EP3138855 - ACTIVATED SIALIC ACID DERIVATIVES FOR PROTEIN DERIVATISATION AND CONJUGATION [Right-click to bookmark this link] | Status | The application is deemed to be withdrawn Status updated on 20.12.2019 Database last updated on 31.08.2024 | |
Former | Grant of patent is intended Status updated on 17.03.2019 | ||
Former | Request for examination was made Status updated on 15.09.2017 | ||
Former | The application has been published Status updated on 03.02.2017 | Most recent event Tooltip | 20.12.2019 | Application deemed to be withdrawn | published on 22.01.2020 [2020/04] | Applicant(s) | For all designated states Lipoxen Technologies Limited London BioScience Innovation Centre 2 Royal College Street London NW1 0NH / GB | [2017/10] | Inventor(s) | 01 /
JAIN, Sanjay Lipoxen Technologies Limited London Bioscience Innovation Centre 2 Royal College Street London, NW1 0NH / GB | 02 /
PAPAIOANNOU, Ioannis Lipoxen Technologies Limited London Bioscience Innovation Centre 2 Royal College Street London, NW1 0NH / GB | 03 /
THOBHANI, Smita Lipoxen Technologies Limited London Bioscience Innovation Centre 2 Royal College Street London, NW1 0NH / GB | [2017/10] | Representative(s) | Icosa, et al 83 avenue Denfert-Rochereau 75014 Paris / FR | [N/P] |
Former [2017/10] | Schlich, George, et al Schlich 9 St Catherine's Road Littlehampton, West Sussex BN17 5HS / GB | Application number, filing date | 16183412.2 | 16.02.2006 | [2017/10] | Priority number, date | EP20050251017 | 23.02.2005 Original published format: EP 05251017 | WO2005GB03160 | 12.08.2005 Original published format: PCT/GB2005/003160 | [2017/10] | Filing language | EN | Procedural language | EN | Publication | Type: | A1 Application with search report | No.: | EP3138855 | Date: | 08.03.2017 | Language: | EN | [2017/10] | Search report(s) | (Supplementary) European search report - dispatched on: | EP | 02.02.2017 | Classification | IPC: | C08B37/00 | [2017/10] | CPC: |
C07H15/26 (EP,US);
A61K47/61 (US);
A61K38/27 (EP,US);
C07H5/06 (EP,US);
C07K17/10 (US);
C08B37/0006 (EP,US);
| Designated contracting states | AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HU, IE, IS, IT, LI, LT, LU, LV, MC, NL, PL, PT, RO, SE, SI, SK, TR [2017/42] |
Former [2017/10] | AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HU, IE, IS, IT, LI, LT, LU, LV, MC, NL, PL, PT, RO, SE, SI, SK, TR | Title | German: | AKTIVIERTE SIALINSÄUREDERIVATE FÜR DIE DERIVATISIERUNG UND KONJUGATION VON PROTEINEN | [2017/10] | English: | ACTIVATED SIALIC ACID DERIVATIVES FOR PROTEIN DERIVATISATION AND CONJUGATION | [2017/10] | French: | DÉRIVÉS D'ACIDE SIALIQUE ACTIVÉS POUR UNE DÉRIVATION ET CONJUGAISON | [2017/10] | Biological material | This application mentions deposited biological material, check the file for details | Examination procedure | 09.08.2016 | Date on which the examining division has become responsible | 08.09.2017 | Amendment by applicant (claims and/or description) | 08.09.2017 | Examination requested [2017/42] | 18.03.2019 | Communication of intention to grant the patent | 30.07.2019 | Application deemed to be withdrawn, date of legal effect [2020/04] | 03.09.2019 | Despatch of communication that the application is deemed to be withdrawn, reason: fee for grant / fee for printing not paid in time [2020/04] | Parent application(s) Tooltip | EP06709777.4 / EP1853634 | Fees paid | Renewal fee | 06.12.2016 | Renewal fee patent year 03 | 06.12.2016 | Renewal fee patent year 04 | 06.12.2016 | Renewal fee patent year 05 | 06.12.2016 | Renewal fee patent year 06 | 06.12.2016 | Renewal fee patent year 07 | 06.12.2016 | Renewal fee patent year 08 | 06.12.2016 | Renewal fee patent year 09 | 06.12.2016 | Renewal fee patent year 10 | 06.12.2016 | Renewal fee patent year 11 | 17.02.2017 | Renewal fee patent year 12 | 26.02.2018 | Renewal fee patent year 13 | 27.02.2019 | Renewal fee patent year 14 |
Opt-out from the exclusive Tooltip competence of the Unified Patent Court | See the Register of the Unified Patent Court for opt-out data | ||
Responsibility for the accuracy, completeness or quality of the data displayed under the link provided lies entirely with the Unified Patent Court. | Documents cited: | Search | [A]US4225487 (CUATRECASAS PEDRO, et al) [A] 1-12 * column 9, lines 17-23,47-55 *; | [A]EP0273388 (KANTO ISHI PHARMA CO LTD [JP]) [A] 1-12 * example 16 *; | [A]EP0371495 (KANTO ISHI PHARMA CO LTD [JP]) [A] 1-12 * example 10 *; | [A]US5534259 (ZALIPSKY SAMUEL [US], et al) [A] 1-12 * figure 7 * * column 6, line 64 - column 7, line 3 *; | [A]US6680054 (REECE PHILLIP A [AU], et al) [A] 1-12 * example 12 *; | [AP]WO2005016973 (LIPOXEN TECHNOLOGIES LTD [GB], et al) [AP] 1-12 * example 3 *; | [E]WO2006016168 (LIPOXEN TECHNOLOGIES LTD [GB], et al) [E] 1-12* the whole document *; | [A] - FAN G-T ET AL, "Stereoselective Synthesis of Neu5Acalpha(2->5)Neu5Gc:The Building Block ofO ligo/Poly(->5-Oglycoly1Neu5Gcalpha2->) Chains in Sea Urchin Egg Cell Surface Glycoprotein", JOURNAL OF ORGANIC CHEMISTRY, AMERICAN CHEMICAL SOCIETY. EASTON, US, (2002), vol. 67, ISSN 0022-3263, pages 7565 - 7568, XP002327875 [A] 1-12 * figure 2 * DOI: http://dx.doi.org/10.1021/jo025988p | [A] - SOFIA M J, "CARBOHYDRATE-BASED COMBINATORIAL LIBRARIES", MOLECULAR DIVERSITY, ESCOM SCIENCE PUBLISHERS, LEIDEN, NL, (1998), vol. 3, ISSN 1381-1991, pages 75 - 94, XP002914140 [A] 1-12 * pages 85,86; figures 11,12 * DOI: http://dx.doi.org/10.1023/A:1009650424835 | by applicant | US4356170 | EP0454898 | US5846951 | WO0187922 | WO2005016973 | - BENDELE, A.; SEELY, J.; RICHEY, C.; SENNELLO, G.; SHOPP, G., "Renal tubular vacuolation in animals treated with polyethylene-glycol conjugated proteins", TOXICOLOGICAL SCIENCES, (1998), vol. 42, pages 152 - 157 | - BERANOVA, M.; WASSERBAUER, R.; VANCUROVA, D.; STIFTER, M.; OCENASKOVA, J.; MORA, M., BIOMATERIALS, (2000), vol. 11, pages 521 - 524 | - BROCCHINI, S., "Polymers in medicine: a game of chess", DRUG DISCOVERY TODAY, (2003), vol. 8, pages 111 - 112 | - CARLSSON, J.; DREVIN, H.; AXEN, R., BIOCHEM JOURNAL, (1978), vol. 173, pages 723 - 737 | - CHENG T; WU, M.; WU,P.; CHERN, J; ROFFER, SR., "Accelerated clearance of polyethylene glycol modified proteins by anti-polyethylene glycol IgM", BIOCONJUGATE CHEMISTRY, (1999), vol. 10, pages 520 - 528 | - CHO, J.W.; TROY, F. A., "PSA engineering: Synthesis of polysialylated neoglycosphingolipid by using the polytransferase from neuroinvasive E.coli K1", PROCEEDINGS OF NATIONAL ACADEMIC SCIENCES, USA, (1994), vol. 91, pages 11427 - 11431 | - CONVERS, C. D.; LEJEUNE, L.; SHUM, K.; GILBERT, C.; SHORR, R.G.L, "Physiological effect of polyethylene glycol conjugation on stroma-free bovine hemoglobin in the conscious dog after partial exchange transfusion", ARTIFICIAL ORGAN, (1997), vol. 21, pages 369 - 378 | - DYER, J.R., "Use of periodate oxidation in biochemical analysis", METHODS OF BIOCHEMICAL ANALYSIS, (1956), vol. 3, pages 111 - 152 | - FERNANDES, A.I.; GREGORIADIS, G., "Polysialylated asparaginase: preparation, activity and pharmacokinetics", BIOCHIMICA ET BIOPHYSICA ACTA, (1997), vol. 1341, pages 26 - 34 | - FERNANDES, A.I., "Gregoriadis, G., Synthesis, characterization and properties of polysialylated catalase", BIOCHIMICA ET BIOPHYSICA ACTA, (1996), vol. 1293, pages 92 - 96 | - FERNANDES, A.I.; GREGORIADIS, G., "The effect of polysialylation on the immunogenicity and antigenicity of asparaginase: implications in its pharmacokinetics", INTERNATIONAL JOURNAL OF PHARMACEUTICS, (2001), vol. 217, pages 215 - 224 | - FLEURY, P.; LANGE, J., "Sur I'oxydation des acides alcools et des sucres par I'acid periodique", COMPTES RENDUS ACADEMIC SCIENCES, (1932), vol. 195, pages 1395 - 1397 | - FURUHATA, TRENDS IN GLYCOSCI. GLYCOTECH., (2004), vol. 18, no. 89, pages 143 - 169 | - "Drug and vaccine delivery systems", GREGORIADIS, G., PharmaTech, WORLD MARKETS RESEARCH CENTRE LIMITED, (2001), pages 172 - 176 | - "Polysialic acids: Potential for long circulating drug, protein, liposome and other microparticle constructs", GREGORIADIS, G.; FERNANDES, A.; MCCORMACK, B.; MITAL, M.; ZHANG, X, Targeting of Drugs, Stealth Therapeutic Systems, PLENUM PRESS, (1998), pages 193 - 205 | - GREGORIADIS, G.; FERNANDES, A.; MITAL, M.; MCCORMACK, B., "Polysialic acids: potential in improving the stability and pharmacokinetics of proteins and other therapeutics", CELLULAR AND MOLECULAR LIFE SCIENCES, (2000), vol. 57, pages 1964 - 1969 | - GREGORIADIS, G.; MCCORMACK, B.; WANG, Z.; LIFELY, R., "Polysialic acids: potential in drug delivery", FEBS LETTERS, (1993), vol. 315, pages 271 - 276 | - HRECZUK-HIRST, D.; JAIN, S.; GENKIN, D.; LAING, P.; GREGORIADIS, G., "Preparation and properties of polysialylated interferon-a-2b", AAPS ANNUAL MEETING, (2002), page M1056 | - HUNTER, A. C; MOGHIMI, S. M., "Therapeutic synthetic polymers: a game of Russian Roulette", DRUG DISCOVERY TODAY, (2002), vol. 7, pages 998 - 1001 | - JAIN, S.; HIRST, D. H.; MCCORMACK, B.; MITAL, M.; EPENETOS, A.; LAING, P.; GREGORIADIS, G., "Polysialylated insulin: synthesis, characterization and biological activity in vivo", BIOCHEMICA ET. BIOPHYSICA ACTA, (2003), vol. 1622, pages 42 - 49 | - JAIN, S.; HIRST, D.H.; LAING, P.; GREGORIADIS, G., "Polysialylation: The natural way to improve the stability and pharmacokinetics of protein and peptide drugs", DRUG DELIVERY SYSTEMS AND SCIENCES, (2004), vol. 4, no. 2, pages 3 - 9 | - JENNINGS, H. J.; LUGOWSKI, C., "Immunogenicity of groups A, B, and C meningococal polysaccharide tetanus toxoid conjugates", JOURNAL OF IMMUNOLOGY, (1981), vol. 127, pages 1011 - 1018 | - JENNINGS, H. J. ET AL., J. IMMUNOL., (1986), vol. 137, pages 1708 - 1713 | - LIFELY, R.; GILHERT, A.S.; MORENO, C.C., "Sialic acid polysaccharide antigen of Neisseria meningitidis and Escherichia coli: esterification between adjacent residues", CARBOHYDRATE RESEARCH, (1981), vol. 94, pages 193 - 203 | - MUFLENHOFF, M.; ECTEHARDT , M.; GERARDY-SCHOHN, R., "Polysialic acid: three-dimensional structure, biosynthesis and function", CURRENT OPINIONS IN STRUCTURAL BIOLOGY, (1998), vol. 8, pages 558 - 564 | - PARK, J.T.; JOHNSON, M.J., "A submicrodetermination of glucose", JOURNAL OF BIOLOGICAL CHEMISTRY, (1949), vol. 181, pages 149 - 151 | - PAWLOWSKI, A. ET AL., VACCINE, (1999), vol. 17, pages 1474 - 1483 | - "Polysialic acid as regulator of cell interactions", RUTISHAUSER, U., Neurobiology of Glycoconjugates, PLENUM PRESS, (1989), pages 367 - 382 | - SATAKE, K., J. BIOCHEM., (1960), vol. 47, page 654 | - SVENNERHOLM, L., "Quantitative estimation of sialic acid II: A colorimetric resorcinol-hydrochloric acid method", BIOCHIMCA ET BIOPHYSICA ACTA, (1957), vol. 24, pages 604 - 611 | - TROY, F. A., "Polysialylation of neural cell adhesion molecules", TRENDS IN GLYCOSCIENCE AND GLYCOTECHNOLOGY, (1990), vol. 2, pages 430 - 449 | - TROY, F.A., "Polysialylation: From bacteria to brain", GLYCOBIOLOGY, (1992), vol. 2, pages 1 - 23 |