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Extract from the Register of European Patents

EP About this file: EP3279188

EP3279188 - AXIALLY CHIRAL ISOMERS, AND PREPARATION METHODS THEREFOR AND PHARMACEUTICAL USES THEREOF [Right-click to bookmark this link]
StatusNo opposition filed within time limit
Status updated on  16.07.2021
Database last updated on 28.03.2026
FormerThe patent has been granted
Status updated on  07.08.2020
FormerGrant of patent is intended
Status updated on  07.06.2020
FormerExamination is in progress
Status updated on  05.07.2019
FormerRequest for examination was made
Status updated on  05.01.2018
FormerThe international publication has been made
Status updated on  18.10.2017
Most recent event   Tooltip06.09.2024Lapse of the patent in a contracting state
New state(s): MT		published on 09.10.2024  [2024/41]
Applicant(s)For all designated states
Medshine Discovery Inc.
Room 218 No.9 Gaoxin Road
Gaoxin Development District
Nanjing, Jiangsu 210032 / CN
[2018/06]
Inventor(s)01 / WANG, Jianfei
288 Futezhong Road
Pudong New Area
Shanghai 200131 / CN
02 / ZHANG, Jing
288 Futezhong Road
Pudong New Area
Shanghai 200131 / CN
03 / ZHANG, Long
288 Futezhong Road
Pudong New Area
Shanghai 200131 / CN
04 / ZHANG, Yang
288 Futezhong Road
Pudong New Area
Shanghai 200131 / CN
05 / LI, Jian
288 Futezhong Road
Pudong New Area
Shanghai 200131 / CN
06 / CHEN, Shuhui
288 Futezhong Road
Pudong New Area
Shanghai 200131 / CN
 [2018/06]
Representative(s)Haseltine Lake Kempner LLP
One Portwall Square
Portwall Lane
Bristol BS1 6BH / GB
[N/P]
Former [2020/37]Haseltine Lake Kempner LLP
Redcliff Quay
120 Redcliff Street
Bristol BS1 6HU / GB
Former [2018/06]Haseltine Lake LLP
Redcliff Quay 120 Redcliff Street
Bristol BS1 6HU / GB
Application number, filing date16771408.801.04.2016
[2018/06]
WO2016CN78239
Priority number, dateCN20151015933103.04.2015         Original published format: CN201510159331
CN20151024103412.05.2015         Original published format: CN201510241034
[2018/06]
Filing languageZH
Procedural languageEN
PublicationType: A1 Application with search report
No.:WO2016155653
Date:06.10.2016
Language:ZH
[2016/40]
Type: A1 Application with search report 
No.:EP3279188
Date:07.02.2018
Language:EN
[2018/06]
Type: B1 Patent specification 
No.:EP3279188
Date:09.09.2020
Language:EN
[2020/37]
Search report(s)International search report - published on:CN06.10.2016
(Supplementary) European search report - dispatched on:EP08.12.2017
ClassificationIPC:C07D249/12, A61K31/4196, A61P19/06, A61P7/00
[2018/06]
CPC:
C07D249/12 (EP,CN,US); A61K31/4196 (EP,US); A61P19/06 (EP);
A61P7/00 (EP); C07B57/00 (CN); C07B2200/07 (CN,US);
Y02P20/54 (US) (-)
Designated contracting statesAL,   AT,   BE,   BG,   CH,   CY,   CZ,   DE,   DK,   EE,   ES,   FI,   FR,   GB,   GR,   HR,   HU,   IE,   IS,   IT,   LI,   LT,   LU,   LV,   MC,   MK,   MT,   NL,   NO,   PL,   PT,   RO,   RS,   SE,   SI,   SK,   SM,   TR [2018/06]
Extension statesBANot yet paid
MENot yet paid
Validation statesMANot yet paid
MDNot yet paid
TitleGerman:AXIAL CHIRALE ISOMERE UND HERSTELLUNGSVERFAHREN DAFÜR SOWIE PHARMAZEUTISCHE VERWENDUNGEN DAVON[2018/06]
English:AXIALLY CHIRAL ISOMERS, AND PREPARATION METHODS THEREFOR AND PHARMACEUTICAL USES THEREOF[2018/06]
French:ISOMÈRES À CHIRALITÉ AXIALE, LEURS PROCÉDÉS DE PRÉPARATION ET LEURS UTILISATIONS PHARMACEUTIQUES[2018/06]
Entry into regional phase18.10.2017Translation filed 
18.10.2017National basic fee paid 
18.10.2017Search fee paid 
18.10.2017Designation fee(s) paid 
18.10.2017Examination fee paid 
Examination procedure18.10.2017Examination requested  [2018/06]
18.10.2017Date on which the examining division has become responsible
06.07.2018Amendment by applicant (claims and/or description)
10.07.2019Despatch of a communication from the examining division (Time limit: M04)
18.11.2019Reply to a communication from the examining division
20.01.2020Despatch of a communication from the examining division (Time limit: M02)
27.03.2020Reply to a communication from the examining division
08.06.2020Communication of intention to grant the patent
03.08.2020Fee for grant paid
03.08.2020Fee for publishing/printing paid
03.08.2020Receipt of the translation of the claim(s)
Opposition(s)10.06.2021No opposition filed within time limit [2021/33]
Fees paidRenewal fee
26.04.2018Renewal fee patent year 03
29.04.2019Renewal fee patent year 04
27.03.2020Renewal fee patent year 05
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Responsibility for the accuracy, completeness or quality of the data displayed under the link provided lies entirely with the Unified Patent Court.
Lapses during opposition  TooltipHU01.04.2016
AL09.09.2020
AT09.09.2020
CY09.09.2020
CZ09.09.2020
DK09.09.2020
EE09.09.2020
FI09.09.2020
HR09.09.2020
LT09.09.2020
LV09.09.2020
MC09.09.2020
MK09.09.2020
MT09.09.2020
PL09.09.2020
RO09.09.2020
RS09.09.2020
SE09.09.2020
SI09.09.2020
SK09.09.2020
SM09.09.2020
TR09.09.2020
NL23.09.2020
BG09.12.2020
NO09.12.2020
GR10.12.2020
IS09.01.2021
PT11.01.2021
IE01.04.2021
LU01.04.2021
BE30.04.2021
CH30.04.2021
LI30.04.2021
[2024/41]
Former [2024/29]HU01.04.2016
AL09.09.2020
AT09.09.2020
CY09.09.2020
CZ09.09.2020
DK09.09.2020
EE09.09.2020
FI09.09.2020
HR09.09.2020
LT09.09.2020
LV09.09.2020
MC09.09.2020
MK09.09.2020
PL09.09.2020
RO09.09.2020
RS09.09.2020
SE09.09.2020
SI09.09.2020
SK09.09.2020
SM09.09.2020
TR09.09.2020
NL23.09.2020
BG09.12.2020
NO09.12.2020
GR10.12.2020
IS09.01.2021
PT11.01.2021
IE01.04.2021
LU01.04.2021
BE30.04.2021
CH30.04.2021
LI30.04.2021
Former [2024/22]HU01.04.2016
AL09.09.2020
AT09.09.2020
CY09.09.2020
CZ09.09.2020
DK09.09.2020
EE09.09.2020
FI09.09.2020
HR09.09.2020
LT09.09.2020
LV09.09.2020
MC09.09.2020
MK09.09.2020
PL09.09.2020
RO09.09.2020
RS09.09.2020
SE09.09.2020
SI09.09.2020
SK09.09.2020
SM09.09.2020
NL23.09.2020
BG09.12.2020
NO09.12.2020
GR10.12.2020
IS09.01.2021
PT11.01.2021
IE01.04.2021
LU01.04.2021
BE30.04.2021
CH30.04.2021
LI30.04.2021
Former [2023/30]HU01.04.2016
AL09.09.2020
AT09.09.2020
CY09.09.2020
CZ09.09.2020
DK09.09.2020
EE09.09.2020
FI09.09.2020
HR09.09.2020
LT09.09.2020
LV09.09.2020
MC09.09.2020
PL09.09.2020
RO09.09.2020
RS09.09.2020
SE09.09.2020
SI09.09.2020
SK09.09.2020
SM09.09.2020
NL23.09.2020
BG09.12.2020
NO09.12.2020
GR10.12.2020
IS09.01.2021
PT11.01.2021
IE01.04.2021
LU01.04.2021
BE30.04.2021
CH30.04.2021
LI30.04.2021
Former [2023/29]HU01.04.2016
AL09.09.2020
AT09.09.2020
CZ09.09.2020
DK09.09.2020
EE09.09.2020
FI09.09.2020
HR09.09.2020
LT09.09.2020
LV09.09.2020
MC09.09.2020
PL09.09.2020
RO09.09.2020
RS09.09.2020
SE09.09.2020
SI09.09.2020
SK09.09.2020
SM09.09.2020
NL23.09.2020
BG09.12.2020
NO09.12.2020
GR10.12.2020
IS09.01.2021
PT11.01.2021
IE01.04.2021
LU01.04.2021
BE30.04.2021
CH30.04.2021
LI30.04.2021
Former [2022/34]AL09.09.2020
AT09.09.2020
CZ09.09.2020
DK09.09.2020
EE09.09.2020
FI09.09.2020
HR09.09.2020
LT09.09.2020
LV09.09.2020
MC09.09.2020
PL09.09.2020
RO09.09.2020
RS09.09.2020
SE09.09.2020
SI09.09.2020
SK09.09.2020
SM09.09.2020
BG09.12.2020
NO09.12.2020
GR10.12.2020
IS09.01.2021
PT11.01.2021
IE01.04.2021
LU01.04.2021
BE30.04.2021
CH30.04.2021
LI30.04.2021
Former [2022/23]AL09.09.2020
AT09.09.2020
CZ09.09.2020
DK09.09.2020
EE09.09.2020
FI09.09.2020
HR09.09.2020
LT09.09.2020
LV09.09.2020
MC09.09.2020
PL09.09.2020
RO09.09.2020
RS09.09.2020
SE09.09.2020
SI09.09.2020
SK09.09.2020
SM09.09.2020
BG09.12.2020
NO09.12.2020
GR10.12.2020
IS09.01.2021
PT11.01.2021
IE01.04.2021
LU01.04.2021
CH30.04.2021
LI30.04.2021
Former [2022/21]AL09.09.2020
AT09.09.2020
CZ09.09.2020
DK09.09.2020
EE09.09.2020
FI09.09.2020
HR09.09.2020
LT09.09.2020
LV09.09.2020
MC09.09.2020
PL09.09.2020
RO09.09.2020
RS09.09.2020
SE09.09.2020
SI09.09.2020
SK09.09.2020
SM09.09.2020
BG09.12.2020
NO09.12.2020
GR10.12.2020
PT11.01.2021
IE01.04.2021
LU01.04.2021
CH30.04.2021
LI30.04.2021
Former [2022/10]AL09.09.2020
AT09.09.2020
CZ09.09.2020
DK09.09.2020
EE09.09.2020
FI09.09.2020
HR09.09.2020
LT09.09.2020
LV09.09.2020
MC09.09.2020
PL09.09.2020
RO09.09.2020
RS09.09.2020
SE09.09.2020
SI09.09.2020
SK09.09.2020
SM09.09.2020
BG09.12.2020
NO09.12.2020
GR10.12.2020
PT11.01.2021
LU01.04.2021
CH30.04.2021
LI30.04.2021
Former [2022/04]AL09.09.2020
AT09.09.2020
CZ09.09.2020
DK09.09.2020
EE09.09.2020
FI09.09.2020
HR09.09.2020
LT09.09.2020
LV09.09.2020
MC09.09.2020
PL09.09.2020
RO09.09.2020
RS09.09.2020
SE09.09.2020
SI09.09.2020
SK09.09.2020
SM09.09.2020
BG09.12.2020
NO09.12.2020
GR10.12.2020
IS09.01.2021
PT11.01.2021
LU01.04.2021
Former [2021/50]AL09.09.2020
AT09.09.2020
CZ09.09.2020
DK09.09.2020
EE09.09.2020
FI09.09.2020
HR09.09.2020
LT09.09.2020
LV09.09.2020
MC09.09.2020
PL09.09.2020
RO09.09.2020
RS09.09.2020
SE09.09.2020
SI09.09.2020
SK09.09.2020
SM09.09.2020
BG09.12.2020
NO09.12.2020
GR10.12.2020
IS09.01.2021
PT11.01.2021
Former [2021/37]AL09.09.2020
AT09.09.2020
CZ09.09.2020
DK09.09.2020
EE09.09.2020
FI09.09.2020
HR09.09.2020
LT09.09.2020
LV09.09.2020
PL09.09.2020
RO09.09.2020
RS09.09.2020
SE09.09.2020
SI09.09.2020
SK09.09.2020
SM09.09.2020
BG09.12.2020
NO09.12.2020
GR10.12.2020
IS09.01.2021
PT11.01.2021
Former [2021/36]AL09.09.2020
AT09.09.2020
CZ09.09.2020
EE09.09.2020
FI09.09.2020
HR09.09.2020
LT09.09.2020
LV09.09.2020
PL09.09.2020
RO09.09.2020
RS09.09.2020
SE09.09.2020
SI09.09.2020
SK09.09.2020
SM09.09.2020
BG09.12.2020
NO09.12.2020
GR10.12.2020
IS09.01.2021
PT11.01.2021
Former [2021/28]AL09.09.2020
AT09.09.2020
CZ09.09.2020
EE09.09.2020
FI09.09.2020
HR09.09.2020
LT09.09.2020
LV09.09.2020
PL09.09.2020
RO09.09.2020
RS09.09.2020
SE09.09.2020
SK09.09.2020
SM09.09.2020
BG09.12.2020
NO09.12.2020
GR10.12.2020
IS09.01.2021
PT11.01.2021
Former [2021/25]AL09.09.2020
AT09.09.2020
CZ09.09.2020
EE09.09.2020
FI09.09.2020
HR09.09.2020
LT09.09.2020
LV09.09.2020
PL09.09.2020
RO09.09.2020
RS09.09.2020
SE09.09.2020
SM09.09.2020
BG09.12.2020
NO09.12.2020
GR10.12.2020
IS09.01.2021
PT11.01.2021
Former [2021/23]AT09.09.2020
CZ09.09.2020
EE09.09.2020
FI09.09.2020
HR09.09.2020
LT09.09.2020
LV09.09.2020
PL09.09.2020
RO09.09.2020
RS09.09.2020
SE09.09.2020
SM09.09.2020
BG09.12.2020
NO09.12.2020
GR10.12.2020
PT11.01.2021
Former [2021/22]CZ09.09.2020
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FI09.09.2020
HR09.09.2020
LT09.09.2020
LV09.09.2020
PL09.09.2020
RO09.09.2020
RS09.09.2020
SE09.09.2020
BG09.12.2020
NO09.12.2020
GR10.12.2020
PT11.01.2021
Former [2021/21]FI09.09.2020
HR09.09.2020
LT09.09.2020
LV09.09.2020
PL09.09.2020
RS09.09.2020
SE09.09.2020
BG09.12.2020
NO09.12.2020
GR10.12.2020
PT11.01.2021
Former [2021/10]FI09.09.2020
HR09.09.2020
LT09.09.2020
LV09.09.2020
PL09.09.2020
RS09.09.2020
SE09.09.2020
BG09.12.2020
NO09.12.2020
GR10.12.2020
Former [2021/09]FI09.09.2020
LT09.09.2020
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BG09.12.2020
NO09.12.2020
GR10.12.2020
Former [2021/08]FI09.09.2020
LT09.09.2020
SE09.09.2020
BG09.12.2020
NO09.12.2020
Former [2021/07]FI09.09.2020
LT09.09.2020
NO09.12.2020
Documents cited:Search[E] WO2017147270  (ARDEA BIOSCIENCES INC et al.) [E] 1-11 * the whole document * * in particular examples 3-8 and claims 1-7 and 9-11 *
 [IY] WO2014008295  (ARDEA BIOSCIENCES INC et al.) [I] 1-11 * the whole document * * in particular paragraphs [0114] and [0218] schemes 5-7 and claims 1-28 *[Y] 1-11
 [Y]   STEVEN R. LAPLANTE ET AL: "Assesing Atropisomer Axial Chirality in Drug Discovery and Development", JOURNAL OF MEDICINAL CHEMISTRY, vol. 54, no. 20, 17 August 2011 (2011-08-17), pages 7005 - 7022, XP055429488, DOI: 10.1021/jm200584g [Y] 1-11 * the whole document * * in partiuclar pages 7010 and 7016-7018 *

DOI:   http://dx.doi.org/10.1021/jm200584g
 [XPI]   CHMP: "Assessment report: Zurampic", 17 December 2015 (2015-12-17), XP055429008, Retrieved from the Internet [retrieved on 20171127] [XP] 1,2,10,11 * the whole document * * in particular pages 9, 39, 53 and 121 *[I] 3-9
 [Y]   KIMBERLY T. BARRETT ET AL: "Spontaneous transfer of chirality in an atropisomerically enriched two-axis system", NATURE, vol. 509, no. 7498, 20 April 2014 (2014-04-20), pages 71 - 75, XP055429221, ISSN: 0028-0836, DOI: 10.1038/nature13189 [Y] 1-11 * the whole document *

DOI:   http://dx.doi.org/10.1038/nature13189
 [T]   JIANFEI WANG ET AL: "Discovery and Assessment of Atropisomers of ( )-Lesinurad", ACS MEDICINAL CHEMISTRY LETTERS, vol. 8, no. 3, 16 February 2017 (2017-02-16), United States, pages 299 - 303, XP055412834, ISSN: 1948-5875, DOI: 10.1021/acsmedchemlett.6b00465 [T] 1-11 * the whole document *

DOI:   http://dx.doi.org/10.1021/acsmedchemlett.6b00465
International search[PX] CN105399694  (ZHEJIANG JINGXIN PHARMACEUTICAL CO LTD et al.) [PX] 1-11 * , see the whole document, particularly embodiments 1-4 *
 [X] CN103524440  (SUZHOU PENGXU PHARMATECH CO LTD et al.) [X] 1-11 * , description, paragraph [0058], and embodiments 7-9 and 17 *
 [X] CN101918377  (ARDEA BIOSCIENCES INC et al.) [X] 1-11 * see embodiments 8 and 15 *
 [X] WO2014008295  (ARDEA BIOSCIENCES INC et al.) [X] 1-11 * see embodiments 1A and 2A *
 [X] WO2014198241  (SUNSHINE LAKE PHARMA CO LTD et al.) [X] 1-11 * see embodiments 8-14 *
 [A] CN101679243  (DAIICHI SANKYO CO et al.) [A] 3-9 * , description, page 4, line 9 to page 5, line 15 *
 [A] CN102093343  (UNIV EAST CHINA SCIENCE & TECH et al.) [A] 1-11 * , see the whole document *
The EPO accepts no responsibility for the accuracy of data originating from other authorities; in particular, it does not guarantee that it is complete, up to date or fit for specific purposes.