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Extract from the Register of European Patents

EP About this file: EP3258938

EP3258938 - PHENOTHIAZINE ANALOGUES AS MITOCHONDRIAL THERAPEUTIC AGENTS [Right-click to bookmark this link]
Status	No opposition filed within time limit Status updated on 08.10.2021 Database last updated on 08.04.2026
Former	The patent has been granted Status updated on 30.10.2020
Former	Grant of patent is intended Status updated on 29.06.2020
Former	Request for examination was made Status updated on 24.11.2017
Former	The international publication has been made Status updated on 15.09.2017
Most recent event Tooltip	19.12.2025	Lapse of the patent in a contracting state New state(s): TR	published on 21.01.2026 [2026/04]
Applicant(s)	For all designated states Arizona Board of Regents on behalf of Arizona State University 1475 North Scottsdale Road SkySong - Suite 200 Scottsdale, Arizona 85257-3538 / US
	[2017/52]
Inventor(s)	01 / HECHT, Sidney 6517 North 26 Street Phoenix, AZ 85016 / US
	02 / KHDOUR, Omar 1025 W. Georgia Avenue Phoenix, AZ 85013 / US
	03 / CHOWDHURY, Sandipan Roy 1050 S Stanley Place P 210 Tempe, AZ 85281 / US
	04 / BANDYOPADHAY, Indrajit Tempe Terrace 1130 East Orange Street Apartment 303 Tempe, AZ 85281 / US
	[2017/52]
Representative(s)	Comoglio, Elena, et al Jacobacci & Partners S.p.A. Corso Emilia 8 10152 Torino / IT
	[2017/52]
Application number, filing date	16752964.3	17.02.2016
	[2017/52]
	WO2016US18233
Priority number, date	US201562117205P	17.02.2015 Original published format: US 201562117205 P
	[2017/52]
Filing language	EN
Procedural language	EN
Publication	Type:	A1 Application with search report
	No.:	WO2016133995
	Date:	25.08.2016
	Language:	EN
	[2016/34]
	Type:	A1 Application with search report
	No.:	EP3258938
	Date:	27.12.2017
	Language:	EN
	The application published by WIPO in one of the EPO official languages on 25.08.2016 takes the place of the publication of the European patent application.
	[2017/52]
	Type:	B1 Patent specification
	No.:	EP3258938
	Date:	02.12.2020
	Language:	EN
	[2020/49]
Search report(s)	International search report - published on:	US	25.08.2016
	(Supplementary) European search report - dispatched on:	EP	04.10.2018
Classification	IPC:	A61K31/5415, C07D279/18	[2017/52]
	CPC:	C07D279/20 (EP,US); A61P21/02 (EP); A61P25/00 (EP); A61P25/14 (EP); A61P25/16 (EP); A61P25/28 (EP); (+) A61P43/00 (EP); A61P9/00 (EP); C07D279/18 (EP,US); C07D417/04 (EP,US); C07D417/14 (EP,US) (-)
Designated contracting states	AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LI, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR [2017/52]
Extension states	BA	14.09.2017
	ME	14.09.2017
Validation states	MA	Not yet paid
	MD	Not yet paid
Title	German:	PHENOTHIAZINANALOGE ALS MITOCHONDRIALES THERAPEUTISCHES MITTEL	[2017/52]
	English:	PHENOTHIAZINE ANALOGUES AS MITOCHONDRIAL THERAPEUTIC AGENTS	[2017/52]
	French:	ANALOGUES DE PHÉNOTHIAZINE UTILISÉS COMME AGENTS THÉRAPEUTIQUES MITOCHONDRIAUX	[2017/52]
Entry into regional phase	14.09.2017	National basic fee paid
	14.09.2017	Search fee paid
	14.09.2017	Designation fee(s) paid
	14.09.2017	Examination fee paid
Examination procedure	14.09.2017	Examination requested [2017/52]
	14.09.2017	Date on which the examining division has become responsible
	30.04.2019	Amendment by applicant (claims and/or description)
	30.06.2020	Communication of intention to grant the patent
	27.10.2020	Fee for grant paid
	27.10.2020	Fee for publishing/printing paid
	27.10.2020	Receipt of the translation of the claim(s)
Opposition(s)	03.09.2021	No opposition filed within time limit [2021/45]
Fees paid	Renewal fee
	27.02.2018	Renewal fee patent year 03
	27.02.2019	Renewal fee patent year 04
	27.02.2020	Renewal fee patent year 05
Opt-out from the exclusive Tooltip competence of the Unified Patent Court	See the Register of the Unified Patent Court for opt-out data
	Responsibility for the accuracy, completeness or quality of the data displayed under the link provided lies entirely with the Unified Patent Court.
Lapses during opposition Tooltip	HU	17.02.2016
	AL	02.12.2020
	AT	02.12.2020
	CY	02.12.2020
	CZ	02.12.2020
	EE	02.12.2020
	ES	02.12.2020
	FI	02.12.2020
	HR	02.12.2020
	IT	02.12.2020
	LT	02.12.2020
	LV	02.12.2020
	MC	02.12.2020
	MK	02.12.2020
	MT	02.12.2020
	NL	02.12.2020
	PL	02.12.2020
	RO	02.12.2020
	RS	02.12.2020
	SE	02.12.2020
	SI	02.12.2020
	SK	02.12.2020
	SM	02.12.2020
	TR	02.12.2020
	IE	17.02.2021
	LU	17.02.2021
	BE	28.02.2021
	BG	02.03.2021
	NO	02.03.2021
	GR	03.03.2021
	IS	02.04.2021
	PT	05.04.2021
	[2026/04]
Former [2024/42]	HU	17.02.2016
	AL	02.12.2020
	AT	02.12.2020
	CY	02.12.2020
	CZ	02.12.2020
	EE	02.12.2020
	ES	02.12.2020
	FI	02.12.2020
	HR	02.12.2020
	IT	02.12.2020
	LT	02.12.2020
	LV	02.12.2020
	MC	02.12.2020
	MK	02.12.2020
	MT	02.12.2020
	NL	02.12.2020
	PL	02.12.2020
	RO	02.12.2020
	RS	02.12.2020
	SE	02.12.2020
	SI	02.12.2020
	SK	02.12.2020
	SM	02.12.2020
	IE	17.02.2021
	LU	17.02.2021
	BE	28.02.2021
	BG	02.03.2021
	NO	02.03.2021
	GR	03.03.2021
	IS	02.04.2021
	PT	05.04.2021
Former [2024/22]	HU	17.02.2016
	AL	02.12.2020
	AT	02.12.2020
	CY	02.12.2020
	CZ	02.12.2020
	EE	02.12.2020
	ES	02.12.2020
	FI	02.12.2020
	HR	02.12.2020
	IT	02.12.2020
	LT	02.12.2020
	LV	02.12.2020
	MC	02.12.2020
	MK	02.12.2020
	NL	02.12.2020
	PL	02.12.2020
	RO	02.12.2020
	RS	02.12.2020
	SE	02.12.2020
	SI	02.12.2020
	SK	02.12.2020
	SM	02.12.2020
	IE	17.02.2021
	LU	17.02.2021
	BE	28.02.2021
	BG	02.03.2021
	NO	02.03.2021
	GR	03.03.2021
	IS	02.04.2021
	PT	05.04.2021
Former [2023/33]	HU	17.02.2016
	AL	02.12.2020
	AT	02.12.2020
	CY	02.12.2020
	CZ	02.12.2020
	EE	02.12.2020
	ES	02.12.2020
	FI	02.12.2020
	HR	02.12.2020
	IT	02.12.2020
	LT	02.12.2020
	LV	02.12.2020
	MC	02.12.2020
	NL	02.12.2020
	PL	02.12.2020
	RO	02.12.2020
	RS	02.12.2020
	SE	02.12.2020
	SI	02.12.2020
	SK	02.12.2020
	SM	02.12.2020
	IE	17.02.2021
	LU	17.02.2021
	BE	28.02.2021
	BG	02.03.2021
	NO	02.03.2021
	GR	03.03.2021
	IS	02.04.2021
	PT	05.04.2021
Former [2023/30]	AL	02.12.2020
	AT	02.12.2020
	CY	02.12.2020
	CZ	02.12.2020
	EE	02.12.2020
	ES	02.12.2020
	FI	02.12.2020
	HR	02.12.2020
	IT	02.12.2020
	LT	02.12.2020
	LV	02.12.2020
	MC	02.12.2020
	NL	02.12.2020
	PL	02.12.2020
	RO	02.12.2020
	RS	02.12.2020
	SE	02.12.2020
	SI	02.12.2020
	SK	02.12.2020
	SM	02.12.2020
	IE	17.02.2021
	LU	17.02.2021
	BE	28.02.2021
	BG	02.03.2021
	NO	02.03.2021
	GR	03.03.2021
	IS	02.04.2021
	PT	05.04.2021
Former [2022/34]	AL	02.12.2020
	AT	02.12.2020
	CZ	02.12.2020
	EE	02.12.2020
	ES	02.12.2020
	FI	02.12.2020
	HR	02.12.2020
	IT	02.12.2020
	LT	02.12.2020
	LV	02.12.2020
	MC	02.12.2020
	NL	02.12.2020
	PL	02.12.2020
	RO	02.12.2020
	RS	02.12.2020
	SE	02.12.2020
	SI	02.12.2020
	SK	02.12.2020
	SM	02.12.2020
	IE	17.02.2021
	LU	17.02.2021
	BE	28.02.2021
	BG	02.03.2021
	NO	02.03.2021
	GR	03.03.2021
	IS	02.04.2021
	PT	05.04.2021
Former [2022/23]	AL	02.12.2020
	AT	02.12.2020
	CZ	02.12.2020
	EE	02.12.2020
	ES	02.12.2020
	FI	02.12.2020
	HR	02.12.2020
	IT	02.12.2020
	LT	02.12.2020
	LV	02.12.2020
	MC	02.12.2020
	NL	02.12.2020
	PL	02.12.2020
	RO	02.12.2020
	RS	02.12.2020
	SE	02.12.2020
	SI	02.12.2020
	SK	02.12.2020
	SM	02.12.2020
	IE	17.02.2021
	LU	17.02.2021
	BG	02.03.2021
	NO	02.03.2021
	GR	03.03.2021
	IS	02.04.2021
	PT	05.04.2021
Former [2022/10]	AL	02.12.2020
	AT	02.12.2020
	CZ	02.12.2020
	EE	02.12.2020
	ES	02.12.2020
	FI	02.12.2020
	HR	02.12.2020
	IT	02.12.2020
	LT	02.12.2020
	LV	02.12.2020
	MC	02.12.2020
	NL	02.12.2020
	PL	02.12.2020
	RO	02.12.2020
	RS	02.12.2020
	SE	02.12.2020
	SI	02.12.2020
	SK	02.12.2020
	SM	02.12.2020
	IE	17.02.2021
	LU	17.02.2021
	BG	02.03.2021
	NO	02.03.2021
	GR	03.03.2021
	PT	05.04.2021
Former [2022/08]	AL	02.12.2020
	AT	02.12.2020
	CZ	02.12.2020
	EE	02.12.2020
	ES	02.12.2020
	FI	02.12.2020
	HR	02.12.2020
	IT	02.12.2020
	LT	02.12.2020
	LV	02.12.2020
	MC	02.12.2020
	NL	02.12.2020
	PL	02.12.2020
	RO	02.12.2020
	RS	02.12.2020
	SE	02.12.2020
	SI	02.12.2020
	SK	02.12.2020
	SM	02.12.2020
	IE	17.02.2021
	LU	17.02.2021
	BG	02.03.2021
	NO	02.03.2021
	GR	03.03.2021
	IS	02.04.2021
	PT	05.04.2021
Former [2022/07]	AL	02.12.2020
	AT	02.12.2020
	CZ	02.12.2020
	EE	02.12.2020
	FI	02.12.2020
	HR	02.12.2020
	IT	02.12.2020
	LT	02.12.2020
	LV	02.12.2020
	MC	02.12.2020
	NL	02.12.2020
	PL	02.12.2020
	RO	02.12.2020
	RS	02.12.2020
	SE	02.12.2020
	SI	02.12.2020
	SK	02.12.2020
	SM	02.12.2020
	IE	17.02.2021
	LU	17.02.2021
	BG	02.03.2021
	NO	02.03.2021
	GR	03.03.2021
	IS	02.04.2021
	PT	05.04.2021
Former [2021/50]	AL	02.12.2020
	AT	02.12.2020
	CZ	02.12.2020
	EE	02.12.2020
	FI	02.12.2020
	HR	02.12.2020
	IT	02.12.2020
	LT	02.12.2020
	LV	02.12.2020
	MC	02.12.2020
	NL	02.12.2020
	PL	02.12.2020
	RO	02.12.2020
	RS	02.12.2020
	SE	02.12.2020
	SI	02.12.2020
	SK	02.12.2020
	SM	02.12.2020
	LU	17.02.2021
	BG	02.03.2021
	NO	02.03.2021
	GR	03.03.2021
	IS	02.04.2021
	PT	05.04.2021
Former [2021/48]	AL	02.12.2020
	AT	02.12.2020
	CZ	02.12.2020
	EE	02.12.2020
	FI	02.12.2020
	HR	02.12.2020
	IT	02.12.2020
	LT	02.12.2020
	LV	02.12.2020
	MC	02.12.2020
	NL	02.12.2020
	PL	02.12.2020
	RO	02.12.2020
	RS	02.12.2020
	SE	02.12.2020
	SK	02.12.2020
	SM	02.12.2020
	LU	17.02.2021
	BG	02.03.2021
	NO	02.03.2021
	GR	03.03.2021
	IS	02.04.2021
	PT	05.04.2021
Former [2021/47]	AL	02.12.2020
	AT	02.12.2020
	CZ	02.12.2020
	EE	02.12.2020
	FI	02.12.2020
	HR	02.12.2020
	LT	02.12.2020
	LV	02.12.2020
	MC	02.12.2020
	NL	02.12.2020
	PL	02.12.2020
	RO	02.12.2020
	RS	02.12.2020
	SE	02.12.2020
	SK	02.12.2020
	SM	02.12.2020
	LU	17.02.2021
	BG	02.03.2021
	NO	02.03.2021
	GR	03.03.2021
	IS	02.04.2021
	PT	05.04.2021
Former [2021/45]	AL	02.12.2020
	AT	02.12.2020
	CZ	02.12.2020
	EE	02.12.2020
	FI	02.12.2020
	HR	02.12.2020
	LT	02.12.2020
	LV	02.12.2020
	MC	02.12.2020
	NL	02.12.2020
	PL	02.12.2020
	RO	02.12.2020
	RS	02.12.2020
	SE	02.12.2020
	SK	02.12.2020
	SM	02.12.2020
	BG	02.03.2021
	NO	02.03.2021
	GR	03.03.2021
	IS	02.04.2021
	PT	05.04.2021
Former [2021/42]	AT	02.12.2020
	CZ	02.12.2020
	EE	02.12.2020
	FI	02.12.2020
	HR	02.12.2020
	LT	02.12.2020
	LV	02.12.2020
	MC	02.12.2020
	NL	02.12.2020
	PL	02.12.2020
	RO	02.12.2020
	RS	02.12.2020
	SE	02.12.2020
	SK	02.12.2020
	SM	02.12.2020
	BG	02.03.2021
	NO	02.03.2021
	GR	03.03.2021
	IS	02.04.2021
	PT	05.04.2021
Former [2021/41]	AT	02.12.2020
	CZ	02.12.2020
	EE	02.12.2020
	FI	02.12.2020
	HR	02.12.2020
	LT	02.12.2020
	LV	02.12.2020
	MC	02.12.2020
	NL	02.12.2020
	PL	02.12.2020
	RO	02.12.2020
	RS	02.12.2020
	SE	02.12.2020
	SK	02.12.2020
	SM	02.12.2020
	BG	02.03.2021
	NO	02.03.2021
	GR	03.03.2021
	PT	05.04.2021
Former [2021/37]	AT	02.12.2020
	CZ	02.12.2020
	EE	02.12.2020
	FI	02.12.2020
	HR	02.12.2020
	LT	02.12.2020
	LV	02.12.2020
	NL	02.12.2020
	PL	02.12.2020
	RO	02.12.2020
	RS	02.12.2020
	SE	02.12.2020
	SK	02.12.2020
	SM	02.12.2020
	BG	02.03.2021
	NO	02.03.2021
	GR	03.03.2021
	PT	05.04.2021
Former [2021/36]	CZ	02.12.2020
	EE	02.12.2020
	FI	02.12.2020
	HR	02.12.2020
	LT	02.12.2020
	LV	02.12.2020
	NL	02.12.2020
	PL	02.12.2020
	RO	02.12.2020
	RS	02.12.2020
	SE	02.12.2020
	SK	02.12.2020
	SM	02.12.2020
	BG	02.03.2021
	NO	02.03.2021
	GR	03.03.2021
	PT	05.04.2021
Former [2021/35]	CZ	02.12.2020
	FI	02.12.2020
	HR	02.12.2020
	LT	02.12.2020
	LV	02.12.2020
	NL	02.12.2020
	PL	02.12.2020
	RO	02.12.2020
	RS	02.12.2020
	SE	02.12.2020
	SK	02.12.2020
	SM	02.12.2020
	BG	02.03.2021
	NO	02.03.2021
	GR	03.03.2021
	PT	05.04.2021
Former [2021/34]	CZ	02.12.2020
	FI	02.12.2020
	HR	02.12.2020
	LT	02.12.2020
	LV	02.12.2020
	NL	02.12.2020
	PL	02.12.2020
	RS	02.12.2020
	SE	02.12.2020
	SM	02.12.2020
	BG	02.03.2021
	NO	02.03.2021
	GR	03.03.2021
	PT	05.04.2021
Former [2021/33]	FI	02.12.2020
	HR	02.12.2020
	LT	02.12.2020
	LV	02.12.2020
	NL	02.12.2020
	PL	02.12.2020
	RS	02.12.2020
	SE	02.12.2020
	SM	02.12.2020
	BG	02.03.2021
	NO	02.03.2021
	GR	03.03.2021
	PT	05.04.2021
Former [2021/32]	FI	02.12.2020
	HR	02.12.2020
	LV	02.12.2020
	NL	02.12.2020
	PL	02.12.2020
	RS	02.12.2020
	SE	02.12.2020
	SM	02.12.2020
	BG	02.03.2021
	NO	02.03.2021
	GR	03.03.2021
Former [2021/30]	FI	02.12.2020
	HR	02.12.2020
	LV	02.12.2020
	NL	02.12.2020
	PL	02.12.2020
	RS	02.12.2020
	SE	02.12.2020
	BG	02.03.2021
	NO	02.03.2021
	GR	03.03.2021
Former [2021/28]	FI	02.12.2020
	HR	02.12.2020
	LV	02.12.2020
	PL	02.12.2020
	RS	02.12.2020
	SE	02.12.2020
	BG	02.03.2021
	NO	02.03.2021
	GR	03.03.2021
Former [2021/25]	FI	02.12.2020
	LV	02.12.2020
	PL	02.12.2020
	RS	02.12.2020
	SE	02.12.2020
	BG	02.03.2021
	NO	02.03.2021
	GR	03.03.2021
Former [2021/23]	FI	02.12.2020
	LV	02.12.2020
	RS	02.12.2020
	SE	02.12.2020
	BG	02.03.2021
	NO	02.03.2021
	GR	03.03.2021
Former [2021/22]	FI	02.12.2020
	RS	02.12.2020
	NO	02.03.2021
Former [2021/20]	FI	02.12.2020
Documents cited:	Search	[A] US2014275045 (HINMAN ANDREW W et al.) [A] 1 * example -; claim - *
	International search	[XY] US2008062838 (SELINFREUND RICHARD H et al.) [X] 55-57, 62/55-57, 63/55-57, 64/55-57, 65/64/55-57, 66/55-57 * ; abstract; paragraphs [0091], [0105]-[0106] *[Y] 58-61, 62/58-61, 63/58-61, 64/58-61, 65/64/58-61, 66/58-61, 102
		[XY] US8759336 (HURT CLARENCE R et al.) [X] 1-3, 8/1-3, 9/1-3, 10/9/1-3,11/1-3, 12/11/1-3 * ; abstract; column 3, lines 40-60; column 18, lines 20-35; column 28, lines 1-5, 55-60 *[Y] 1-2, 4-7, 8/4-7, 9/4-7, 10/9/4-7, 11/4-7, 12/11/4-7
		[Y] US2014275045 (HINMAN ANDREW W et al.) [Y] 1-2, 4-7, 8/4-7, 9/4-7, 10/9/4-7, 11/4-7, 12/11/4-7 * ; abstract; paragraphs [0042], [0055], [0084] *
		[Y] US2013224634 (BERNETH HORST et al.) [Y] 58-60, 62/58-60, 63/58-60, 64/58-60, 165/64/58-60, 66/58-60 * ; abstract; paragraphs [0711], [0897] *
		[Y] US4338180 (NAKAMURA MICHIHIRO et al.) [Y] 61, 62/61, 63/61, 64/61, 65/64/61, 66/61, 102 * ; abstract; column 2, lines 5-10, 20-50; column 4, lines 23-28, 40-50 *
		[Y] DATABASE NCBI PUBCHEM. 26 March 2005 (2005-03-26), Database accession no. 68485 [Y] 1-3, 8/1-3, 9/1-3, 10/9/1-3, 11/1-3, 12/11/1-3 * ; page 3 *
	by applicant	DIMAURO ET AL., AM. J. MED. GENET., vol. 106, 2001, pages 18 - 26 [Y] 58-61, 62/58-61, 63/58-61, 64/58-61, 65/64/58-61, 66/58-61, 102
		LEONARD ET AL., LANCET., vol. 355, 2000, pages 299 - 304 [Y] 1-2, 4-7, 8/4-7, 9/4-7, 10/9/4-7, 11/4-7, 12/11/4-7
		WILSON ET AL., NAT. GENET., vol. 16, 1997, pages 352 - 357 [Y] 1-3, 8/1-3, 9/1-3, 10/9/1-3, 11/1-3, 12/11/1-3 * ; page 3 *
		WILSON ET AL., J. NEUROL. SCI., vol. 207, 2003, pages 103 - 105
		CAMPUZANO ET AL., SCIENCE, vol. 271, 1996, pages 1423 - 1427
		CAMPUZANO ET AL., HUM. MOL. GENET., vol. 6, 1997, pages 1771 - 1780
		BENCZE ET AL., J.C.S. CHEM. COMMUN., 2007, pages 1798 - 1800
		PARK ET AL., J. BIOL. CHEM., vol. 278, 2003, pages 31340 - 31351
		YOON ET AL., J. AM CHEM. SOC., vol. 125, 2003, pages 6078 - 6084
		YOON ET AL., J. BIOL. CHEM., vol. 279, 2004, pages 25943 - 25946
		BULTEAU ET AL., SCIENCE, vol. 305, 2004, pages 242 - 245
		GONZALEZ-CABO ET AL., HUM. MOL. GENET., vol. 14, 2005, pages 2091 - 2098
		BRADLEY ET AL., HUM. MOL. GENET., vol. 9, 2000, pages 275 - 282
		SMITHMARCH: "Reactions, Mechanisms, and Structure", 2001, WILEY-INTERSCIENCE, article "March's Advanced Organic Chemistry"
		VOGEL, A: "Including Qualitative Organic Analysis", 1978, LONGMAN, article "Textbook of Practical Organic Chemistry"
		"Introduction to Modern Liquid Chromatography", 1979, JOHN WILEY AND SONS
		"Thin Layer Chromatography", 1969, SPRINGER-VERLAG
		J. F. W. MCOMIE: "Protective Groups in Organic Chemistry", 1973, PLENUM PRESS
		T. W. GREENEP. G. M. WUTS: "Protective Groups in Organic Synthesis", 1999, WILEY
		"The Peptides", vol. 3, 1981, ACADEMIC PRESS
		HOUBEN-WEYL: "Methoden der organischen Chemie", vol. 15/1, 1974, GEORG THIEME VERLAG
		H.-D. JAKUBKEH. JESCHEIT: "Aminosauren, Peptide, Proteine", VERLAG CHEMIE
		JOCHEN LEHMANN: "Chemie der Kohlenhydrate: Monosaccharide and Derivate", 1974, GEORG THIEME VERLAG, STUTTGART
		ARCE ET AL., BIOORG. MED. CHEM., vol. 20, 2012, pages 5188
		KHDOUR ET AL., ACS MED. CHEM. LETT., vol. 4, 2013, pages 724
		SMITH, A. L, METHODS ENZYMOL., vol. 10, 1967, pages 81
		MATSUNO-YAGI, A.HATEFI, Y. J., J. BIOL. CHEM., vol. 260, 1985, pages 11424

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