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Extract from the Register of European Patents

EP About this file: EP3173489

EP3173489 - ASSESSMENT OF CELLULAR SIGNALING PATHWAY ACTIVITY USING PROBABILISTIC MODELING OF TARGET GENE EXPRESSION [Right-click to bookmark this link]
StatusNo opposition filed within time limit
Status updated on  26.07.2019
Database last updated on 21.03.2026
FormerThe patent has been granted
Status updated on  17.08.2018
FormerGrant of patent is intended
Status updated on  01.03.2018
FormerRequest for examination was made
Status updated on  08.12.2017
FormerThe application has been published
Status updated on  28.04.2017
Most recent event   Tooltip08.07.2022Lapse of the patent in a contracting state
New state(s): MK		published on 10.08.2022  [2022/32]
Applicant(s)For all designated states
Koninklijke Philips N.V.
High Tech Campus 5
5656 AE Eindhoven / NL
[2017/22]
Inventor(s)01 / VERHAEGH, Wilhelmus, Franciscus, Johannes
Philips IP&S
Philips International B.V. Intellectual
Property & Standards High Tech Campus 5
5656 AE Eindhoven / NL
02 / VAN DE STOLPE, Anja
Philips IP&S
Philips International B.V. Intellectual
Property & Standards High Tech Campus 5
5656 AE Eindhoven / NL
03 / VAN OOIJEN, Hendrik Jan
Philips IP&S
Philips International B.V. Intellectual
Property & Standards High Tech Campus 5
5656 AE Eindhoven / NL
04 / DULLA, Kalyana, Chakravarthi
Philips IP&S
Philips International B.V. Intellectual
Property & Standards High Tech Campus 5
5656 AE Eindhoven / NL
05 / ALVES DE INDA, Marcia
Philips IP&S
Philips International B.V. Intellectual
Property & Standards High Tech Campus 5
5656 AE Eindhoven / NL
06 / HOFFMANN, Ralf
Philips IP&S
Philips International B.V. Intellectual
Property & Standards High Tech Campus 5
5656 AE Eindhoven / NL
 [2017/22]
Representative(s)Kroeze, Johannes Antonius
Philips Intellectual Property & Standards
High Tech Campus 5
5656 AE Eindhoven / NL
[2017/22]
Application number, filing date16192584.719.07.2012
[2017/22]
Priority number, dateUS201161509137P19.07.2011         Original published format: US 201161509137 P
EP2011017814819.08.2011         Original published format: EP 11178148
[2017/22]
Filing languageEN
Procedural languageEN
PublicationType: A1 Application with search report 
No.:EP3173489
Date:31.05.2017
Language:EN
[2017/22]
Type: B1 Patent specification 
No.:EP3173489
Date:19.09.2018
Language:EN
[2018/38]
Search report(s)(Supplementary) European search report - dispatched on:EP09.02.2017
ClassificationIPC:C12Q1/68, G06F19/24
[2017/22]
CPC:
G16B5/00 (EP,CN,RU,US); G16B5/20 (EP,CN,RU,US); C12Q1/6809 (EP,CN,US);
C12Q1/68 (RU); C12Q1/6886 (EP,CN,US); G06N5/048 (RU);
G16B20/00 (EP,RU,US); G16B20/20 (EP,CN,RU,US); G16B20/30 (EP,CN,RU,US);
G16B25/00 (EP,CN,RU,US); G16B40/00 (EP,CN,US); G16B40/20 (EP,CN,RU,US);
C12Q2600/106 (EP,CN,US); C12Q2600/112 (CN); C12Q2600/158 (EP,CN,US) (-)
C-Set:
C12Q1/6809, C12Q2537/165 (CN,EP,US)
Designated contracting statesAL,   AT,   BE,   BG,   CH,   CY,   CZ,   DE,   DK,   EE,   ES,   FI,   FR,   GB,   GR,   HR,   HU,   IE,   IS,   IT,   LI,   LT,   LU,   LV,   MC,   MK,   MT,   NL,   NO,   PL,   PT,   RO,   RS,   SE,   SI,   SK,   SM,   TR [2018/02]
Former [2017/22]AL,  AT,  BE,  BG,  CH,  CY,  CZ,  DE,  DK,  EE,  ES,  FI,  FR,  GB,  GR,  HR,  HU,  IE,  IS,  IT,  LI,  LT,  LU,  LV,  MC,  MK,  MT,  NL,  NO,  PL,  PT,  RO,  RS,  SE,  SI,  SK,  SM,  TR 
TitleGerman:BEURTEILUNG DER AKTIVITÄT EINES ZELLULÄREN SIGNALISIERUNGSPFADES UNTER VERWENDUNG DER PROBABILISTISCHEN MODELLIERUNG EINER ZIELGENEXPRESSION[2017/22]
English:ASSESSMENT OF CELLULAR SIGNALING PATHWAY ACTIVITY USING PROBABILISTIC MODELING OF TARGET GENE EXPRESSION[2017/22]
French:ÉVALUATION DE L'ACTIVITÉ DE LA VOIE DE SIGNALISATION CELLULAIRE UTILISANT UNE MODÉLISATION PROBABILISTE DE L'EXPRESSION DU GÈNE CIBLE[2017/22]
Examination procedure06.10.2016Date on which the examining division has become responsible
27.11.2017Amendment by applicant (claims and/or description)
30.11.2017Examination requested  [2018/02]
02.03.2018Communication of intention to grant the patent
29.06.2018Fee for grant paid
29.06.2018Fee for publishing/printing paid
29.06.2018Receipt of the translation of the claim(s)
Parent application(s)   TooltipEP12751371.1  / EP2734643
Divisional application(s)EP18180343.8  / EP3418396
EP20209212.8  / EP3831957
EP22177533.1  / EP4130291
Opposition(s)20.06.2019No opposition filed within time limit [2019/35]
Fees paidRenewal fee
06.02.2017Renewal fee patent year 03
06.02.2017Renewal fee patent year 04
06.02.2017Renewal fee patent year 05
31.07.2017Renewal fee patent year 06
31.07.2018Renewal fee patent year 07
Opt-out from the exclusive  Tooltip
competence of the Unified
Patent Court		 See the Register of the Unified Patent Court for opt-out data
Responsibility for the accuracy, completeness or quality of the data displayed under the link provided lies entirely with the Unified Patent Court.
Lapses during opposition  TooltipHU19.07.2012
AL19.09.2018
AT19.09.2018
CY19.09.2018
CZ19.09.2018
EE19.09.2018
FI19.09.2018
HR19.09.2018
LT19.09.2018
LV19.09.2018
MC19.09.2018
MK19.09.2018
MT19.09.2018
PL19.09.2018
RO19.09.2018
RS19.09.2018
SI19.09.2018
SK19.09.2018
SM19.09.2018
TR19.09.2018
BG19.12.2018
NO19.12.2018
GR20.12.2018
IS19.01.2019
PT19.01.2019
[2022/32]
Former [2021/34]HU19.07.2012
AL19.09.2018
AT19.09.2018
CY19.09.2018
CZ19.09.2018
EE19.09.2018
FI19.09.2018
HR19.09.2018
LT19.09.2018
LV19.09.2018
MC19.09.2018
MT19.09.2018
PL19.09.2018
RO19.09.2018
RS19.09.2018
SI19.09.2018
SK19.09.2018
SM19.09.2018
TR19.09.2018
BG19.12.2018
NO19.12.2018
GR20.12.2018
IS19.01.2019
PT19.01.2019
Former [2021/32]HU19.07.2012
AL19.09.2018
AT19.09.2018
CY19.09.2018
CZ19.09.2018
EE19.09.2018
FI19.09.2018
HR19.09.2018
LT19.09.2018
LV19.09.2018
MC19.09.2018
PL19.09.2018
RO19.09.2018
RS19.09.2018
SI19.09.2018
SK19.09.2018
SM19.09.2018
TR19.09.2018
BG19.12.2018
NO19.12.2018
GR20.12.2018
IS19.01.2019
PT19.01.2019
Former [2021/26]AL19.09.2018
AT19.09.2018
CY19.09.2018
CZ19.09.2018
EE19.09.2018
FI19.09.2018
HR19.09.2018
LT19.09.2018
LV19.09.2018
MC19.09.2018
PL19.09.2018
RO19.09.2018
RS19.09.2018
SI19.09.2018
SK19.09.2018
SM19.09.2018
TR19.09.2018
BG19.12.2018
NO19.12.2018
GR20.12.2018
IS19.01.2019
PT19.01.2019
Former [2020/17]AL19.09.2018
AT19.09.2018
CZ19.09.2018
EE19.09.2018
FI19.09.2018
HR19.09.2018
LT19.09.2018
LV19.09.2018
MC19.09.2018
PL19.09.2018
RO19.09.2018
RS19.09.2018
SI19.09.2018
SK19.09.2018
SM19.09.2018
TR19.09.2018
BG19.12.2018
NO19.12.2018
GR20.12.2018
IS19.01.2019
PT19.01.2019
Former [2020/14]AL19.09.2018
AT19.09.2018
CZ19.09.2018
EE19.09.2018
FI19.09.2018
HR19.09.2018
LT19.09.2018
LV19.09.2018
MC19.09.2018
PL19.09.2018
RO19.09.2018
RS19.09.2018
SI19.09.2018
SK19.09.2018
SM19.09.2018
BG19.12.2018
NO19.12.2018
GR20.12.2018
IS19.01.2019
PT19.01.2019
Former [2019/50]AL19.09.2018
AT19.09.2018
CZ19.09.2018
EE19.09.2018
FI19.09.2018
HR19.09.2018
LT19.09.2018
LV19.09.2018
PL19.09.2018
RO19.09.2018
RS19.09.2018
SI19.09.2018
SK19.09.2018
SM19.09.2018
BG19.12.2018
NO19.12.2018
GR20.12.2018
IS19.01.2019
PT19.01.2019
Former [2019/26]AL19.09.2018
AT19.09.2018
CZ19.09.2018
EE19.09.2018
FI19.09.2018
HR19.09.2018
LT19.09.2018
LV19.09.2018
PL19.09.2018
RO19.09.2018
RS19.09.2018
SK19.09.2018
SM19.09.2018
BG19.12.2018
NO19.12.2018
GR20.12.2018
IS19.01.2019
PT19.01.2019
Former [2019/23]AL19.09.2018
AT19.09.2018
CZ19.09.2018
EE19.09.2018
FI19.09.2018
HR19.09.2018
LT19.09.2018
LV19.09.2018
PL19.09.2018
RO19.09.2018
RS19.09.2018
SK19.09.2018
BG19.12.2018
NO19.12.2018
GR20.12.2018
IS19.01.2019
Former [2019/22]AL19.09.2018
CZ19.09.2018
FI19.09.2018
HR19.09.2018
LT19.09.2018
LV19.09.2018
PL19.09.2018
RO19.09.2018
RS19.09.2018
BG19.12.2018
NO19.12.2018
GR20.12.2018
IS19.01.2019
Former [2019/21]AL19.09.2018
FI19.09.2018
HR19.09.2018
LT19.09.2018
LV19.09.2018
RS19.09.2018
BG19.12.2018
NO19.12.2018
GR20.12.2018
IS19.01.2019
Former [2019/12]AL19.09.2018
FI19.09.2018
HR19.09.2018
LT19.09.2018
LV19.09.2018
RS19.09.2018
BG19.12.2018
NO19.12.2018
GR20.12.2018
Former [2019/11]FI19.09.2018
HR19.09.2018
LT19.09.2018
RS19.09.2018
BG19.12.2018
NO19.12.2018
GR20.12.2018
Former [2019/08]FI19.09.2018
LT19.09.2018
NO19.12.2018
Former [2019/07]LT19.09.2018
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DOI:   http://dx.doi.org/10.1158/0008-5472.CAN-09-1709
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DOI:   http://dx.doi.org/10.1038/NRD2154
 [A]   L ADAMS ET AL: "Multi-comparative systems biology analysis reveals time-course biosignatures of in vivo bovine pathway responses to B.melitensis, S.enterica Typhimurium and M.avium paratuberculosis", BMC PROCEEDINGS, vol. 5, no. Suppl 4, 1 January 2011 (2011-01-01), pages S6, XP055018507, ISSN: 1753-6561, DOI: 10.1186/1753-6561-5-S4-S6

DOI:   http://dx.doi.org/10.1186/1753-6561-5-S4-S6
 [A]   H. A KESTLER ET AL: "From individual Wnt pathways towards a Wnt signalling network", PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B: BIOLOGICAL SCIENCES, vol. 363, no. 1495, 12 April 2008 (2008-04-12), pages 1333 - 1347, XP055018513, ISSN: 0962-8436, DOI: 10.1098/rstb.2007.2251

DOI:   http://dx.doi.org/10.1098/rstb.2007.2251
 [A]   SU JUNJIE ET AL: "Accurate and reliable cancer classification based on probabilistic inference of pathway activity.", PLOS ONE, vol. 4, no. 12, E8161, December 2009 (2009-12-01), pages 1 - 10, XP002684530, ISSN: 1932-6203

DOI:   http://dx.doi.org/10.1371/journal.pone.0008161
 [A]   ROGERS SIMON ET AL: "Bayesian model-based inference of transcription factor activity", BMC BIOINFORMATICS, BIOMED CENTRAL, LONDON, GB, vol. 8, no. Suppl 2, 3 May 2007 (2007-05-03), pages S2, XP021021916, ISSN: 1471-2105, DOI: 10.1186/1471-2105-8-S2-S2

DOI:   http://dx.doi.org/10.1186/1471-2105-8-S2-S2
 [X]   NIIDA ATSUSHI ET AL: "Integrative bioinformatics analysis of transcriptional regulatory programs in breast cancer cells", BMC BIOINFORMATICS, BIOMED CENTRAL, LONDON, GB, vol. 9, no. 1, 29 September 2008 (2008-09-29), pages 404, XP021041796, ISSN: 1471-2105, DOI: 10.1186/1471-2105-9-404 [X] 16-18 * abstract * * page 9126, column 2 * * page 9129, column 2, paragraphs 2-3 * * page 9131, column 1, paragraph 2 - column 2, paragraph 2 *

DOI:   http://dx.doi.org/10.1186/1471-2105-9-404
 [A]   MARIA STELLA CARRO ET AL: "The transcriptional network for mesenchymal transformation of brain tumours", NATURE, vol. 463, no. 7279, 21 January 2010 (2010-01-21), pages 318 - 325, XP055032072, ISSN: 0028-0836, DOI: 10.1038/nature08712 [A] 1-18 * abstract * * page 997, column 1, paragraph 1 *

DOI:   http://dx.doi.org/10.1038/nature08712
 [A]   WEI KEAT LIM ET AL: "Master regulators used as breast cancer metastasis classifier", PAC SYMP BIOCOMPUT. 2009, 1 January 2009 (2009-01-01), pages 504 - 515, XP055078924, Retrieved from the Internet [retrieved on 20130912], DOI: 10.1142/9789812836939_0048 [A] 1-18 * abstract * * pages 2,4; figure 1; table 2 *

DOI:   http://dx.doi.org/10.1142/9789812836939_0048
 [A]   C. J. VASKE ET AL: "Inference of patient-specific pathway activities from multi-dimensional cancer genomics data using PARADIGM", BIOINFORMATICS, vol. 26, no. 12, 15 June 2010 (2010-06-15), pages i237 - i245, XP055039050, ISSN: 1367-4803, DOI: 10.1093/bioinformatics/btq182 [A] 1-18 * abstract * * page 1341, column 1, paragraph 2 *

DOI:   http://dx.doi.org/10.1093/bioinformatics/btq182
 [A]   NEIL D LAWRENCE: "Modelling transcriptional regulation using Gaussian Processes.", CONFERENCE PAPER IN ADVANCES IN NEURAL INFORMATION PROCESSING SYSTEMS, 1 December 2006 (2006-12-01), XP055340116, Retrieved from the Internet [retrieved on 20170130] [A] 1-18 * abstract * * page 2, column 1, paragraph 4 - column 2, paragraph 2 *
 [A]   W. VERHAEGH ET AL: "Selection of Personalized Patient Therapy through the Use of Knowledge-Based Computational Models That Identify Tumor-Driving Signal Transduction Pathways", CANCER RESEARCH, vol. 74, no. 11, 1 June 2014 (2014-06-01), pages 2936 - 2945, XP055212377, ISSN: 0008-5472, DOI: 10.1158/0008-5472.CAN-13-2515 [A] 1-18

DOI:   http://dx.doi.org/10.1158/0008-5472.CAN-13-2515
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   NUSSE, R., WNT TARGET GENES, 1 May 2012 (2012-05-01), Retrieved from the Internet
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DOI:   http://dx.doi.org/10.1038/NMETH947
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DOI:   http://dx.doi.org/10.1016/S0092-8674(02)01014-0
The EPO accepts no responsibility for the accuracy of data originating from other authorities; in particular, it does not guarantee that it is complete, up to date or fit for specific purposes.