blank Quick help
blank Maintenance news

Scheduled maintenance

Regular maintenance outages:
between 05.00 and 05.15 hrs CET (Monday to Sunday).

Other outages
Availability

2022.02.11

More...
blank News flashes

News Flashes

New version of the European Patent Register – SPC proceedings information in the Unitary Patent Register.

2024-07-24

More...
blank Related links

Release notes
European Patent Register Assistant
European Patent Register Resource Book
European Patent Register – pocket guide
FAQ - European Patent Register
Federated Register (Flyer)
Global Dossier (Flyer)
Register events
Deep link coverage
Federated Register content
The Patent Information Tour
Fair use charter

Extract from the Register of European Patents

EP About this file: EP3265083

EP3265083 - SUBSTITUTED UREA DEPSIPEPTIDE ANALOGS AS ACTIVATORS OF THE CLPP ENDOPEPTIDASE [Right-click to bookmark this link]
StatusNo opposition filed within time limit
Status updated on  12.05.2023
Database last updated on 15.11.2024
FormerThe patent has been granted
Status updated on  03.06.2022
FormerGrant of patent is intended
Status updated on  23.02.2022
FormerExamination is in progress
Status updated on  31.01.2022
FormerGrant of patent is intended
Status updated on  19.09.2021
FormerExamination is in progress
Status updated on  21.01.2020
FormerRequest for examination was made
Status updated on  08.12.2017
FormerThe international publication has been made
Status updated on  04.10.2017
Most recent event   Tooltip15.11.2024Lapse of the patent in a contracting state
New state(s): BG		published on 18.12.2024 [2024/51]
Applicant(s)For all designated states
St. Jude Children's Research Hospital
262 Danny Thomas Place
Memphis, TN 38105 / US
[2018/02]
Inventor(s)01 / LEE, Richard E.
8233 Byre Hollow Cove
Cordova, TN 38013 / US
02 / ZHAO, Ying
1316 Island Shore Dr.
Memphis, TN 38103 / US
03 / JIUYU, Liu
1017 Stanhope Road
Collierville, TN 38017 / US
 [2018/07]
Former [2018/02]01 / LEE, Richard E.
8233 Byre Hollow Cove
Cordova, TN 38013 / US
02 / ZHAO, Ying
126 Harbor Club Circle South
Apartment 202
Memphis, TN 38103 / US
03 / JIUYU, Liu
1017 Stanhope Road
Collierville, TN 38017 / US
Representative(s)Carpmaels & Ransford LLP
One Southampton Row
London WC1B 5HA / GB
[2022/27]
Former [2018/02]McGuire, Gillian Margaret
Carpmaels & Ransford LLP
One Southampton Row
London WC1B 5HA / GB
Application number, filing date16759625.304.03.2016
[2018/02]
WO2016US21043
Priority number, dateUS201562128497P04.03.2015         Original published format: US 201562128497 P
[2018/02]
Filing languageEN
Procedural languageEN
PublicationType: A1 Application with search report
No.:WO2016141351
Date:09.09.2016
Language:EN
[2016/36]
Type: A1 Application with search report 
No.:EP3265083
Date:10.01.2018
Language:EN
The application published by WIPO in one of the EPO official languages on 09.09.2016 takes the place of the publication of the European patent application.
[2018/02]
Type: B1 Patent specification 
No.:EP3265083
Date:06.07.2022
Language:EN
[2022/27]
Search report(s)International search report - published on:US09.09.2016
(Supplementary) European search report - dispatched on:EP21.09.2018
ClassificationIPC:A61K31/407, A61K38/08, A61K38/12, A61K38/14, A61K38/15, A61K9/00, A61P31/04, C07D498/14, C07D498/22, C07K7/06, C07K11/02
[2018/43]
CPC:
A61K38/12 (EP,US); C07K11/02 (US); A61K31/407 (EP,US);
A61K38/14 (EP,US); A61K38/15 (EP,US); A61K45/06 (EP,US);
A61K47/02 (EP,US); A61K9/0019 (EP,US); A61K9/2018 (EP,US);
A61P31/04 (EP); C07D498/14 (EP,US); C07D498/22 (EP,US);
C07K7/06 (EP,US); Y02A50/30 (US) (-)
C-Set:
A61K31/407, A61K2300/00 (US,EP);
A61K38/12, A61K2300/00 (US,EP);
A61K38/14, A61K2300/00 (EP,US)
Former IPC [2018/02]A61K31/407, A61K38/08, A61K38/12
Designated contracting statesAL,   AT,   BE,   BG,   CH,   CY,   CZ,   DE,   DK,   EE,   ES,   FI,   FR,   GB,   GR,   HR,   HU,   IE,   IS,   IT,   LI,   LT,   LU,   LV,   MC,   MK,   MT,   NL,   NO,   PL,   PT,   RO,   RS,   SE,   SI,   SK,   SM,   TR [2018/02]
Extension statesBANot yet paid
MENot yet paid
Validation statesMANot yet paid
MDNot yet paid
TitleGerman:SUBSTITUIERTE HARNSTOFFE-DEPSIPEPTID-ANALOGA ALS AKTIVATOREN DER CLPP-ENDOPEPTIDASE[2018/02]
English:SUBSTITUTED UREA DEPSIPEPTIDE ANALOGS AS ACTIVATORS OF THE CLPP ENDOPEPTIDASE[2018/02]
French:ANALOGUES DE DEPSIPEPTIDE D'URÉE SUBSTITUÉS À UTILISER EN TANT QU'ACTIVATEURS DE L'ENDOPEPTIDASE CLPP[2018/02]
Entry into regional phase04.10.2017National basic fee paid 
04.10.2017Search fee paid 
04.10.2017Designation fee(s) paid 
04.10.2017Examination fee paid 
Examination procedure04.10.2017Examination requested  [2018/02]
04.10.2017Date on which the examining division has become responsible
18.04.2019Amendment by applicant (claims and/or description)
24.01.2020Despatch of a communication from the examining division (Time limit: M04)
02.06.2020Reply to a communication from the examining division
20.10.2020Despatch of a communication from the examining division (Time limit: M04)
26.01.2021Reply to a communication from the examining division
20.09.2021Communication of intention to grant the patent
31.01.2022Disapproval of the communication of intention to grant the patent by the applicant or resumption of examination proceedings by the EPO
24.02.2022Communication of intention to grant the patent
31.05.2022Fee for grant paid
31.05.2022Fee for publishing/printing paid
31.05.2022Receipt of the translation of the claim(s)
Opposition(s)11.04.2023No opposition filed within time limit [2023/24]
Fees paidRenewal fee
27.03.2018Renewal fee patent year 03
27.03.2019Renewal fee patent year 04
27.03.2020Renewal fee patent year 05
29.03.2021Renewal fee patent year 06
28.03.2022Renewal fee patent year 07
Opt-out from the exclusive  Tooltip
competence of the Unified
Patent Court		 See the Register of the Unified Patent Court for opt-out data
Responsibility for the accuracy, completeness or quality of the data displayed under the link provided lies entirely with the Unified Patent Court.
Lapses during opposition  TooltipAL06.07.2022
AT06.07.2022
BG06.07.2022
CZ06.07.2022
DK06.07.2022
EE06.07.2022
ES06.07.2022
FI06.07.2022
HR06.07.2022
IT06.07.2022
LT06.07.2022
LV06.07.2022
MC06.07.2022
NL06.07.2022
PL06.07.2022
RO06.07.2022
RS06.07.2022
SE06.07.2022
SI06.07.2022
SK06.07.2022
SM06.07.2022
NO06.10.2022
GR07.10.2022
IS06.11.2022
PT07.11.2022
IE04.03.2023
LU04.03.2023
BE31.03.2023
[2024/51]
Former [2024/11]AL06.07.2022
AT06.07.2022
CZ06.07.2022
DK06.07.2022
EE06.07.2022
ES06.07.2022
FI06.07.2022
HR06.07.2022
IT06.07.2022
LT06.07.2022
LV06.07.2022
MC06.07.2022
NL06.07.2022
PL06.07.2022
RO06.07.2022
RS06.07.2022
SE06.07.2022
SI06.07.2022
SK06.07.2022
SM06.07.2022
NO06.10.2022
GR07.10.2022
IS06.11.2022
PT07.11.2022
IE04.03.2023
LU04.03.2023
BE31.03.2023
Former [2024/08]AL06.07.2022
AT06.07.2022
CZ06.07.2022
DK06.07.2022
EE06.07.2022
ES06.07.2022
FI06.07.2022
HR06.07.2022
LT06.07.2022
LV06.07.2022
MC06.07.2022
NL06.07.2022
PL06.07.2022
RO06.07.2022
RS06.07.2022
SE06.07.2022
SI06.07.2022
SK06.07.2022
SM06.07.2022
NO06.10.2022
GR07.10.2022
IS06.11.2022
PT07.11.2022
IE04.03.2023
LU04.03.2023
Former [2024/02]AL06.07.2022
AT06.07.2022
CZ06.07.2022
DK06.07.2022
EE06.07.2022
ES06.07.2022
FI06.07.2022
HR06.07.2022
LT06.07.2022
LV06.07.2022
MC06.07.2022
NL06.07.2022
PL06.07.2022
RO06.07.2022
RS06.07.2022
SE06.07.2022
SI06.07.2022
SK06.07.2022
SM06.07.2022
NO06.10.2022
GR07.10.2022
IS06.11.2022
PT07.11.2022
LU04.03.2023
Former [2023/48]AL06.07.2022
AT06.07.2022
CZ06.07.2022
DK06.07.2022
EE06.07.2022
ES06.07.2022
FI06.07.2022
HR06.07.2022
LT06.07.2022
LV06.07.2022
MC06.07.2022
NL06.07.2022
PL06.07.2022
RO06.07.2022
RS06.07.2022
SE06.07.2022
SI06.07.2022
SK06.07.2022
SM06.07.2022
NO06.10.2022
GR07.10.2022
IS06.11.2022
PT07.11.2022
Former [2023/37]AL06.07.2022
AT06.07.2022
CZ06.07.2022
DK06.07.2022
EE06.07.2022
ES06.07.2022
FI06.07.2022
HR06.07.2022
LT06.07.2022
LV06.07.2022
NL06.07.2022
PL06.07.2022
RO06.07.2022
RS06.07.2022
SE06.07.2022
SI06.07.2022
SK06.07.2022
SM06.07.2022
NO06.10.2022
GR07.10.2022
IS06.11.2022
PT07.11.2022
Former [2023/29]AL06.07.2022
AT06.07.2022
CZ06.07.2022
DK06.07.2022
EE06.07.2022
ES06.07.2022
FI06.07.2022
HR06.07.2022
LT06.07.2022
LV06.07.2022
NL06.07.2022
PL06.07.2022
RO06.07.2022
RS06.07.2022
SE06.07.2022
SK06.07.2022
SM06.07.2022
NO06.10.2022
GR07.10.2022
IS06.11.2022
PT07.11.2022
Former [2023/23]AT06.07.2022
CZ06.07.2022
DK06.07.2022
EE06.07.2022
ES06.07.2022
FI06.07.2022
HR06.07.2022
LT06.07.2022
LV06.07.2022
NL06.07.2022
PL06.07.2022
RO06.07.2022
RS06.07.2022
SE06.07.2022
SK06.07.2022
SM06.07.2022
NO06.10.2022
GR07.10.2022
IS06.11.2022
PT07.11.2022
Former [2023/22]AT06.07.2022
CZ06.07.2022
DK06.07.2022
ES06.07.2022
FI06.07.2022
HR06.07.2022
LT06.07.2022
LV06.07.2022
NL06.07.2022
PL06.07.2022
RO06.07.2022
RS06.07.2022
SE06.07.2022
SM06.07.2022
NO06.10.2022
GR07.10.2022
IS06.11.2022
PT07.11.2022
Former [2023/21]DK06.07.2022
ES06.07.2022
FI06.07.2022
HR06.07.2022
LT06.07.2022
LV06.07.2022
NL06.07.2022
PL06.07.2022
RS06.07.2022
SE06.07.2022
SM06.07.2022
NO06.10.2022
GR07.10.2022
IS06.11.2022
PT07.11.2022
Former [2023/20]ES06.07.2022
FI06.07.2022
HR06.07.2022
LT06.07.2022
LV06.07.2022
NL06.07.2022
PL06.07.2022
RS06.07.2022
SE06.07.2022
SM06.07.2022
NO06.10.2022
GR07.10.2022
IS06.11.2022
PT07.11.2022
Former [2023/12]ES06.07.2022
FI06.07.2022
HR06.07.2022
LT06.07.2022
LV06.07.2022
NL06.07.2022
PL06.07.2022
RS06.07.2022
SE06.07.2022
NO06.10.2022
GR07.10.2022
IS06.11.2022
PT07.11.2022
Former [2023/11]ES06.07.2022
FI06.07.2022
HR06.07.2022
LT06.07.2022
LV06.07.2022
NL06.07.2022
PL06.07.2022
RS06.07.2022
SE06.07.2022
NO06.10.2022
GR07.10.2022
PT07.11.2022
Former [2023/10]ES06.07.2022
FI06.07.2022
HR06.07.2022
LT06.07.2022
LV06.07.2022
NL06.07.2022
RS06.07.2022
SE06.07.2022
NO06.10.2022
GR07.10.2022
PT07.11.2022
Former [2023/09]ES06.07.2022
FI06.07.2022
LT06.07.2022
LV06.07.2022
NL06.07.2022
RS06.07.2022
SE06.07.2022
NO06.10.2022
PT07.11.2022
Former [2023/08]ES06.07.2022
FI06.07.2022
LT06.07.2022
NL06.07.2022
RS06.07.2022
SE06.07.2022
NO06.10.2022
Former [2023/06]NL06.07.2022
Documents cited:Search[XY]US4492650  (MICHEL KARL H [US], et al) [X] 1,4-7,10-12,14 * the whole document *[Y] 1-15;
 [XP]WO2015031871  (ST JUDE CHILDRENS RES HOSPITAL [US]) [XP] 1-15 * the whole document * * pages 78, 92 * * paragraphs [0504] - [0505] * * paragraph [0461] *;
 [XY]  - GOODREID JORDAN D ET AL, "Total synthesis and antibacterial testing of the A54556 cyclic acyldepsipeptides isolated from Streptomyces hawaiiensis.", JOURNAL OF NATURAL PRODUCTS 24 OCT 2014, (20141024), vol. 77, no. 10, ISSN 1520-6025, pages 2170 - 2181, XP002784526 [X] 1,4-7,10-14 * the whole document * * middle; page 2176, column r * [Y] 1-15
 [XY]  - DANIEL W. CARNEY ET AL, "Restriction of the Conformational Dynamics of the Cyclic Acyldepsipeptide Antibiotics Improves Their Antibacterial Activity", JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, (20140205), vol. 136, no. 5, doi:10.1021/ja410385c, ISSN 0002-7863, pages 1922 - 1929, XP055131384 [X] 1,4-7,10-12,14 * the whole document * * compounds 1a-1g * [Y] 1-15

DOI:   http://dx.doi.org/10.1021/ja410385c
International search[A]US2005107288  (HINZEN BERTHOLD [DE], et al) [A] 1-3, 4/1-2, 5/1-2, 6/1-3, 7/1-3, 8/1-3, 9/1-3, 10/1-2, 11/1-3,12/1-3, 13/1-3 * ; entire document *;
 [X]WO2012135615  (UNIV BROWN [US], et al) [X] 1-3, 4/1-2, 5/1-2, 6/1-3, 7/1-3, 8/1-3, 9/1-3, 10/1-2, 11/1-3,12/1-3, 13/1-3 * ; paragraphs [0018], [0020], [0027], [0036], [0039]-[0040], [0048], [0076], [0079], [0082] *;
 [A]WO2012135846  (UNIV NORTHEASTERN [US], et al) [A] 1-3, 4/1-2, 5/1-2, 6/1-3, 7/1-3, 8/1-3, 9/1-3, 10/1-2, 11/1-3,12/1-3, 13/1-3* ; entire document *
by applicant   - LEWIS, K., Ann. Rev. Microbiol., (20100000), vol. 64, pages 357 - 372
    - LEVIN, B.R.ROZEN, D. E., Nat. Rev. Microbiol., (20060000), vol. 4, pages 556 - 562
    - "Aromaticity", MORRISONBOYD, Organic Chemistry, (19870000), pages 477 - 497
    - Remington's Pharmaceutical Sciences, Mack Publishing Co.
The EPO accepts no responsibility for the accuracy of data originating from other authorities; in particular, it does not guarantee that it is complete, up to date or fit for specific purposes.