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Extract from the Register of European Patents

EP About this file: EP3268009

EP3268009 - METHODS FOR MODULATING BONE DENSITY [Right-click to bookmark this link]
StatusThe application is deemed to be withdrawn
Status updated on  26.03.2021
Database last updated on 03.10.2024
FormerExamination is in progress
Status updated on  11.07.2020
FormerRequest for examination was made
Status updated on  15.12.2017
FormerThe international publication has been made
Status updated on  01.09.2017
Most recent event   Tooltip26.03.2021Application deemed to be withdrawnpublished on 28.04.2021  [2021/17]
Applicant(s)For all designated states
Intercept Pharmaceuticals, Inc.
10 Hudson Yards, 37th FL
New York, NY 10001 / US
[2018/03]
Inventor(s)01 / SHAPIRO, David
P.O. Box 8530
5110 Via Avante
Rancho Santa Fe, CA 92067 / US
02 / LUCIANO, Adorini
Via Bronzino 8
20133 Milano / IT
 [2018/03]
Representative(s)Cooley (UK) LLP
22 Bishopsgate
London EC2N 4BQ / GB
[N/P]
Former [2018/03]Cooley (UK) LLP
Dashwood
69 Old Broad Street
London EC2M 1QS / GB
Application number, filing date16762337.008.03.2016
[2018/03]
WO2016US21344
Priority number, dateUS201562130144P09.03.2015         Original published format: US 201562130144 P
[2018/03]
Filing languageEN
Procedural languageEN
PublicationType: A1 Application with search report
No.:WO2016144946
Date:15.09.2016
Language:EN
[2016/37]
Type: A1 Application with search report 
No.:EP3268009
Date:17.01.2018
Language:EN
The application published by WIPO in one of the EPO official languages on 15.09.2016 takes the place of the publication of the European patent application.
[2018/03]
Search report(s)International search report - published on:US15.09.2016
(Supplementary) European search report - dispatched on:EP07.11.2018
ClassificationIPC:A61K31/575, A61P19/10, C07J9/00, C07J51/00
[2018/50]
CPC:
A61K31/575 (EP,KR,US); A61K47/542 (US); A61P1/16 (EP);
A61P19/08 (EP); A61P19/10 (EP); A61P43/00 (EP);
C07J51/00 (EP,KR,US); C07J9/005 (EP,KR,US) (-)
Former IPC [2018/03]A61K31/575, A61P19/10, C07J9/00
Designated contracting statesAL,   AT,   BE,   BG,   CH,   CY,   CZ,   DE,   DK,   EE,   ES,   FI,   FR,   GB,   GR,   HR,   HU,   IE,   IS,   IT,   LI,   LT,   LU,   LV,   MC,   MK,   MT,   NL,   NO,   PL,   PT,   RO,   RS,   SE,   SI,   SK,   SM,   TR [2018/03]
TitleGerman:VERFAHREN ZUR MODULIERUNG DER KNOCHENDICHTE[2018/03]
English:METHODS FOR MODULATING BONE DENSITY[2018/03]
French:PROCÉDÉS DE MODULATION DE LA DENSITÉ OSSEUSE[2018/03]
Entry into regional phase06.10.2017National basic fee paid 
06.10.2017Search fee paid 
06.10.2017Designation fee(s) paid 
06.10.2017Examination fee paid 
Examination procedure06.10.2017Examination requested  [2018/03]
06.10.2017Date on which the examining division has become responsible
23.05.2019Amendment by applicant (claims and/or description)
15.07.2020Despatch of a communication from the examining division (Time limit: M04)
26.11.2020Application deemed to be withdrawn, date of legal effect  [2021/17]
17.12.2020Despatch of communication that the application is deemed to be withdrawn, reason: reply to the communication from the examining division not received in time  [2021/17]
Fees paidRenewal fee
27.03.2018Renewal fee patent year 03
27.03.2019Renewal fee patent year 04
27.03.2020Renewal fee patent year 05
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Responsibility for the accuracy, completeness or quality of the data displayed under the link provided lies entirely with the Unified Patent Court.
Documents cited:Search[X]WO03073991  (CELLTECH R & D INC [US], et al) [X] 1-3,10-15 * abstract * * claim - *;
 [X]JP2012072095  (TOKYO INST TECH, et al) [X] 1-3,10-15 * abstract * * claim - *;
 [Y]WO2014184271  (TES PHARMA SRL [IT]) [Y] 1-15 * abstract ** claim - *;
 [X]  - SILVIA RUIZ-GASPÀ ET AL, "Ursodeoxycholic acid decreases bilirubin-induced osteoblast apoptosis", EUROPEAN JOURNAL OF CLINICAL INVESTIGATION, GB, (20141201), vol. 44, no. 12, doi:10.1111/eci.12355, ISSN 0014-2972, pages 1206 - 1214, XP055510885 [X] 1-3,5-8,10-15 * abstract * * page 1212, column l, paragraph l - page 1213, column l, paragraph l *

DOI:   http://dx.doi.org/10.1111/eci.12355
 [X]  - A Verma, "Ursodeoxycholic Acid Enhances Fractional Calcium Absorption in Primary Biliary Cirrhosis", Osteoporosis International, doi:https://doi.org/10.1007/s001980200092, (20020801), pages 677 - 682, URL: https://link.springer.com/content/pdf/10.1007/s001980200092.pdf, (20180928), XP055510914 [X] 1-3,5-8,10-15 * abstract * * page 681, column l, paragraphs 2-3 *

DOI:   http://dx.doi.org/https://doi.org/10.1007/s001980200092
 [X]  - MARTA DUBREUIL ET AL, "Ursodeoxycholic acid increases differentiation and mineralization and neutralizes the damaging effects of bilirubin on osteoblastic cells", LIVER INTERNATIONAL, GB, (20130801), vol. 33, no. 7, doi:10.1111/liv.12153, ISSN 1478-3223, pages 1029 - 1038, XP055510923 [X] 1-3,5-8,10-15 * abstract * * page 1036, column r, paragraph 2 - page 1037, column l, paragraph 1 *

DOI:   http://dx.doi.org/10.1111/liv.12153
 [XY]  - SUN WOOK CHO ET AL, "Positive regulation of osteogenesis by bile acid through FXR : POSITIVE REGULATION OF OSTEOGENESIS BY BILE ACID THROUGH FXR", JOURNAL OF BONE AND MINERAL RESEARCH, US, (20131001), vol. 28, no. 10, doi:10.1002/jbmr.1961, ISSN 0884-0431, pages 2109 - 2121, XP055510907 [X] 1-4 * abstract * * page 2118; figure 7 * * page 2119, column r, paragraph l - page 2120, column l, paragraph l * [Y] 1-15

DOI:   http://dx.doi.org/10.1002/jbmr.1961
 [Y]  - K. KOWDLEY ET AL, "P374 LONG-TERM TREATMENT OF PRIMARY BILIARY CIRRHOSIS WITH THE FXR AGONIST OBETICHOLIC ACID SHOWS DURABLE EFFICACY", JOURNAL OF HEPATOLOGY, AMSTERDAM, NL, (20140401), vol. 60, no. 1, doi:10.1016/S0168-8278(14)60536-5, ISSN 0168-8278, pages S192 - S193, XP055511302 [Y] 1-15 * the whole document *

DOI:   http://dx.doi.org/10.1016/S0168-8278(14)60536-5
 [Y]  - Hirschfield, "Efficacy of Obeticholic Acid in Patients With Primary Biliary Cirrhosis and Inadequate Response to Ursodeoxycholic Acid", Gastroenterology, United States, doi:10.1053/j.gastro.2014.12.005, (20141211), pages 751 - 761.e8, URL: file:///C:\Users\JG51779\AppData\Roaming\Mozilla\Firefox\Profiles\JG51779\CiteNPLTemp\CiteNPLWebPage.pdf, (20180928), XP055510903 [Y] 1-15 * the whole document *

DOI:   http://dx.doi.org/10.1053/j.gastro.2014.12.005
International search[A]US2005107475  (JONES STACEY A [US], et al) [A] 1-4, 7, 9, 12-27* entire document *;
 [A]US2008096921  (NAVAS FRANK III [US], et al) [A] 1-4, 7, 9, 12-27 * entire document *;
 [A]WO2013192097  (INTERCEPT PHARMACEUTICALS INC [US]) [A] 1-4, 7, 9, 12-27 * entire document *;
 [A]WO2014021694  (SNU R&DB FOUNDATION [KR]) [A] 1-4, 7, 9, 12-27 * machine translation *;
 [A]US2014371190  (PELLICCIARI ROBERTO [IT]) [A] 1-4, 7, 9, 12-27 * entire document *
The EPO accepts no responsibility for the accuracy of data originating from other authorities; in particular, it does not guarantee that it is complete, up to date or fit for specific purposes.