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Extract from the Register of European Patents

EP About this file: EP3230744

EP3230744 - COMPOSITIONS AND METHODS FOR PERFORMING METHYLATION DETECTION ASSAYS [Right-click to bookmark this link]
StatusNo opposition filed within time limit
Status updated on  18.03.2022
Database last updated on 09.09.2024
FormerThe patent has been granted
Status updated on  09.04.2021
FormerGrant of patent is intended
Status updated on  19.01.2021
FormerRequest for examination was made
Status updated on  30.11.2020
FormerGrant of patent is intended
Status updated on  13.08.2020
FormerRequest for examination was made
Status updated on  15.09.2017
FormerThe international publication has been made
Status updated on  16.06.2017
Most recent event   Tooltip06.09.2024Lapse of the patent in a contracting state
New state(s): MT		published on 09.10.2024 [2024/41]
Applicant(s)For all designated states
Exact Sciences Development Company, LLC
5505 Endeavor Lane
Madison, Wisconsin 53719 / US
[2021/18]
Former [2018/02]For all designated states
Exact Sciences Development Company, LLC
441 Charmany Drive
Madison, Wisconsin 53719 / US
Former [2017/42]For all designated states
Exact Sciences Corporation
441 Charmany Drive
Madison, Wisconsin 53719 / US
Inventor(s)01 / ALLAWI, Hatim T.
901 Winding Way
Middleton, Wisconsin 53562 / US
02 / LIDGARD, Graham P.
652 Bear Claw Way
Apt. 313
Middleton, Wisconsin 53562 / US
 [2017/42]
Representative(s)Glawe, Delfs, Moll
Partnerschaft mbB von
Patent- und Rechtsanwälten
Postfach 13 03 91
20103 Hamburg / DE
[2021/19]
Former [2017/42]Glawe, Delfs, Moll
Partnerschaft mbB
von Patent- und Rechtsanwälten
Postfach 13 03 91
20103 Hamburg / DE
Application number, filing date15868202.111.12.2015
[2017/42]
WO2015US65272
Priority number, dateUS201462091069P12.12.2014         Original published format: US 201462091069 P
[2017/42]
Filing languageEN
Procedural languageEN
PublicationType: A1 Application with search report
No.:WO2016094813
Date:16.06.2016
Language:EN
[2016/24]
Type: A1 Application with search report 
No.:EP3230744
Date:18.10.2017
Language:EN
The application published by WIPO in one of the EPO official languages on 16.06.2016 takes the place of the publication of the European patent application.
[2017/42]
Type: B1 Patent specification 
No.:EP3230744
Date:12.05.2021
Language:EN
[2021/19]
Search report(s)International search report - published on:US16.06.2016
(Supplementary) European search report - dispatched on:EP13.06.2018
ClassificationIPC:G01N33/574, C12Q1/6881, C12Q1/6886
[2018/28]
CPC:
C12Q1/6886 (EP,US); C12Q1/6881 (EP,US); C12Q2600/112 (US);
C12Q2600/118 (EP,US); C12Q2600/154 (EP,US); C12Q2600/158 (EP,US);
C12Q2600/166 (EP) (-)
Former IPC [2017/42]G01N33/574
Designated contracting statesAL,   AT,   BE,   BG,   CH,   CY,   CZ,   DE,   DK,   EE,   ES,   FI,   FR,   GB,   GR,   HR,   HU,   IE,   IS,   IT,   LI,   LT,   LU,   LV,   MC,   MK,   MT,   NL,   NO,   PL,   PT,   RO,   RS,   SE,   SI,   SK,   SM,   TR [2017/42]
Extension statesBANot yet paid
MENot yet paid
Validation statesMANot yet paid
MDNot yet paid
TitleGerman:VORRICHTUNGEN UND VERFAHREN ZUR DURCHFÜHRUNG VON METHYLIERUNGSERKENNUNGSTESTS[2017/42]
English:COMPOSITIONS AND METHODS FOR PERFORMING METHYLATION DETECTION ASSAYS[2017/42]
French:COMPOSITIONS ET PROCÉDÉS POUR EFFECTUER DES ESSAIS DE DÉTECTION DE MÉTHYLATION[2017/42]
Entry into regional phase15.06.2017National basic fee paid 
15.06.2017Search fee paid 
15.06.2017Designation fee(s) paid 
15.06.2017Examination fee paid 
Examination procedure15.06.2017Examination requested  [2017/42]
15.06.2017Date on which the examining division has become responsible
21.12.2018Amendment by applicant (claims and/or description)
14.08.2020Communication of intention to grant the patent
30.11.2020Disapproval of the communication of intention to grant the patent by the applicant or resumption of examination proceedings by the EPO
30.11.2020Fee for grant paid
30.11.2020Fee for publishing/printing paid
27.01.2021Communication of intention to grant the patent
31.03.2021Receipt of the translation of the claim(s)
Divisional application(s)EP21166494.1  / EP3889611
Opposition(s)15.02.2022No opposition filed within time limit [2022/16]
Fees paidRenewal fee
27.12.2017Renewal fee patent year 03
31.12.2018Renewal fee patent year 04
27.12.2019Renewal fee patent year 05
28.12.2020Renewal fee patent year 06
Opt-out from the exclusive  Tooltip
competence of the Unified
Patent Court		 See the Register of the Unified Patent Court for opt-out data
Responsibility for the accuracy, completeness or quality of the data displayed under the link provided lies entirely with the Unified Patent Court.
Lapses during opposition  TooltipHU11.12.2015
AL12.05.2021
AT12.05.2021
CY12.05.2021
CZ12.05.2021
DK12.05.2021
EE12.05.2021
FI12.05.2021
HR12.05.2021
LT12.05.2021
LV12.05.2021
MC12.05.2021
MK12.05.2021
MT12.05.2021
NL12.05.2021
PL12.05.2021
RO12.05.2021
RS12.05.2021
SE12.05.2021
SI12.05.2021
SK12.05.2021
SM12.05.2021
TR12.05.2021
BG12.08.2021
NO12.08.2021
GR13.08.2021
IS12.09.2021
PT13.09.2021
LU11.12.2021
BE31.12.2021
CH31.12.2021
LI31.12.2021
[2024/41]
Former [2024/29]HU11.12.2015
AL12.05.2021
AT12.05.2021
CY12.05.2021
CZ12.05.2021
DK12.05.2021
EE12.05.2021
FI12.05.2021
HR12.05.2021
LT12.05.2021
LV12.05.2021
MC12.05.2021
MK12.05.2021
NL12.05.2021
PL12.05.2021
RO12.05.2021
RS12.05.2021
SE12.05.2021
SI12.05.2021
SK12.05.2021
SM12.05.2021
TR12.05.2021
BG12.08.2021
NO12.08.2021
GR13.08.2021
IS12.09.2021
PT13.09.2021
LU11.12.2021
BE31.12.2021
CH31.12.2021
LI31.12.2021
Former [2024/22]HU11.12.2015
AL12.05.2021
AT12.05.2021
CY12.05.2021
CZ12.05.2021
DK12.05.2021
EE12.05.2021
FI12.05.2021
HR12.05.2021
LT12.05.2021
LV12.05.2021
MC12.05.2021
MK12.05.2021
NL12.05.2021
PL12.05.2021
RO12.05.2021
RS12.05.2021
SE12.05.2021
SI12.05.2021
SK12.05.2021
SM12.05.2021
BG12.08.2021
NO12.08.2021
GR13.08.2021
IS12.09.2021
PT13.09.2021
LU11.12.2021
BE31.12.2021
CH31.12.2021
LI31.12.2021
Former [2023/30]HU11.12.2015
AL12.05.2021
AT12.05.2021
CY12.05.2021
CZ12.05.2021
DK12.05.2021
EE12.05.2021
FI12.05.2021
HR12.05.2021
LT12.05.2021
LV12.05.2021
MC12.05.2021
NL12.05.2021
PL12.05.2021
RO12.05.2021
RS12.05.2021
SE12.05.2021
SI12.05.2021
SK12.05.2021
SM12.05.2021
BG12.08.2021
NO12.08.2021
GR13.08.2021
IS12.09.2021
PT13.09.2021
LU11.12.2021
BE31.12.2021
CH31.12.2021
LI31.12.2021
Former [2023/29]HU11.12.2015
AL12.05.2021
AT12.05.2021
CZ12.05.2021
DK12.05.2021
EE12.05.2021
FI12.05.2021
HR12.05.2021
LT12.05.2021
LV12.05.2021
MC12.05.2021
NL12.05.2021
PL12.05.2021
RO12.05.2021
RS12.05.2021
SE12.05.2021
SI12.05.2021
SK12.05.2021
SM12.05.2021
BG12.08.2021
NO12.08.2021
GR13.08.2021
IS12.09.2021
PT13.09.2021
LU11.12.2021
BE31.12.2021
CH31.12.2021
LI31.12.2021
Former [2023/03]AL12.05.2021
AT12.05.2021
CZ12.05.2021
DK12.05.2021
EE12.05.2021
FI12.05.2021
HR12.05.2021
LT12.05.2021
LV12.05.2021
MC12.05.2021
NL12.05.2021
PL12.05.2021
RO12.05.2021
RS12.05.2021
SE12.05.2021
SI12.05.2021
SK12.05.2021
SM12.05.2021
BG12.08.2021
NO12.08.2021
GR13.08.2021
IS12.09.2021
PT13.09.2021
LU11.12.2021
BE31.12.2021
CH31.12.2021
LI31.12.2021
Former [2023/01]AL12.05.2021
AT12.05.2021
CZ12.05.2021
DK12.05.2021
EE12.05.2021
FI12.05.2021
HR12.05.2021
LT12.05.2021
LV12.05.2021
MC12.05.2021
NL12.05.2021
PL12.05.2021
RO12.05.2021
RS12.05.2021
SE12.05.2021
SI12.05.2021
SK12.05.2021
SM12.05.2021
BG12.08.2021
NO12.08.2021
GR13.08.2021
IS12.09.2021
PT13.09.2021
LU11.12.2021
BE31.12.2021
Former [2022/46]AL12.05.2021
AT12.05.2021
CZ12.05.2021
DK12.05.2021
EE12.05.2021
FI12.05.2021
HR12.05.2021
LT12.05.2021
LV12.05.2021
MC12.05.2021
NL12.05.2021
PL12.05.2021
RO12.05.2021
RS12.05.2021
SE12.05.2021
SI12.05.2021
SK12.05.2021
SM12.05.2021
BG12.08.2021
NO12.08.2021
GR13.08.2021
IS12.09.2021
PT13.09.2021
LU11.12.2021
Former [2022/33]AL12.05.2021
AT12.05.2021
CZ12.05.2021
DK12.05.2021
EE12.05.2021
FI12.05.2021
HR12.05.2021
LT12.05.2021
LV12.05.2021
MC12.05.2021
NL12.05.2021
PL12.05.2021
RO12.05.2021
RS12.05.2021
SE12.05.2021
SI12.05.2021
SK12.05.2021
SM12.05.2021
BG12.08.2021
NO12.08.2021
GR13.08.2021
IS12.09.2021
PT13.09.2021
Former [2022/29]AL12.05.2021
AT12.05.2021
CZ12.05.2021
DK12.05.2021
EE12.05.2021
FI12.05.2021
HR12.05.2021
LT12.05.2021
LV12.05.2021
NL12.05.2021
PL12.05.2021
RO12.05.2021
RS12.05.2021
SE12.05.2021
SI12.05.2021
SK12.05.2021
SM12.05.2021
BG12.08.2021
NO12.08.2021
GR13.08.2021
IS12.09.2021
PT13.09.2021
Former [2022/26]AL12.05.2021
AT12.05.2021
CZ12.05.2021
DK12.05.2021
EE12.05.2021
FI12.05.2021
HR12.05.2021
LT12.05.2021
LV12.05.2021
NL12.05.2021
PL12.05.2021
RO12.05.2021
RS12.05.2021
SE12.05.2021
SK12.05.2021
SM12.05.2021
BG12.08.2021
NO12.08.2021
GR13.08.2021
IS12.09.2021
PT13.09.2021
Former [2022/23]AT12.05.2021
CZ12.05.2021
DK12.05.2021
EE12.05.2021
FI12.05.2021
HR12.05.2021
LT12.05.2021
LV12.05.2021
NL12.05.2021
PL12.05.2021
RO12.05.2021
RS12.05.2021
SE12.05.2021
SK12.05.2021
SM12.05.2021
BG12.08.2021
NO12.08.2021
GR13.08.2021
IS12.09.2021
PT13.09.2021
Former [2022/10]AT12.05.2021
CZ12.05.2021
DK12.05.2021
EE12.05.2021
FI12.05.2021
HR12.05.2021
LT12.05.2021
LV12.05.2021
NL12.05.2021
PL12.05.2021
RO12.05.2021
RS12.05.2021
SE12.05.2021
SK12.05.2021
SM12.05.2021
BG12.08.2021
NO12.08.2021
GR13.08.2021
PT13.09.2021
IS22.12.2021
Former [2022/09]AT12.05.2021
CZ12.05.2021
DK12.05.2021
FI12.05.2021
HR12.05.2021
LT12.05.2021
LV12.05.2021
NL12.05.2021
PL12.05.2021
RO12.05.2021
RS12.05.2021
SE12.05.2021
SK12.05.2021
SM12.05.2021
BG12.08.2021
NO12.08.2021
GR13.08.2021
IS12.09.2021
PT13.09.2021
Former [2022/08]AT12.05.2021
CZ12.05.2021
DK12.05.2021
FI12.05.2021
HR12.05.2021
LT12.05.2021
LV12.05.2021
NL12.05.2021
PL12.05.2021
RS12.05.2021
SE12.05.2021
SM12.05.2021
BG12.08.2021
NO12.08.2021
GR13.08.2021
IS12.09.2021
PT13.09.2021
Former [2022/07]AT12.05.2021
FI12.05.2021
HR12.05.2021
LT12.05.2021
LV12.05.2021
NL12.05.2021
PL12.05.2021
RS12.05.2021
SE12.05.2021
SM12.05.2021
BG12.08.2021
NO12.08.2021
GR13.08.2021
IS12.09.2021
PT13.09.2021
Former [2022/04]AT12.05.2021
FI12.05.2021
HR12.05.2021
LT12.05.2021
LV12.05.2021
NL12.05.2021
PL12.05.2021
RS12.05.2021
SE12.05.2021
BG12.08.2021
NO12.08.2021
GR13.08.2021
IS12.09.2021
PT13.09.2021
Former [2021/52]AT12.05.2021
FI12.05.2021
HR12.05.2021
LT12.05.2021
LV12.05.2021
PL12.05.2021
RS12.05.2021
SE12.05.2021
BG12.08.2021
NO12.08.2021
GR13.08.2021
IS12.09.2021
PT13.09.2021
Former [2021/51]AT12.05.2021
FI12.05.2021
HR12.05.2021
LT12.05.2021
LV12.05.2021
RS12.05.2021
SE12.05.2021
BG12.08.2021
NO12.08.2021
GR13.08.2021
IS12.09.2021
PT13.09.2021
Former [2021/50]AT12.05.2021
FI12.05.2021
HR12.05.2021
LT12.05.2021
LV12.05.2021
SE12.05.2021
BG12.08.2021
NO12.08.2021
GR13.08.2021
PT13.09.2021
Former [2021/49]AT12.05.2021
FI12.05.2021
HR12.05.2021
LT12.05.2021
LV12.05.2021
SE12.05.2021
BG12.08.2021
NO12.08.2021
GR13.08.2021
Former [2021/47]AT12.05.2021
FI12.05.2021
LT12.05.2021
BG12.08.2021
Former [2021/46]AT12.05.2021
FI12.05.2021
LT12.05.2021
Documents cited:Search[XI]  - Hongchuan Jin ET AL, "Circulating Methylated DNA as Biomarkers for Cancer Detection", Methylation - From DNA, RNA and Histones to Diseases and Treatment, InTech, (20121128), doi:10.5772/51419, ISBN 978-953-51-0881-8, XP055479454 [X] 1-3 * page 139 * * page 143 - page 144 * [I] 4-7

DOI:   http://dx.doi.org/10.5772/51419
 [XI]  - MOHAMED I. HUSSEINY ET AL, "Tissue-Specific Methylation of Human Insulin Gene and PCR Assay for Monitoring Beta Cell Death", PLOS ONE, (20140410), vol. 9, no. 4, doi:10.1371/journal.pone.0094591, page e94591, XP055197433 [X] 4-7 * page 8; figure 6 * [I] 1-3

DOI:   http://dx.doi.org/10.1371/journal.pone.0094591
 [I]  - SIRI STRAND ET AL, "Prognostic DNA Methylation Markers for Prostate Cancer", INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, (20140918), vol. 15, no. 9, doi:10.3390/ijms150916544, pages 16544 - 16576, XP055479116 [I] 1-15 * page 16562 *

DOI:   http://dx.doi.org/10.3390/ijms150916544
 [A]  - D. A. HABER ET AL, "Blood-Based Analyses of Cancer: Circulating Tumor Cells and Circulating Tumor DNA", CANCER DISCOVERY, (20140506), vol. 4, no. 6, doi:10.1158/2159-8290.CD-13-1014, ISSN 2159-8274, pages 650 - 661, XP055479355 [A] 1-15 * page 4 *

DOI:   http://dx.doi.org/10.1158/2159-8290.CD-13-1014
 [A]  - A. T. J. I. GO ET AL, "Non-invasive aneuploidy detection using free fetal DNA and RNA in maternal plasma: recent progress and future possibilities", HUMAN REPRODUCTION UPDATE, (20101112), vol. 17, no. 3, doi:10.1093/humupd/dmq054, ISSN 1355-4786, pages 372 - 382, XP055052831 [A] 1-15 * page 376; table 1 *

DOI:   http://dx.doi.org/10.1093/humupd/dmq054
 [A]  - BASANT KUMAR THAKUR ET AL, "Double-stranded DNA in exosomes: a novel biomarker in cancer detection", CELL RESEARCH - XIBAO YANJIU, GB, CN, (20140408), vol. 24, no. 6, doi:10.1038/cr.2014.44, ISSN 1001-0602, pages 766 - 769, XP055240739 [A] 1-15 * the whole document *

DOI:   http://dx.doi.org/10.1038/cr.2014.44
International search[XY]US2004234960  (OLEK ALEXANDER [DE], et al) [X] 58-63, 67-69, 109 * entire document * [Y] 64-66;
 [XY]US2009191548  (BERLIN KURT [DE], et al) [X] 1-4, 6, 7, 9-16, 18, 19, 21-23, 25-27, 29-41, 43, 44, 46, 70, 96 * entire document * [Y] 5, 8, 17, 20, 24, 28, 42, 45, 82;
 [Y]US2009253142  (ALLAWI HATIM T [US], et al) [Y] 8, 20, 28, 45, 64-66* entire document *;
 [XY]US2013022974  (CHINNAIYAN ARUL M [US], et al) [X] 47-57, 102, 107 * entire document * [Y] 5, 17, 24, 42, 82
The EPO accepts no responsibility for the accuracy of data originating from other authorities; in particular, it does not guarantee that it is complete, up to date or fit for specific purposes.