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Extract from the Register of European Patents

EP About this file: EP3313831

EP3313831 - N-SUBSTITUTED HYDROXAMIC ACIDS WITH CARBON-BASED LEAVING GROUPS AS EFFICIENT HNO DONORS AND USES THEREOF [Right-click to bookmark this link]
StatusNo opposition filed within time limit
Status updated on  14.01.2022
Database last updated on 11.09.2024
FormerThe patent has been granted
Status updated on  05.02.2021
FormerGrant of patent is intended
Status updated on  20.09.2020
FormerExamination is in progress
Status updated on  08.01.2020
FormerRequest for examination was made
Status updated on  30.03.2018
FormerThe international publication has been made
Status updated on  30.12.2016
Most recent event   Tooltip27.04.2024Lapse of the patent in a contracting state
New state(s): MK		published on 29.05.2024  [2024/22]
Applicant(s)For all designated states
The Johns Hopkins University
3400 North Charles Street
Baltimore, MD 21218 / US
[2018/18]
Inventor(s)01 / TOSCANO, John, P.
18 Tree Farm Court
Glen Arm, MD 21057 / US
02 / NOURIAN, Saghar
7246 Dockside Lane
Columbia, MD 21045 / US
 [2018/18]
Representative(s)Dehns
St. Bride's House
10 Salisbury Square
London EC4Y 8JD / GB
[2021/10]
Former [2018/18]Beacham, Annabel Rose
Dehns
St Bride's House
10 Salisbury Square
London EC4Y 8JD / GB
Application number, filing date16738303.325.06.2016
[2018/18]
WO2016US39453
Priority number, dateUS201562185310P26.06.2015         Original published format: US 201562185310 P
[2018/18]
Filing languageEN
Procedural languageEN
PublicationType: A1 Application with search report
No.:WO2016210392
Date:29.12.2016
Language:EN
[2016/52]
Type: A1 Application with search report 
No.:EP3313831
Date:02.05.2018
Language:EN
The application published by WIPO in one of the EPO official languages on 29.12.2016 takes the place of the publication of the European patent application.
[2018/18]
Type: B1 Patent specification 
No.:EP3313831
Date:10.03.2021
Language:EN
[2021/10]
Search report(s)International search report - published on:EP29.12.2016
ClassificationIPC:C07D311/42, C07D231/50, C07D239/62, A61K31/515, A61K31/4152, A61P9/00
[2018/18]
CPC:
A61K31/515 (EP,US); A61K31/352 (EP,US); A61K31/4152 (EP,US);
A61P9/00 (EP,US); C07D231/50 (EP,US); C07D239/62 (EP,US);
C07D311/42 (EP,US) (-)
Designated contracting statesAL,   AT,   BE,   BG,   CH,   CY,   CZ,   DE,   DK,   EE,   ES,   FI,   FR,   GB,   GR,   HR,   HU,   IE,   IS,   IT,   LI,   LT,   LU,   LV,   MC,   MK,   MT,   NL,   NO,   PL,   PT,   RO,   RS,   SE,   SI,   SK,   SM,   TR [2018/18]
Extension statesBANot yet paid
MENot yet paid
Validation statesMANot yet paid
MDNot yet paid
TitleGerman:N-SUBSTITUIERTE HYDROXAMSÄUREN MIT KOHLENSTOFFHALTIGEN ABGANGSGRUPPEN ALS EFFIZIENTE HNO-DONATOREN UND VERWENDUNGEN DAVON[2018/18]
English:N-SUBSTITUTED HYDROXAMIC ACIDS WITH CARBON-BASED LEAVING GROUPS AS EFFICIENT HNO DONORS AND USES THEREOF[2018/18]
French:ACIDES HYDROXAMIQUES N-SUBSTITUÉS COMPORTANT DES GROUPES PARTANTS À BASE DE CARBONE SERVANT DE DONNEURS DE HNO EFFICACES ET UTILISATIONS DE CEUX-CI[2018/18]
Entry into regional phase11.01.2018National basic fee paid 
11.01.2018Designation fee(s) paid 
11.01.2018Examination fee paid 
Examination procedure11.01.2018Examination requested  [2018/18]
11.01.2018Date on which the examining division has become responsible
08.10.2018Despatch of communication that the application is deemed to be withdrawn, reason: reply to the Extended European Search Report/Written Opinion of the International Searching Authority/International Preliminary Examination Report/Supplementary international search report not received in time
08.10.2018Despatch of communication of loss of particular rights: Claims {1}
16.11.2018Amendment by applicant (claims and/or description)
13.01.2020Despatch of a communication from the examining division (Time limit: M06)
23.07.2020Reply to a communication from the examining division
21.09.2020Communication of intention to grant the patent
29.01.2021Fee for grant paid
29.01.2021Fee for publishing/printing paid
29.01.2021Receipt of the translation of the claim(s)
Opposition(s)13.12.2021No opposition filed within time limit [2022/07]
Request for further processing for:16.11.2018Request for further processing filed
16.11.2018Full payment received (date of receipt of payment)
Request granted
27.11.2018Decision despatched
Fees paidRenewal fee
11.06.2018Renewal fee patent year 03
13.06.2019Renewal fee patent year 04
15.06.2020Renewal fee patent year 05
Opt-out from the exclusive  Tooltip
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Patent Court		 See the Register of the Unified Patent Court for opt-out data
Responsibility for the accuracy, completeness or quality of the data displayed under the link provided lies entirely with the Unified Patent Court.
Lapses during opposition  TooltipHU25.06.2016
AL10.03.2021
AT10.03.2021
CY10.03.2021
CZ10.03.2021
DK10.03.2021
EE10.03.2021
FI10.03.2021
HR10.03.2021
LT10.03.2021
LV10.03.2021
MC10.03.2021
MK10.03.2021
NL10.03.2021
PL10.03.2021
RO10.03.2021
RS10.03.2021
SE10.03.2021
SI10.03.2021
SK10.03.2021
SM10.03.2021
BG10.06.2021
NO10.06.2021
GR11.06.2021
IE25.06.2021
LU25.06.2021
BE30.06.2021
CH30.06.2021
LI30.06.2021
IS10.07.2021
PT12.07.2021
[2024/22]
Former [2023/33]HU25.06.2016
AL10.03.2021
AT10.03.2021
CY10.03.2021
CZ10.03.2021
DK10.03.2021
EE10.03.2021
FI10.03.2021
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MC10.03.2021
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PL10.03.2021
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SE10.03.2021
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BG10.06.2021
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GR11.06.2021
IE25.06.2021
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BE30.06.2021
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IS10.07.2021
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IS10.07.2021
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BG10.06.2021
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BE30.06.2021
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BG10.06.2021
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GR11.06.2021
IE25.06.2021
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CH30.06.2021
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IS10.07.2021
PT12.07.2021
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SM10.03.2021
BG10.06.2021
NO10.06.2021
GR11.06.2021
IE25.06.2021
LU25.06.2021
CH30.06.2021
LI30.06.2021
PT12.07.2021
Former [2022/18]AL10.03.2021
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BG10.06.2021
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GR11.06.2021
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PT12.07.2021
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BG10.06.2021
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SM10.03.2021
BG10.06.2021
NO10.06.2021
GR11.06.2021
PT12.07.2021
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AT10.03.2021
CZ10.03.2021
DK10.03.2021
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FI10.03.2021
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BG10.06.2021
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GR11.06.2021
IS10.07.2021
PT12.07.2021
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GR11.06.2021
IS10.07.2021
PT12.07.2021
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FI10.03.2021
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NO10.06.2021
GR11.06.2021
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FI10.03.2021
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SK10.03.2021
SM10.03.2021
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NO10.06.2021
GR11.06.2021
IS10.07.2021
PT12.07.2021
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SK10.03.2021
SM10.03.2021
BG10.06.2021
NO10.06.2021
GR11.06.2021
PT12.07.2021
Former [2021/48]AT10.03.2021
CZ10.03.2021
EE10.03.2021
FI10.03.2021
HR10.03.2021
LT10.03.2021
LV10.03.2021
NL10.03.2021
RS10.03.2021
SE10.03.2021
SM10.03.2021
BG10.06.2021
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Cited inInternational search[Y]WO2013059194  (UNIV JOHNS HOPKINS [US]) [Y] 1-52 * pages 1,17,24 *;
 [XP]WO2015183838  (UNIV JOHNS HOPKINS [US]) [XP] 1-25,27,30 * see intermediates for preparing compounds of examples 8,10',12,15,16 *;
 [Y]  - DARYL A. GUTHRIE ET AL, "Curtailing the Hydroxylaminobarbituric Acid-Hydantoin Rearrangement To Favor HNO Generation", THE JOURNAL OF ORGANIC CHEMISTRY, (20150113), vol. 80, no. 3, doi:10.1021/jo5023316, ISSN 0022-3263, pages 1349 - 1356, XP055200290 [Y] 1-52 * the whole document *

DOI:   http://dx.doi.org/10.1021/jo5023316
 [Y]  - DARYL A. GUTHRIE ET AL, "Development of N -Substituted Hydroxylamines as Efficient Nitroxyl (HNO) Donors", JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, (20120201), vol. 134, no. 4, doi:10.1021/ja2103923, ISSN 0002-7863, pages 1962 - 1965, XP055045552 [Y] 1-52 * the whole document *

DOI:   http://dx.doi.org/10.1021/ja2103923
 [Y]  - DARYL A. GUTHRIE ET AL, ""Catch-and-Release" of HNO with Pyrazolones", THE JOURNAL OF ORGANIC CHEMISTRY, (20150206), vol. 80, no. 3, doi:10.1021/jo502330w, ISSN 0022-3263, pages 1338 - 1348, XP055198821 [Y] 1-52 * the whole document *

DOI:   http://dx.doi.org/10.1021/jo502330w
 [Y]  - ART D. SUTTON ET AL, "Optimization of HNO Production from N , O - bis -Acylated Hydroxylamine Derivatives", ORGANIC LETTERS, US, (20120120), vol. 14, no. 2, doi:10.1021/ol203016c, ISSN 1523-7060, pages 472 - 475, XP055296716 [Y] 1-52 * the whole document *

DOI:   http://dx.doi.org/10.1021/ol203016c
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