2, 3/1-2 * ; paragraphs [0006]-[0011], [0014], [0020], [0023]-[0029], [0039] * [Y] 17, 20;
 [A]US2004121980  (MARTIN JOSEPH ARMSTRONG [US], et al) [A] 1-2, 3/1-2, 17, 20* ; entire document *;
 [Y]US2007042988  (KLUMPP KLAUS [US], et al) [Y] 17, 20 * ; paragraphs [0025]-[0026], [0029]-[0030], [0036]-[0037], [0077] *;
 [A]US2013018011  (JAVANBAKHT HASSAN [US], et al) [A] 1-2, 3/1-2, 17, 20 * ; entire document *
by applicantWO9816184
 WO0203997
 WO2013096679
 WO2015054465
 WO2015200219
    - LEE, N. et al., Clin Infect Dis, (20130000), vol. 57, no. 8, pages 1069 - 77
    - NAIR, H. et al., Lancet, (20100000), vol. 375, no. 9725, pages 1545 - 55
    - "Nucleoside Inhibitors of Hepatitis C Virus", KLUMPP, K. et al., Hepatitis C: Antiviral Drug Discovery and Development, Caister Academic Press, (20110000), pages 293 - 311
    - TIONG-YIP, C. L. et al., Antimicrob. Agents Chemother., (20140000), vol. 58, no. 7, pages 3867 - 3873
    - XIONG, H. et al., Bioorg. Med. Chem. Lett., (20130000), vol. 23, no. 24, pages 6789 - 6793
    - MASON, S. W., Nucleic Acids Res, (20040000), vol. 32, no. 16, pages 4758 - 4767
    - NOMURA M et al., J Med Chem, (19990000), vol. 42, no. 15, pages 2901 - 8
    - KODAMA EI et al., Antimicrob Agents Chemother, (20010000), vol. 45, no. 5, pages 1539 - 46
    - KIRCHHOFF C et al., Tetrahedron letters, (20030000), vol. 44, no. 34, pages 6475 - 8
    - FIESER, Fieser's Reagents for Organic Synthesis, Wiley & Sons, (19910000), vol. 1-40
    - RODD, Chemistry of Carbon Compounds, Elsevier Science Publishers, (19890000), vol. 1-5
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The EPO accepts no responsibility for the accuracy of data originating from other authorities; in particular, it does not guarantee that it is complete, up to date or fit for specific purposes.