EP3227455 - FUSION PARTNERS FOR PEPTIDE PRODUCTION [Right-click to bookmark this link] | Status | No opposition filed within time limit Status updated on 17.05.2024 Database last updated on 20.07.2024 | |
Former | The patent has been granted Status updated on 09.06.2023 | ||
Former | Grant of patent is intended Status updated on 01.02.2023 | ||
Former | Examination is in progress Status updated on 06.08.2020 | ||
Former | Request for examination was made Status updated on 08.09.2017 | ||
Former | The international publication has been made Status updated on 16.06.2017 | Most recent event Tooltip | 19.07.2024 | Lapse of the patent in a contracting state New state(s): LU | published on 21.08.2024 [2024/34] | Applicant(s) | For all designated states Pfenex Inc. 10790 Roselle Street San Diego, CA 92121 / US | [2023/28] |
Former [2017/41] | For all designated states Pfenex Inc. 10790 Roselle Street San Diego, CA 92121 / US | Inventor(s) | 01 /
RETALLACK, Diane M. 13420 Carriage Road Poway, California 92064 / US | 02 /
CHAPMAN, Adam 4910 Southcrest Avenue San Diego, California 92110 / US | 03 /
BRUCK, Torben R. 8859 Los Coches Road Lakeside, California 92040 / US | 04 /
JIN, Hongfan 11978 Caneridge Road San Diego, California 92128 / US | [2017/41] | Representative(s) | Wichmann, Hendrik Wuesthoff & Wuesthoff Patentanwälte und Rechtsanwalt PartG mbB Schweigerstraße 2 81541 München / DE | [N/P] |
Former [2023/28] | Wichmann, Hendrik Wuesthoff & Wuesthoff Patentanwälte PartG mbB Schweigerstraße 2 81541 München / DE | ||
Former [2017/41] | Campabadal i Monfà, Gemma Wilson Sonsini Goodrich & Rosati LLP Rue Montoyer 47 1000 Bruxelles / BE | Application number, filing date | 15866061.3 | 30.11.2015 | [2017/41] | WO2015US63027 | Priority number, date | US201462086119P | 01.12.2014 Original published format: US 201462086119 P | [2017/41] | Filing language | EN | Procedural language | EN | Publication | Type: | A1 Application with search report | No.: | WO2016089782 | Date: | 09.06.2016 | Language: | EN | [2016/23] | Type: | A1 Application with search report | No.: | EP3227455 | Date: | 11.10.2017 | Language: | EN | The application published by WIPO in one of the EPO official languages on 09.06.2016 takes the place of the publication of the European patent application. | [2017/41] | Type: | B1 Patent specification | No.: | EP3227455 | Date: | 12.07.2023 | Language: | EN | [2023/28] | Search report(s) | International search report - published on: | US | 09.06.2016 | (Supplementary) European search report - dispatched on: | EP | 01.06.2018 | Classification | IPC: | C12P21/04, C12P21/06, C12N1/20, C12N15/00, C12N15/67, C12N15/74, C07K14/535, C07K14/62, C07K14/635, C12N9/64 | [2018/27] | CPC: |
C07K14/635 (EP,KR,US);
C07K14/195 (KR);
C07K14/535 (EP,KR,US);
C07K14/62 (EP,KR,US);
C12N9/6424 (EP,KR,US);
C12Y304/21009 (EP,KR,US);
|
Former IPC [2017/41] | C12P21/04, C12P21/06, C12N1/20, C12N15/00, C12N15/67, C12N15/74 | Designated contracting states | AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LI, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR [2017/41] | Extension states | BA | Not yet paid | ME | Not yet paid | Validation states | MA | Not yet paid | MD | Not yet paid | Title | German: | FUSIONSPARTNER ZUR HERSTELLUNG VON PEPTIDEN | [2017/41] | English: | FUSION PARTNERS FOR PEPTIDE PRODUCTION | [2017/41] | French: | PARTENAIRES DE FUSION POUR LA PRODUCTION DE PEPTIDES | [2017/41] | Entry into regional phase | 15.06.2017 | National basic fee paid | 15.06.2017 | Search fee paid | 15.06.2017 | Designation fee(s) paid | 15.06.2017 | Examination fee paid | Examination procedure | 15.06.2017 | Examination requested [2017/41] | 15.06.2017 | Date on which the examining division has become responsible | 02.01.2019 | Amendment by applicant (claims and/or description) | 05.08.2020 | Despatch of a communication from the examining division (Time limit: M04) | 09.12.2020 | Reply to a communication from the examining division | 25.08.2021 | Despatch of a communication from the examining division (Time limit: M02) | 04.11.2021 | Reply to a communication from the examining division | 02.02.2023 | Communication of intention to grant the patent | 01.06.2023 | Fee for grant paid | 01.06.2023 | Fee for publishing/printing paid | 01.06.2023 | Receipt of the translation of the claim(s) | Opposition(s) | 15.04.2024 | No opposition filed within time limit [2024/25] | Fees paid | Renewal fee | 13.11.2017 | Renewal fee patent year 03 | 14.11.2018 | Renewal fee patent year 04 | 14.11.2019 | Renewal fee patent year 05 | 13.11.2020 | Renewal fee patent year 06 | 30.11.2021 | Renewal fee patent year 07 | 13.10.2022 | Renewal fee patent year 08 |
Opt-out from the exclusive Tooltip competence of the Unified Patent Court | See the Register of the Unified Patent Court for opt-out data | ||
Responsibility for the accuracy, completeness or quality of the data displayed under the link provided lies entirely with the Unified Patent Court. | Lapses during opposition Tooltip | CZ | 12.07.2023 | EE | 12.07.2023 | FI | 12.07.2023 | HR | 12.07.2023 | LT | 12.07.2023 | LV | 12.07.2023 | MC | 12.07.2023 | NL | 12.07.2023 | PL | 12.07.2023 | RO | 12.07.2023 | RS | 12.07.2023 | SE | 12.07.2023 | SK | 12.07.2023 | SM | 12.07.2023 | NO | 12.10.2023 | GR | 13.10.2023 | IS | 12.11.2023 | PT | 13.11.2023 | LU | 30.11.2023 | [2024/34] |
Former [2024/32] | CZ | 12.07.2023 | |
EE | 12.07.2023 | ||
FI | 12.07.2023 | ||
HR | 12.07.2023 | ||
LT | 12.07.2023 | ||
LV | 12.07.2023 | ||
MC | 12.07.2023 | ||
NL | 12.07.2023 | ||
PL | 12.07.2023 | ||
RO | 12.07.2023 | ||
RS | 12.07.2023 | ||
SE | 12.07.2023 | ||
SK | 12.07.2023 | ||
SM | 12.07.2023 | ||
NO | 12.10.2023 | ||
GR | 13.10.2023 | ||
IS | 12.11.2023 | ||
PT | 13.11.2023 | ||
Former [2024/23] | CZ | 12.07.2023 | |
EE | 12.07.2023 | ||
FI | 12.07.2023 | ||
HR | 12.07.2023 | ||
LT | 12.07.2023 | ||
LV | 12.07.2023 | ||
NL | 12.07.2023 | ||
PL | 12.07.2023 | ||
RO | 12.07.2023 | ||
RS | 12.07.2023 | ||
SE | 12.07.2023 | ||
SK | 12.07.2023 | ||
SM | 12.07.2023 | ||
NO | 12.10.2023 | ||
GR | 13.10.2023 | ||
IS | 12.11.2023 | ||
PT | 13.11.2023 | ||
Former [2024/20] | FI | 12.07.2023 | |
HR | 12.07.2023 | ||
LT | 12.07.2023 | ||
LV | 12.07.2023 | ||
NL | 12.07.2023 | ||
PL | 12.07.2023 | ||
RS | 12.07.2023 | ||
SE | 12.07.2023 | ||
SM | 12.07.2023 | ||
NO | 12.10.2023 | ||
GR | 13.10.2023 | ||
IS | 12.11.2023 | ||
PT | 13.11.2023 | ||
Former [2024/10] | FI | 12.07.2023 | |
HR | 12.07.2023 | ||
LT | 12.07.2023 | ||
LV | 12.07.2023 | ||
NL | 12.07.2023 | ||
PL | 12.07.2023 | ||
RS | 12.07.2023 | ||
SE | 12.07.2023 | ||
NO | 12.10.2023 | ||
GR | 13.10.2023 | ||
IS | 12.11.2023 | ||
PT | 13.11.2023 | ||
Former [2024/09] | FI | 12.07.2023 | |
LT | 12.07.2023 | ||
NL | 12.07.2023 | ||
SE | 12.07.2023 | ||
NO | 12.10.2023 | ||
GR | 13.10.2023 | ||
IS | 12.11.2023 | ||
Former [2024/08] | LT | 12.07.2023 | |
NL | 12.07.2023 | ||
NO | 12.10.2023 | ||
GR | 13.10.2023 | ||
Former [2024/05] | NL | 12.07.2023 | Documents cited: | Search | [XI]WO2006078273 (US HEALTH [US], et al) [X] 1,5,12,13 * paragraph [[0026]] - paragraph [[0032]]; figures 1-15 * * Fusion protein; paragraph [[0038]] - paragraph [[0042]]; claims 1-8 * * Methods; paragraph [[0043]] - paragraph [[0048]]; figure 12; examples 1,2; claims 12-30; table 1 * [I] 9,14,15; | [XI]EP1873251 (CHEMOTHERAPEUTISCHES FORSCHUNGSINSTITUT GEORG SPEYER HAUS [DE]) [X] 1,2,5,8,9,12,13 * paragraph [[0007]] - paragraph [[0011]] * * paragraph [[0013]] - paragraph [[0017]] * * Also paragraphs [0077] and [0078]; paragraph [[0019]] - paragraph [[0024]]; figures 1-8; examples 1-4; claims 1-22 * [I] 14,15; | [XI] - KYRATSOUS C A ET AL, "Chaperone-fusion expression plasmid vectors for improved solubility of recombinant proteins in Escherichia coli", GENE, ELSEVIER, AMSTERDAM, NL, vol. 440, no. 1-2, doi:10.1016/J.GENE.2009.03.011, ISSN 0378-1119, (20090326), pages 9 - 15, (20090326), XP026127941 [X] 1,5,10,12,13 * abstract * * Introduction, last 2 paragraphs,;; figures 1, 2 * * Results and Discussion 3.1-3.5;; figures 3-5 * [I] 9,14,15 DOI: http://dx.doi.org/10.1016/j.gene.2009.03.011 | International search | [A]WO2005069913 (DOW GLOBAL TECHNOLOGIES INC [US], et al) [A] 1-3, 5/(1-3), 11* . Especially claims 1-4 *; | [XY] - KYRATSOUS et al., "Chaperone-fusion expression plasmid vectors for improved solubility of recombinant proteins in Escherichia coli.", GENE, (20090701), vol. 440, no. 1-2, doi:doi:10.1016/j.gene.2009.03.011, pages 9 - 15, XP026119223 [X] 1, 2, 5/1, 5/2 * Especially abstract, pg 10 col 1 para 1, pg 11 fig 1, pg 12 col 1 para 5 * [Y] 3, 5/3, 11 DOI: http://dx.doi.org/10.1016/j.gene.2009.03.011 | [Y] - Uniprot I2BRJ0, (20141001), URL: http://www.uniprot.org/uniprot/I2BRJ0.txt?version=12, (20160414) [Y] 3, 5/3, 11 * . Especially pg 1. * | by applicant | US4551433 | EP0207459 | US4695455 | US4755465 | US4861595 | US5055294 | US5128130 | US5169760 | US5281532 | US5648237 | US5750374 | US5935824 | WO03010204 | US2006040352 | WO2006078273 | US7150974 | US2007292918 | EP1873251 | US2008269070 | US7476532 | US7618799 | US2010137162 | US7794972 | US7833752 | US7985564 | US8017355 | US8288127 | US8455218 | US8569015 | US8603824 | US9169304 | - KYRATSOUS et al., Gene, (20090000), vol. 440, no. 1-2, pages 9 - 15 | - JIN et al., "Crystal Structure of Human Parathyroid Hormone 1-34 at 0.9 Å Resolution", J. Biol. Chem., (20000000), vol. 275, no. 35, pages 27238 - 44, XP002976117 | - Guidebook to Molecular Chaperones and Protein-Folding Catalysts, University Press Inc., (19970000), pages 463 - 465 | - MA et al., "Correlations between Shine-Dalgarno Sequences and Gene Features Such as Predicted Expression Levels and Operon Structures", J. Bact., (20020000), vol. 184, no. 20, pages 5733 - 45 | - LICHTY et al., Comparison of affinity tags for protein purification,'' Protein Expression and Purification, (20050000), vol. 41, pages 98 - 105 | - TERPE K., "Overview of Tag Protein Fusions: from molecular and biochemical fundamentals to commercial systems", Applied Microbiology and Biotechnology, (20030000), no. 60, pages 523 - 533, XP002298417 | - WELCH et al., "Design Parameters to Control Synthetic Gene Expression in Escherichia coli", PLoS One, (20090000), vol. 4, no. 9, doi:10.1371/journal.pone.0007002, page e7002, XP002670364 DOI: http://dx.doi.org/10.1371/journal.pone.0007002 | - J. SANCHEZ-ROMEROV. DE LORENZO, Manual of Industrial Microbiology and Biotechnology, ASM Press, (19990000), pages 460 - 74 | - H. SCHWEIZER, Current Opinion in Biotechnology, (20010000), vol. 12, pages 439 - 445 | - MANOIL, Methods in Enzymol, (20000000), vol. 326, pages 125 - 47 | - D. FRISHMAN et al., Gene, (19990708), vol. 234, no. 2, pages 257 - 65 | - B. E. SUZEK et al., Bioinformatics, (20011200), vol. 17, no. 12, pages 1123 - 30 | - O. IKEHATA et al., Eur. J. Biochem., (19890000), vol. 181, no. 3, pages 563 - 70 | - CHEN et al., "Determination of the optimal aligned spacing between the Shine-Dalgarno sequence and the translation initiation codon of Escherichia coli mRNAs", Nucleic Acids Research, (19940000), vol. 22, no. 23, pages 4953 - 4957, XP001156191 | - BARDWELL et al., Phosphate Microorg, (19940000), pages 270 - 5 | - SCHNEIDER et al., "Auxotrophic markers pyrF and proC can replace antibiotic markers on protein production plasmids in high-cell-density Pseudomonasfluorescens fermentation", Biotechnol. Progress, (20050000), vol. 21, no. 2, doi:10.1021/bp049696g, pages 343 - 8, XP002421514 DOI: http://dx.doi.org/10.1021/bp049696g | - "Gram(-) Proteobacteria Subgroup 1'' or ''Gram-Negative Aerobic Rods and Cocci", Bergey's Manual of Determinative Bacteriology, The Williams & Wilkins Co., (19740000), pages 217 - 289 | - DAVIS, B. D.MINGIOLI, E. S., J. Bact., (19500000), vol. 60, pages 17 - 28 | - RIESENBERG, D et al., "High cell density cultivation of Escherichia coli at controlled specific growth rate", J. Biotechnol., (19910000), vol. 20, no. 1, doi:10.1016/0168-1656(91)90032-Q, pages 17 - 27, XP023939064 DOI: http://dx.doi.org/10.1016/0168-1656(91)90032-Q | - RETALLACK et al., Prot. Exp. and Purif., (20120000), vol. 81, pages 157 - 165 | - NISSENSON et al., "Activation of the Parathyroid Hormone Receptor-Adenylate Cyclase System in Osteosarcoma Cells by a Human Renal Carcinoma Factor", Cancer Res, (19850000), vol. 45, pages 5358 - 5363 | - SHIMIZU et al., "Parathyroid hormone (1-14) and (1-11) analogs conformationally constrained by a-aminoisobutyric acid mediate full agonist responses via the Juxtamembrane region of the PTH-1 receptor", J. Biol. Chem., (20010000), vol. 276, doi:10.1074/jbc.M106827200, pages 49003 - 49012, XP002347602 DOI: http://dx.doi.org/10.1074/jbc.M106827200 | - SCHNEIDER et al., "Auxotrophic markers pyrF and proC can replace antibiotic markers on protein production plasmids in high-cell-density Pseudomonas fluorescens fermentation", Biotechnol. Progress, (20050000), vol. 21, no. 2, doi:10.1021/bp049696g, pages 343 - 8, XP002421514 DOI: http://dx.doi.org/10.1021/bp049696g |