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Extract from the Register of European Patents

EP About this file: EP3226688

EP3226688 - TRICYCLIC COMPOUNDS AS INHIBITORS OF MUTANT IDH ENZYMES [Right-click to bookmark this link]
Former [2017/41]NOVEL TRICYCLIC COMPOUNDS AS INHIBITORS OF MUTANT IDH ENZYMES
[2020/08]
StatusNo opposition filed within time limit
Status updated on  10.05.2021
Database last updated on 25.09.2024
FormerThe patent has been granted
Status updated on  29.05.2020
FormerGrant of patent is intended
Status updated on  26.01.2020
FormerExamination is in progress
Status updated on  02.08.2019
FormerRequest for examination was made
Status updated on  08.09.2017
FormerThe international publication has been made
Status updated on  06.07.2017
Most recent event   Tooltip15.07.2022Lapse of the patent in a contracting state
New state(s): BE		published on 17.08.2022  [2022/33]
Applicant(s)For all designated states
Merck Sharp & Dohme Corp.
126 East Lincoln Avenue
Rahway, NJ 07065-0907 / US
[2017/41]
Inventor(s)01 / FISCHER, Christian
33 Avenue Louis Pasteur
Boston, Massachusetts 02115-5727 / US
02 / BOGEN, Stephane, L.
126 East Lincoln Avenue
Rahway, New Jersey 07065-0907 / US
03 / CHILDERS, Matthew, L.
33 Avenue Louis Pasteur
Boston, Massachusetts 02115-5727 / US
04 / LLINAS, Francesc Xavier Fradera
33 Avenue Louis Pasteur
Boston, Massachusetts 02115-5727 / US
05 / ELLIS, J. Michael
33 Avenue Louis Pasteur
Boston, Massachusetts 02115-5727 / US
06 / ESPOSITE, Sara
211 Sea Sprite Lane
Neptune, New Jersey 07753 / US
07 / HONG, Qingmei
2000 Galloping Hill Road
Kenilworth, New Jersey 07033 / US
08 / HUANG, Chunhui
2000 Galloping Hill Road
Kenilworth, New Jersey 07033 / US
09 / KIM, Alexander, J.
349 Yorkshire Place
Morganville, New Jersey 07751 / US
10 / LAMPE, John, W.
409 Widdington Lane
Cary, North Carolina 27519-5900 / US
11 / MACHACEK, Michelle, R.
33 Avenue Louis Pasteur
Boston, Massachusetts 02115-5727 / US
12 / MCMASTERS, Daniel, R.
33 Avenue Louis Pasteur
Boston, Massachusetts 02115-5727 / US
13 / OTTE, Ryan, D.
33 Avenue Louis Pasteur
Boston, Massachusetts 02115-5727 / US
14 / PARKER, Dann, L., Jr.
2000 Galloping Hill Road
Kenilworth, New Jersey 07033 / US
15 / REUTERSHAN, Michael
33 Avenue Louis Pasteur
Boston, Massachusetts 02115-5727 / US
16 / SCIAMMETTA, Nunzio
33 Avenue Louis Pasteur
Boston, Massachusetts 02115-5727 / US
17 / SHAO, Pengcheng, P.
2000 Galloping Hill Road
Kenilworth, New Jersey 07033 / US
18 / SLOMAN, David, L.
33 Avenue Louis Pasteur
Boston, Massachusetts 02115-5727 / US
19 / UJJAINWALLA, Feroze
2000 Galloping Hill Road
Kenilworth, New Jersey 07033 / US
20 / WHITE, Catherine
33 Avenue Louis Pasteur
Boston, Massachusetts 02115-5727 / US
21 / WU, Zhicai
2000 Galloping Hill Road
Kenilworth, New Jersey 07033 / US
 [2017/41]
Representative(s)Böhles, Elena
Merck Sharp & Dohme (UK) Limited
120 Moorgate
London EC2M 6UR / GB
[N/P]
Former [2017/41]Böhles, Elena
Merck Sharp & Dohme Limited
Hertford Road
Hoddesdon, Herts EN11 9BU / GB
Application number, filing date15865691.801.12.2015
[2017/41]
WO2015US63061
Priority number, dateUS201462088262P05.12.2014         Original published format: US 201462088262 P
[2017/41]
Filing languageEN
Procedural languageEN
PublicationType: A1 Application with search report
No.:WO2016089797
Date:09.06.2016
Language:EN
[2016/23]
Type: A1 Application with search report 
No.:EP3226688
Date:11.10.2017
Language:EN
The application published by WIPO in one of the EPO official languages on 09.06.2016 takes the place of the publication of the European patent application.
[2017/41]
Type: B1 Patent specification 
No.:EP3226688
Date:01.07.2020
Language:EN
[2020/27]
Search report(s)International search report - published on:US09.06.2016
(Supplementary) European search report - dispatched on:EP23.08.2018
ClassificationIPC:A01N43/00, A61K31/551, C07D471/14
[2018/39]
CPC:
C07D498/08 (EP,US); A61K31/551 (EP,US); C07D471/04 (EP,US);
C07D471/08 (EP,US); C07D471/14 (EP,US); C07D498/04 (EP,US);
C07D498/10 (EP,US); A01N43/00 (US) (-)
Former IPC [2017/41]A01N43/00
Designated contracting statesAL,   AT,   BE,   BG,   CH,   CY,   CZ,   DE,   DK,   EE,   ES,   FI,   FR,   GB,   GR,   HR,   HU,   IE,   IS,   IT,   LI,   LT,   LU,   LV,   MC,   MK,   MT,   NL,   NO,   PL,   PT,   RO,   RS,   SE,   SI,   SK,   SM,   TR [2017/41]
Extension statesBANot yet paid
MENot yet paid
Validation statesMANot yet paid
MDNot yet paid
TitleGerman:TRICYCLISCHE VERBINDUNGEN ALS INHIBITOREN VON MUTANTEN IDH-ENZYMEN[2020/08]
English:TRICYCLIC COMPOUNDS AS INHIBITORS OF MUTANT IDH ENZYMES[2020/08]
French:COMPOSÉS TRICYCLIQUES SERVANT D'INHIBITEURS D'ENZYMES IDH MUTANTES[2020/08]
Former [2017/41]NEUARTIGE TRICYCLISCHE VERBINDUNGEN ALS INHIBITOREN VON MUTANTEN IDH-ENZYMEN
Former [2017/41]NOVEL TRICYCLIC COMPOUNDS AS INHIBITORS OF MUTANT IDH ENZYMES
Former [2017/41]COMPOSÉS TRICYCLIQUES INNOVANTS SERVANT D'INHIBITEURS D'ENZYMES IDH MUTANTES
Entry into regional phase05.07.2017National basic fee paid 
05.07.2017Search fee paid 
05.07.2017Designation fee(s) paid 
05.07.2017Examination fee paid 
Examination procedure05.07.2017Examination requested  [2017/41]
05.07.2017Date on which the examining division has become responsible
19.03.2019Amendment by applicant (claims and/or description)
06.08.2019Despatch of a communication from the examining division (Time limit: M04)
05.12.2019Reply to a communication from the examining division
27.01.2020Communication of intention to grant the patent
26.05.2020Fee for grant paid
26.05.2020Fee for publishing/printing paid
26.05.2020Receipt of the translation of the claim(s)
Opposition(s)06.04.2021No opposition filed within time limit [2021/23]
Fees paidRenewal fee
08.12.2017Renewal fee patent year 03
10.12.2018Renewal fee patent year 04
10.12.2019Renewal fee patent year 05
Opt-out from the exclusive  Tooltip
competence of the Unified
Patent Court		 See the Register of the Unified Patent Court for opt-out data
Responsibility for the accuracy, completeness or quality of the data displayed under the link provided lies entirely with the Unified Patent Court.
Lapses during opposition  TooltipHU01.12.2015
AL01.07.2020
AT01.07.2020
CY01.07.2020
CZ01.07.2020
DK01.07.2020
EE01.07.2020
ES01.07.2020
FI01.07.2020
HR01.07.2020
IT01.07.2020
LT01.07.2020
LV01.07.2020
MC01.07.2020
MK01.07.2020
MT01.07.2020
NL01.07.2020
PL01.07.2020
RO01.07.2020
RS01.07.2020
SE01.07.2020
SI01.07.2020
SK01.07.2020
SM01.07.2020
TR01.07.2020
BG01.10.2020
NO01.10.2020
GR02.10.2020
IS01.11.2020
PT02.11.2020
IE01.12.2020
LU01.12.2020
BE31.12.2020
CH31.12.2020
LI31.12.2020
[2022/33]
Former [2022/32]HU01.12.2015
AL01.07.2020
AT01.07.2020
CY01.07.2020
CZ01.07.2020
DK01.07.2020
EE01.07.2020
ES01.07.2020
FI01.07.2020
HR01.07.2020
IT01.07.2020
LT01.07.2020
LV01.07.2020
MC01.07.2020
MK01.07.2020
MT01.07.2020
NL01.07.2020
PL01.07.2020
RO01.07.2020
RS01.07.2020
SE01.07.2020
SI01.07.2020
SK01.07.2020
SM01.07.2020
TR01.07.2020
BG01.10.2020
NO01.10.2020
GR02.10.2020
IS01.11.2020
PT02.11.2020
IE01.12.2020
LU01.12.2020
CH31.12.2020
LI31.12.2020
Former [2022/27]HU01.12.2015
AL01.07.2020
AT01.07.2020
CY01.07.2020
CZ01.07.2020
DK01.07.2020
EE01.07.2020
ES01.07.2020
FI01.07.2020
HR01.07.2020
IT01.07.2020
LT01.07.2020
LV01.07.2020
MC01.07.2020
MT01.07.2020
NL01.07.2020
PL01.07.2020
RO01.07.2020
RS01.07.2020
SE01.07.2020
SI01.07.2020
SK01.07.2020
SM01.07.2020
TR01.07.2020
BG01.10.2020
NO01.10.2020
GR02.10.2020
IS01.11.2020
PT02.11.2020
IE01.12.2020
LU01.12.2020
CH31.12.2020
LI31.12.2020
Former [2021/52]AL01.07.2020
AT01.07.2020
CZ01.07.2020
DK01.07.2020
EE01.07.2020
ES01.07.2020
FI01.07.2020
HR01.07.2020
IT01.07.2020
LT01.07.2020
LV01.07.2020
MC01.07.2020
NL01.07.2020
PL01.07.2020
RO01.07.2020
RS01.07.2020
SE01.07.2020
SI01.07.2020
SK01.07.2020
SM01.07.2020
BG01.10.2020
NO01.10.2020
GR02.10.2020
IS01.11.2020
PT02.11.2020
IE01.12.2020
LU01.12.2020
CH31.12.2020
LI31.12.2020
Former [2021/46]AL01.07.2020
AT01.07.2020
CZ01.07.2020
DK01.07.2020
EE01.07.2020
ES01.07.2020
FI01.07.2020
HR01.07.2020
IT01.07.2020
LT01.07.2020
LV01.07.2020
MC01.07.2020
NL01.07.2020
PL01.07.2020
RO01.07.2020
RS01.07.2020
SE01.07.2020
SI01.07.2020
SK01.07.2020
SM01.07.2020
BG01.10.2020
NO01.10.2020
GR02.10.2020
IS01.11.2020
PT02.11.2020
IE01.12.2020
LU01.12.2020
Former [2021/40]AL01.07.2020
AT01.07.2020
CZ01.07.2020
DK01.07.2020
EE01.07.2020
ES01.07.2020
FI01.07.2020
HR01.07.2020
IT01.07.2020
LT01.07.2020
LV01.07.2020
MC01.07.2020
NL01.07.2020
PL01.07.2020
RO01.07.2020
RS01.07.2020
SE01.07.2020
SI01.07.2020
SK01.07.2020
SM01.07.2020
BG01.10.2020
NO01.10.2020
GR02.10.2020
IS01.11.2020
PT02.11.2020
Former [2021/36]AL01.07.2020
AT01.07.2020
CZ01.07.2020
DK01.07.2020
EE01.07.2020
ES01.07.2020
FI01.07.2020
HR01.07.2020
IT01.07.2020
LT01.07.2020
LV01.07.2020
NL01.07.2020
PL01.07.2020
RO01.07.2020
RS01.07.2020
SE01.07.2020
SI01.07.2020
SK01.07.2020
SM01.07.2020
BG01.10.2020
NO01.10.2020
GR02.10.2020
IS01.11.2020
PT02.11.2020
Former [2021/28]AL01.07.2020
AT01.07.2020
CZ01.07.2020
DK01.07.2020
EE01.07.2020
ES01.07.2020
FI01.07.2020
HR01.07.2020
IT01.07.2020
LT01.07.2020
LV01.07.2020
NL01.07.2020
PL01.07.2020
RO01.07.2020
RS01.07.2020
SE01.07.2020
SK01.07.2020
SM01.07.2020
BG01.10.2020
NO01.10.2020
GR02.10.2020
IS01.11.2020
PT02.11.2020
Former [2021/25]AL01.07.2020
AT01.07.2020
CZ01.07.2020
DK01.07.2020
EE01.07.2020
ES01.07.2020
FI01.07.2020
HR01.07.2020
IT01.07.2020
LT01.07.2020
LV01.07.2020
NL01.07.2020
PL01.07.2020
RO01.07.2020
RS01.07.2020
SE01.07.2020
SM01.07.2020
BG01.10.2020
NO01.10.2020
GR02.10.2020
IS01.11.2020
PT02.11.2020
Former [2021/22]AT01.07.2020
CZ01.07.2020
DK01.07.2020
EE01.07.2020
ES01.07.2020
FI01.07.2020
HR01.07.2020
IT01.07.2020
LT01.07.2020
LV01.07.2020
NL01.07.2020
PL01.07.2020
RO01.07.2020
RS01.07.2020
SE01.07.2020
SM01.07.2020
BG01.10.2020
NO01.10.2020
GR02.10.2020
IS01.11.2020
PT02.11.2020
Former [2021/20]AT01.07.2020
CZ01.07.2020
DK01.07.2020
ES01.07.2020
FI01.07.2020
HR01.07.2020
IT01.07.2020
LT01.07.2020
LV01.07.2020
NL01.07.2020
PL01.07.2020
RS01.07.2020
SE01.07.2020
BG01.10.2020
NO01.10.2020
GR02.10.2020
IS01.11.2020
PT02.11.2020
Former [2021/17]AT01.07.2020
CZ01.07.2020
ES01.07.2020
FI01.07.2020
HR01.07.2020
LT01.07.2020
LV01.07.2020
NL01.07.2020
PL01.07.2020
RS01.07.2020
SE01.07.2020
BG01.10.2020
NO01.10.2020
GR02.10.2020
IS01.11.2020
PT02.11.2020
Former [2021/11]AT01.07.2020
CZ01.07.2020
ES01.07.2020
FI01.07.2020
HR01.07.2020
LT01.07.2020
LV01.07.2020
PL01.07.2020
RS01.07.2020
SE01.07.2020
BG01.10.2020
NO01.10.2020
GR02.10.2020
IS01.11.2020
PT02.11.2020
Former [2021/09]AT01.07.2020
CZ01.07.2020
ES01.07.2020
FI01.07.2020
LT01.07.2020
SE01.07.2020
BG01.10.2020
NO01.10.2020
GR02.10.2020
PT02.11.2020
Former [2021/08]ES01.07.2020
FI01.07.2020
LT01.07.2020
SE01.07.2020
BG01.10.2020
NO01.10.2020
PT02.11.2020
Former [2021/07]FI01.07.2020
LT01.07.2020
BG01.10.2020
NO01.10.2020
Former [2021/01]BG01.10.2020
Documents cited:Search[A]WO03000692  (FERRING BV [NL], et al) [A] 1-18 * page 60, line 22 - line 25; example 83; claims 1,24 *;
 [A]WO2009063993  (TAKEDA PHARMACEUTICAL [JP], et al) [A] 1-18 * example 40; table 1 *;
 [A]US2009227565  (FAILLI AMEDEO A [US], et al)[A] 1-18
International search[A]WO0043398  (ORTHO MCNEIL PHARM INC [US]) [A] 1-3, 19-20* ; entire document *;
 [A]US6235900  (FAILLI AMEDEO A [US], et al) [A] 1-3, 19-20 * ; entire document *;
 [A]US6620807  (STEFFAN ROBERT J [US], et al) [A] 1-3, 19-20 * ; col 4, In 34-35 *;
 [A]US7022699  (FAILLI AMEDEO ARTURO [US], et al) [A] 1-3, 19-20 * ; entire document *;
 [X]US2009227565  (FAILLI AMEDEO A [US], et al) [X] 1-3, 19-20 * ; para [0115] *
by applicantWO0102369
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 WO02068470
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 WO2004056875
 WO2004072286
 US7488802
 US7521051
 WO2009063993
 WO2010027827
 WO2010077634
 WO2011066342
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    - L. DANG et al., Trends Mol. Med., (20100000), vol. 16, page 387
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The EPO accepts no responsibility for the accuracy of data originating from other authorities; in particular, it does not guarantee that it is complete, up to date or fit for specific purposes.