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Extract from the Register of European Patents

EP About this file: EP3328410

EP3328410 - METHOD FOR INCREASING THE GLUTATHIONE LEVEL IN CELLS [Right-click to bookmark this link]
StatusNo opposition filed within time limit
Status updated on  30.07.2021
Database last updated on 02.11.2024
FormerThe patent has been granted
Status updated on  21.08.2020
FormerGrant of patent is intended
Status updated on  16.04.2020
FormerExamination is in progress
Status updated on  03.05.2019
FormerRequest for examination was made
Status updated on  04.05.2018
FormerThe international publication has been made
Status updated on  03.02.2017
Most recent event   Tooltip06.09.2024Lapse of the patent in a contracting state
New state(s): MT		published on 09.10.2024  [2024/41]
Applicant(s)For all designated states
Merck Patent GmbH
Frankfurter Strasse 250
64293 Darmstadt / DE
[2018/23]
Inventor(s)01 / ZIMMER, Aline
Gruener Weg 12
64521 Gross-Gerau / DE
 [2018/23]
Application number, filing date16734192.401.07.2016
[2018/23]
WO2016EP01118
Priority number, dateEP2015017906530.07.2015         Original published format: EP 15179065
[2018/23]
Filing languageEN
Procedural languageEN
PublicationType: A1 Application with search report
No.:WO2017016631
Date:02.02.2017
Language:EN
[2017/05]
Type: A1 Application with search report 
No.:EP3328410
Date:06.06.2018
Language:EN
The application published by WIPO in one of the EPO official languages on 02.02.2017 takes the place of the publication of the European patent application.
[2018/23]
Type: B1 Patent specification 
No.:EP3328410
Date:23.09.2020
Language:EN
[2020/39]
Search report(s)International search report - published on:EP02.02.2017
ClassificationIPC:A61K38/06, C12N5/00
[2018/23]
CPC:
C12N5/0018 (EP,KR,US); C12N2500/32 (EP,KR,US); C12N2500/60 (KR)
Designated contracting statesAL,   AT,   BE,   BG,   CH,   CY,   CZ,   DE,   DK,   EE,   ES,   FI,   FR,   GB,   GR,   HR,   HU,   IE,   IS,   IT,   LI,   LT,   LU,   LV,   MC,   MK,   MT,   NL,   NO,   PL,   PT,   RO,   RS,   SE,   SI,   SK,   SM,   TR [2018/23]
Extension statesBANot yet paid
MENot yet paid
Validation statesMANot yet paid
MDNot yet paid
TitleGerman:VERFAHREN ZUR ERHÖHUNG DES GLUTATHION LEVELS IN ZELLEN[2020/18]
English:METHOD FOR INCREASING THE GLUTATHIONE LEVEL IN CELLS[2018/23]
French:PROCÉDÉ POUR AUGMENTER LE NIVEAU GLUTATHIONE DANS DES CELLULES[2020/18]
Former [2018/23]VERFAHREN ZUR ERHÖHUNG DES GLUTATHIONSPIEGELS IN ZELLEN
Former [2018/23]PROCÉDÉ POUR AUGMENTER LE TAUX DE GLUTATHIONE DANS LES CELLULES
Entry into regional phase29.01.2018National basic fee paid 
29.01.2018Designation fee(s) paid 
29.01.2018Examination fee paid 
Examination procedure29.01.2018Examination requested  [2018/23]
29.01.2018Date on which the examining division has become responsible
29.08.2018Amendment by applicant (claims and/or description)
07.05.2019Despatch of a communication from the examining division (Time limit: M04)
06.09.2019Reply to a communication from the examining division
17.04.2020Communication of intention to grant the patent
12.08.2020Fee for grant paid
12.08.2020Fee for publishing/printing paid
12.08.2020Receipt of the translation of the claim(s)
Opposition(s)24.06.2021No opposition filed within time limit [2021/35]
Fees paidRenewal fee
11.07.2018Renewal fee patent year 03
15.07.2019Renewal fee patent year 04
14.07.2020Renewal fee patent year 05
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Responsibility for the accuracy, completeness or quality of the data displayed under the link provided lies entirely with the Unified Patent Court.
Lapses during opposition  TooltipHU01.07.2016
AL23.09.2020
AT23.09.2020
CY23.09.2020
CZ23.09.2020
DK23.09.2020
EE23.09.2020
FI23.09.2020
HR23.09.2020
IT23.09.2020
LT23.09.2020
LV23.09.2020
MC23.09.2020
MK23.09.2020
MT23.09.2020
PL23.09.2020
RO23.09.2020
RS23.09.2020
SE23.09.2020
SI23.09.2020
SK23.09.2020
SM23.09.2020
BG23.12.2020
NO23.12.2020
GR24.12.2020
IS23.01.2021
PT25.01.2021
[2024/41]
Former [2024/22]HU01.07.2016
AL23.09.2020
AT23.09.2020
CY23.09.2020
CZ23.09.2020
DK23.09.2020
EE23.09.2020
FI23.09.2020
HR23.09.2020
IT23.09.2020
LT23.09.2020
LV23.09.2020
MC23.09.2020
MK23.09.2020
PL23.09.2020
RO23.09.2020
RS23.09.2020
SE23.09.2020
SI23.09.2020
SK23.09.2020
SM23.09.2020
BG23.12.2020
NO23.12.2020
GR24.12.2020
IS23.01.2021
PT25.01.2021
Former [2023/30]HU01.07.2016
AL23.09.2020
AT23.09.2020
CY23.09.2020
CZ23.09.2020
DK23.09.2020
EE23.09.2020
FI23.09.2020
HR23.09.2020
IT23.09.2020
LT23.09.2020
LV23.09.2020
MC23.09.2020
PL23.09.2020
RO23.09.2020
RS23.09.2020
SE23.09.2020
SI23.09.2020
SK23.09.2020
SM23.09.2020
BG23.12.2020
NO23.12.2020
GR24.12.2020
IS23.01.2021
PT25.01.2021
Former [2023/27]HU01.07.2016
AL23.09.2020
AT23.09.2020
CZ23.09.2020
DK23.09.2020
EE23.09.2020
FI23.09.2020
HR23.09.2020
IT23.09.2020
LT23.09.2020
LV23.09.2020
MC23.09.2020
PL23.09.2020
RO23.09.2020
RS23.09.2020
SE23.09.2020
SI23.09.2020
SK23.09.2020
SM23.09.2020
BG23.12.2020
NO23.12.2020
GR24.12.2020
IS23.01.2021
PT25.01.2021
Former [2022/18]AL23.09.2020
AT23.09.2020
CZ23.09.2020
DK23.09.2020
EE23.09.2020
FI23.09.2020
HR23.09.2020
IT23.09.2020
LT23.09.2020
LV23.09.2020
MC23.09.2020
PL23.09.2020
RO23.09.2020
RS23.09.2020
SE23.09.2020
SI23.09.2020
SK23.09.2020
SM23.09.2020
BG23.12.2020
NO23.12.2020
GR24.12.2020
IS23.01.2021
PT25.01.2021
Former [2021/48]AL23.09.2020
AT23.09.2020
CZ23.09.2020
DK23.09.2020
EE23.09.2020
FI23.09.2020
HR23.09.2020
IT23.09.2020
LT23.09.2020
LV23.09.2020
PL23.09.2020
RO23.09.2020
RS23.09.2020
SE23.09.2020
SI23.09.2020
SK23.09.2020
SM23.09.2020
BG23.12.2020
NO23.12.2020
GR24.12.2020
IS23.01.2021
PT25.01.2021
Former [2021/37]AL23.09.2020
AT23.09.2020
CZ23.09.2020
DK23.09.2020
EE23.09.2020
FI23.09.2020
HR23.09.2020
LT23.09.2020
LV23.09.2020
PL23.09.2020
RO23.09.2020
RS23.09.2020
SE23.09.2020
SI23.09.2020
SK23.09.2020
SM23.09.2020
BG23.12.2020
NO23.12.2020
GR24.12.2020
IS23.01.2021
PT25.01.2021
Former [2021/36]AL23.09.2020
AT23.09.2020
CZ23.09.2020
EE23.09.2020
FI23.09.2020
HR23.09.2020
LT23.09.2020
LV23.09.2020
PL23.09.2020
RO23.09.2020
RS23.09.2020
SE23.09.2020
SI23.09.2020
SK23.09.2020
SM23.09.2020
BG23.12.2020
NO23.12.2020
GR24.12.2020
IS23.01.2021
PT25.01.2021
Former [2021/28]AL23.09.2020
AT23.09.2020
CZ23.09.2020
EE23.09.2020
FI23.09.2020
HR23.09.2020
LT23.09.2020
LV23.09.2020
PL23.09.2020
RO23.09.2020
RS23.09.2020
SE23.09.2020
SK23.09.2020
SM23.09.2020
BG23.12.2020
NO23.12.2020
GR24.12.2020
IS23.01.2021
PT25.01.2021
Former [2021/25]AL23.09.2020
AT23.09.2020
CZ23.09.2020
EE23.09.2020
FI23.09.2020
HR23.09.2020
LT23.09.2020
LV23.09.2020
PL23.09.2020
RO23.09.2020
RS23.09.2020
SE23.09.2020
SM23.09.2020
BG23.12.2020
NO23.12.2020
GR24.12.2020
IS23.01.2021
PT25.01.2021
Former [2021/23]AT23.09.2020
CZ23.09.2020
EE23.09.2020
FI23.09.2020
HR23.09.2020
LT23.09.2020
LV23.09.2020
RO23.09.2020
RS23.09.2020
SE23.09.2020
SM23.09.2020
BG23.12.2020
NO23.12.2020
GR24.12.2020
PT25.01.2021
Former [2021/22]CZ23.09.2020
EE23.09.2020
FI23.09.2020
HR23.09.2020
LT23.09.2020
LV23.09.2020
RO23.09.2020
RS23.09.2020
SE23.09.2020
BG23.12.2020
NO23.12.2020
GR24.12.2020
PT25.01.2021
Former [2021/21]FI23.09.2020
HR23.09.2020
LT23.09.2020
LV23.09.2020
RS23.09.2020
SE23.09.2020
BG23.12.2020
NO23.12.2020
GR24.12.2020
PT25.01.2021
Former [2021/20]FI23.09.2020
HR23.09.2020
LT23.09.2020
LV23.09.2020
RS23.09.2020
SE23.09.2020
BG23.12.2020
NO23.12.2020
GR24.12.2020
Former [2021/10]FI23.09.2020
HR23.09.2020
LV23.09.2020
RS23.09.2020
SE23.09.2020
BG23.12.2020
NO23.12.2020
GR24.12.2020
Former [2021/08]FI23.09.2020
SE23.09.2020
BG23.12.2020
NO23.12.2020
Former [2021/07]FI23.09.2020
NO23.12.2020
Cited inInternational search[Y]US5208249  (ROWE W BRUCE [US], et al) [Y] 1-11 * columns 3-4 *;
 [Y]AU652988B  (CLINTEC NUTRITION CO) [Y] 1-11 * page 5, paragraph last; claims 1,4,11 *;
 [Y]  - TAKESHI NAKATANI ET AL, "Enhancement of thioredoxin/glutaredoxin-mediated L-cysteine synthesis from S-sulfocysteine increases L-cysteine production in Escherichia coli", MICROBIAL CELL FACTORIES, BIOMED CENTRAL, GB, (20120518), vol. 11, no. 1, doi:10.1186/1475-2859-11-62, ISSN 1475-2859, page 62, XP021129015 [Y] 1-11 * page 4; figure 1 *

DOI:   http://dx.doi.org/10.1186/1475-2859-11-62
 [Y]  - R. BANERJEE, "Redox outside the Box: Linking Extracellular Redox Remodeling with Intracellular Redox Metabolism", JOURNAL OF BIOLOGICAL CHEMISTRY, US, (20120210), vol. 287, no. 7, doi:10.1074/jbc.R111.287995, ISSN 0021-9258, pages 4397 - 4402, XP055291492 [Y] 1-11 * the whole document *

DOI:   http://dx.doi.org/10.1074/jbc.R111.287995
by applicantUS2011077303
 US2013338165
 US2014100283
    - I.H.SEGEL; M.J.JOHNSON, ANALYTICAL BIOCHEMISTRY, (1963), vol. 5, pages 330 - 337
    - J.S. CHURCH; D.J. EVANS, SPECTROCHIMICA ACTA PART A, (2008), vol. 69, pages 256 - 262
The EPO accepts no responsibility for the accuracy of data originating from other authorities; in particular, it does not guarantee that it is complete, up to date or fit for specific purposes.