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EP About this file: EP3281632

EP3281632 - ARGON FOR USE IN THE PREVENTION OF BOTH CARDIAC AND CEREBRAL INJURY INDUCED BY ISCHEMIA/REPERFUSION FOLLOWING CARDIAC ARREST [Right-click to bookmark this link]
Status	The application is deemed to be withdrawn Status updated on 16.04.2021 Database last updated on 16.11.2024
Former	Examination is in progress Status updated on 30.11.2018
Former	Request for examination was made Status updated on 17.08.2018
Former	The application has been published Status updated on 12.01.2018
Most recent event Tooltip	16.04.2021	Application deemed to be withdrawn	published on 19.05.2021 [2021/20]
Applicant(s)	For all designated states Societa' Italiana Acetilene & Derivati S.I.A.D. S.p.A. in breve S.I.A.D. S.p.A. Via S. Bernardino, 92 24126 Bergamo / IT
	[N/P]
Former [2018/07]	For all designated states Societa'Italiana Acetilene & Derivati S.I.A.D. S.p.A. in breve S.I.A.D. S.p.A. Via S. Bernardino, 92 24126 Bergamo / IT
Inventor(s)	01 / BISSOLOTTI, Giorgio SOCIETA' ITALIANA ACETILENE E DERIVATI S.I.A.D. SPA, IN BREVE SIAD SPA Via S. Bernardino, 92 24100 BERGAMO / IT
	02 / RISTAGNO, Giuseppe ISTITUTO DI RICERCHE FARMACOLOGICHE "MARIO NEGRI" Dipartimento di Ricerca Cardiovascolare IRCCS Via La Masa, 19 20156 MILANO / IT
	03 / LATINI, Roberto ISTITUTO DI RICERCHE FARMACOLOGICHE "MARIO NEGRI" Dipartimento di Ricerca Cardiovascolare IRCCS Via La Masa, 19 20156 MILANO / IT
	04 / WIK, Lars ISTITUTO DI RICERCHE FARMACOLOGICHE "MARIO NEGRI" Dipartimento di Ricerca Cardiovascolare IRCCS Via La Masa, 19 20156 MILANO / IT
	[2018/07]
Representative(s)	Bianchetti & Minoja with Trevisan & Cuonzo IPS SRL Via Plinio, 63 20129 Milano / IT
	[N/P]
Former [2018/07]	Bianchetti Bracco Minoja S.r.l. Via Plinio, 63 20129 Milano / IT
Application number, filing date	16183930.3	12.08.2016
	[2018/07]
Filing language	EN
Procedural language	EN
Publication	Type:	A1 Application with search report
	No.:	EP3281632
	Date:	14.02.2018
	Language:	EN
	[2018/07]
Search report(s)	(Supplementary) European search report - dispatched on:	EP	31.01.2017
Classification	IPC:	A61K33/00, A61P9/10, A61P25/00	[2018/07]
	CPC:	A61K33/00 (EP); A61P25/00 (EP); A61P9/10 (EP)
Designated contracting states	AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LI, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR [2018/38]
Former [2018/07]	AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LI, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR
Extension states	BA	Not yet paid
	ME	Not yet paid
Validation states	MA	Not yet paid
	MD	Not yet paid
Title	German:	ARGON ZUR VERWENDUNG BEI DER VORBEUGUNG VON HERZ- UND HIRNVERLETZUNG INFOLGE VON ISCHÄMIE/REPERFUSION NACH EINEM HERZSTILLSTAND	[2018/07]
	English:	ARGON FOR USE IN THE PREVENTION OF BOTH CARDIAC AND CEREBRAL INJURY INDUCED BY ISCHEMIA/REPERFUSION FOLLOWING CARDIAC ARREST	[2018/07]
	French:	ARGON POUR UTILISATION DANS LA PRÉVENTION D'UNE LÉSION CARDIAQUE ET CÉRÉBRALE INDUITE PAR L'ISCHÉMIE/RÉPERFUSION APRÈS UN ARRÊT CARDIAQUE	[2018/07]
Examination procedure	12.08.2016	Date on which the examining division has become responsible
	08.08.2018	Amendment by applicant (claims and/or description)
	08.08.2018	Examination requested [2018/38]
	30.11.2018	Despatch of a communication from the examining division (Time limit: M06)
	27.03.2019	Observations by third parties
	27.05.2019	Reply to a communication from the examining division
	05.09.2019	Despatch of a communication from the examining division (Time limit: M08)
	14.05.2020	Reply to a communication from the examining division
	29.07.2020	Despatch of a communication from the examining division (Time limit: M04)
	09.12.2020	Application deemed to be withdrawn, date of legal effect [2021/20]
	14.01.2021	Despatch of communication that the application is deemed to be withdrawn, reason: reply to the communication from the examining division not received in time [2021/20]
Fees paid	Renewal fee
	08.08.2018	Renewal fee patent year 03
	07.08.2019	Renewal fee patent year 04
	04.08.2020	Renewal fee patent year 05
Opt-out from the exclusive Tooltip competence of the Unified Patent Court	See the Register of the Unified Patent Court for opt-out data
	Responsibility for the accuracy, completeness or quality of the data displayed under the link provided lies entirely with the Unified Patent Court.
Documents cited:	Search	[Y] - ANNE BRÜCKEN ET AL, "Dose dependent neuroprotection of the noble gas argon after cardiac arrest in rats is not mediated by KATP-Channel opening", RESUSCITATION., IE, (20140601), vol. 85, no. 6, doi:10.1016/j.resuscitation.2014.02.014, ISSN 0300-9572, pages 826 - 832, XP055330642 [Y] 1-8 Discussion DOI: http://dx.doi.org/10.1016/j.resuscitation.2014.02.014
		[Y] - PATRICK ZUERCHER ET AL, "A randomized trial of the effects of the noble gases helium and argon on neuroprotection in a rodent cardiac arrest model", BMC NEUROLOGY, (20160404), vol. 219, no. 1, doi:10.1186/s12883-016-0565-8, page 1, XP055330644 [Y] 1-8 Discussion DOI: http://dx.doi.org/10.1186/s12883-016-0565-8
		[Y] - A. BRUCKEN ET AL, "Argon reduces neurohistopathological damage and preserves functional recovery after cardiac arrest in rats", BRITISH JOURNAL OF ANAESTHESIA., GB, (20130207), vol. 110, no. suppl 1, doi:10.1093/bja/aes509, ISSN 0007-0912, pages i106 - i112, XP055330646 [Y] 1-8 Discussion DOI: http://dx.doi.org/10.1093/bja/aes509
		[I] - DEREK S NOWRANGI ET AL, "Argon gas: a potential neuroprotectant and promising medical therapy", MEDICAL GAS RESEARCH, London, UK, (20140101), vol. 4, no. 1, doi:10.1007/s00701-006-0770-0, ISSN 2045-9912, page 3, XP055330792 [I] 1-8 * abstract * * table 3 * DOI: http://dx.doi.org/10.1186/2045-9912-4-3
		[I] - ANKE HÖLLIG ET AL, "Argon: Systematic Review on Neuro- and Organoprotective Properties of an "Inert" Gas", INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, (20141010), vol. 15, no. 10, doi:10.3390/ijms151018175, pages 18175 - 18196, XP055330793 [I] 1-8 * the whole document * DOI: http://dx.doi.org/10.3390/ijms151018175
		[Y] - BRITTA MAYER ET AL, "Argon Induces Protective Effects in Cardiomyocytes during the Second Window of Preconditioning", INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, (20160719), vol. 17, no. 7, doi:10.3390/ijms17071159, page 1159, XP055330794 [Y] 1-8 * abstract * DOI: http://dx.doi.org/10.3390/ijms17071159
		[Y] - PAUL S. PAGEL ET AL, "Noble Gases Without Anesthetic Properties Protect Myocardium Against Infarction by Activating Prosurvival Signaling Kinases and Inhibiting Mitochondrial Permeability Transition In Vivo", ANESTHESIA AND ANALGESIA., US, (20070901), vol. 105, no. 3, doi:10.1213/01.ane.0000278083.31991.36, ISSN 0003-2999, pages 562 - 569, XP055330796 [Y] 1-8 * the whole document * DOI: http://dx.doi.org/10.1213/01.ane.0000278083.31991.36
		[Y] - BRÜCKEN ANNE ET AL, "Delayed Argon Administration Provides Robust Protection Against Cardiac Arrest-Induced Neurological Damage", NEUROCRITICAL CARE, SPRINGER, NEW YORK, vol. 22, no. 1, doi:10.1007/S12028-014-0029-1, ISSN 1541-6933, (20140801), pages 112 - 120, (20140801), XP035436058 [Y] 1-8 * abstract * DOI: http://dx.doi.org/10.1007/s12028-014-0029-1
		[Y] - LOETSCHER PHILIP D ET AL, "Argon: Neuroprotection in in vitro models of cerebral ischemia and traumatic brain injury", CRITICAL CARE, BIOMED CENTRAL LTD., LONDON, GB, (20091217), vol. 13, no. 6, ISSN 1364-8535, page R206, XP021070805 [Y] 1-8 * abstract *
		[Y] - BROAD KEVIN D ET AL, "Inhaled 45-50% argon augments hypothermic brain protection in a piglet model of perinatal asphyxia", NEUROBIOLOGY OF DISEASE, ELSEVIER, AMSTERDAM, NL, (20151210), vol. 87, doi:10.1016/J.NBD.2015.12.001, ISSN 0969-9961, pages 29 - 38, XP029391058 [Y] 1-8 * abstract * DOI: http://dx.doi.org/10.1016/j.nbd.2015.12.001
		[I] - MARK COBURN ET AL, "Argon", EUROPEAN JOURNAL OF ANAESTHESIOLOGY, (20121201), vol. 29, no. 12, doi:10.1097/EJA.0b013e328357bfdd, ISSN 0265-0215, pages 549 - 551, XP055124017 [I] 1-8 * the whole document * DOI: http://dx.doi.org/10.1097/EJA.0b013e328357bfdd
		[I] - RISTAGNO GIUSEPPE ET AL, Postresuscitation treatment with argon improves early neurological recovery in a porcine model of cardiac arrest., SHOCK (AUGUSTA, GA.) JAN 2014, VOL. 41, NR. 1, PAGE(S) 72 - 78, (201401), ISSN 1540-0514, XP002765419 [I] 1-8 * the whole document * DOI: http://dx.doi.org/10.1097/SHK.0000000000000049
	by applicant	- ADRIE C; ADIB-CONQUY M; LAURENT I ET AL., "Successful cardiopulmonary resuscitation after cardiac arrest as a ''sepsis-like'' syndrome", CIRCULATION, (2002), vol. 106, pages 562 - 8
		- "A randomized clinical study of thiopental loading in comatose survivors of cardiac arrest", N ENGL J MED, (1986), vol. 314, pages 397 - 403
		- BROAD KD; FIERENS I; FLEISS B ET AL., "Inhaled 45-50% argon augments hypothermic brain protection in a piglet model of perinatal asphyxia", NEUROBIOL DIS, (2016), vol. 87, doi:doi:10.1016/j.nbd.2015.12.001, pages 29 - 38, XP029391058 DOI: http://dx.doi.org/10.1016/j.nbd.2015.12.001
		- BRUCKEN A; CIZEN A; FERA C ET AL., "Argon reduces neurohistopathological damage and preserves functional recovery after cardiac arrest in rats", BR J ANAESTH, (2013), vol. 110, no. 1, pages I106 - 12
		- BRUCKEN A; KURNAZ P; BLEILEVENS C ET AL., "Dose dependent neuroprotection of the noble gas argon after cardiac arrest in rats is not mediated by K(ATP)-channel opening", RESUSCITATION, (2014), vol. 85, doi:doi:10.1016/j.resuscitation.2014.02.014, pages 826 - 32, XP055330642 DOI: http://dx.doi.org/10.1016/j.resuscitation.2014.02.014
		- BRUCKEN A; KURNAZ P; BLEILEVENS C ET AL., NEUROCRIT CARE, (2015), vol. 22, pages 112 - 20
		- COBURN M; SANDERS RD; FRIES M ET AL., "Argon: The «lazy» noble gas with organprotective properties", EUR J OF ANAESTHESIOLOGY, (2012), vol. 29, pages 549 - 51
		- DAVID HN; HAELEWYN B; DEGOULET M ET AL., "Ex vivo and in vivo neuroprotection induced by argon when given after an exitotoxic or ischemic insult", PLOS ONE, (2012), vol. 7, page E30934
		- FRIES M; BRUCKEN A; QIZEN A ET AL., "Combining xenon and mild therapeutic hypothermia preserves neurological function after prolonged cardiac arrest in pigs", CRIT CARE MED, (2012), vol. 40, pages 1297 - 1303
		- FRIES M; NOLTE KW; COBURN M ET AL., "Xenon reduces neurohistopathological damage and improves the early neurological deficit after cardiac arrest in pigs", CRIT CARE MED, (2008), vol. 36, pages 2420 - 6
		- JAWAD N; RIZVI M; GU J ET AL., "Neuroprotection (and lack of neuroprotection) afforded by a series of noble gases in an in vitro model of neuronal injury", NEUROSCI LETT, (2009), vol. 460, doi:doi:10.1016/j.neulet.2009.05.069, pages 232 - 6, XP026219307 DOI: http://dx.doi.org/10.1016/j.neulet.2009.05.069
		- LAURENT I; MONCHI M; CHICHE JD ET AL., "Reversible myocardial dysfunction in survivors of out-of-hospital cardiac arrest.", J AM COLL CARDIOL, (2002), vol. 40, pages 2110 - 6
		- LIPPERT FK; RAFFAY V; GEORGIOU M ET AL., "European Resuscitation Council Guidelines for Resuscitation 2010 Section 10. The ethics of resuscitation and end-of-life decisions", RESUSCITATION, (2010), vol. 81, doi:doi:10.1016/j.resuscitation.2010.08.013, pages 1445 - 51, XP027437690 DOI: http://dx.doi.org/10.1016/j.resuscitation.2010.08.013
		- LOETSCHER PD; ROSSAINT J; ROSSAINT R ET AL., "Argon: neuroprotection in in vitro models of cerebral ischemia and traumatic brain injury", CRIT CARE, (2009), vol. 13, page R206, XP021070805
		- NOLAN JP; NEUMAR RW; ADRIE C ET AL., "Post-cardiac arrest syndrome: Epidemiology, pathophysiology, treatment, and prognostication A Scientific Statement from the International Liaison Committee on Resuscitation", RESUSCITATION, (2008), vol. 79, pages 350 - 79
		- OLASVEENGEN TM; LUND-KORDAHL I; STEEN PA ET AL., "Out-of hospital advanced life support with or without a physician: effects on quality of CPR and outcome", RESUSCITATION, (2009), vol. 80, doi:doi:10.1016/j.resuscitation.2009.07.018, pages 1248 - 52, XP026700818 DOI: http://dx.doi.org/10.1016/j.resuscitation.2009.07.018
		- PAGEL PS; KROLIKOWSKI JG; SHIM YH ET AL., "Noble gases without anesthetic properties protect myocardium against infarction by activating pro survival signalling kinases and inhibiting mitochondrial permability transition in vivo", ANEST ANALG, (2007), vol. 105, pages 562 - 9
		- PEBERDY MA; CALLAWAY CW; NEUMAR RW ET AL., "Part 9: post-cardiac arrest care: 2010 American Heart Association guidelines for cardiopulmonary resuscitation and emergency cardiovascular care", CIRCULATION, (2010), vol. 122, pages 768 - 86
		- RISTAGNO G; FUMAGALLI F; RUSSO I ET AL., "Postresuscitation treatment with argon improves early neurological recovery in a porcine model of cardiac arrest", SHOCK, (2014), vol. 41, doi:doi:10.1097/SHK.0000000000000049, pages 72 - 8, XP002765419 DOI: http://dx.doi.org/10.1097/SHK.0000000000000049
		- RISTAGNO G; LATINI R; VAAHERSALO J ET AL., "Early activation of the kynurenine pathway predicts early death and long-term outcome in patients resuscitated from out-of-hospital cardiac arrest", J AM HEART ASSOC, (2014), vol. 3, no. 4
		- RYANG YM; FAHLENKAMP AV; ROSSAINT R ET AL., "Neuroprotective effects of argon in an in vivo model of transient cerebral artery occlusion in rats", CRIT CARE MED, (2011), vol. 39, doi:doi:10.1097/CCM.0b013e31821209be, pages 1448 - 53, XP009169625 DOI: http://dx.doi.org/10.1097/CCM.0b013e31821209be
		- SANDRONI C; CAVALLARO F; CALLAWAY CW ET AL., "Predictors of poor neurological outcome in adult comatose survivors of cardiac arrest: A systematic review and meta-analysis. Part 1: Patients not treated with therapeutic hypothermia", RESUSCITATION, (2013), vol. 84, pages 1310 - 23
		- SANDRONI C; CAVALLARO F; CALLAWAY CW ET AL., "Predictors of poor neurological outcome in adult comatose survivors of cardiac arrest: A systematic review and meta-analysis. Part 2: Patients treated with therapeutic hypothermia", RESUSCITATION, (2013), vol. 84, pages 1324 - 38
		- YARIN YM; AMARJARGAL N; FUCHS J ET AL., "Argon protects hypoxia-, cisplatin- and gentamycin-exposed hair cells in the newborn rat's organ of corti", HEAR RES, (2005), vol. 210, doi:doi:10.1016/j.heares.2004.09.015, pages 1 - 9, XP025268367 DOI: http://dx.doi.org/10.1016/j.heares.2004.09.015
		- ZHUANG L; YANG T; ZHAO H ET AL., "The protective profile of argon, helium, and xenon in a model of neonatal asphyxia in rats", CRIT CARE MED, (2012), vol. 40, doi:doi:10.1097/CCM.0b013e3182452164, pages 1724 - 1730, XP009169571 DOI: http://dx.doi.org/10.1097/CCM.0b013e3182452164

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