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EP3319639
European procedure
Extract from the Register of European Patents
EP Citations: EP3319639
| Cited in | International search | Type: | Patent literature | Publication No.: | US6867192
[XD] (ARMOUR DUNCAN ROBERT et al.) | Type: | Patent literature | Publication No.: | WO0195879
[X] (GLAXO GROUP LTD et al.) | Type: | Patent literature | Publication No.: | US2013217657
[Y] (LINDSTROM RICHARD L et al.) | Type: | Patent literature | Publication No.: | US2007105761
[Y] (CHAPPELL TODD W et al.) | Type: | Patent literature | Publication No.: | WO2006125119
[YD] (SARCODE et al.) | Type: | Non-patent literature | Publication information: | [Y] KRAUSS ACHIM H ET AL: "Effects of a novel integrin antagonist, GW559090, in an experimental dry eye model (Program number 2472)", IOVS, vol. 56, no. 7, June 2015 (2015-06-01), & ANNUAL MEETING OF THE ASSOCIATION-FOR-RESEARCH-IN-VISION-AND-OPHTHALMOLOGY (ARVO); DENVER, CO, USA; MAY 03 -07, 2015, XP002761163, ISSN: 0146-0404 | Type: | Non-patent literature | Publication information: | [Y] CLARA ANDONIAN: "Ocular and Systemic Pharmacokinetics of GW559090, an Alpha-4 Integrin Antagonist, in Mouse, Rabbit and Dog Following Topical Administration", IOVS, 1 June 2015 (2015-06-01), pages 1 - 2, XP055297655, Retrieved from the Internet | Type: | Non-patent literature | Publication information: | [Y] ANONYMOUS: "An inhaled VLA-4 antagonist", EXPERT OPINION ON THERAPEUTIC PATENTS., vol. 12, no. 5, 1 May 2002 (2002-05-01), GB, pages 755 - 757, XP055297660, ISSN: 1354-3776, DOI: 10.1517/13543776.12.5.755 | DOI: | http://dx.doi.org/10.1517/13543776.12.5.755 | Type: | Non-patent literature | Publication information: | [XPYI] ACHIM H. KRAUSS ET AL: "Improvement of Outcome Measures of Dry Eye by a Novel Integrin Antagonist in the Murine Desiccating Stress Model", INVESTIGATIVE OPTHALMOLOGY & VISUAL SCIENCE, vol. 56, no. 10, 8 September 2015 (2015-09-08), US, pages 5888 - 5895, XP055297503, ISSN: 1552-5783, DOI: 10.1167/iovs.15-17249 | DOI: | http://dx.doi.org/10.1167/iovs.15-17249 | Type: | Non-patent literature | Publication information: | [XPYI] CONTRERAS-RUIZ LAURA ET AL: "Sjgren's syndrome associated dry eye in a mouse model is ameliorated by topical application of integrin [alpha]4 antagonist GW559090", EXPERIMENTAL EYE RESEARCH, vol. 143, 14 October 2015 (2015-10-14), pages 1 - 8, XP029336639, ISSN: 0014-4835, DOI: 10.1016/J.EXER.2015.10.008 | DOI: | http://dx.doi.org/10.1016/j.exer.2015.10.008 | Cited in | Examination | Type: | Non-patent literature | Publication information: | DAVENPORT RICHARD J ET AL: "Alpha4-integrin antagonsim - an effective approach for the treatment of inflammatory diseases?", DRUG DISCOVERY TODAY, vol. 12, no. 13-14, July 2007 (2007-07-01), pages 569 - 576, ISSN: 1359-6446(print) | Type: | Non-patent literature | Publication information: | RAVENSBERG A J ET AL: "The effect of a single inhaled dose of a VLA-4 antagonist on allergen-induced airway responses and airway inflammation in patients with asthma", ALLERGY (OXFORD), vol. 61, no. 9, September 2006 (2006-09-01), pages 1097 - 1103, ISSN: 0105-4538 | Type: | Non-patent literature | Publication information: | FDA: "FDA Guidance for Estimating the Maximum Safe Starting Dose in Initial Clinical Trials for Therapeutics in Adult Healthy Volunteers", PHARMACOLOGY AND TOXICOLOGY, July 2005 (2005-07-01), pages 1 - 27 | Cited in | by applicant | Type: | Patent literature | Publication No.: | WO2006125119
| Type: | Patent literature | Publication No.: | US6867192
| Type: | Non-patent literature | Publication information: | "REMINGTON'S PHARMACEUTICAL SCIENCES", 1995 | Type: | Non-patent literature | Publication information: | CHOTIKAVANICH S; DE PAIVA CS; LI DQ; CHEN JJ; BIAN F; FARLEY WJ; PFLUGFELDER SC: "Production and Activity of Matrix Metalloproteinase-9 on the Ocular Surface Increase in Dysfunctional Tear Syndrome", INVEST OPHTHALMOL VIS SCI, vol. 50, 2009, pages 3203 - 3209 | Type: | Non-patent literature | Publication information: | COHEN L.B.; NANAU R.M.; DELZOR F.; NEUMAN M.G.: "Biologic therapies in inflammatory bowel disease", TRANSLATIONAL RESEARCH : THE JOURNAL OF LABORATORY AND CLINICAL MEDICINE, vol. 163, 2014, pages 533 - 556 | Type: | Non-patent literature | Publication information: | CORRALES R.M.; STERN M.E.; DE PAIVA C.S.; WELCH J.; LI D.Q.; PFLUGFELDER S.C.: "Desiccating stress stimulates expression of matrix metalloproteinases by the corneal epithelium", INVEST OPHTHALMOL VIS SCI., vol. 47, 2006, pages 3293 - 3302 | Type: | Non-patent literature | Publication information: | COURSEY T.G.; BOHAT R.; BARBOSA F.L.; PFLUGFELDER S.C.; DE PAIVA C.S.: "Desiccating stress-induced chemokine expression in the epithelium is dependent on upregulation of NKG2D/RAE-1 and release of IFN-gamma in experimental dry eye", J IMMUNOL., vol. 193, 2014, pages 5264 - 5272 | Type: | Non-patent literature | Publication information: | COURSEY T.G.; GANDHI N.B.; VOLPE E.A.; PFLUGFELDER S.C.; DE PAIVA C.S.: "Chemokine receptors CCR6 and CXCR3 are necessary for CD4(+) T cell mediated ocular surface disease in experimental dry eye disease", PLOS ONE, vol. 8, 2013, pages E78508 | Type: | Non-patent literature | Publication information: | CROSS A.H.; NAISMITH R.T.: "Established and novel disease-modifying treatments in multiple sclerosis", J INTERN MED., vol. 275, 2014, pages 350 - 363 | Type: | Non-patent literature | Publication information: | COX D.; BRENNAN M.; MORAN N.: "Integrins as therapeutic targets: lessons and opportunities", NAT REV DRUG DISCOV, vol. 9, 2010, pages 804 - 20 | Type: | Non-patent literature | Publication information: | DE PAIVA C.S.; CHOTIKAVANICH S.; PANGELINAN S.B.; PITCHER J.D., III; FANG B.; ZHENG X.; MA P.; FARLEY W.J.; SIEMASKO K.S.; NIEDERK: "IL-17 disrupts corneal barrier following desiccating stress", MUCOSAL IMMUNOL, vol. 2, no. 3, 2009, pages 243 - 253 | Type: | Non-patent literature | Publication information: | DE PAIVA C.S.; CORRALES R.M.; VILLARREAL A.L.; FARLEY W.; LI D.Q.; STERN M.E.; PFLUGFELDER S.C.: "Corticosteroid and doxycycline suppress MMP-9 and inflammatory cytokine expression, MAPK activation in the corneal epithelium in experimental dry eye", EXP EYE RES, vol. 83, 2006, pages 526 - 535, XP024945505, DOI: doi:10.1016/j.exer.2006.02.004 | DOI: | http://dx.doi.org/10.1016/j.exer.2006.02.004 | Type: | Non-patent literature | Publication information: | DE PAIVA C.S.; CORRALES R.M.; VILLARREAL A.L.; FARLEY W.; LI D.Q.; STERN M.E.; PFLUGFELDER S.C.: "Apical corneal barrier disruption in experimental murine dry eye is abrogated by methylprednisolone and doxycycline", INVEST OPHTHALMOL VIS SCI., vol. 47, 2006, pages 2847 - 2856 | Type: | Non-patent literature | Publication information: | DE PAIVA C.S.; PANGELINAN S.B.; CHANG E.; YOON K.C.; FARLEY W.J.; LI D.Q.; PFLUGFELDER S.C.: "Essential role for c-Jun N-terminal kinase 2 in corneal epithelial response to desiccating stress", ARCH OPHTHALMOL., vol. 127, 2009, pages 1625 - 1631, XP002692392, DOI: doi:10.1001/archophthalmol.2009.316 | DOI: | http://dx.doi.org/10.1001/archophthalmol.2009.316 | Type: | Non-patent literature | Publication information: | DE PAIVA C.S.; VOLPE E.A.; GANDHI N.B.; ZHANG X.; ZHENG X.; PITCHER J.D., III; FARLEY W.J.; STERN M.E.; NIEDERKORN J.Y.; LI D.Q.: "Disruption of TGF-beta Signaling Improves Ocular Surface Epithelial Disease in Experimental Autoimmune Keratoconjunctivitis Sicca", PLOS ONE. 2011, vol. 6, 14 December 2011 (2011-12-14), pages E29017 | Type: | Non-patent literature | Publication information: | DURSUN D.; WANG M.; MONROY D.; LI D.Q.; LOKESHWAR B.L.; STERN M.E.; PFLUGFELDER S.C.: "A mouse model of keratoconjunctivitis sicca", INVEST OPHTHALMOL VIS SCI., vol. 43, 2002, pages 632 - 638 | Type: | Non-patent literature | Publication information: | ECOIFFIER T.; EL ANNAN J.; RASHID S.; SCHAUMBERG D.; DANA R.: "Modulation of integrin alpha4beta1 (VLA-4) in dry eye disease", ARCH OPHTHALMOL., vol. 126, 2008, pages 1695 - 1699 | Type: | Non-patent literature | Publication information: | EDWARDS J.C.; WILKINSON L.S.; SPEIGHT P.; ISENBERG D.A: "Vascular cell adhesion molecule 1 and alpha 4 and beta 1 integrins in lymphocyte aggregates in Sjogren's syndrome and rheumatoid arthritis", ANN RHEUM DIS., vol. 52, 1993, pages 806 - 811 | Type: | Non-patent literature | Publication information: | GOLDSTEIN MH, TUBRIDY KL, AGAHIGIAN J, FURFINE E, MAGILL M, KOVALCHIN J, GOLDEN K, ZARBIS-PAPASTOITSIS G, SOONG F, SALAPATEK AM, S: "Study of a Novel Interleukin-1 Receptor Inhibitor (EBI-005) in the Treatment of Moderate-to-Severe Allergic Conjunctivitis", EYE CONTACT LENS, vol. 41, 2015, pages 145 - 55 | Type: | Non-patent literature | Publication information: | GUTCHER I.; DONKOR M.K.; MA Q.; RUDENSKY A.Y.; FLAVELL R.A.; LI M.O.: "Autocrine transforming growth factor-beta1 promotes in vivo Th17 cell differentiation", IMMUNITY, vol. 34, 2011, pages 396 - 408, XP028369802, DOI: doi:10.1016/j.immuni.2011.03.005 | DOI: | http://dx.doi.org/10.1016/j.immuni.2011.03.005 | Type: | Non-patent literature | Publication information: | HOU J; TOWNSON SA; KOVALCHIN JT; MASCI A; KINER O; SHU Y; KING BM; SCHIRMER E; GOLDEN K; THOMAS C: "Design of a superior cytokine antagonist for topical ophthalmic use", PROC NATL ACAD SCI U S A., vol. 110, 2013, pages 3913 - 8, XP055102568, DOI: doi:10.1073/pnas.1217996110 | DOI: | http://dx.doi.org/10.1073/pnas.1217996110 | Type: | Non-patent literature | Publication information: | LUDWIG A.: "The use of mucoadhesive polymers in ocular drug delivery", ADV DRUG DELIV REV, vol. 57, 2005, pages 1595 - 639, XP025284002, DOI: doi:10.1016/j.addr.2005.07.005 | DOI: | http://dx.doi.org/10.1016/j.addr.2005.07.005 | Type: | Non-patent literature | Publication information: | LUO L.; LI D.Q.; DOSHI A.; FARLEY W.; CORRALES R.M.; PFLUGFELDER S.C.: "Experimental dry eye stimulates production of inflammatory cytokines and MMP-9 and activates MAPK signaling pathways on the ocular surface", INVEST OPHTHALMOL VIS SCI., vol. 45, 2004, pages 4293 - 4301, XP009108480, DOI: doi:10.1167/iovs.03-1145 | DOI: | http://dx.doi.org/10.1167/iovs.03-1145 | Type: | Non-patent literature | Publication information: | MARSH P.; PFLUGFELDER S.C.: "Topical nonpreserved methylprednisolone therapy for keratoconjunctivitis sicca in Sjogren syndrome", OPHTHALMOLOGY, vol. 106, 1999, pages 811 - 816, XP002212352 | Type: | Non-patent literature | Publication information: | MASSINGALE M.L.; LI X.; VALLABHAJOSYULA M.; CHEN D.; WEI Y.; ASBELL P.A.: "Analysis of inflammatory cytokines in the tears of dry eye patients", CORNEA, vol. 28, 2009, pages 1023 - 1027 | Type: | Non-patent literature | Publication information: | NIEDERKORN J.Y.; STERN M.E.; PFLUGFELDER S.C.; DE PAIVA C.S.; CORRALES R.M.; GAO J.; SIEMASKO K.: "Desiccating Stress Induces T Cell-Mediated Sjogren's Syndrome-Like Lacrimal Keratoconjunctivitis", J IMMUNOL., vol. 176, 2006, pages 3950 - 3957 | Type: | Non-patent literature | Publication information: | NOJIMA Y.; HUMPHRIES M.J.; MOULD A.P.; KOMORIYA A.; YAMADA K.M.; SCHLOSSMAN S.F.; MORIMOTO C: "VLA-4 meidates CD3-dependent CD4+ T cell activation via the CS1 alternatively sliced domain of fibronectin", J EXP MED, vol. 172, 1990, pages 1185 - 92 | Type: | Non-patent literature | Publication information: | PFLUGFELDER S.C.; DE PAIVA C.S.; LI D.Q.; STERN M.E: "Epithelial-immune cell interaction in dry eye", CORNEA, vol. 27, no. 1, 2008, pages 9 - 11 | Type: | Non-patent literature | Publication information: | PFLUGFELDER S.C.; FARLEY W.; LUO L.; CHEN L.Z.; DE PAIVA C.S.; OLMOS L.C.; LI D.Q.; FINI M.E.: "Matrix metalloproteinase-9 knockout confers resistance to corneal epithelial barrier disruption in experimental dry eye", AM J PATHOL., vol. 166, 2005, pages 61 - 71 | Type: | Non-patent literature | Publication information: | PFLUGFELDER S.C.; JONES D.; JI Z.; AFONSO A.; MONROY D.: "Altered cytokine balance in the tear fluid and conjunctiva of patients with Sjogren's syndrome keratoconjunctivitis sicca", CURR EYE RES., vol. 19, 1999, pages 201 - 211, XP008034582, DOI: doi:10.1076/ceyr.19.3.201.5309 | DOI: | http://dx.doi.org/10.1076/ceyr.19.3.201.5309 | Type: | Non-patent literature | Publication information: | RAVENSBERG A.J.; LUIJK B.; WESTERS P.; HIEMSTRA P.S.; STERK P.J.; LAMMERS J.W.; RABE K.F.: "The effect of a single inhaled dose of a VLA-4 antagonist on allergen-induced airway responses and airway inflammation in patients with asthma", ALLERGY, vol. 61, 2006, pages 1097 - 1103 | Type: | Non-patent literature | Publication information: | "Research in dry eye: report of the Research Subcommittee of the International Dry Eye Workshop", OCUL SURF, vol. 5, 2007, pages 179 - 193 | Type: | Non-patent literature | Publication information: | SCHAUMBURG C.S.; SIEMASKO K.F.; DE PAIVA C.S.; PFLUGFELDER SC; STERN M.E: "Ocular Surface Antigen Presenting Cells are Necessary for Activation of Autoreactive T cells and Development of Autoimmune Lacrimal Keratoconjunctivtis", J IMMUNOL., vol. 187, 2011, pages 3653 - 3662 | Type: | Non-patent literature | Publication information: | SHEPPARD J.D.; TORKILDSEN G.L.; LONSDALE J.D.; D'AMBROSIO F.A., JR.; MCLAURIN E.B.; EIFERMAN R.A.; KENNEDY K.S.; SEMBA C.P.: "Lifitegrast ophthalmic solution 5.0% for treatment of dry eye disease: results of the OPUS-1 phase 3 study", OPHTHALMOLOGY, vol. 121, 2014, pages 475 - 483 | Type: | Non-patent literature | Publication information: | STERN M.E.; SCHAUMBURG C.S.; DANA R.; CALONGE M.; NIEDERKORN J.Y.; PFLUGFELDER S.C.: "Autoimmunity at the ocular surface: pathogenesis and regulation", MUCOSAL IMMUNOL., vol. 3, 2010, pages 425 - 442 | Type: | Non-patent literature | Publication information: | STERN M.E.; SCHAUMBURG C.S.; PFLUGFELDER S.C.: "Dry eye as a mucosal autoimmune disease", INT REV IMMUNOL., vol. 32, 2013, pages 19 - 41 | Type: | Non-patent literature | Publication information: | STOCKINGER, B.; 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SCHAUMBURG C.S.; COURSEY T.G.; SIEMASKO K.F.; VOLPE E.A.; GANDHI N.B.; LI D.Q.; NIEDERKORN J.Y.; STERN M.E.; PFLUGFELDER: "CD8(+) cells regulate the T helper-17 response in an experimental murine model of Sjogren syndrome", MUCOSAL IMMUNOL., vol. 7, 2014, pages 417 - 427 | Type: | Non-patent literature | Publication information: | ZHANG X.; VOLPE E.A.; GANDHI N.B.; SCHAUMBURG C.S.; SIEMASKO K.F.; PANGELINAN S.B.; KELLY S.D.; HAYDAY A.C.; LI D.Q.; STERN M.E.: "NK cells promote Th-17 mediated corneal barrier disruption in dry eye", PLOS ONE, vol. 7, 2012, pages E36822 | Type: | Non-patent literature | Publication information: | ZHENG X.; DE PAIVA C.S.; RAO K.; LI D.Q.; FARLEY W.J.; STERN M.; PFLUGFELDER S.C.: "Evaluation of the transforming growth factor-beta activity in normal and dry eye human tears by CCL-185 cell bioassay", CORNEA, vol. 29, 2010, pages 1048 - 1054 | Type: | Non-patent literature | Publication information: | ZOUKHRI D.: "Effect of inflammation on lacrimal gland function", EXP EYE RES, vol. 82, 2006, pages 885 - 98, XP024945408, DOI: doi:10.1016/j.exer.2005.10.018 | DOI: | http://dx.doi.org/10.1016/j.exer.2005.10.018 |