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Extract from the Register of European Patents

EP Citations: EP3167888

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Type:Patent literature
Publication No.:US2005191298  [X]
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Type:Non-patent literature
Publication information:[X]   HILLMEN P ET AL: "Eculizumab, a C5 complement blocking antibody, is the first therapy to reduce transfusion requirements in patients with paroxysmal nocturnal haemoglobinuria (PNH)", BRITISH JOURNAL OF HAEMATOLOGY, WILEY-BLACKWELL PUBLISHING LTD, GB, vol. 121, no. Suppl.1, 1 May 2003 (2003-05-01), pages 87, XP009144758, ISSN: 0007-1048
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Publication information:[DX]   HILLMEN P ET AL: "EFFECT OF ECULIZUMAB ON HEMOLYSIS AND TRANSFUSION REQUIREMENTS IN PATIENTS WITH PAROXYSMAL NOCTRURNAL HEMAGLOBINURIA", NEW ENGLAND JOURNAL OF MEDICINE, MASSACHUSETTS MEDICAL SOCIETY, BOSTON, MA, US, vol. 350, no. 6, 5 February 2004 (2004-02-05), pages 552 - 559, XP009057948, ISSN: 1533-4406, DOI: 10.1056/NEJMOA031688
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Publication information:[X]   HARDING J: "Eculizumab", DRUGS OF THE FUTURE, PROUS SCIENCE, ES, vol. 29, no. 7, 1 July 2004 (2004-07-01), pages 673 - 676, XP008113000, ISSN: 0377-8282, DOI: 10.1358/DOF.2004.029.07.819330
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Publication information:[X]   HILL ANITA: "Eculizumab for the treatment of paroxysmal nocturnal hemoglobinuria", CLINICAL ADVANCES IN HEMATOLOGY & ONCOLOGY, MILLENNIUM MEDICAL PUB., NEW YORK, NY, US, vol. 3, no. 11, 1 November 2005 (2005-11-01), pages 849 - 850, XP001538426, ISSN: 1543-0790
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Publication information:[X]   DATABASE REGISTRY [online] CHEMICAL ABSTRACTS SERVICE, COLUMBUS, OHIO, US; 14 February 1999 (1999-02-14), XP002767828, retrieved from STN accession no. 219685-50-4 Database accession no. 219685-50-4
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Publication information:  THOMAS T C ET AL: "Inhibition of complement activity by humanized anti-C5 antibody and single-chain Fv", MOLECULAR IMMUNOLOGY, PERGAMON, GB, vol. 33, no. 17-18, 1 January 1996 (1996-01-01), pages 1389 - 1401, XP002262113, ISSN: 0161-5890, DOI: 10.1016/S0161-5890(96)00078-8
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Type:Patent literature
Publication No.:US2003232972  
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Publication No.:US6355245  
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Publication No.:US2005191298  
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Publication information:  D01: The Final Order of the Hamburg Local Division of June 26, 2024 in case UPC_CFI_124/2024, ORD_38032/2024
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Publication information:  D02: Overview over claims sought by Alexion and discussed in TBA decisions
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Publication information:  D03: INN Publication for eculizumab
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Publication information:  D04: Decision of the CoA of the UPC dated December 20, 2024
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Publication information:  D05: Proprietors submissions in relation to EP 1 720 571
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Publication information:  D06: Proprietors submission of 2 August 2011 in relation to US 11/127,438
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Publication information:  D07: Proprietors Submission at the EPO of 15 November 2012
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Publication information:  CHEN H, KIM J, KENDALL D A: "Competition between functional signal peptides demonstrates variation in affinity for the secretion pathway", JOURNAL OF BACTERIOLOGY, AMERICAN SOCIETY FOR MICROBIOLOGY, US, vol. 178, no. 23, 1 December 1996 (1996-12-01), US , pages 6658 - 6664, XP093260223, ISSN: 0021-9193, DOI: 10.1128/jb.178.23.6658-6664.1996
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Publication information:  CROMWELL MARY E M , HILARIO E, JACOBSON F: "Protein aggregation and bioprocessing.", AAPS JOURNAL, AMERICAN ASSOCIATION OF PHARMACEUTICAL SCIENTISTS, US, vol. 8, no. 3, 1 September 2006 (2006-09-01), US , pages E572 - E579, XP002557046, ISSN: 1550-7416, DOI: 10.1208/aapsj080366
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Publication information:  WANG, W.: "Protein aggregation and its inhibition in biopharmaceutics", INTERNATIONAL JOURNAL OF PHARMACEUTICS, ELSEVIER, AMSTERDAM, NL, vol. 289, no. 1-2, 31 January 2005 (2005-01-31), AMSTERDAM, NL, pages 1 - 30, XP004706998, ISSN: 0378-5173, DOI: 10.1016/j.ijpharm.2004.11.014
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Publication information:  ANONYMOUS: "GUIDELINE ON IMMUNOGENICITY ASSESSMENT OF BIOTECHNOLOGY-DERIVED THERAPEUTIC PROTEINS ", EMEA, COMMITTEE FOR MEDICINAL PRODUCTS FOR HUMAN USE (CHMP), 1 December 2007 (2007-12-01), pages 1 - 18, XP093260233
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Publication information:  ALLEN DEBORAH: "PROPERTIES AND BIOLOGICAL ACTIVITIES* OF CLASSES AND SUBCLASSES OF HUMAN SERUM IMMUNOGLOBULINS", IMMUNOLOGY, THIRD EDITION, 1 January 1997 (1997-01-01), pages 125, XP093260238
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Publication information:  FRANK MICHAEL M, MILETIC VOJISLAV D, JIANG HAIXIANG: "Immunoglobulin in the Control of Complement Action", IMMUNOLOGIC RESEARCH, vol. 22, no. 2, 1 January 2000 (2000-01-01), pages 137 - 146, XP093260241
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Publication information:  THOMAS THOMAS C. ET AL: "Inhibition of complement activity by humanized anti-C5 antibody and single-chain Fv", MOLECULAR IMMUNOLOGY, PERGAMON, GB, vol. 33, no. 17-18, 1 December 1996 (1996-12-01), GB , pages 1389 - 1401, XP093260245, ISSN: 0161-5890, DOI: 10.1016/S0161-5890(96)00078-8
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Publication information:  MUELLER J.P. ET AL: "Humanized porcine VCAM-specific monoclonal antibidies with chimeric igG2/G4 constant regions block human leukocyte binding to porcine endothelial cells.", MOLECULAR IMMUNOLOGY, PERGAMON, GB, vol. 34, no. 6, 1 January 1997 (1997-01-01), GB , pages 441 - 452, XP002988985, ISSN: 0161-5890, DOI: 10.1016/S0161-5890(97)00042-4
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Publication information:  HARDING J: "Eculizumab", DRUGS OF THE FUTURE, PROUS SCIENCE, ES, vol. 29, no. 7, 1 July 2004 (2004-07-01), ES , pages 673 - 676, XP008113000, ISSN: 0377-8282, DOI: 10.1358/dof.2004.029.07.819330
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Publication information:  RUSSO NOONAN: "Alexion Pharmaceuticals Reports Positive Phase III Results for Eculizumab From Pivotal TRIUMPH Efficacy Trial in Paroxysmal Nocturnal Hemoglobinuria Patients", PRESS RELEASE, 26 January 2006 (2006-01-26), pages 1 - 4, XP093260307
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Publication information:  ANONYMOUS: "ALEXION Completes Enrollment in Phase II Membranous Nephritis Clinical Trial with 5G1.1", PRESS RELEASE, 20 February 2002 (2002-02-20), pages 1 - 2, XP093260315
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Publication information:  TACKEN PAUL J ET AL: "Effective induction of naive and recall T-cell responses by targeting antigen to human dendritic cells via a humanized anti-DC-SIGN antibody.", BLOOD, W.B. SAUNDERS, AMSTERDAM, NL, vol. 106, no. 4, 15 August 2005 (2005-08-15), AMSTERDAM, NL, pages 1278 - 1285, XP002449006, ISSN: 0006-4971, DOI: 10.1182/blood-2005-01-0318
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Publication information:  PRESTA, L.G.: "Engineering of therapeutic antibodies to minimize immunogenicity and optimize function", ADVANCED DRUG DELIVERY REVIEWS, ELSEVIER, AMSTERDAM , NL, vol. 58, no. 5-6, 7 August 2006 (2006-08-07), Amsterdam , NL , pages 640 - 656, XP005611419, ISSN: 0169-409X, DOI: 10.1016/j.addr.2006.01.026
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Publication information:  D23: Sequence alignment with D11 and D12
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Publication information:  D26: Grounds for the decision to refuse the patent application, dated February 11, 2020
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Publication information:  D27: T 1515/20
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Publication information:  D28: Final Order UPC LD Hamburg (UPC_CFI_123/2004)
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Publication information:  D29: Final Order UPC Court of Appeal (UPC_CFI_123/2004)
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Publication information:  D30: Final Order UPC Court of Appeal (UPC_CFI_124/2004)
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Publication information:  D31: Case Law of the BoA, 10th edition, p. 122 124; I.C.4.2
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Publication information:  D32: T 0153/85
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Publication information:  D33: CAS Database Registry for Eculizumab (RN 219685-50-4, 14 February 1999)
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Publication information:  HILLMEN P C ET AL: "Eculizumab, a C5 complement blocking antibody, is the first therapy to reduce transfusion requirements in patients with paroxysmal nocturnal haemoglobinuria (PNH)", BRITISH JOURNAL OF HAEMATOLOG, BLACKWELL PUBLISHING, vol. 121, no. Suppl. 1, 1 January 2003 (2003-01-01), pages 87 - 95, XP093260326
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Publication information:  HILLMEN P, ET AL.: "EFFECT OF ECULIZUMAB ON HEMOLYSIS AND TRANSFUSION REQUIREMENTS IN PATIENTS WITH PAROXYSMAL NOCTRURNAL HEMAGLOBINURIA", NEW ENGLAND JOURNAL OF MEDICINE, THE - NEJM, MASSACHUSETTS MEDICAL SOCIETY, US, vol. 350, no. 06, 5 February 2004 (2004-02-05), US , pages 552 - 559, XP009057948, ISSN: 1533-4406, DOI: 10.1056/NEJMoa031688
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Type:Non-patent literature
Publication information:  HILL ANITA: "Eculizumab for the treatment of paroxysmal nocturnal hemoglobinuria.", CLINICAL ADVANCES IN HEMATOLOGY & ONCOLOGY, MILLENIUM MEDICAL PUB , NEW YORK , NY, US, vol. 3, no. 11, 1 November 2005 (2005-11-01), US , pages 849 - 850, XP001538426, ISSN: 1543-0790
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Publication information:  MARINA NORIS, FEDERICA MESCIA, GIUSEPPE REMUZZI: "STEC-HUS, atypical HUS and TTP are all diseases of complement activation", NATURE REVIEWS. NEPHROLOGY, NATURE PUBLISHING GROUP, GB, vol. 8, no. 11, GB , pages 622 - 633, XP055259427, ISSN: 1759-5061, DOI: 10.1038/nrneph.2012.195
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Publication information:  TAKAHIKO HORIUCHI, TSUKAMOTO HIROSHI: "Complement-targeted therapy: development of C5- and C5a-targeted inhibition", INFLAMMATION AND REGENERATION, vol. 36, no. 1, 1 December 2016 (2016-12-01), pages 1 - 5, XP055644542, DOI: 10.1186/s41232-016-0013-6
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Publication information:  HAMILTON RG, ABMLI D, MOHAN CHANDRA: "Human IgG subclass measurements in the clinical laboratory", CLINICAL CHEMISTRY, OXFORD UNIVERSITY PRESS, US, vol. 33, no. 10, 1 October 1987 (1987-10-01), US , pages 1707 - 1725, XP093260502, ISSN: 0009-9147, DOI: 10.1093/clinchem/33.10.1707
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Publication information:  DAUGHERTY, A.L. MRSNY, R.J.: "Formulation and delivery issues for monoclonal antibody therapeutics", ADVANCED DRUG DELIVERY REVIEWS, ELSEVIER, AMSTERDAM , NL, vol. 58, no. 5-6, 7 August 2006 (2006-08-07), Amsterdam , NL , pages 686 - 706, XP005611422, ISSN: 0169-409X, DOI: 10.1016/j.addr.2006.03.011
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Publication information:  WANG W; SINGH S; ZENG D L; KING K; NEMA S: "ANTIBODY STRUCTURE, INSTABILITY, AND FORMULATION", JOURNAL OF PHARMACEUTICAL SCIENCES, ELSEVIER INC, HOBOKEN, vol. 96, no. 1, 1 January 2007 (2007-01-01), Hoboken, pages 1 - 26, XP009084505, ISSN: 0022-3549, DOI: 10.1002/jps.20727
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Publication information:  PAUL R HINTON, JOANNA M XOING, MARY G JOHLFS, ET AL: "An engineered human IgG1 antibody with longer serum half-life.", JOURNAL OF IMMUNOLOGY, WILLIAMS & WILKINS, vol. 176, no. 1, 1 January 2006 (2006-01-01), pages 346 - 356, XP002484005, ISSN: 0022-1767, DOI: 10.4049/jimmunol.176.1.346
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Publication information:  FEINSTEIN, A. ; RICHARDSON, N. ; TAUSSIG, M.I.: "Immunoglobulin flexibility in complement activation", IMMUNOLOGY TODAY, ELSEVIER PUBLICATIONS, CAMBRIDGE., GB, vol. 7, no. 6, 1 June 1986 (1986-06-01), GB , pages 169 - 174, XP023943155, ISSN: 0167-5699, DOI: 10.1016/0167-5699(86)90168-4
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Publication information:  D47: Application US 08/487283
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Publication information:  KAPLAN MARIANA: "Eculizumab (Alexion).", CURRENT OPINION IN INVESTIGATIONAL DRUGS, PHARMAPRESS, US, vol. 3, no. 7, 1 July 2002 (2002-07-01), US , pages 1017 - 1023, XP009506295, ISSN: 1472-4472
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Publication information:  D50: EP 11 001 632.6 Decision revoking the European patent
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Publication information:  GOGESCH PATRICIA ET AL: "The Role of Fc Receptors on the Effectiveness of Therapeutic Monoclonal Antibodies", INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, vol. 22, no. 16, pages 8947, XP093069323, DOI: 10.3390/ijms22168947
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