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Extract from the Register of European Patents

EP About this file: EP3319965

EP3319965 - NOVEL COMPOUNDS FOR USE IN TREATING OR PREVENTING CANCEROUS DISEASES [Right-click to bookmark this link]
StatusNo opposition filed within time limit
Status updated on  10.03.2023
Database last updated on 31.08.2024
FormerThe patent has been granted
Status updated on  02.04.2022
FormerGrant of patent is intended
Status updated on  19.11.2021
FormerExamination is in progress
Status updated on  17.09.2021
FormerGrant of patent is intended
Status updated on  17.05.2021
FormerExamination is in progress
Status updated on  28.05.2019
FormerRequest for examination was made
Status updated on  13.04.2018
FormerThe international publication has been made
Status updated on  13.01.2017
Most recent event   Tooltip14.06.2024Lapse of the patent in a contracting state
New state(s): TR
published on 17.07.2024  [2024/29]
Applicant(s)For all designated states
Biomedical Research Foundation of the Academy of Athens
4 Soranou Efessiou
11527 Athens / GR
[2018/20]
Inventor(s)01 / STELLAS, Dimitris
12 Anavritis St.
11143 Athens / GR
02 / TAMVAKOPOULOS, Constantin
4 Ilektras St.
Kifissia
14562 Athens / GR
03 / KLINAKIS, Apostolos
5 Ellis Alexiou St.
Agia Marina
71410 Iraklio / GR
04 / EFSTRATIADIS, Argiris
37-39 Kleomenous St.
10676 Athens / GR
05 / COURNIA, Zoe
8B Nileos St.
14564 Kifissia / GR
 [2018/20]
Representative(s)Eder, Michael
df-mp Dörries Frank-Molnia & Pohlman
Patentanwälte Rechtsanwälte PartG mbB
Theatinerstrasse 16
80333 München / DE
[2018/20]
Application number, filing date16736480.108.07.2016
[2018/20]
WO2016EP66340
Priority number, dateEP2015017591808.07.2015         Original published format: EP 15175918
[2018/20]
Filing languageEN
Procedural languageEN
PublicationType: A1 Application with search report
No.:WO2017005919
Date:12.01.2017
Language:EN
[2017/02]
Type: A1 Application with search report 
No.:EP3319965
Date:16.05.2018
Language:EN
The application published by WIPO in one of the EPO official languages on 12.01.2017 takes the place of the publication of the European patent application.
[2018/20]
Type: B1 Patent specification 
No.:EP3319965
Date:04.05.2022
Language:EN
[2022/18]
Search report(s)International search report - published on:EP12.01.2017
ClassificationIPC:A61K31/196, A61K31/337, C07D487/04, A61K31/365, A61K31/415, A61K31/4196, A61K31/444, A61K31/517, A61K31/519, A61K31/566, A61K31/58, A61K31/635, A61K31/704, A61K31/7068, A61P35/02
[2021/11]
CPC:
C07D487/04 (EP,US); A61K31/415 (EP,US); A61K31/4196 (EP,US);
A61K31/519 (EP,US); A61K31/58 (EP,US); A61K31/635 (EP,US);
A61K31/7068 (EP,US); A61P35/02 (EP,US); C07B43/06 (US);
A61K2300/00 (US); A61K31/196 (EP,US); A61K31/337 (EP,US);
A61K31/365 (EP,US); A61K31/444 (EP,US); A61K31/517 (EP,US);
A61K31/566 (EP,US); A61K31/704 (EP,US) (-)
C-Set:
A61K31/415, A61K2300/00 (EP,US);
A61K31/4196, A61K2300/00 (US,EP);
A61K31/519, A61K2300/00 (EP,US);
A61K31/58, A61K2300/00 (US,EP);
A61K31/635, A61K2300/00 (EP,US);
A61K31/7068, A61K2300/00 (US,EP)
(-)
Former IPC [2018/20]C07D487/04, A61P35/00, A61K31/51
Designated contracting statesAL,   AT,   BE,   BG,   CH,   CY,   CZ,   DE,   DK,   EE,   ES,   FI,   FR,   GB,   GR,   HR,   HU,   IE,   IS,   IT,   LI,   LT,   LU,   LV,   MC,   MK,   MT,   NL,   NO,   PL,   PT,   RO,   RS,   SE,   SI,   SK,   SM,   TR [2018/20]
Extension statesBANot yet paid
MENot yet paid
Validation statesMANot yet paid
MDNot yet paid
TitleGerman:NEUE VERBINDUNGEN ZUR BEHANDLUNG ODER PRÄVENTION VON KREBSERKRANKUNGEN[2021/20]
English:NOVEL COMPOUNDS FOR USE IN TREATING OR PREVENTING CANCEROUS DISEASES[2018/20]
French:NOUVEAUX COMPOSÉS UTILISABLES DANS LE TRAITEMENT OU LA PRÉVENTION DE MALADIES CANCÉREUSES[2018/20]
Former [2018/20]NEUARTIGE VERBINDUNGEN ZUR VERWENDUNG BEI DER BEHANDLUNG ODER VORBEUGUNG VON KREBSERKRANKUNGEN
Entry into regional phase05.01.2018National basic fee paid 
05.01.2018Designation fee(s) paid 
05.01.2018Examination fee paid 
Examination procedure05.01.2018Examination requested  [2018/20]
05.01.2018Date on which the examining division has become responsible
16.08.2018Amendment by applicant (claims and/or description)
03.06.2019Despatch of a communication from the examining division (Time limit: M07)
03.01.2020Reply to a communication from the examining division
30.06.2020Despatch of a communication from the examining division (Time limit: M04)
10.11.2020Reply to a communication from the examining division
18.05.2021Communication of intention to grant the patent
15.09.2021Disapproval of the communication of intention to grant the patent by the applicant or resumption of examination proceedings by the EPO
15.09.2021Fee for grant paid
15.09.2021Fee for publishing/printing paid
26.11.2021Communication of intention to grant the patent
28.03.2022Receipt of the translation of the claim(s)
Opposition(s)07.02.2023No opposition filed within time limit [2023/15]
Fees paidRenewal fee
30.07.2018Renewal fee patent year 03
22.07.2019Renewal fee patent year 04
21.08.2020Renewal fee patent year 05
28.07.2021Renewal fee patent year 06
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Patent Court
See the Register of the Unified Patent Court for opt-out data
Responsibility for the accuracy, completeness or quality of the data displayed under the link provided lies entirely with the Unified Patent Court.
Lapses during opposition  TooltipHU08.07.2016
AL04.05.2022
AT04.05.2022
CY04.05.2022
CZ04.05.2022
DK04.05.2022
EE04.05.2022
ES04.05.2022
FI04.05.2022
HR04.05.2022
IT04.05.2022
LT04.05.2022
LV04.05.2022
MC04.05.2022
MK04.05.2022
NL04.05.2022
PL04.05.2022
RO04.05.2022
RS04.05.2022
SE04.05.2022
SI04.05.2022
SK04.05.2022
SM04.05.2022
TR04.05.2022
IE08.07.2022
LU08.07.2022
BE31.07.2022
CH31.07.2022
FR31.07.2022
LI31.07.2022
BG04.08.2022
GB04.08.2022
NO04.08.2022
GR05.08.2022
IS04.09.2022
PT05.09.2022
DE01.02.2023
[2024/29]
Former [2024/22]HU08.07.2016
AL04.05.2022
AT04.05.2022
CY04.05.2022
CZ04.05.2022
DK04.05.2022
EE04.05.2022
ES04.05.2022
FI04.05.2022
HR04.05.2022
IT04.05.2022
LT04.05.2022
LV04.05.2022
MC04.05.2022
MK04.05.2022
NL04.05.2022
PL04.05.2022
RO04.05.2022
RS04.05.2022
SE04.05.2022
SI04.05.2022
SK04.05.2022
SM04.05.2022
IE08.07.2022
LU08.07.2022
BE31.07.2022
CH31.07.2022
FR31.07.2022
LI31.07.2022
BG04.08.2022
GB04.08.2022
NO04.08.2022
GR05.08.2022
IS04.09.2022
PT05.09.2022
DE01.02.2023
Former [2024/20]HU08.07.2016
AL04.05.2022
AT04.05.2022
CY04.05.2022
CZ04.05.2022
DK04.05.2022
EE04.05.2022
ES04.05.2022
FI04.05.2022
HR04.05.2022
IT04.05.2022
LT04.05.2022
LV04.05.2022
MC04.05.2022
NL04.05.2022
PL04.05.2022
RO04.05.2022
RS04.05.2022
SE04.05.2022
SI04.05.2022
SK04.05.2022
SM04.05.2022
IE08.07.2022
LU08.07.2022
BE31.07.2022
CH31.07.2022
FR31.07.2022
LI31.07.2022
BG04.08.2022
GB04.08.2022
NO04.08.2022
GR05.08.2022
IS04.09.2022
PT05.09.2022
DE01.02.2023
Former [2024/18]HU08.07.2016
AL04.05.2022
AT04.05.2022
CZ04.05.2022
DK04.05.2022
EE04.05.2022
ES04.05.2022
FI04.05.2022
HR04.05.2022
IT04.05.2022
LT04.05.2022
LV04.05.2022
MC04.05.2022
NL04.05.2022
PL04.05.2022
RO04.05.2022
RS04.05.2022
SE04.05.2022
SI04.05.2022
SK04.05.2022
SM04.05.2022
IE08.07.2022
LU08.07.2022
BE31.07.2022
CH31.07.2022
FR31.07.2022
LI31.07.2022
BG04.08.2022
GB04.08.2022
NO04.08.2022
GR05.08.2022
IS04.09.2022
PT05.09.2022
DE01.02.2023
Former [2024/11]AL04.05.2022
AT04.05.2022
CZ04.05.2022
DK04.05.2022
EE04.05.2022
ES04.05.2022
FI04.05.2022
HR04.05.2022
IT04.05.2022
LT04.05.2022
LV04.05.2022
MC04.05.2022
NL04.05.2022
PL04.05.2022
RO04.05.2022
RS04.05.2022
SE04.05.2022
SI04.05.2022
SK04.05.2022
SM04.05.2022
IE08.07.2022
LU08.07.2022
BE31.07.2022
CH31.07.2022
FR31.07.2022
LI31.07.2022
BG04.08.2022
GB04.08.2022
NO04.08.2022
GR05.08.2022
IS04.09.2022
PT05.09.2022
DE01.02.2023
Former [2023/47]AL04.05.2022
AT04.05.2022
CZ04.05.2022
DK04.05.2022
EE04.05.2022
ES04.05.2022
FI04.05.2022
HR04.05.2022
LT04.05.2022
LV04.05.2022
MC04.05.2022
NL04.05.2022
PL04.05.2022
RO04.05.2022
RS04.05.2022
SE04.05.2022
SI04.05.2022
SK04.05.2022
SM04.05.2022
IE08.07.2022
LU08.07.2022
BE31.07.2022
CH31.07.2022
FR31.07.2022
LI31.07.2022
BG04.08.2022
GB04.08.2022
NO04.08.2022
GR05.08.2022
IS04.09.2022
PT05.09.2022
DE01.02.2023
Former [2023/33]AL04.05.2022
AT04.05.2022
CZ04.05.2022
DK04.05.2022
EE04.05.2022
ES04.05.2022
FI04.05.2022
HR04.05.2022
LT04.05.2022
LV04.05.2022
MC04.05.2022
NL04.05.2022
PL04.05.2022
RO04.05.2022
RS04.05.2022
SE04.05.2022
SI04.05.2022
SK04.05.2022
SM04.05.2022
IE08.07.2022
LU08.07.2022
BE31.07.2022
CH31.07.2022
FR31.07.2022
LI31.07.2022
BG04.08.2022
NO04.08.2022
GR05.08.2022
IS04.09.2022
PT05.09.2022
DE01.02.2023
Former [2023/25]AL04.05.2022
AT04.05.2022
CZ04.05.2022
DK04.05.2022
EE04.05.2022
ES04.05.2022
FI04.05.2022
HR04.05.2022
LT04.05.2022
LV04.05.2022
MC04.05.2022
NL04.05.2022
PL04.05.2022
RO04.05.2022
RS04.05.2022
SE04.05.2022
SI04.05.2022
SK04.05.2022
SM04.05.2022
LU08.07.2022
BE31.07.2022
CH31.07.2022
FR31.07.2022
LI31.07.2022
BG04.08.2022
NO04.08.2022
GR05.08.2022
IS04.09.2022
PT05.09.2022
DE01.02.2023
Former [2023/23]AL04.05.2022
AT04.05.2022
CZ04.05.2022
DK04.05.2022
EE04.05.2022
ES04.05.2022
FI04.05.2022
HR04.05.2022
LT04.05.2022
LV04.05.2022
MC04.05.2022
NL04.05.2022
PL04.05.2022
RO04.05.2022
RS04.05.2022
SE04.05.2022
SK04.05.2022
SM04.05.2022
LU08.07.2022
CH31.07.2022
FR31.07.2022
LI31.07.2022
BG04.08.2022
NO04.08.2022
GR05.08.2022
IS04.09.2022
PT05.09.2022
DE01.02.2023
Former [2023/22]AL04.05.2022
AT04.05.2022
CZ04.05.2022
DK04.05.2022
EE04.05.2022
ES04.05.2022
FI04.05.2022
HR04.05.2022
LT04.05.2022
LV04.05.2022
MC04.05.2022
NL04.05.2022
PL04.05.2022
RO04.05.2022
RS04.05.2022
SE04.05.2022
SK04.05.2022
SM04.05.2022
LU08.07.2022
CH31.07.2022
FR31.07.2022
LI31.07.2022
BG04.08.2022
NO04.08.2022
GR05.08.2022
IS04.09.2022
PT05.09.2022
Former [2023/21]AL04.05.2022
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CZ04.05.2022
DK04.05.2022
EE04.05.2022
ES04.05.2022
FI04.05.2022
HR04.05.2022
LT04.05.2022
LV04.05.2022
MC04.05.2022
NL04.05.2022
PL04.05.2022
RO04.05.2022
RS04.05.2022
SE04.05.2022
SK04.05.2022
SM04.05.2022
LU08.07.2022
CH31.07.2022
LI31.07.2022
BG04.08.2022
NO04.08.2022
GR05.08.2022
IS04.09.2022
PT05.09.2022
Former [2023/17]AL04.05.2022
AT04.05.2022
CZ04.05.2022
DK04.05.2022
EE04.05.2022
ES04.05.2022
FI04.05.2022
HR04.05.2022
LT04.05.2022
LV04.05.2022
MC04.05.2022
NL04.05.2022
PL04.05.2022
RO04.05.2022
RS04.05.2022
SE04.05.2022
SK04.05.2022
SM04.05.2022
BG04.08.2022
NO04.08.2022
GR05.08.2022
IS04.09.2022
PT05.09.2022
Former [2023/11]AT04.05.2022
CZ04.05.2022
DK04.05.2022
EE04.05.2022
ES04.05.2022
FI04.05.2022
HR04.05.2022
LT04.05.2022
LV04.05.2022
MC04.05.2022
NL04.05.2022
PL04.05.2022
RO04.05.2022
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SK04.05.2022
SM04.05.2022
BG04.08.2022
NO04.08.2022
GR05.08.2022
IS04.09.2022
PT05.09.2022
Former [2023/09]AT04.05.2022
CZ04.05.2022
DK04.05.2022
EE04.05.2022
ES04.05.2022
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BG04.08.2022
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PT05.09.2022
Former [2023/07]AT04.05.2022
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Cited inInternational search[YD]  - ANKE KIESSLING ET AL, "Selective Inhibition of c-Myc/Max Dimerization by a Pyrazolo[1,5-a]pyrimidine", CHEMMEDCHEM, (20070514), vol. 2, no. 5, doi:10.1002/cmdc.200600294, ISSN 1860-7179, pages 627 - 630, XP055118564 [YD] 1-15 * the whole document *

DOI:   http://dx.doi.org/10.1002/cmdc.200600294
 [Y]  - JEREMY L. YAP ET AL, "Small-molecule inhibitors of dimeric transcription factors: Antagonism of protein-protein and protein-DNA interactions", MEDCHEMCOMM, United Kingdom, (20120101), vol. 3, no. 5, doi:10.1039/c2md00289b, ISSN 2040-2503, page 541, XP055299857 [Y] 1-15 * figure 4 *

DOI:   http://dx.doi.org/10.1039/c2md00289b
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    - BERG, T. ET AL., "Small-molecule antagonists of Myc Max dimerization inhibit Myc-induced transformation of chicken embryo fibroblasts", PROC NATL ACAD SCI U S A, (2002), vol. 99, doi:doi:10.1073/pnas.062036999, pages 3830 - 3835, XP002995347

DOI:   http://dx.doi.org/10.1073/pnas.062036999
    - D'AGNANO, I. ET AL., "Oligopeptides Impairing the Myc-Max Heterodimerization Inhibit Lung Cancer Cell Proliferation by Reducing Myc Transcriptional Activity", J CELL PHYSIOL, (2007), vol. 210, pages 72 - 80
    - GOMEZ-CURET, I. ET AL., "c-Myc inhibition negatively impacts lymphoma growth", J PEDIATR SURG, (2006), vol. 41, doi:doi:10.1016/j.jpedsurg.2005.10.025, pages 207 - 211, XP005235919

DOI:   http://dx.doi.org/10.1016/j.jpedsurg.2005.10.025
    - GUO, J. ET AL., "Efficacy, pharmacokinetics, tissue distribution, and metabolism of the Myc-Max disruptor, 10058-F4 [Z,E]-5-[4-ethylbenzylidine]-2-thioxothiazolidin-4-one, in mice", CANCER CHEMOTHER PHARMACOL, (2009), vol. 63, pages 615 - 625, XP019708041
    - HUANGA, MJ., "A small-molecule c-Myc inhibitor, 10058-F4, induces cell-cycle arrest, apoptosis, and myeloid differentiation of human acute myeloid leukemia", EXP HEMATOL, (2006), vol. 34, pages 1480 - 1489
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