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Extract from the Register of European Patents

EP About this file: EP3238746

EP3238746 - HIGH-DENSITY LIPOPROTEIN, AND DELIVERY OF DRUG TO POSTERIOR SEGMENT OF EYE BY OCULAR INSTILLATION OF SAID CYTOPHILIC PEPTIDE-FUSED HIGH-DENSITY LIPOPROTEIN [Right-click to bookmark this link]
StatusNo opposition filed within time limit
Status updated on  25.10.2024
Database last updated on 14.03.2026
FormerThe patent has been granted
Status updated on  17.11.2023
FormerGrant of patent is intended
Status updated on  12.07.2023
FormerExamination is in progress
Status updated on  06.09.2019
FormerRequest for examination was made
Status updated on  29.09.2017
FormerThe international publication has been made
Status updated on  21.07.2017
Most recent event   Tooltip19.12.2025Lapse of the patent in a contracting state
New state(s): TR		published on 21.01.2026  [2026/04]
Applicant(s)For all designated states
Kyoto University
36-1, Yoshida-honmachi Sakyo-ku
Kyoto-shi, Kyoto 606-8501 / JP
For all designated states
NOSTA AG
Malzgasse 17
4052 Basel / CH
[2021/44]
Former [2017/44]For all designated states
Kyoto University
36-1, Yoshida-honmachi Sakyo-ku
Kyoto-shi, Kyoto 606-8501 / JP
Inventor(s)01 / SUDA, Kenji
c/o Kyoto University
36-1 Yoshida-honmachi
Sakyo-ku
Kyoto-shi Kyoto 606-8501 / JP
02 / MURAKAMI, Tatsuya
c/o Kyoto University
36-1 Yoshida-honmachi
Sakyo-ku
Kyoto-shi Kyoto 606-8501 / JP
03 / YOSHIMURA, Nagahisa
c/o Kyoto University
36-1Yoshida-honmachi
Sakyo-ku
Kyoto-shi Kyoto 606-8501 / JP
04 / GOTOH, Norimoto
c/o Kyoto University
36-1 Yoshida-honmachi
Sakyo-ku
Kyoto-shi Kyoto 606-8501 / JP
 [2017/44]
Representative(s)Hoffmann Eitle
Patent- und Rechtsanwälte PartmbB
Arabellastraße 30
81925 München / DE
[2017/44]
Application number, filing date15873258.625.12.2015
[2017/44]
WO2015JP86203
Priority number, dateJP2014026301825.12.2014         Original published format: JP 2014263018
[2017/44]
Filing languageJA
Procedural languageEN
PublicationType: A1 Application with search report
No.:WO2016104690
Date:30.06.2016
Language:JA
[2016/26]
Type: A1 Application with search report 
No.:EP3238746
Date:01.11.2017
Language:EN
[2017/44]
Type: B1 Patent specification 
No.:EP3238746
Date:20.12.2023
Language:EN
[2023/51]
Search report(s)International search report - published on:JP30.06.2016
(Supplementary) European search report - dispatched on:EP28.05.2018
ClassificationIPC:A61K47/42, A61K9/08, A61K9/127, A61K45/00, A61K47/24, A61P3/10, A61P9/10, A61P27/02, A61P27/06, A61P27/10, A61P27/12, A61P29/00, A61K31/506
[2023/29]
CPC:
A61K47/42 (EP,US); A61K47/64 (US); A61K31/506 (EP,US);
A61K45/00 (EP,US); A61K47/6455 (US); A61K47/6917 (US);
A61K9/0048 (EP,US); A61P27/02 (EP,US); A61P27/06 (EP,US);
A61P27/10 (EP,US); A61P27/12 (EP,US); A61P29/00 (EP);
A61P3/10 (EP); A61P9/10 (EP,US); C07K14/775 (US);
C07K19/00 (US); C07K7/06 (US); C07K7/08 (US);
A61K47/24 (EP,US); C07K2319/01 (US) (-)
Former IPC [2017/44]A61K47/42, A61K9/08, A61K9/127, A61K45/00, A61K47/24, A61P3/10, A61P9/10, A61P27/02, A61P27/06, A61P27/10, A61P27/12, A61P29/00
Designated contracting statesAL,   AT,   BE,   BG,   CH,   CY,   CZ,   DE,   DK,   EE,   ES,   FI,   FR,   GB,   GR,   HR,   HU,   IE,   IS,   IT,   LI,   LT,   LU,   LV,   MC,   MK,   MT,   NL,   NO,   PL,   PT,   RO,   RS,   SE,   SI,   SK,   SM,   TR [2017/44]
Extension statesBANot yet paid
MENot yet paid
Validation statesMANot yet paid
MDNot yet paid
TitleGerman:HOCHDICHTES LIPOPROTEIN UND VERABREICHUNG EINES ARZNEIMITTELS IM HINTEREN AUGENSEGMENT DURCH OKULARE INSTILLATION DIESES ZYTOPHILEN HOCHDICHTEN LIPOPROTEINS MIT KONDENSIERTEM PEPTID[2017/44]
English:HIGH-DENSITY LIPOPROTEIN, AND DELIVERY OF DRUG TO POSTERIOR SEGMENT OF EYE BY OCULAR INSTILLATION OF SAID CYTOPHILIC PEPTIDE-FUSED HIGH-DENSITY LIPOPROTEIN[2017/44]
French:LIPOPROTÉINE HAUTE DENSITÉ ET ADMINISTRATION DE MÉDICAMENT AU SEGMENT POSTÉRIEUR DE L' OEIL PAR INSTILLATION OCULAIRE DE LADITE LIPOPROTÉINE HAUTE DENSITÉ FUSIONNÉE À UN PEPTIDE CYTOPHILE[2023/29]
Former [2017/44]LIPOPROTÉINE HAUTE DENSITÉ ET ADMINISTRATION DE MÉDICAMENT AU SEGMENT POSTÉRIEUR DE L' IL PAR INSTILLATION OCULAIRE DE LADITE LIPOPROTÉINE HAUTE DENSITÉ FUSIONNÉE À UN PEPTIDE CYTOPHILE
Entry into regional phase21.07.2017Translation filed 
21.07.2017National basic fee paid 
21.07.2017Search fee paid 
21.07.2017Designation fee(s) paid 
21.07.2017Examination fee paid 
Examination procedure14.06.2016Request for preliminary examination filed
International Preliminary Examining Authority: JP
21.07.2017Examination requested  [2017/44]
21.07.2017Date on which the examining division has become responsible
10.12.2018Amendment by applicant (claims and/or description)
10.09.2019Despatch of a communication from the examining division (Time limit: M04)
17.01.2020Reply to a communication from the examining division
24.04.2020Despatch of a communication from the examining division (Time limit: M06)
03.11.2020Reply to a communication from the examining division
12.01.2021Despatch of a communication from the examining division (Time limit: M04)
19.05.2021Reply to a communication from the examining division
21.10.2021Despatch of a communication from the examining division (Time limit: M04)
25.02.2022Reply to a communication from the examining division
14.11.2022Despatch of a communication from the examining division (Time limit: M04)
12.01.2023Reply to a communication from the examining division
13.07.2023Communication of intention to grant the patent
09.11.2023Fee for grant paid
09.11.2023Fee for publishing/printing paid
09.11.2023Receipt of the translation of the claim(s)
Opposition(s)23.09.2024No opposition filed within time limit [2024/48]
Fees paidRenewal fee
14.12.2017Renewal fee patent year 03
13.12.2018Renewal fee patent year 04
09.12.2019Renewal fee patent year 05
10.12.2020Renewal fee patent year 06
13.12.2021Renewal fee patent year 07
14.12.2022Renewal fee patent year 08
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Lapses during opposition  TooltipCY25.12.2015
HU25.12.2015
AT20.12.2023
CZ20.12.2023
DK20.12.2023
EE20.12.2023
ES20.12.2023
FI20.12.2023
HR20.12.2023
IT20.12.2023
LT20.12.2023
LV20.12.2023
MC20.12.2023
NL20.12.2023
PL20.12.2023
RO20.12.2023
RS20.12.2023
SE20.12.2023
SI20.12.2023
SK20.12.2023
SM20.12.2023
TR20.12.2023
IE25.12.2023
LU25.12.2023
BE31.12.2023
BG20.03.2024
NO20.03.2024
GR21.03.2024
IS20.04.2024
PT22.04.2024
[2026/04]
Former [2025/39]CY25.12.2015
HU25.12.2015
AT20.12.2023
CZ20.12.2023
DK20.12.2023
EE20.12.2023
ES20.12.2023
FI20.12.2023
HR20.12.2023
IT20.12.2023
LT20.12.2023
LV20.12.2023
MC20.12.2023
NL20.12.2023
PL20.12.2023
RO20.12.2023
RS20.12.2023
SE20.12.2023
SI20.12.2023
SK20.12.2023
SM20.12.2023
IE25.12.2023
LU25.12.2023
BE31.12.2023
BG20.03.2024
NO20.03.2024
GR21.03.2024
IS20.04.2024
PT22.04.2024
Former [2025/36]CY25.12.2015
AT20.12.2023
CZ20.12.2023
DK20.12.2023
EE20.12.2023
ES20.12.2023
FI20.12.2023
HR20.12.2023
IT20.12.2023
LT20.12.2023
LV20.12.2023
MC20.12.2023
NL20.12.2023
PL20.12.2023
RO20.12.2023
RS20.12.2023
SE20.12.2023
SI20.12.2023
SK20.12.2023
SM20.12.2023
IE25.12.2023
LU25.12.2023
BE31.12.2023
BG20.03.2024
NO20.03.2024
GR21.03.2024
IS20.04.2024
PT22.04.2024
Former [2024/49]AT20.12.2023
CZ20.12.2023
DK20.12.2023
EE20.12.2023
ES20.12.2023
FI20.12.2023
HR20.12.2023
IT20.12.2023
LT20.12.2023
LV20.12.2023
MC20.12.2023
NL20.12.2023
PL20.12.2023
RO20.12.2023
RS20.12.2023
SE20.12.2023
SI20.12.2023
SK20.12.2023
SM20.12.2023
IE25.12.2023
LU25.12.2023
BE31.12.2023
BG20.03.2024
NO20.03.2024
GR21.03.2024
IS20.04.2024
PT22.04.2024
Former [2024/47]AT20.12.2023
CZ20.12.2023
DK20.12.2023
EE20.12.2023
ES20.12.2023
FI20.12.2023
HR20.12.2023
IT20.12.2023
LT20.12.2023
LV20.12.2023
MC20.12.2023
NL20.12.2023
PL20.12.2023
RO20.12.2023
RS20.12.2023
SE20.12.2023
SK20.12.2023
SM20.12.2023
IE25.12.2023
LU25.12.2023
BE31.12.2023
BG20.03.2024
NO20.03.2024
GR21.03.2024
IS20.04.2024
PT22.04.2024
Former [2024/46]AT20.12.2023
CZ20.12.2023
EE20.12.2023
ES20.12.2023
FI20.12.2023
HR20.12.2023
IT20.12.2023
LT20.12.2023
LV20.12.2023
MC20.12.2023
NL20.12.2023
PL20.12.2023
RO20.12.2023
RS20.12.2023
SE20.12.2023
SK20.12.2023
SM20.12.2023
IE25.12.2023
LU25.12.2023
BG20.03.2024
NO20.03.2024
GR21.03.2024
IS20.04.2024
PT22.04.2024
Former [2024/45]AT20.12.2023
CZ20.12.2023
EE20.12.2023
ES20.12.2023
FI20.12.2023
HR20.12.2023
IT20.12.2023
LT20.12.2023
LV20.12.2023
MC20.12.2023
NL20.12.2023
PL20.12.2023
RO20.12.2023
RS20.12.2023
SE20.12.2023
SK20.12.2023
SM20.12.2023
LU25.12.2023
BG20.03.2024
NO20.03.2024
GR21.03.2024
IS20.04.2024
PT22.04.2024
Former [2024/40]AT20.12.2023
CZ20.12.2023
EE20.12.2023
ES20.12.2023
FI20.12.2023
HR20.12.2023
IT20.12.2023
LT20.12.2023
LV20.12.2023
NL20.12.2023
PL20.12.2023
RO20.12.2023
RS20.12.2023
SE20.12.2023
SK20.12.2023
SM20.12.2023
LU25.12.2023
BG20.03.2024
NO20.03.2024
GR21.03.2024
IS20.04.2024
PT22.04.2024
Former [2024/36]AT20.12.2023
CZ20.12.2023
EE20.12.2023
ES20.12.2023
FI20.12.2023
HR20.12.2023
IT20.12.2023
LT20.12.2023
LV20.12.2023
NL20.12.2023
PL20.12.2023
RO20.12.2023
RS20.12.2023
SE20.12.2023
SK20.12.2023
SM20.12.2023
BG20.03.2024
NO20.03.2024
GR21.03.2024
IS20.04.2024
PT22.04.2024
Former [2024/35]AT20.12.2023
CZ20.12.2023
EE20.12.2023
ES20.12.2023
FI20.12.2023
HR20.12.2023
LT20.12.2023
LV20.12.2023
NL20.12.2023
RO20.12.2023
RS20.12.2023
SE20.12.2023
SM20.12.2023
BG20.03.2024
NO20.03.2024
GR21.03.2024
IS20.04.2024
Former [2024/34]EE20.12.2023
ES20.12.2023
FI20.12.2023
HR20.12.2023
LT20.12.2023
LV20.12.2023
NL20.12.2023
RS20.12.2023
SE20.12.2023
SM20.12.2023
BG20.03.2024
NO20.03.2024
GR21.03.2024
IS20.04.2024
Former [2024/33]ES20.12.2023
FI20.12.2023
HR20.12.2023
LT20.12.2023
LV20.12.2023
NL20.12.2023
RS20.12.2023
SE20.12.2023
SM20.12.2023
BG20.03.2024
NO20.03.2024
GR21.03.2024
IS20.04.2024
Former [2024/32]ES20.12.2023
FI20.12.2023
HR20.12.2023
LT20.12.2023
LV20.12.2023
NL20.12.2023
RS20.12.2023
SE20.12.2023
BG20.03.2024
NO20.03.2024
GR21.03.2024
IS20.04.2024
Former [2024/26]ES20.12.2023
FI20.12.2023
HR20.12.2023
LT20.12.2023
LV20.12.2023
NL20.12.2023
RS20.12.2023
SE20.12.2023
BG20.03.2024
NO20.03.2024
GR21.03.2024
Former [2024/24]ES20.12.2023
FI20.12.2023
HR20.12.2023
LT20.12.2023
RS20.12.2023
SE20.12.2023
BG20.03.2024
NO20.03.2024
GR21.03.2024
Former [2024/21]FI20.12.2023
LT20.12.2023
BG20.03.2024
GR21.03.2024
Former [2024/20]GR21.03.2024
Documents cited:Search[A] WO2012012870  (INST CARDIOLOGIE MONTREAL et al.) [A] 1-15 * paragraph [0145] - paragraph [0148] * * claim 28 *
 [XAI]   YUQIN WANG JAN JOHANSSON BIRGITTA AGERBERTH HANS JRNVALL WILLIAM J GRIFFITHS: "The antimicrobial peptide LL-37 binds to the human plasma protein apolipoprotein A-I", RAPID COMMUNICATIONS IN MASS SPECTROMETRY, JOHN WILEY & SONS, GB, vol. 18, no. 5, 15 March 2004 (2004-03-15), pages 588 - 589, XP009505425, ISSN: 0951-4198, [retrieved on 20040206], DOI: 10.1002/RCM.1361 [X] 1,5,8-11,14,15 * the whole document * [A] 4,13 [I] 2,3,6,7,12

DOI:   http://dx.doi.org/10.1002/rcm.1361
 [XAI]   YUQIN WANG ET AL: "Apolipoprotein A-I Binds and Inhibits the Human Antibacterial/Cytotoxic Peptide LL-37", JOURNAL OF BIOLOGICAL CHEMISTRY, AMERICAN SOCIETY FOR BIOCHEMISTRY AND MOLECULAR BIOLOGY, vol. 273, no. 50, 11 December 1998 (1998-12-11), pages 33115 - 333118, XP009505426, ISSN: 0021-9258, DOI: 10.1074/JBC.273.50.33115 [X] 1,5,8-11,14,15 * the whole document * [A] 4,13 [I] 2,3,6,7,12

DOI:   http://dx.doi.org/10.1074/jbc.273.50.33115
 [A]   MARCHESI ET AL: "Apolipoprotein A-I"M"i"l"a"n"o/POPC complex attenuates post-ischemic ventricular dysfunction in the isolated rabbit heart", ATHEROSCLEROSIS, ELSEVIER, AMSTERDAM, NL, vol. 197, no. 2, 22 October 2007 (2007-10-22), pages 572 - 578, XP022559364, ISSN: 0021-9150, DOI: 10.1016/J.ATHEROSCLEROSIS.2007.08.028 [A] 1-15 * abstract *

DOI:   http://dx.doi.org/10.1016/j.atherosclerosis.2007.08.028
International search[XY] JP2010280570  (UNIV KYOTO et al.) [X] 1-11, 16, 17 * , claims; paragraphs [0002], [0006]; examples (Family: none) *[Y] 12-15, 18
 [XY]   TATSUYA MURAKAMI ET AL.: "Idenshi Kogaku o Riyo shita Saibo Shinnyugata Lipo Tanpakushitsu Nano Ryushi no Sakusei", DRUG DELIVERY SYSTEM, vol. 24, no. 3, 9 June 2009 (2009-06-09), pages 301, XP009504245, ISSN: 0913-5006 [X] 1-11, 16, 17 * , entire text *[Y] 12-15, 18
 [XY]   MATHEW S. ET AL.: "Exclusive Photothermal Heat Generation by a Gadolinium Bis(naphthalocyanine) Complex and Inclusion into Modified High-Density Lipoprotein Nanocarriers for Therapeutic Applications", ACS NANO, vol. 7, no. 10, 20 September 2013 (2013-09-20), pages 8908 - 8916, XP055460396 [X] 1-11, 16, 17 * , Abstract, Conclusions *[Y] 12-15, 18

DOI:   http://dx.doi.org/10.1021/nn403384k
 [XY]   MURAKAMI T. ET AL.: "Intracellular drug delivery by genetically engineered high-density lipoprotein nanoparticles", NANOMEDICINE, vol. 5, no. 6, 2010, pages 867 - 879, XP009504246 [X] 1-11, 16, 17 * , Abstract, Materials & methods *[Y] 12-15, 18

DOI:   http://dx.doi.org/10.2217/nnm.10.66
 [XY]   KIM H. ET AL.: "Cation-sei Peptide Yugo Kohiju Lipo Tanpakushitsu no Kaihatsu", THE ANNUAL MEETING OF THE JAPANESE SOCIETY FOR BIOMATERIALS YOKOSHU, vol. 35, 25 November 2013 (2013-11-25), pages 338, XP009504253 [X] 1-11, 16, 17 * , entire text *[Y] 12-15, 18
 [XA]   MURAKAMI T. ET AL.: "Size control of lipid-based drug carrier by drug loading", MOLECULAR BIOSYSTEMS, vol. 6, no. 5, 25 February 2010 (2010-02-25), pages 789 - 791, XP055446854 [X] 1, 6, 8-10 * , Abstract, Conclusions, Fig. 1, Fig. 3 * [A] 2-5, 7, 11-18

DOI:   http://dx.doi.org/10.1039/c001442g
 [XA]   TATSUYA MURAKAMI ET AL.: "DDS Oyo o Mezashita Lipo Tanpakushitsu no Kokinoka", DRUG DELIVERY SYSTEM, vol. 23, no. 3, 6 June 2008 (2008-06-06), pages 383, XP009504244, ISSN: 0913-5006 [X] 1, 6, 8-10 * , entire text *[A] 2-5, 7, 11-18
 [Y]   KOHEI TAHARA ET AL.: "Koganbu eno Yakubutsu Sotatsu o Mokuteki to shita Seitai Tekigosei Nano Ryushi Tengan Seizai no Kaihatsu", DAIWA SECURITIES HEALTH FOUNDATION KENKYU GYOSEKISHU, vol. 36, 1 March 2013 (2013-03-01), pages 73 - 76, XP009504249 [Y] 12-15, 18 * , abstract *
 [Y]   KOHEI HIRONAKA ET AL.: "Koganbu Sotatsu o Mezashita Liposome Tengan Seizai no Sekkei", ABSTRACTS OF ANNUAL MEETING OF PHARMACEUTICAL SOCIETY OF JAPAN, vol. 128, no. 4, 5 March 2008 (2008-03-05), pages 112, XP009504248, ISSN: 0918-9823 [Y] 12-15, 18 * , entire text *
 [Y]   KEIICHI KARASAWA ET AL.: "Koganbu Sotatsu o Mokuteki to shita Poly-L-Arginine Shushoku Liposome ni Kansuru Kenkyu", ANNUAL MEETING OF THE JAPAN SOCIETY OF DRUG DELIVERY SYSTEM, vol. 28, 5 June 2012 (2012-06-05), pages 172, XP009504254 [Y] 12-15, 18 * , entire text *
 [Y]   KAUR INDU PAL ET AL.: "Nanotherapy for posterior eye disease", JOURNAL OF CONTROLLED RELEASE, vol. 193, 24 May 2014 (2014-05-24), pages 100 - 112, XP029084267, DOI: doi:10.1016/j.jconrel.2014.05.031 [Y] 12-15, 18 * , Abstract, 2.Routes for Posterior Delivery *

DOI:   http://dx.doi.org/10.1016/j.jconrel.2014.05.031
The EPO accepts no responsibility for the accuracy of data originating from other authorities; in particular, it does not guarantee that it is complete, up to date or fit for specific purposes.