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Extract from the Register of European Patents

EP About this file: EP3064508

EP3064508 - METHOD OF PRODUCING RECOMBINANT HIGH MOLECULAR WEIGHT VWF IN CELL CULTURE [Right-click to bookmark this link]
StatusPatent maintained as amended
Status updated on  10.02.2023
Database last updated on 13.09.2024
FormerThe patent has been granted
Status updated on  26.07.2019
FormerGrant of patent is intended
Status updated on  21.02.2019
FormerExamination is in progress
Status updated on  28.07.2017
FormerRequest for examination was made
Status updated on  10.03.2017
Most recent event   Tooltip10.02.2023Patent maintained (B2 publication)published on 15.03.2023  [2023/11]
Applicant(s)For all designated states
Baxalta GmbH
Thurgauerstrasse 130
8152 Glattpark (Opfikon) / CH
For all designated states
Baxalta Incorporated
1200 Lakeside Drive
Bannockburn, IL 60015 / US
[2020/17]
Former [2017/47]For all designated states
Baxalta GmbH
Zählerweg 4
6300 Zug / CH
For all designated states
Baxalta Incorporated
1200 Lakeside Drive
Bannockburn, IL 60015 / US
Former [2016/36]For all designated states
Baxalta GmbH
Thurgauerstrasse 130
8152 Glattpark, Opfikon / CH
For all designated states
Baxalta Incorporated
1200 Lakeside Drive
Bannockburn, IL 60015 / US
Inventor(s)01 / Grillberger, Leopold
Finsterergasse 1a
1220 Vienna / AT
02 / Reiter, Manfred
Gebrueder-Lang-Gasse 11/17
1150 Vienna / AT
03 / Mundt, Wolfgang
Florianigasse 57/1/2/6
1080 Vienna / AT
 [2016/36]
Representative(s)Hoffmann Eitle
Patent- und Rechtsanwälte PartmbB
Arabellastraße 30
81925 München / DE
[2016/36]
Application number, filing date16153131.408.07.2011
[2016/36]
Priority number, dateUS20100362635P08.07.2010         Original published format: US 362635 P
[2016/36]
Filing languageEN
Procedural languageEN
PublicationType: A1 Application with search report 
No.:EP3064508
Date:07.09.2016
Language:EN
[2016/36]
Type: B1 Patent specification 
No.:EP3064508
Date:28.08.2019
Language:EN
[2019/35]
Type: B2 New European patent specification 
No.:EP3064508
Date:15.03.2023
Language:EN
[2023/11]
Search report(s)(Supplementary) European search report - dispatched on:EP04.08.2016
ClassificationIPC:C07K14/755, C12N5/00, A61K38/36, C12N5/10, A61K39/00, C12N9/64, A61K38/00, A61K38/37, A61K9/00, C12P21/00
[2018/26]
CPC:
C07K14/755 (EP,CN,EA,IL,KR,US); C12N5/0018 (EA,IL,KR); A61K9/0019 (EA,IL,KR,US);
A61K38/00 (EP,EA,IL,KR,US); A61K38/36 (EP,EA,IL,KR,US); A61K38/37 (EP,EA,IL,KR,US);
A61P29/00 (EP,EA,IL); A61P33/06 (EP,EA,IL); A61P7/00 (EP,EA,IL);
A61P7/04 (EP,EA,IL); C07K1/00 (EA,IL); C07K14/745 (EA,IL);
C12N5/00 (EA,IL); C12N5/10 (EA,IL); C12N9/6489 (EP,CN,EA,IL,KR,US);
C12P21/00 (EA,IL,KR,US); C12Y304/24087 (EP,CN,EA,IL,KR,US); C12N2500/10 (EA,IL,KR);
C12N2500/24 (EP,EA,IL,KR,US); C12N2501/998 (EA,IL,KR); C12N2511/00 (EP,EA,IL,KR,US) (-)
Former IPC [2016/36]C07K14/755, C12N5/00, A61K38/36, C12N5/10, A61K39/00, C12N9/64, A61K38/00
Designated contracting statesAL,   AT,   BE,   BG,   CH,   CY,   CZ,   DE,   DK,   EE,   ES,   FI,   FR,   GB,   GR,   HR,   HU,   IE,   IS,   IT,   LI,   LT,   LU,   LV,   MC,   MK,   MT,   NL,   NO,   PL,   PT,   RO,   RS,   SE,   SI,   SK,   SM,   TR [2017/15]
Former [2016/36]AL,  AT,  BE,  BG,  CH,  CY,  CZ,  DE,  DK,  EE,  ES,  FI,  FR,  GB,  GR,  HR,  HU,  IE,  IS,  IT,  LI,  LT,  LU,  LV,  MC,  MK,  MT,  NL,  NO,  PL,  PT,  RO,  RS,  SE,  SI,  SK,  SM,  TR 
TitleGerman:VERFAHREN ZUR HERSTELLUNG VON REKOMBINANTEM VWF MIT HOHEM MOLEKULARGEWICHT IN EINER ZELLKULTUR[2016/36]
English:METHOD OF PRODUCING RECOMBINANT HIGH MOLECULAR WEIGHT VWF IN CELL CULTURE[2016/36]
French:PROCÉDÉ DE PRODUCTION DE VWF DE POIDS MOLÉCULAIRE ÉLEVÉ RECOMBINANT DANS UNE CULTURE CELLULAIRE[2016/36]
Examination procedure28.01.2016Date on which the examining division has become responsible
23.02.2017Amendment by applicant (claims and/or description)
07.03.2017Examination requested  [2017/15]
28.07.2017Despatch of a communication from the examining division (Time limit: M04)
10.10.2017Reply to a communication from the examining division
30.01.2018Despatch of a communication from the examining division (Time limit: M04)
11.05.2018Reply to a communication from the examining division
25.06.2018Despatch of a communication from the examining division (Time limit: M06)
04.01.2019Reply to a communication from the examining division
22.02.2019Communication of intention to grant the patent
27.02.2019Observations by third parties
04.07.2019Fee for grant paid
04.07.2019Fee for publishing/printing paid
04.07.2019Receipt of the translation of the claim(s)
Parent application(s)   TooltipEP11736502.3  / EP2590998
Divisional application(s)EP19191438.1  / EP3626736
Opposition(s)Opponent(s)01  28.05.2020  30.05.2020  ADMISSIBLE
James Poole Limited
One Southampton Row
London WC1B 5HA / GB
Opponent's representative
Carpmaels & Ransford LLP
One Southampton Row
London WC1B 5HA / GB
 [2021/37]
Former [2020/28]
Opponent(s)01  28.05.2020  30.05.2020  ADMISSIBLE
James Poole Limited
One Southampton Row
London WC1B 5HA / GB
Opponent's representative
Wise, Daniel Joseph
Carpmaels & Ransford LLP
One Southampton Row
London WC1B 5HA / GB
16.06.2020Invitation to proprietor to file observations on the notice of opposition
22.10.2020Reply of patent proprietor to notice(s) of opposition
09.05.2022Legal effect of interlocutory decision in opposition
09.05.2022Date of oral proceedings
27.07.2022Despatch of interlocutory decision in opposition
27.07.2022Despatch of minutes of oral proceedings
21.11.2022Despatch of communication that the patent will be maintained as amended
08.02.2023Fee for printing new specification paid
Fees paidRenewal fee
28.01.2016Renewal fee patent year 03
28.01.2016Renewal fee patent year 04
28.01.2016Renewal fee patent year 05
27.07.2016Renewal fee patent year 06
27.07.2017Renewal fee patent year 07
24.07.2018Renewal fee patent year 08
22.07.2019Renewal fee patent year 09
Opt-out from the exclusive  Tooltip
competence of the Unified
Patent Court		 See the Register of the Unified Patent Court for opt-out data
Responsibility for the accuracy, completeness or quality of the data displayed under the link provided lies entirely with the Unified Patent Court.
Lapses during opposition  TooltipAL28.08.2019
CY28.08.2019
EE28.08.2019
LT28.08.2019
LV28.08.2019
MC28.08.2019
MK28.08.2019
MT28.08.2019
RS28.08.2019
SK28.08.2019
SM28.08.2019
NO28.11.2019
GR29.11.2019
IS28.12.2019
LU08.07.2020
[2022/32]
Former [2022/28]AL28.08.2019
CY28.08.2019
EE28.08.2019
LT28.08.2019
LV28.08.2019
MC28.08.2019
MT28.08.2019
RS28.08.2019
SK28.08.2019
SM28.08.2019
NO28.11.2019
GR29.11.2019
IS28.12.2019
LU08.07.2020
Former [2021/20]AL28.08.2019
EE28.08.2019
LT28.08.2019
LV28.08.2019
MC28.08.2019
RS28.08.2019
SK28.08.2019
SM28.08.2019
NO28.11.2019
GR29.11.2019
IS28.12.2019
LU08.07.2020
Former [2021/15]AL28.08.2019
EE28.08.2019
LT28.08.2019
LV28.08.2019
MC28.08.2019
RS28.08.2019
SK28.08.2019
SM28.08.2019
NO28.11.2019
GR29.11.2019
IS28.12.2019
Former [2020/36]AL28.08.2019
EE28.08.2019
LT28.08.2019
LV28.08.2019
RS28.08.2019
SK28.08.2019
SM28.08.2019
NO28.11.2019
GR29.11.2019
IS28.12.2019
Former [2020/27]AL28.08.2019
EE28.08.2019
LT28.08.2019
LV28.08.2019
RS28.08.2019
SK28.08.2019
SM28.08.2019
NO28.11.2019
GR29.11.2019
IS24.02.2020
Former [2020/24]AL28.08.2019
EE28.08.2019
LT28.08.2019
LV28.08.2019
RS28.08.2019
NO28.11.2019
GR29.11.2019
IS24.02.2020
Former [2020/22]AL28.08.2019
EE28.08.2019
LT28.08.2019
LV28.08.2019
RS28.08.2019
NO28.11.2019
GR29.11.2019
IS28.12.2019
Former [2020/15]AL28.08.2019
LT28.08.2019
LV28.08.2019
RS28.08.2019
NO28.11.2019
GR29.11.2019
IS28.12.2019
Former [2020/12]LT28.08.2019
LV28.08.2019
RS28.08.2019
NO28.11.2019
GR29.11.2019
IS28.12.2019
Former [2020/08]LT28.08.2019
NO28.11.2019
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 [A]EP1096017  (WELFIDE CORP [JP]) [A] 1-15 * paragraphs [0012] , [0015] - [0017] - [0020] , [0030] , [0031] , [0039] , [0040] *;
 [X]WO2008082669  (NEKTAR THERAPEUTICS AL CORP [US], et al) [X] 8-15* p.71 par.271p.72 Tbl.3, p.73 Tbl.4, p.69 par.263, p.74 Par.282-285 *;
 [A]WO2008109410  (WYETH CORP [US], et al) [A] 1-15 * paragraphs [0005] , [0006] , [0058] , [0081] , [0107] *;
 [YD]WO2009086309  (BAXTER INT [US], et al) [YD] 1-3,5-7 * page 2, line 10 * * page 9, line 10 * * page 10, lines 11-26 * * page 14, line 17 * * page 15, line 30 * * page 16, lines 9-14 * * page 17, line 28 *;
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DOI:   http://dx.doi.org/10.1021/bp9602360
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OppositionUS4767704
 EP1096017
 WO2008082669
 WO2008109410
 WO2009086309
    - M.-S. Lao, D. Toth, "Effects of Ammonium and Lactate on Growth and Metabolism of a Recombinant Chinese Hamster Ovary Cell Culture", Biotechnology Progress, American Chemical Society, (19971007), vol. 13, no. 5, doi:10.1021/bp9602360, ISSN 87567938, pages 688 - 691, XP055115728

DOI:   http://dx.doi.org/10.1021/bp9602360
    - Fatemeh Davami, Farnaz Eghbalpour, Leila Nematollahi, Farzaneh Barkhordari, Fereidoun Mahboudi, "Effects of Peptone Supplementation in Different Culture Media on Growth, Metabolic Pathway and Productivity of CHO DG44 Cells; a New Insight into Amino Acid Profiles", Iranian biomedical journal, Pasteur Institute of Iran, Iran, Iran, doi:10.7508/ibj.2015.04.002, (20150101), pages 194 - 205, URL: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4649854/pdf/ibj-19-194.pdf, XP055750435

DOI:   http://dx.doi.org/10.7508/ibj.2015.04.002
    - Y Sakai, Et Al, "GROWTH INHIBITION AND HEAVY METAL ACCUMULATION IN CHO CELLS", Animal Cell Technology: Developments towards the 21st Century, Kluwer, (19950101), pages 1111 - 1115, XP055750458

DOI:   http://dx.doi.org/10.1007/978-94-011-0437-1_174
    - Claudia Altamirano, Et Al, "Advances in improving mammalian cells metabolism for recombinant protein production", EJB ELECTRONIC JOURNAL OF BIOTECHNOLOGY, CONICYT, SANTIAGO, CL, CL, vol. 16, no. 3, doi:10.2225/vol16-issue3-fulltext-2, ISSN 0717-3458, pages 1 - 14, XP055750886

DOI:   http://dx.doi.org/10.2225/vol16-issue3-fulltext-2
    - J E Sadler, "von Willebrand factor assembly and secretion", Journal of Thrombosis and Haemostasis, (20090101), vol. 7, no. 1, pages 24 - 27, XP055750907

DOI:   http://dx.doi.org/10.1111/j.1538-7836.2009.03375.x
    - D D Wagner, T Mayadas, V J Marder, "Initial glycosylation and acidic pH in the Golgi apparatus are required for multimerization of von Willebrand factor.", The journal of cell biology, The Rockefeller University Press, US, US, (19860401), vol. 102, no. 4, doi:10.1083/jcb.102.4.1320, ISSN 0021-9525, pages 1320 - 1324, XP055750915

DOI:   http://dx.doi.org/10.1083/jcb.102.4.1320
    - MAYADAS T.N., WAGNER D.D., "IN VITRO MULTIMERIZATION OF VON WILLEBRAND FACTOR IS TRIGGERED BY LOW PH.", Journal of Biological Chemistry, American Society for Biochemistry and Molecular Biology, US, US, (19890101), vol. 264., no. 23., ISSN 0021-9258, page 13497 + 503., XP000885940
    - KAUFMAN, R.J. ET AL., "Effect of von Willebrand factor coexpression on the synthesis and secretion of Factor VIII in Chinese Hamster Ovary cells", MOLECULAR AND CELLULAR BIOLOGY, (19890301), vol. 9, no. 3, pages 1233 - 1242, XP002440263

DOI:   http://dx.doi.org/10.1128/MCB.9.3.1233
    - VOORBERG J , FONTIJN R, MOURIK VAN J A, PANNEKOEK H, "DOMAINS INVOLVED IN MULTIMER ASSEMBLY OF VON WILLEBRAND FACTOR VWF MULTIMERIZATION IS INDEPENDENT OF DIMERIZATION", The EMBO Journal, European Molecular Biology Organization, (19900101), vol. 9, no. 3, ISSN 0261-4189, pages 797 - 803, XP002674469
    - DMEM/F-12 media components
    - M.-S. Lao, D. Toth, "Effects of Ammonium and Lactate on Growth and Metabolism of a Recombinant Chinese Hamster Ovary Cell Culture", Biotechnology Progress, American Chemical Society, (19971007), vol. 13, no. 5, doi:10.1021/bp9602360, ISSN 87567938, pages 688 - 691
    - Fatemeh Davami, Farnaz Eghbalpour, Leila Nematollahi, Farzaneh Barkhordari, Fereidoun Mahboudi, "Effects of Peptone Supplementation in Different Culture Media on Growth, Metabolic Pathway and Productivity of CHO DG44 Cells; a New Insight into Amino Acid Profiles", Iranian biomedical journal, Pasteur Institute of Iran, Iran, Iran, doi:10.7508/ibj.2015.04.002, (20150101), pages 194 - 205, URL: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4649854/pdf/ibj-19-194.pdf
    - Y Sakai, Et Al, "GROWTH INHIBITION AND HEAVY METAL ACCUMULATION IN CHO CELLS", Animal Cell Technology: Developments towards the 21st Century, Kluwer, (19950101), pages 1111 - 1115
    - Claudia Altamirano, Et Al, "Advances in improving mammalian cells metabolism for recombinant protein production", EJB ELECTRONIC JOURNAL OF BIOTECHNOLOGY, CONICYT, SANTIAGO, CL, CL, vol. 16, no. 3, doi:10.2225/vol16-issue3-fulltext-2, ISSN 0717-3458, pages 1 - 14
    - J E Sadler, "von Willebrand factor assembly and secretion", Journal of Thrombosis and Haemostasis, (20090101), vol. 7, no. 1, pages 24 - 27
    - D D Wagner, T Mayadas, V J Marder, "Initial glycosylation and acidic pH in the Golgi apparatus are required for multimerization of von Willebrand factor.", The journal of cell biology, The Rockefeller University Press, US, US, (19860401), vol. 102, no. 4, doi:10.1083/jcb.102.4.1320, ISSN 0021-9525, pages 1320 - 1324
    - MAYADAS T.N., WAGNER D.D., "IN VITRO MULTIMERIZATION OF VON WILLEBRAND FACTOR IS TRIGGERED BY LOW PH.", Journal of Biological Chemistry, American Society for Biochemistry and Molecular Biology, US, US, (19890101), vol. 264., no. 23., ISSN 0021-9258, page 13497 + 503.
    - KAUFMAN, R.J. ET AL., "Effect of von Willebrand factor coexpression on the synthesis and secretion of Factor VIII in Chinese Hamster Ovary cells", MOLECULAR AND CELLULAR BIOLOGY, (19890301), vol. 9, no. 3, pages 1233 - 1242
    - VOORBERG J , FONTIJN R, MOURIK VAN J A, PANNEKOEK H, "DOMAINS INVOLVED IN MULTIMER ASSEMBLY OF VON WILLEBRAND FACTOR VWF MULTIMERIZATION IS INDEPENDENT OF DIMERIZATION", The EMBO Journal, European Molecular Biology Organization, (19900101), vol. 9, no. 3, ISSN 0261-4189, pages 797 - 803
The EPO accepts no responsibility for the accuracy of data originating from other authorities; in particular, it does not guarantee that it is complete, up to date or fit for specific purposes.