Extract from the Register of European Patents

EP About this file: EP3240801

EP3240801 - COMBINATION TUMOR IMMUNOTHERAPY [Right-click to bookmark this link]
StatusNo opposition filed within time limit
Status updated on  26.11.2021
Database last updated on 08.04.2026
FormerThe patent has been granted
Status updated on  18.12.2020
FormerGrant of patent is intended
Status updated on  02.11.2020
FormerExamination is in progress
Status updated on  05.06.2019
FormerRequest for examination was made
Status updated on  06.10.2017
FormerThe international publication has been made
Status updated on  23.06.2017
Most recent event   Tooltip26.11.2021No opposition filed within time limitpublished on 29.12.2021  [2021/52]
Applicant(s)For all designated states
Checkmate Pharmaceuticals, Inc.
1 Broadway, 14th Floor
Cambridge, MA 02142 / US
[2021/03]
Former [2017/45]For all designated states
Checkmate Pharmaceuticals, Inc.
1 Broadway, 14th Floor
Cambridge MA 02142 / US
Inventor(s)01 / KRIEG, Arthur, M.
49 Trowbridge Street Unit 3
Cambridge, MA 02138 / US
 [2017/45]
Representative(s)Gill, Siân Victoria
Venner Shipley LLP
200 Aldersgate
London EC1A 4HD / GB
[2021/03]
Former [2017/45]Jump, Timothy John Simon, et al
Venner Shipley LLP
200 Aldersgate
London EC1A 4HD / GB
Application number, filing date15876030.622.12.2015
[2017/45]
WO2015US67269
Priority number, dateUS201462098568P31.12.2014         Original published format: US 201462098568 P
US201562106526P22.01.2015         Original published format: US 201562106526 P
US201562118165P19.02.2015         Original published format: US 201562118165 P
[2017/45]
Filing languageEN
Procedural languageEN
PublicationType: A1 Application with search report
No.:WO2016109310
Date:07.07.2016
Language:EN
[2016/27]
Type: A1 Application with search report 
No.:EP3240801
Date:08.11.2017
Language:EN
The application published by WIPO in one of the EPO official languages on 07.07.2016 takes the place of the publication of the European patent application.
[2017/45]
Type: B1 Patent specification 
No.:EP3240801
Date:20.01.2021
Language:EN
[2021/03]
Search report(s)International search report - published on:US07.07.2016
(Supplementary) European search report - dispatched on:EP26.06.2018
ClassificationIPC:A61K31/7125, C07K14/56, A61P35/00, C07K16/28
[2020/48]
CPC:
A61K31/7125 (EP,US); A61K31/70 (US); A61K31/713 (EP,US);
A61K39/39541 (EP,US); A61K45/06 (EP,US); A61P35/00 (EP,US);
C07K16/104 (EP,US); C07K16/2818 (EP,US); C12N15/117 (EP,US);
A61K2039/505 (EP,US); A61K39/00 (EP,US); C12N2310/17 (EP,US);
C12N2320/31 (EP,US) (-)
C-Set:
A61K31/713, A61K2300/00 (US,EP);
A61K39/39541, A61K2300/00 (EP,US)
Former IPC [2018/30]C07K14/56, A61P35/00, C07K16/28
Former IPC [2017/45]C07K14/56
Designated contracting statesAL,   AT,   BE,   BG,   CH,   CY,   CZ,   DE,   DK,   EE,   ES,   FI,   FR,   GB,   GR,   HR,   HU,   IE,   IS,   IT,   LI,   LT,   LU,   LV,   MC,   MK,   MT,   NL,   NO,   PL,   PT,   RO,   RS,   SE,   SI,   SK,   SM,   TR [2017/45]
Extension statesBANot yet paid
MENot yet paid
Validation statesMANot yet paid
MDNot yet paid
TitleGerman:KOMBINATIONSTUMORIMMUNTHERAPIE[2017/45]
English:COMBINATION TUMOR IMMUNOTHERAPY[2017/45]
French:IMMUNOTHÉRAPIE ANTI-TUMORALE COMBINÉE[2017/45]
Entry into regional phase23.06.2017National basic fee paid 
23.06.2017Search fee paid 
23.06.2017Designation fee(s) paid 
23.06.2017Examination fee paid 
Examination procedure23.06.2017Examination requested  [2017/45]
23.06.2017Date on which the examining division has become responsible
22.01.2019Amendment by applicant (claims and/or description)
11.06.2019Despatch of a communication from the examining division (Time limit: M06)
17.12.2019Reply to a communication from the examining division
20.10.2020Cancellation of oral proceeding that was planned for 09.11.2020
03.11.2020Communication of intention to grant the patent
09.11.2020Date of oral proceedings (cancelled)
15.12.2020Fee for grant paid
15.12.2020Fee for publishing/printing paid
15.12.2020Receipt of the translation of the claim(s)
Divisional application(s)EP21151085.4  / EP3835312
Opposition(s)21.10.2021No opposition filed within time limit [2021/52]
Fees paidRenewal fee
28.12.2017Renewal fee patent year 03
12.12.2018Renewal fee patent year 04
13.12.2019Renewal fee patent year 05
14.12.2020Renewal fee patent year 06
Opt-out from the exclusive  Tooltip
competence of the Unified
Patent Court
See the Register of the Unified Patent Court for opt-out data
Responsibility for the accuracy, completeness or quality of the data displayed under the link provided lies entirely with the Unified Patent Court.
Documents cited:Search[XI] WO2012006634  (TRUSTEES OF THE UNIVERSITY OF ILLINIOIS BOARD OF et al.) [X] 1-13 * examples 1-2; claims 16-21 *[I] 14,15
 [Y] WO03024481  (CYTOS BIOTECHNOLOGY AG et al.) [Y] 14,15 * claims 21,92 *
 [XYI]   MANGSBO SARA M ET AL: "Enhanced Tumor Eradication by Combining CTLA-4 or PD-1 Blockade With CpG Therapy", JOURNAL OF IMMUNOTHERAPY, LIPPINCOTT WILLIAMS & WILKINS, US, vol. 33, no. 3, 1 April 2010 (2010-04-01), pages 225 - 235, XP009144370, ISSN: 1524-9557 [X] 1,3-12 * the whole document *[Y] 2,14,15 [I] 13
 [Y]   STEFAN NIERKENS ET AL: "Route of Administration of the TLR9 Agonist CpG Critically Determines the Efficacy of Cancer Immunotherapy in Mice", PLOS ONE, vol. 4, no. 12, 1 January 2009 (2009-01-01), pages e8368 - e8368, XP055042111, ISSN: 1932-6203, DOI: 10.1371/journal.pone.0008368 [Y] 2 * abstract *

DOI:   http://dx.doi.org/10.1371/journal.pone.0008368
 [I]   WONG R M ET AL: "TLR-9 signaling and TCR stimulation co-regulate CD8+ T cell-associated PD-1 expression", IMMUNOLOGY LETTERS, ELSEVIER BV, NL, vol. 127, no. 1, 2 December 2009 (2009-12-02), pages 60 - 67, XP026745618, ISSN: 0165-2478, [retrieved on 20090912], DOI: 10.1016/J.IMLET.2009.09.002 [I] 1-15 * page 64, column l - column r; figure 6 *

DOI:   http://dx.doi.org/10.1016/j.imlet.2009.09.002
 [T]   LEMKE CAITLIN D ET AL: "Combination Lymphoma Immunotherapy Using Checkpoint Blockade and Intratumoral Virus-like Particles Containing CpG TLR9 Agonist - Abstract 3023", BLOOD, & 58TH ANNUAL MEETING AND EXPOSITION OF THE AMERICAN-SOCIETY-OF-HEMATOLOGY; SAN DIEGO, CA, USA; DECEMBER 03 -06, 2016, vol. 128, no. 22, 2 December 2016 (2016-12-02), XP002771299 [T] * the whole document *
 [A]   QI XU-FENG ET AL: "CpG oligodeoxynucleotide induces apoptosis and cell cycle arrest in A20 lymphoma cells via TLR9-mediated pathways", MOLECULAR IMMUNOLOGY, PERGAMON, GB, vol. 54, no. 3, 26 January 2013 (2013-01-26), pages 327 - 337, XP028998721, ISSN: 0161-5890, DOI: 10.1016/J.MOLIMM.2013.01.001 [A] 1-15 * the whole document *

DOI:   http://dx.doi.org/10.1016/j.molimm.2013.01.001
 [A]   KIM Y H ET AL: "Phase I trial of a Toll-like receptor 9 agonist, PF-3512676 (CPG 7909), in patients with treatment-refractory, cutaneous T-cell lymphoma", JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY, MOSBY, INC, US, vol. 63, no. 6, 1 December 2010 (2010-12-01), pages 975 - 983, XP027499048, ISSN: 0190-9622, [retrieved on 20101118], DOI: 10.1016/J.JAAD.2009.12.052 [A] 1-15 * abstract *

DOI:   http://dx.doi.org/10.1016/j.jaad.2009.12.052
 [A]   ASSAF A ET AL: "A threshold level of TLR9 mRNA predicts cellular responsiveness to CpG-ODN in haematological and non-haematological tumour cell lines", CELLULAR IMMUNOLOGY, ACADEMIC PRESS, SAN DIEGO, CA, US, vol. 259, no. 1, 1 January 2009 (2009-01-01), pages 90 - 99, XP026459070, ISSN: 0008-8749, [retrieved on 20090606] [A] 1-15 * the whole document *
 [A]   MASON K A ET AL: "Molecular targeting of toll-like receptor 9 with CpG oligodeoxynucleotides (ODN) for enhancement of tumor radioresponse", INTERNATIONAL JOURNAL OF RADIATION: ONCOLOGY BIOLOGY PHYS, PERGAMON PRESS, USA, vol. 60, no. 1, 1 September 2004 (2004-09-01), pages S346, XP004557674, ISSN: 0360-3016 [A] 1-15 * abstract *
International search[XY] US2012251494  (KEDL ROSS et al.) [X] 1-3, 25-27, 49-51 * entire document *[Y] 28
 [A] US2009082295  (JUNGNELIUS JARL ULF BIRGER et al.) [A] 1-3, 25-28, 49-51 * entire document *
 [Y]   KRUG ET AL.: "Identification of CpG oligonucleotide sequences with high induction of IFN-aip in plasmacytoid dendritic cells''.", EUROPEAN JOURNAL OF IMMUNOLOGY, vol. 31, no. 7, 1 July 2001 (2001-07-01), pages 2154 - 2163, XP002292085 [Y] 28 * entire document *

DOI:   http://dx.doi.org/10.1002/1521-4141(200107)31:7<2154::AID-IMMU2154>3.0.CO;2-U
 [A]   BUTT ET AL.: "Immunosuppressive networks and checkpoints controlling antitumor immunity and their blockade in the development of cancer immunotherapeutics and vaccines''.", ONCOGENE, vol. 1, no. 9, 21 October 2013 (2013-10-21) [A] 1-3, 25-28, 49-51 * entire document *
 [A]   KORTYLEWSKI ET AL.: "In vivo delivery of sirNA to immune cells by conjugation to a tlr9 agonist enhances antitumor immune responses''.", NATURE BIOTECHNOLOGY, vol. 27, no. 10, October 2009 (2009-10-01), pages 925, XP055460942 [A] 1-3, 25-28, 49-51 * entire document *

DOI:   http://dx.doi.org/10.1038/nbt.1564
Examination  HARTMANN EVELYN ET AL: "Identification and functional analysis of tumor-infiltrating plasmacytoid dendritic cells in head and neck cancer.", CANCER RESEARCH 01 OCT 2003, vol. 63, no. 19, 1 October 2003 (2003-10-01), pages 6478 - 6487, ISSN: 0008-5472 [X] 1,3-12 * the whole document *[Y] 2,14,15 [I] 13
   LABIDI-GALY SANA INTIDHAR ET AL: "Quantitative and functional alterations of plasmacytoid dendritic cells contribute to immune tolerance in ovarian cancer.", CANCER RESEARCH 15 AUG 2011, vol. 71, no. 16, 15 August 2011 (2011-08-15), pages 5423 - 5434, ISSN: 1538-7445 [I] 14,15
   SISIRAK VANJA ET AL: "Impaired IFN-[alpha] production by plasmacytoid dendritic cells favors regulatory T-cell expansion that may contribute to breast cancer progression.", CANCER RESEARCH 15 OCT 2012, vol. 72, no. 20, 15 October 2012 (2012-10-15), pages 5188 - 5197, ISSN: 1538-7445 [Y] 2 * abstract *
   ZOU W ET AL: "Stromal-derived factor-1 in human tumors recruits and alters the function of plasmacytoid precursor dendritic cells.", NATURE MEDICINE DEC 2001, vol. 7, no. 12, December 2001 (2001-12-01), pages 1339 - 1346, ISSN: 1078-8956
   WATKINS STEPHANIE K ET AL: "FOXO3 programs tumor-associated DCs to become tolerogenic in human and murine prostate cancer.", THE JOURNAL OF CLINICAL INVESTIGATION APR 2011, vol. 121, no. 4, April 2011 (2011-04-01), pages 1361 - 1372, ISSN: 1558-8238 [I] 1-15 * page 64, column l - column r; figure 6 *
   CONRAD CURDIN ET AL: "Plasmacytoid dendritic cells promote immunosuppression in ovarian cancer via ICOS costimulation of Foxp3(+) T-regulatory cells.", CANCER RESEARCH 15 OCT 2012, vol. 72, no. 20, 15 October 2012 (2012-10-15), pages 5240 - 5249, ISSN: 1538-7445 [T] * the whole document *
   FAGET JULIEN ET AL: "ICOS-ligand expression on plasmacytoid dendritic cells supports breast cancer progression by promoting the accumulation of immunosuppressive CD4+ T cells.", CANCER RESEARCH 01 DEC 2012, vol. 72, no. 23, 1 December 2012 (2012-12-01), pages 6130 - 6141, ISSN: 1538-7445 [A] 1-15 * the whole document *
   KRUG A ET AL: "Identification of CpG oligonucleotide sequences with high induction of IFN-alpha/beta in plasmacytoid dendritic cells.", EUROPEAN JOURNAL OF IMMUNOLOGY JUL 2001, vol. 31, no. 7, July 2001 (2001-07-01), pages 2154 - 2163, ISSN: 0014-2980 [A] 1-15 * abstract *
   BATES P J ET AL: "Antiproliferative activity of G-rich oligonucleotides correlates with protein binding.", THE JOURNAL OF BIOLOGICAL CHEMISTRY 10 SEP 1999, vol. 274, no. 37, 10 September 1999 (1999-09-10), pages 26369 - 26377, ISSN: 0021-9258 [A] 1-15 * the whole document *
   SHEN WEIYIN ET AL: "Antitumor mechanisms of oligodeoxynucleotides with CpG and polyG motifs in murine prostate cancer cells: decrease of NF-kappaB and AP-1 binding activities and induction of apoptosis.", ANTISENSE & NUCLEIC ACID DRUG DEVELOPMENT JUN 2002, vol. 12, no. 3, June 2002 (2002-06-01), pages 155 - 164, ISSN: 1087-2906 [A] 1-15 * abstract *
   ROTHENFUSSER SIMON ET AL: "CpG-A and CpG-B oligonucleotides differentially enhance human peptide-specific primary and memory CD8+ T-cell responses in vitro.", BLOOD 15 MAR 2004, vol. 103, no. 6, 15 March 2004 (2004-03-15), pages 2162 - 2169, ISSN: 0006-4971
   KATSUDA MASAHIRO ET AL: "Comparison of different classes of CpG-ODN in augmenting the generation of human epitope peptide-specific CTLs.", INTERNATIONAL JOURNAL OF ONCOLOGY NOV 2011, vol. 39, no. 5, November 2011 (2011-11-01), pages 1295 - 1302, ISSN: 1791-2423
   PENG GUANGYONG ET AL: "Toll-like receptor 8-mediated reversal of CD4+ regulatory T cell function.", SCIENCE (NEW YORK, N.Y.) 26 AUG 2005, vol. 309, no. 5739, 26 August 2005 (2005-08-26), pages 1380 - 1384, ISSN: 1095-9203
   HONDA KENYA ET AL: "Spatiotemporal regulation of MyD88-IRF-7 signalling for robust type-I interferon induction.", NATURE 21 APR 2005, vol. 434, no. 7036, 21 April 2005 (2005-04-21), pages 1035 - 1040, ISSN: 1476-4687
   GUIDUCCI CRISTIANA ET AL: "Properties regulating the nature of the plasmacytoid dendritic cell response to Toll-like receptor 9 activation.", THE JOURNAL OF EXPERIMENTAL MEDICINE 07 AUG 2006, vol. 203, no. 8, 7 August 2006 (2006-08-07), pages 1999 - 2008, ISSN: 0022-1007
   CHAN MEI PO ET AL: "DNase II-dependent DNA digestion is required for DNA sensing by TLR9.", NATURE COMMUNICATIONS 20 JAN 2015, vol. 6, 20 January 2015 (2015-01-20), pages 5853, ISSN: 2041-1723
   ALCULUMBRE SOLANA G ET AL: "Diversification of human plasmacytoid predendritic cells in response to a single stimulus.", NATURE IMMUNOLOGY JAN 2018, vol. 19, no. 1, January 2018 (2018-01-01), pages 63 - 75, ISSN: 1529-2916
by applicantWO2012006634
 US5922845
 US5837243
 US8017591
 US7635468
 US7074772
 US6849725
 US6451593
 US6451563
 US2003125279
 US9501570
 US9719791
 US6194388
 US6239116
 US6949520
 US7776344
 WO03024481
 US2003099668
 US2012301499
 WO2004084940
 US7517520
 US2010098722
 WO2007068747
 US2007184068
 US8574564
 WO2007144150
 US8541559
 WO2008073960
 US8586728
 US7566703
 US8198251
 US8834900
 US2008045473
 US8580268
 US2014163213
 US4469863
 US5023243
 EP0092574
 US7795235
 US8283328
 US8304396
 US5177198
 US5859231
 US6160109
 US6207819
 US9917100
 WO0006588
 WO9501363
 US5658738
 US5668265
 US6808710
 US7488802
 US8728474
 US7943743
 US9930895
 WO0037504
 EP1262193
 US47208799
 US6682736
 US94893901
 US2002086014
 US98839609
 US2009117132
 US201113168206
 US2012003179
 US2003086930
 US2002088014
 US5770429
 US2004120948
 US5703057
 US4816567
 EP0216846
 EP0256055
 EP0323997
 EP89303964
 US2003207336
 US2003157108
 WO0181405
 WO0024893
 WO03031464
 WO9858964
 WO9922764
 US2004063911
 US2004132640
 US2004142856
 US2004072290
 US6602684
 US2003207346
 US4640835
 US4496689
 US4301144
 US4670417
 US4791192
 US4179337
 US4816397
 US5916771
 US5759808
 US6765087
 WO0114424
 WO9300431
 WO0032231
 US2004198680
   ZITVOGEL L. ET AL., IMMUNITY, vol. 39, no. l, 2013, pages 74 - 88
   VICARITRINCHIERI, IMMUNOL. REV., 2004
   LU, FRONTIERS IMMUNOL, 2014
   KIMCANTOR, CANCER IMMUNOL RES, vol. 2, 2014, pages 929 - 936
   HERBST ET AL., NATURE, vol. 515, 2014, pages 563 - 567
   KIMCANTOR, CANCER IMMUNOL. RES., vol. 2, 2014, pages 926 - 936
   KRIEG, NUCLEIC ACID THER., vol. 22, no. 2, 2012, pages 77 - 89
   KRUIT ET AL., J CLIN ONCOL, 2013
   TARHINI ET AL., J IMMUNOTHER, 2013
   LOVGREN ET AL., CANCER IMMUNOL IMMUNOTHER, 2012
   KARBACH ET AL., CLIN CANCER RES, 2011
   KARBACH ET AL., INT J CANCER, 2010
   SPEISER ET AL., JCI, 2005
   MANGSBO ET AL., J. IMMUNOTHER, vol. 33, 2010, pages 225
   RAJASAGI ET AL., BLOOD, vol. 124, no. 3, 2014, pages 453 - 462
   PRASANNA ET AL., J THORACIC DIS., vol. 6, no. 4, 2014, pages 287 - 302
   POSTOW ET AL., N. ENGL. J. MED., vol. 366, no. 10, 2012, pages 925 - 31
   GRIMALDI ET AL., ONCOIMMUNOL., vol. 3, 2014, pages e28780
   BARNES ET AL., BIOTECH & BIOENGINEERING, vol. 73, 2001, pages 261 - 270
   AUSUBEL ET AL.: "Current Protocols in Molecular Biology", 2002, JOHN WILEY & SONS
   PEARSON, METHODS ENZYMOL., vol. 183, 1990, pages 63 - 98
   THORNTON ET AL., NATURE, vol. 354, 1991, pages 105
   PEARSON, METHODS MOL. BIOL., vol. 243, 1994, pages 307 - 31
   GONNET ET AL., SCIENCE, vol. 256, 1992, pages 1443 - 45
   "Proteins, Structures and Molecular Principles", 1984, W. H. FREEMAN AND COMPANY
   PEARSON, METHODS MOL. BIOL., vol. 132, 2000, pages 185 - 219
   ALTSCHUL ET AL., J. MOL. BIOL., vol. 215, 1990, pages 403 - 410
   ALTSCHUL ET AL., NUCLEIC ACIDS RES., vol. 25, 1997, pages 3389 - 402
   CHOTHIA ET AL., NATURE, vol. 341, 1989, pages 544 - 546
   CHOTHIALESK, J. MOL. BIOL., vol. 196, 1987, pages 901 - 917
   BIRD ET AL., SCIENCE, vol. 242, 1988, pages 423 - 426
   HUSTON ET AL., PROC. NATL. ACAD. SCI. USA, vol. 85, 1988, pages 5879 - 5883
   ZEILDER, J. IMMUNOL., vol. 163, 1999, pages 1246 - 1252
   SOMASUNDARAM, HUM. ANTIBODIES, vol. 9, 1999, pages 47 - 54
   KELER, CANCER RES., vol. 57, 1997, pages 4008 - 4014
   HOLLIGER ET AL., PROC. NATL. ACAD. SCI. USA, vol. 90, 1993, pages 6444 - 6448
   POLLAK ET AL., STRUCTURE, vol. 2, 1994, pages 1121 - 1123
   KRIEG ET AL., J. IMMUNOTHER., vol. 27, 2004, pages 460 - 471
   TAUBE ET AL., CLIN CANCER RES., 2014
   SIEGAL ET AL., SCIENCE, 1999
   HARTMANN ET AL., EUR. J. IMMUNOL., vol. 33, 2003, pages 1633 - 1641
   MARSHALL ET AL., J. LEUKOCYTE BIOL., vol. 73, 2003, pages 781 - 792
   VOLLMER ET AL., EUR. J. IMMUNOL., vol. 34, 2004, pages 251 - 262
   MOSEMAN ET AL., J. IMMUNOL., vol. 173, no. 7, 2004, pages 4433 - 4442
   CHEN ET AL., J. IMMUNOL., vol. 181, no. 8, 2008, pages 5396 - 5404
   MOLENKAMP BG ET AL., CLIN CANCER RES., vol. 13, no. 10, 2007, pages 2961 - 2969
   MUMMOFT, BIOESSAYS, vol. 35, no. 7, 2013, pages 623 - 631
   SATO ET AL., IMMUNOL RES., vol. 51, no. 2-3, 2011, pages 170 - 182
   UHLMANN E ET AL., CHEM REV, vol. 90, 1990, pages 543
   GOODCHILD J, BIOCONJUGATE CHEM, vol. 1, 1990, pages 165
   SELIGER, H. ET AL.: "Oligonucleotide analogs with terminal 3'-3'- and 5'-5'-internucleotidic linkages as antisense inhibitors of viral gene expression", NUCLEOSIDES & NUCLEOTIDES, vol. 10, no. 1-3, 1991, pages 469 - 77
   M. D. MATTEUCCIM. H. CARUTHERS, TETRAHEDRON LETT., vol. 21, 1980, pages 719
   R. P. IYERW. EGANJ. B. REGANS. L. BEAUCAGE, J. AM. CHEM. SOC., vol. 112, 1990, pages 1253
   SERGUEEV, JAM CHEM SOC, vol. 120, 1998, pages 9417 - 27
   KRIEG ET AL., OLIGONUCLEOTIDES, vol. 13, no. 6, 2003, pages 491 - 499
   "Synthesis and Properties & Synthesis and Analytical Techniques", 1993, HUMANA PRESS, article "Protocols for Oligonucleotides and Analogs"
   CROOKE S T ET AL., ANNU REV PHARMACOL TOXICOL, vol. 36, 1996, pages 107 - 129
   HUNZIKER J ET AL., MOD SYNTH METHODS, vol. 7, 1995, pages 331 - 417
   UHLMANN EPEYMAN A: "Protocols for Oligonucleotides and Analogs", vol. 20, 1993, HUMANA PRESS, article "Methods in Molecular Biology", pages: 355 ff
   STIRCHAK E P ET AL., OLIGONUCLEOTIDES RES, vol. 17, 1989, pages 6129 - 41
   NIELSEN P E ET AL., BIOCONJUG CHEM, vol. 5, 1994, pages 3 - 7
   FROEHLER J, JAM CHEM SOC, vol. 114, 1992, pages 8320
   VANDENDRIESSCHE ET AL., TETRAHEDRON, vol. 49, 1993, pages 7223
   TARKOV M ET AL., HELV CHIMACTA, vol. 76, 1993, pages 481
   JIANG ET AL.: "Pseudo-cyclic oligonucleotides: in vitro and in vivo properties", BIOORGANIC & MEDICINAL CHEMISTRY, vol. 7, no. 12, 1999, pages 2727 - 2735, XP085050417, DOI: 10.1016/S0968-0896(99)00217-5

DOI:   http://dx.doi.org/10.1016/S0968-0896(99)00217-5
   DURAND, M. ET AL.: "Triple-helix formation by an oligonucleotide containing one (dA) and two (dT) sequences bridged by two hexaethylene glycol chains", BIOCHEMISTRY, vol. 31, no. 38, 1992, pages 9197 - 204, XP002329296, DOI: 10.1021/bi00153a012

DOI:   http://dx.doi.org/10.1021/bi00153a012
   FONTANEL, MARIE LAURENCE ET AL.: "Sterical recognition by T4 polynucleotide kinase of non-nucleosidic moieties 5'-attached to oligonucleotides", OLIGONUCLEOTIDES RESEARCH, vol. 22, no. 11, 1994, pages 2022 - 7, XP002098767
   SCHMIDT M ET AL., ALLERGY, vol. 61, 2006, pages 56 - 63
   KAPP, K ET AL., MOL THER NUCLEIC ACIDS, vol. 3, 2014, pages e170
   RAMALHO ORTIGAO ET AL., ANTISENSE RESEARCH AND DEVELOPMENT, vol. 2, 1992, pages 129 - 46
   "GenBank", Database accession no. NP_001032720
   FRANSEN MF ET AL., ONCOIMMUNOLOGY, vol. 2, no. 11, 1 November 2013 (2013-11-01), pages e26493
   LONBERG ET AL., NATURE, vol. 368, 1994, pages 856 - 859
   TOMIZUKA ET AL., PROC NATL ACAD SCI USA, vol. 97, 2000, pages 722
   KUROIWA ET AL., NATURE BIOTECHNOL, vol. 18, 2000, pages 1086
   WINTERHARRIS, IMMUNOL. TODAY, vol. 14, 1993, pages 43 - 46
   WRIGHT ET AL., CRIT. REVIEWS IN IMMUNOL., vol. 12, 1992, pages 125 - 168
   THOTAKURA ET AL., METH. ENZYMOL., vol. 138, 1987, pages 350 - 97
   HAKIMUDDIN ET AL., ARCH. BIOCHEM. BIOPHYS., vol. 259, 1987, pages 52
   MILLWARD M. ET AL., BR. J. CANCER, vol. 108, no. 10, 2013, pages 1998 - 2004
   BRODY ET AL., J. CLIN. ONCOL., vol. 28, no. 28, 2010, pages 4324 - 4332
   KIM ET AL., BLOOD, vol. 119, no. 2, 2012, pages 355 - 363
   BURNETTE ET AL., CANCER RES., vol. 71, 2011, pages 2488 - 2496
   GOMES DOS SANTOS AL ET AL., CURR PHARM BIOTECHNOL., vol. 6, no. 1, 2005, pages 7 - 15
   JOSHI VB ET AL., AAPS J., vol. 15, no. 1, 2013, pages 85 - 94
   ARIMA H ET AL., CURR TOP MED CHEM., vol. 14, no. 4, 2014, pages 465 - 77
   "Sustained and Controlled Release Drug Delivery Systems", 1978, MARCEL DEKKER, INC.
   KRIEG AM ET AL., OLIGONUCLEOTIDE, vol. 13, no. 6, 2003, pages 491 - 9
   BEEH ET AL., J ALLERGY CLIN IMMUNOL, vol. 131, 2013, pages 866 - 74
The EPO accepts no responsibility for the accuracy of data originating from other authorities; in particular, it does not guarantee that it is complete, up to date or fit for specific purposes.