| EP3240801 - COMBINATION TUMOR IMMUNOTHERAPY [Right-click to bookmark this link] | Status | No opposition filed within time limit Status updated on 26.11.2021 Database last updated on 08.04.2026 | |
| Former | The patent has been granted Status updated on 18.12.2020 | ||
| Former | Grant of patent is intended Status updated on 02.11.2020 | ||
| Former | Examination is in progress Status updated on 05.06.2019 | ||
| Former | Request for examination was made Status updated on 06.10.2017 | ||
| Former | The international publication has been made Status updated on 23.06.2017 | Most recent event Tooltip | 26.11.2021 | No opposition filed within time limit | published on 29.12.2021 [2021/52] | Applicant(s) | For all designated states Checkmate Pharmaceuticals, Inc. 1 Broadway, 14th Floor Cambridge, MA 02142 / US | [2021/03] |
| Former [2017/45] | For all designated states Checkmate Pharmaceuticals, Inc. 1 Broadway, 14th Floor Cambridge MA 02142 / US | Inventor(s) | 01 /
KRIEG, Arthur, M. 49 Trowbridge Street Unit 3 Cambridge, MA 02138 / US | [2017/45] | Representative(s) | Gill, Siân Victoria Venner Shipley LLP 200 Aldersgate London EC1A 4HD / GB | [2021/03] |
| Former [2017/45] | Jump, Timothy John Simon, et al Venner Shipley LLP 200 Aldersgate London EC1A 4HD / GB | Application number, filing date | 15876030.6 | 22.12.2015 | [2017/45] | WO2015US67269 | Priority number, date | US201462098568P | 31.12.2014 Original published format: US 201462098568 P | US201562106526P | 22.01.2015 Original published format: US 201562106526 P | US201562118165P | 19.02.2015 Original published format: US 201562118165 P | [2017/45] | Filing language | EN | Procedural language | EN | Publication | Type: | A1 Application with search report | No.: | WO2016109310 | Date: | 07.07.2016 | Language: | EN | [2016/27] | Type: | A1 Application with search report | No.: | EP3240801 | Date: | 08.11.2017 | Language: | EN | The application published by WIPO in one of the EPO official languages on 07.07.2016 takes the place of the publication of the European patent application. | [2017/45] | Type: | B1 Patent specification | No.: | EP3240801 | Date: | 20.01.2021 | Language: | EN | [2021/03] | Search report(s) | International search report - published on: | US | 07.07.2016 | (Supplementary) European search report - dispatched on: | EP | 26.06.2018 | Classification | IPC: | A61K31/7125, C07K14/56, A61P35/00, C07K16/28 | [2020/48] | CPC: |
A61K31/7125 (EP,US);
A61K31/70 (US);
A61K31/713 (EP,US);
A61K39/39541 (EP,US);
A61K45/06 (EP,US);
A61P35/00 (EP,US);
C07K16/104 (EP,US);
C07K16/2818 (EP,US);
C12N15/117 (EP,US);
A61K2039/505 (EP,US);
A61K39/00 (EP,US);
C12N2310/17 (EP,US);
C12N2320/31 (EP,US)
(-)
| C-Set: |
A61K31/713, A61K2300/00 (US,EP);
A61K39/39541, A61K2300/00 (EP,US) |
| Former IPC [2018/30] | C07K14/56, A61P35/00, C07K16/28 | ||
| Former IPC [2017/45] | C07K14/56 | Designated contracting states | AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LI, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR [2017/45] | Extension states | BA | Not yet paid | ME | Not yet paid | Validation states | MA | Not yet paid | MD | Not yet paid | Title | German: | KOMBINATIONSTUMORIMMUNTHERAPIE | [2017/45] | English: | COMBINATION TUMOR IMMUNOTHERAPY | [2017/45] | French: | IMMUNOTHÉRAPIE ANTI-TUMORALE COMBINÉE | [2017/45] | Entry into regional phase | 23.06.2017 | National basic fee paid | 23.06.2017 | Search fee paid | 23.06.2017 | Designation fee(s) paid | 23.06.2017 | Examination fee paid | Examination procedure | 23.06.2017 | Examination requested [2017/45] | 23.06.2017 | Date on which the examining division has become responsible | 22.01.2019 | Amendment by applicant (claims and/or description) | 11.06.2019 | Despatch of a communication from the examining division (Time limit: M06) | 17.12.2019 | Reply to a communication from the examining division | 20.10.2020 | Cancellation of oral proceeding that was planned for 09.11.2020 | 03.11.2020 | Communication of intention to grant the patent | 09.11.2020 | Date of oral proceedings (cancelled) | 15.12.2020 | Fee for grant paid | 15.12.2020 | Fee for publishing/printing paid | 15.12.2020 | Receipt of the translation of the claim(s) | Divisional application(s) | EP21151085.4 / EP3835312 | Opposition(s) | 21.10.2021 | No opposition filed within time limit [2021/52] | Fees paid | Renewal fee | 28.12.2017 | Renewal fee patent year 03 | 12.12.2018 | Renewal fee patent year 04 | 13.12.2019 | Renewal fee patent year 05 | 14.12.2020 | Renewal fee patent year 06 |
| Opt-out from the exclusive Tooltip competence of the Unified Patent Court | See the Register of the Unified Patent Court for opt-out data | ||
| Responsibility for the accuracy, completeness or quality of the data displayed under the link provided lies entirely with the Unified Patent Court. | Documents cited: | Search | [XI] WO2012006634 (TRUSTEES OF THE UNIVERSITY OF ILLINIOIS BOARD OF et al.) [X] 1-13 * examples 1-2; claims 16-21 *[I] 14,15 | [Y] WO03024481 (CYTOS BIOTECHNOLOGY AG et al.) [Y] 14,15 * claims 21,92 * | [XYI] MANGSBO SARA M ET AL: "Enhanced Tumor Eradication by Combining CTLA-4 or PD-1 Blockade With CpG Therapy", JOURNAL OF IMMUNOTHERAPY, LIPPINCOTT WILLIAMS & WILKINS, US, vol. 33, no. 3, 1 April 2010 (2010-04-01), pages 225 - 235, XP009144370, ISSN: 1524-9557 [X] 1,3-12 * the whole document *[Y] 2,14,15 [I] 13 | [Y] STEFAN NIERKENS ET AL: "Route of Administration of the TLR9 Agonist CpG Critically Determines the Efficacy of Cancer Immunotherapy in Mice", PLOS ONE, vol. 4, no. 12, 1 January 2009 (2009-01-01), pages e8368 - e8368, XP055042111, ISSN: 1932-6203, DOI: 10.1371/journal.pone.0008368 [Y] 2 * abstract * DOI: http://dx.doi.org/10.1371/journal.pone.0008368 | [I] WONG R M ET AL: "TLR-9 signaling and TCR stimulation co-regulate CD8+ T cell-associated PD-1 expression", IMMUNOLOGY LETTERS, ELSEVIER BV, NL, vol. 127, no. 1, 2 December 2009 (2009-12-02), pages 60 - 67, XP026745618, ISSN: 0165-2478, [retrieved on 20090912], DOI: 10.1016/J.IMLET.2009.09.002 [I] 1-15 * page 64, column l - column r; figure 6 * DOI: http://dx.doi.org/10.1016/j.imlet.2009.09.002 | [T] LEMKE CAITLIN D ET AL: "Combination Lymphoma Immunotherapy Using Checkpoint Blockade and Intratumoral Virus-like Particles Containing CpG TLR9 Agonist - Abstract 3023", BLOOD, & 58TH ANNUAL MEETING AND EXPOSITION OF THE AMERICAN-SOCIETY-OF-HEMATOLOGY; SAN DIEGO, CA, USA; DECEMBER 03 -06, 2016, vol. 128, no. 22, 2 December 2016 (2016-12-02), XP002771299 [T] * the whole document * | [A] QI XU-FENG ET AL: "CpG oligodeoxynucleotide induces apoptosis and cell cycle arrest in A20 lymphoma cells via TLR9-mediated pathways", MOLECULAR IMMUNOLOGY, PERGAMON, GB, vol. 54, no. 3, 26 January 2013 (2013-01-26), pages 327 - 337, XP028998721, ISSN: 0161-5890, DOI: 10.1016/J.MOLIMM.2013.01.001 [A] 1-15 * the whole document * DOI: http://dx.doi.org/10.1016/j.molimm.2013.01.001 | [A] KIM Y H ET AL: "Phase I trial of a Toll-like receptor 9 agonist, PF-3512676 (CPG 7909), in patients with treatment-refractory, cutaneous T-cell lymphoma", JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY, MOSBY, INC, US, vol. 63, no. 6, 1 December 2010 (2010-12-01), pages 975 - 983, XP027499048, ISSN: 0190-9622, [retrieved on 20101118], DOI: 10.1016/J.JAAD.2009.12.052 [A] 1-15 * abstract * DOI: http://dx.doi.org/10.1016/j.jaad.2009.12.052 | [A] ASSAF A ET AL: "A threshold level of TLR9 mRNA predicts cellular responsiveness to CpG-ODN in haematological and non-haematological tumour cell lines", CELLULAR IMMUNOLOGY, ACADEMIC PRESS, SAN DIEGO, CA, US, vol. 259, no. 1, 1 January 2009 (2009-01-01), pages 90 - 99, XP026459070, ISSN: 0008-8749, [retrieved on 20090606] [A] 1-15 * the whole document * | [A] MASON K A ET AL: "Molecular targeting of toll-like receptor 9 with CpG oligodeoxynucleotides (ODN) for enhancement of tumor radioresponse", INTERNATIONAL JOURNAL OF RADIATION: ONCOLOGY BIOLOGY PHYS, PERGAMON PRESS, USA, vol. 60, no. 1, 1 September 2004 (2004-09-01), pages S346, XP004557674, ISSN: 0360-3016 [A] 1-15 * abstract * | International search | [XY] US2012251494 (KEDL ROSS et al.) [X] 1-3, 25-27, 49-51 * entire document *[Y] 28 | [A] US2009082295 (JUNGNELIUS JARL ULF BIRGER et al.) [A] 1-3, 25-28, 49-51 * entire document * | [Y] KRUG ET AL.: "Identification of CpG oligonucleotide sequences with high induction of IFN-aip in plasmacytoid dendritic cells''.", EUROPEAN JOURNAL OF IMMUNOLOGY, vol. 31, no. 7, 1 July 2001 (2001-07-01), pages 2154 - 2163, XP002292085 [Y] 28 * entire document * DOI: http://dx.doi.org/10.1002/1521-4141(200107)31:7<2154::AID-IMMU2154>3.0.CO;2-U | [A] BUTT ET AL.: "Immunosuppressive networks and checkpoints controlling antitumor immunity and their blockade in the development of cancer immunotherapeutics and vaccines''.", ONCOGENE, vol. 1, no. 9, 21 October 2013 (2013-10-21) [A] 1-3, 25-28, 49-51 * entire document * | [A] KORTYLEWSKI ET AL.: "In vivo delivery of sirNA to immune cells by conjugation to a tlr9 agonist enhances antitumor immune responses''.", NATURE BIOTECHNOLOGY, vol. 27, no. 10, October 2009 (2009-10-01), pages 925, XP055460942 [A] 1-3, 25-28, 49-51 * entire document * DOI: http://dx.doi.org/10.1038/nbt.1564 | Examination | HARTMANN EVELYN ET AL: "Identification and functional analysis of tumor-infiltrating plasmacytoid dendritic cells in head and neck cancer.", CANCER RESEARCH 01 OCT 2003, vol. 63, no. 19, 1 October 2003 (2003-10-01), pages 6478 - 6487, ISSN: 0008-5472 [X] 1,3-12 * the whole document *[Y] 2,14,15 [I] 13 | LABIDI-GALY SANA INTIDHAR ET AL: "Quantitative and functional alterations of plasmacytoid dendritic cells contribute to immune tolerance in ovarian cancer.", CANCER RESEARCH 15 AUG 2011, vol. 71, no. 16, 15 August 2011 (2011-08-15), pages 5423 - 5434, ISSN: 1538-7445 [I] 14,15 | SISIRAK VANJA ET AL: "Impaired IFN-[alpha] production by plasmacytoid dendritic cells favors regulatory T-cell expansion that may contribute to breast cancer progression.", CANCER RESEARCH 15 OCT 2012, vol. 72, no. 20, 15 October 2012 (2012-10-15), pages 5188 - 5197, ISSN: 1538-7445 [Y] 2 * abstract * | ZOU W ET AL: "Stromal-derived factor-1 in human tumors recruits and alters the function of plasmacytoid precursor dendritic cells.", NATURE MEDICINE DEC 2001, vol. 7, no. 12, December 2001 (2001-12-01), pages 1339 - 1346, ISSN: 1078-8956 | WATKINS STEPHANIE K ET AL: "FOXO3 programs tumor-associated DCs to become tolerogenic in human and murine prostate cancer.", THE JOURNAL OF CLINICAL INVESTIGATION APR 2011, vol. 121, no. 4, April 2011 (2011-04-01), pages 1361 - 1372, ISSN: 1558-8238 [I] 1-15 * page 64, column l - column r; figure 6 * | CONRAD CURDIN ET AL: "Plasmacytoid dendritic cells promote immunosuppression in ovarian cancer via ICOS costimulation of Foxp3(+) T-regulatory cells.", CANCER RESEARCH 15 OCT 2012, vol. 72, no. 20, 15 October 2012 (2012-10-15), pages 5240 - 5249, ISSN: 1538-7445 [T] * the whole document * | FAGET JULIEN ET AL: "ICOS-ligand expression on plasmacytoid dendritic cells supports breast cancer progression by promoting the accumulation of immunosuppressive CD4+ T cells.", CANCER RESEARCH 01 DEC 2012, vol. 72, no. 23, 1 December 2012 (2012-12-01), pages 6130 - 6141, ISSN: 1538-7445 [A] 1-15 * the whole document * | KRUG A ET AL: "Identification of CpG oligonucleotide sequences with high induction of IFN-alpha/beta in plasmacytoid dendritic cells.", EUROPEAN JOURNAL OF IMMUNOLOGY JUL 2001, vol. 31, no. 7, July 2001 (2001-07-01), pages 2154 - 2163, ISSN: 0014-2980 [A] 1-15 * abstract * | BATES P J ET AL: "Antiproliferative activity of G-rich oligonucleotides correlates with protein binding.", THE JOURNAL OF BIOLOGICAL CHEMISTRY 10 SEP 1999, vol. 274, no. 37, 10 September 1999 (1999-09-10), pages 26369 - 26377, ISSN: 0021-9258 [A] 1-15 * the whole document * | SHEN WEIYIN ET AL: "Antitumor mechanisms of oligodeoxynucleotides with CpG and polyG motifs in murine prostate cancer cells: decrease of NF-kappaB and AP-1 binding activities and induction of apoptosis.", ANTISENSE & NUCLEIC ACID DRUG DEVELOPMENT JUN 2002, vol. 12, no. 3, June 2002 (2002-06-01), pages 155 - 164, ISSN: 1087-2906 [A] 1-15 * abstract * | ROTHENFUSSER SIMON ET AL: "CpG-A and CpG-B oligonucleotides differentially enhance human peptide-specific primary and memory CD8+ T-cell responses in vitro.", BLOOD 15 MAR 2004, vol. 103, no. 6, 15 March 2004 (2004-03-15), pages 2162 - 2169, ISSN: 0006-4971 | KATSUDA MASAHIRO ET AL: "Comparison of different classes of CpG-ODN in augmenting the generation of human epitope peptide-specific CTLs.", INTERNATIONAL JOURNAL OF ONCOLOGY NOV 2011, vol. 39, no. 5, November 2011 (2011-11-01), pages 1295 - 1302, ISSN: 1791-2423 | PENG GUANGYONG ET AL: "Toll-like receptor 8-mediated reversal of CD4+ regulatory T cell function.", SCIENCE (NEW YORK, N.Y.) 26 AUG 2005, vol. 309, no. 5739, 26 August 2005 (2005-08-26), pages 1380 - 1384, ISSN: 1095-9203 | HONDA KENYA ET AL: "Spatiotemporal regulation of MyD88-IRF-7 signalling for robust type-I interferon induction.", NATURE 21 APR 2005, vol. 434, no. 7036, 21 April 2005 (2005-04-21), pages 1035 - 1040, ISSN: 1476-4687 | GUIDUCCI CRISTIANA ET AL: "Properties regulating the nature of the plasmacytoid dendritic cell response to Toll-like receptor 9 activation.", THE JOURNAL OF EXPERIMENTAL MEDICINE 07 AUG 2006, vol. 203, no. 8, 7 August 2006 (2006-08-07), pages 1999 - 2008, ISSN: 0022-1007 | CHAN MEI PO ET AL: "DNase II-dependent DNA digestion is required for DNA sensing by TLR9.", NATURE COMMUNICATIONS 20 JAN 2015, vol. 6, 20 January 2015 (2015-01-20), pages 5853, ISSN: 2041-1723 | ALCULUMBRE SOLANA G ET AL: "Diversification of human plasmacytoid predendritic cells in response to a single stimulus.", NATURE IMMUNOLOGY JAN 2018, vol. 19, no. 1, January 2018 (2018-01-01), pages 63 - 75, ISSN: 1529-2916 | by applicant | WO2012006634 | US5922845 | US5837243 | US8017591 | US7635468 | US7074772 | US6849725 | US6451593 | US6451563 | US2003125279 | US9501570 | US9719791 | US6194388 | US6239116 | US6949520 | US7776344 | WO03024481 | US2003099668 | US2012301499 | WO2004084940 | US7517520 | US2010098722 | WO2007068747 | US2007184068 | US8574564 | WO2007144150 | US8541559 | WO2008073960 | US8586728 | US7566703 | US8198251 | US8834900 | US2008045473 | US8580268 | US2014163213 | US4469863 | US5023243 | EP0092574 | US7795235 | US8283328 | US8304396 | US5177198 | US5859231 | US6160109 | US6207819 | US9917100 | WO0006588 | WO9501363 | US5658738 | US5668265 | US6808710 | US7488802 | US8728474 | US7943743 | US9930895 | WO0037504 | EP1262193 | US47208799 | US6682736 | US94893901 | US2002086014 | US98839609 | US2009117132 | US201113168206 | US2012003179 | US2003086930 | US2002088014 | US5770429 | US2004120948 | US5703057 | US4816567 | EP0216846 | EP0256055 | EP0323997 | EP89303964 | US2003207336 | US2003157108 | WO0181405 | WO0024893 | WO03031464 | WO9858964 | WO9922764 | US2004063911 | US2004132640 | US2004142856 | US2004072290 | US6602684 | US2003207346 | US4640835 | US4496689 | US4301144 | US4670417 | US4791192 | US4179337 | US4816397 | US5916771 | US5759808 | US6765087 | WO0114424 | WO9300431 | WO0032231 | US2004198680 | ZITVOGEL L. ET AL., IMMUNITY, vol. 39, no. l, 2013, pages 74 - 88 | VICARITRINCHIERI, IMMUNOL. REV., 2004 | LU, FRONTIERS IMMUNOL, 2014 | KIMCANTOR, CANCER IMMUNOL RES, vol. 2, 2014, pages 929 - 936 | HERBST ET AL., NATURE, vol. 515, 2014, pages 563 - 567 | KIMCANTOR, CANCER IMMUNOL. RES., vol. 2, 2014, pages 926 - 936 | KRIEG, NUCLEIC ACID THER., vol. 22, no. 2, 2012, pages 77 - 89 | KRUIT ET AL., J CLIN ONCOL, 2013 | TARHINI ET AL., J IMMUNOTHER, 2013 | LOVGREN ET AL., CANCER IMMUNOL IMMUNOTHER, 2012 | KARBACH ET AL., CLIN CANCER RES, 2011 | KARBACH ET AL., INT J CANCER, 2010 | SPEISER ET AL., JCI, 2005 | MANGSBO ET AL., J. IMMUNOTHER, vol. 33, 2010, pages 225 | RAJASAGI ET AL., BLOOD, vol. 124, no. 3, 2014, pages 453 - 462 | PRASANNA ET AL., J THORACIC DIS., vol. 6, no. 4, 2014, pages 287 - 302 | POSTOW ET AL., N. ENGL. J. MED., vol. 366, no. 10, 2012, pages 925 - 31 | GRIMALDI ET AL., ONCOIMMUNOL., vol. 3, 2014, pages e28780 | BARNES ET AL., BIOTECH & BIOENGINEERING, vol. 73, 2001, pages 261 - 270 | AUSUBEL ET AL.: "Current Protocols in Molecular Biology", 2002, JOHN WILEY & SONS | PEARSON, METHODS ENZYMOL., vol. 183, 1990, pages 63 - 98 | THORNTON ET AL., NATURE, vol. 354, 1991, pages 105 | PEARSON, METHODS MOL. BIOL., vol. 243, 1994, pages 307 - 31 | GONNET ET AL., SCIENCE, vol. 256, 1992, pages 1443 - 45 | "Proteins, Structures and Molecular Principles", 1984, W. H. FREEMAN AND COMPANY | PEARSON, METHODS MOL. BIOL., vol. 132, 2000, pages 185 - 219 | ALTSCHUL ET AL., J. MOL. BIOL., vol. 215, 1990, pages 403 - 410 | ALTSCHUL ET AL., NUCLEIC ACIDS RES., vol. 25, 1997, pages 3389 - 402 | CHOTHIA ET AL., NATURE, vol. 341, 1989, pages 544 - 546 | CHOTHIALESK, J. MOL. BIOL., vol. 196, 1987, pages 901 - 917 | BIRD ET AL., SCIENCE, vol. 242, 1988, pages 423 - 426 | HUSTON ET AL., PROC. NATL. ACAD. SCI. USA, vol. 85, 1988, pages 5879 - 5883 | ZEILDER, J. IMMUNOL., vol. 163, 1999, pages 1246 - 1252 | SOMASUNDARAM, HUM. ANTIBODIES, vol. 9, 1999, pages 47 - 54 | KELER, CANCER RES., vol. 57, 1997, pages 4008 - 4014 | HOLLIGER ET AL., PROC. NATL. ACAD. SCI. USA, vol. 90, 1993, pages 6444 - 6448 | POLLAK ET AL., STRUCTURE, vol. 2, 1994, pages 1121 - 1123 | KRIEG ET AL., J. IMMUNOTHER., vol. 27, 2004, pages 460 - 471 | TAUBE ET AL., CLIN CANCER RES., 2014 | SIEGAL ET AL., SCIENCE, 1999 | HARTMANN ET AL., EUR. J. IMMUNOL., vol. 33, 2003, pages 1633 - 1641 | MARSHALL ET AL., J. LEUKOCYTE BIOL., vol. 73, 2003, pages 781 - 792 | VOLLMER ET AL., EUR. J. IMMUNOL., vol. 34, 2004, pages 251 - 262 | MOSEMAN ET AL., J. IMMUNOL., vol. 173, no. 7, 2004, pages 4433 - 4442 | CHEN ET AL., J. IMMUNOL., vol. 181, no. 8, 2008, pages 5396 - 5404 | MOLENKAMP BG ET AL., CLIN CANCER RES., vol. 13, no. 10, 2007, pages 2961 - 2969 | MUMMOFT, BIOESSAYS, vol. 35, no. 7, 2013, pages 623 - 631 | SATO ET AL., IMMUNOL RES., vol. 51, no. 2-3, 2011, pages 170 - 182 | UHLMANN E ET AL., CHEM REV, vol. 90, 1990, pages 543 | GOODCHILD J, BIOCONJUGATE CHEM, vol. 1, 1990, pages 165 | SELIGER, H. ET AL.: "Oligonucleotide analogs with terminal 3'-3'- and 5'-5'-internucleotidic linkages as antisense inhibitors of viral gene expression", NUCLEOSIDES & NUCLEOTIDES, vol. 10, no. 1-3, 1991, pages 469 - 77 | M. D. MATTEUCCIM. H. CARUTHERS, TETRAHEDRON LETT., vol. 21, 1980, pages 719 | R. P. IYERW. EGANJ. B. REGANS. L. BEAUCAGE, J. AM. CHEM. SOC., vol. 112, 1990, pages 1253 | SERGUEEV, JAM CHEM SOC, vol. 120, 1998, pages 9417 - 27 | KRIEG ET AL., OLIGONUCLEOTIDES, vol. 13, no. 6, 2003, pages 491 - 499 | "Synthesis and Properties & Synthesis and Analytical Techniques", 1993, HUMANA PRESS, article "Protocols for Oligonucleotides and Analogs" | CROOKE S T ET AL., ANNU REV PHARMACOL TOXICOL, vol. 36, 1996, pages 107 - 129 | HUNZIKER J ET AL., MOD SYNTH METHODS, vol. 7, 1995, pages 331 - 417 | UHLMANN EPEYMAN A: "Protocols for Oligonucleotides and Analogs", vol. 20, 1993, HUMANA PRESS, article "Methods in Molecular Biology", pages: 355 ff | STIRCHAK E P ET AL., OLIGONUCLEOTIDES RES, vol. 17, 1989, pages 6129 - 41 | NIELSEN P E ET AL., BIOCONJUG CHEM, vol. 5, 1994, pages 3 - 7 | FROEHLER J, JAM CHEM SOC, vol. 114, 1992, pages 8320 | VANDENDRIESSCHE ET AL., TETRAHEDRON, vol. 49, 1993, pages 7223 | TARKOV M ET AL., HELV CHIMACTA, vol. 76, 1993, pages 481 | JIANG ET AL.: "Pseudo-cyclic oligonucleotides: in vitro and in vivo properties", BIOORGANIC & MEDICINAL CHEMISTRY, vol. 7, no. 12, 1999, pages 2727 - 2735, XP085050417, DOI: 10.1016/S0968-0896(99)00217-5 DOI: http://dx.doi.org/10.1016/S0968-0896(99)00217-5 | DURAND, M. ET AL.: "Triple-helix formation by an oligonucleotide containing one (dA) and two (dT) sequences bridged by two hexaethylene glycol chains", BIOCHEMISTRY, vol. 31, no. 38, 1992, pages 9197 - 204, XP002329296, DOI: 10.1021/bi00153a012 DOI: http://dx.doi.org/10.1021/bi00153a012 | FONTANEL, MARIE LAURENCE ET AL.: "Sterical recognition by T4 polynucleotide kinase of non-nucleosidic moieties 5'-attached to oligonucleotides", OLIGONUCLEOTIDES RESEARCH, vol. 22, no. 11, 1994, pages 2022 - 7, XP002098767 | SCHMIDT M ET AL., ALLERGY, vol. 61, 2006, pages 56 - 63 | KAPP, K ET AL., MOL THER NUCLEIC ACIDS, vol. 3, 2014, pages e170 | RAMALHO ORTIGAO ET AL., ANTISENSE RESEARCH AND DEVELOPMENT, vol. 2, 1992, pages 129 - 46 | "GenBank", Database accession no. NP_001032720 | FRANSEN MF ET AL., ONCOIMMUNOLOGY, vol. 2, no. 11, 1 November 2013 (2013-11-01), pages e26493 | LONBERG ET AL., NATURE, vol. 368, 1994, pages 856 - 859 | TOMIZUKA ET AL., PROC NATL ACAD SCI USA, vol. 97, 2000, pages 722 | KUROIWA ET AL., NATURE BIOTECHNOL, vol. 18, 2000, pages 1086 | WINTERHARRIS, IMMUNOL. TODAY, vol. 14, 1993, pages 43 - 46 | WRIGHT ET AL., CRIT. REVIEWS IN IMMUNOL., vol. 12, 1992, pages 125 - 168 | THOTAKURA ET AL., METH. ENZYMOL., vol. 138, 1987, pages 350 - 97 | HAKIMUDDIN ET AL., ARCH. BIOCHEM. BIOPHYS., vol. 259, 1987, pages 52 | MILLWARD M. ET AL., BR. J. CANCER, vol. 108, no. 10, 2013, pages 1998 - 2004 | BRODY ET AL., J. CLIN. ONCOL., vol. 28, no. 28, 2010, pages 4324 - 4332 | KIM ET AL., BLOOD, vol. 119, no. 2, 2012, pages 355 - 363 | BURNETTE ET AL., CANCER RES., vol. 71, 2011, pages 2488 - 2496 | GOMES DOS SANTOS AL ET AL., CURR PHARM BIOTECHNOL., vol. 6, no. 1, 2005, pages 7 - 15 | JOSHI VB ET AL., AAPS J., vol. 15, no. 1, 2013, pages 85 - 94 | ARIMA H ET AL., CURR TOP MED CHEM., vol. 14, no. 4, 2014, pages 465 - 77 | "Sustained and Controlled Release Drug Delivery Systems", 1978, MARCEL DEKKER, INC. | KRIEG AM ET AL., OLIGONUCLEOTIDE, vol. 13, no. 6, 2003, pages 491 - 9 | BEEH ET AL., J ALLERGY CLIN IMMUNOL, vol. 131, 2013, pages 866 - 74 |