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Extract from the Register of European Patents

EP About this file: EP3273994

EP3273994 - CAR T-CELL THERAPY DIRECTED TO LHR FOR THE TREATMENT OF SOLID TUMORS [Right-click to bookmark this link]
StatusNo opposition filed within time limit
Status updated on  07.10.2022
Database last updated on 25.09.2024
FormerThe patent has been granted
Status updated on  29.10.2021
FormerGrant of patent is intended
Status updated on  09.06.2021
FormerExamination is in progress
Status updated on  30.03.2021
FormerGrant of patent is intended
Status updated on  12.01.2021
FormerExamination is in progress
Status updated on  02.07.2019
FormerRequest for examination was made
Status updated on  29.12.2017
FormerThe international publication has been made
Status updated on  11.11.2016
Most recent event   Tooltip13.09.2024Lapse of the patent in a contracting state
New state(s): MT		published on 16.10.2024 [2024/42]
Applicant(s)For all designated states
University of Southern California
1150 South Olive Street, Suite 2300
Los Angeles, CA 90015 / US
[2018/05]
Inventor(s)01 / EPSTEIN, Alan L.
c/o University of Southern California
1150 South Olive Street
Suite 2300
Los Angeles, California 90015 / US
02 / HU, Peisheng
c/o University of Southern California
1150 South Olive Street
Suite 2300
Los Angeles, California 90015 / US
03 / PINSKI, Jacek K.
c/o University of Southern California
1150 South Olive Street
Suite 2300
Los Angeles, California 90015 / US
 [2018/05]
Representative(s)Tomkins & Co
5 Dartmouth Road
Dublin 6 / IE
[2018/05]
Application number, filing date16773871.525.03.2016
[2018/05]
WO2016US24354
Priority number, dateUS201562139623P27.03.2015         Original published format: US 201562139623 P
[2018/05]
Filing languageEN
Procedural languageEN
PublicationType: A2 Application without search report
No.:WO2016160618
Date:06.10.2016
Language:EN
[2016/40]
Type: A2 Application without search report 
No.:EP3273994
Date:31.01.2018
Language:EN
The application published by WIPO in one of the EPO official languages on 06.10.2016 takes the place of the publication of the European patent application.
[2018/05]
Type: B1 Patent specification 
No.:EP3273994
Date:01.12.2021
Language:EN
[2021/48]
Search report(s)International search report - published on:US10.11.2016
(Supplementary) European search report - dispatched on:EP08.08.2018
ClassificationIPC:A61K39/395, C07K14/59, C07K14/72, C07K16/28, C07K16/30
[2018/05]
CPC:
G01N33/57415 (EP,US); C07K16/2869 (EP,US); A61K35/17 (US);
A61K39/4611 (EP); A61K39/4631 (EP); A61K39/464402 (EP);
A61K39/464468 (EP); A61K39/46447 (EP); A61P35/00 (EP,US);
C07K14/7051 (EP,US); C07K14/70517 (EP,US); C07K14/70521 (EP);
C07K14/70578 (EP,US); C07K14/723 (EP); C07K16/2809 (US);
C07K16/3007 (EP,US); C07K16/3069 (US); G01N33/57434 (EP,US);
G01N33/57449 (US); G01N33/76 (EP,US); A61K2035/124 (US);
A61K2039/505 (US); A61K2239/29 (EP); A61K2239/31 (EP);
A61K2239/38 (EP); A61K2239/59 (EP); C07K2317/24 (US);
C07K2317/31 (EP); C07K2317/54 (US); C07K2317/55 (EP,US);
C07K2317/56 (US); C07K2317/565 (US); C07K2317/622 (EP,US);
C07K2317/76 (US); C07K2319/00 (EP); C07K2319/02 (EP,US);
C07K2319/03 (EP,US); C07K2319/30 (EP); C07K2319/33 (EP);
G01N2800/52 (EP,US) (-)
Designated contracting statesAL,   AT,   BE,   BG,   CH,   CY,   CZ,   DE,   DK,   EE,   ES,   FI,   FR,   GB,   GR,   HR,   HU,   IE,   IS,   IT,   LI,   LT,   LU,   LV,   MC,   MK,   MT,   NL,   NO,   PL,   PT,   RO,   RS,   SE,   SI,   SK,   SM,   TR [2018/05]
Extension statesBANot yet paid
MENot yet paid
Validation statesMANot yet paid
MDNot yet paid
TitleGerman:CAR-T-ZELLTHERAPIE GEGEN LHR ZUR BEHANDLUNG VON SOLIDEN TUMOREN[2018/05]
English:CAR T-CELL THERAPY DIRECTED TO LHR FOR THE TREATMENT OF SOLID TUMORS[2018/05]
French:THÉRAPIE À BASE DE LYMPHOCYTES T CAR DIRIGÉS CONTRE LE RÉCEPTEUR LHR POUR LE TRAITEMENT DES TUMEURS SOLIDES[2018/05]
Entry into regional phase13.10.2017National basic fee paid 
13.10.2017Search fee paid 
13.10.2017Designation fee(s) paid 
13.10.2017Examination fee paid 
Examination procedure13.10.2017Examination requested  [2018/05]
13.10.2017Date on which the examining division has become responsible
20.02.2019Amendment by applicant (claims and/or description)
05.07.2019Despatch of a communication from the examining division (Time limit: M06)
05.11.2019Reply to a communication from the examining division
04.11.2020Cancellation of oral proceeding that was planned for 09.11.2020
09.11.2020Date of oral proceedings (cancelled)
13.01.2021Communication of intention to grant the patent
26.03.2021Disapproval of the communication of intention to grant the patent by the applicant or resumption of examination proceedings by the EPO
10.06.2021Communication of intention to grant the patent
18.10.2021Fee for grant paid
18.10.2021Fee for publishing/printing paid
18.10.2021Receipt of the translation of the claim(s)
Opposition(s)02.09.2022No opposition filed within time limit [2022/45]
Fees paidRenewal fee
13.03.2018Renewal fee patent year 03
28.03.2019Renewal fee patent year 04
23.09.2020Renewal fee patent year 05
01.04.2021Renewal fee patent year 06
Penalty fee
Additional fee for renewal fee
31.03.202005   M06   Fee paid on   23.09.2020
31.03.202106   M06   Fee paid on   18.05.2021
Opt-out from the exclusive  Tooltip
competence of the Unified
Patent Court		 See the Register of the Unified Patent Court for opt-out data
Responsibility for the accuracy, completeness or quality of the data displayed under the link provided lies entirely with the Unified Patent Court.
Lapses during opposition  TooltipHU25.03.2016
AL01.12.2021
AT01.12.2021
CY01.12.2021
CZ01.12.2021
DK01.12.2021
EE01.12.2021
FI01.12.2021
HR01.12.2021
IT01.12.2021
LT01.12.2021
LV01.12.2021
MC01.12.2021
MK01.12.2021
MT01.12.2021
NL01.12.2021
PL01.12.2021
RO01.12.2021
RS01.12.2021
SE01.12.2021
SI01.12.2021
SK01.12.2021
SM01.12.2021
TR01.12.2021
BG01.03.2022
NO01.03.2022
GR02.03.2022
GB25.03.2022
IE25.03.2022
LU25.03.2022
ES26.03.2022
BE31.03.2022
CH31.03.2022
FR31.03.2022
LI31.03.2022
IS01.04.2022
PT01.04.2022
[2024/42]
Former [2024/29]HU25.03.2016
AL01.12.2021
AT01.12.2021
CY01.12.2021
CZ01.12.2021
DK01.12.2021
EE01.12.2021
FI01.12.2021
HR01.12.2021
IT01.12.2021
LT01.12.2021
LV01.12.2021
MC01.12.2021
MK01.12.2021
NL01.12.2021
PL01.12.2021
RO01.12.2021
RS01.12.2021
SE01.12.2021
SI01.12.2021
SK01.12.2021
SM01.12.2021
TR01.12.2021
BG01.03.2022
NO01.03.2022
GR02.03.2022
GB25.03.2022
IE25.03.2022
LU25.03.2022
ES26.03.2022
BE31.03.2022
CH31.03.2022
FR31.03.2022
LI31.03.2022
IS01.04.2022
PT01.04.2022
Former [2024/22]HU25.03.2016
AL01.12.2021
AT01.12.2021
CY01.12.2021
CZ01.12.2021
DK01.12.2021
EE01.12.2021
FI01.12.2021
HR01.12.2021
IT01.12.2021
LT01.12.2021
LV01.12.2021
MC01.12.2021
MK01.12.2021
NL01.12.2021
PL01.12.2021
RO01.12.2021
RS01.12.2021
SE01.12.2021
SI01.12.2021
SK01.12.2021
SM01.12.2021
BG01.03.2022
NO01.03.2022
GR02.03.2022
GB25.03.2022
IE25.03.2022
LU25.03.2022
ES26.03.2022
BE31.03.2022
CH31.03.2022
FR31.03.2022
LI31.03.2022
IS01.04.2022
PT01.04.2022
Former [2024/20]HU25.03.2016
AL01.12.2021
AT01.12.2021
CY01.12.2021
CZ01.12.2021
DK01.12.2021
EE01.12.2021
FI01.12.2021
HR01.12.2021
IT01.12.2021
LT01.12.2021
LV01.12.2021
MC01.12.2021
NL01.12.2021
PL01.12.2021
RO01.12.2021
RS01.12.2021
SE01.12.2021
SI01.12.2021
SK01.12.2021
SM01.12.2021
BG01.03.2022
NO01.03.2022
GR02.03.2022
GB25.03.2022
IE25.03.2022
LU25.03.2022
ES26.03.2022
BE31.03.2022
CH31.03.2022
FR31.03.2022
LI31.03.2022
IS01.04.2022
PT01.04.2022
Former [2024/18]HU25.03.2016
AL01.12.2021
AT01.12.2021
CZ01.12.2021
DK01.12.2021
EE01.12.2021
FI01.12.2021
HR01.12.2021
IT01.12.2021
LT01.12.2021
LV01.12.2021
MC01.12.2021
NL01.12.2021
PL01.12.2021
RO01.12.2021
RS01.12.2021
SE01.12.2021
SI01.12.2021
SK01.12.2021
SM01.12.2021
BG01.03.2022
NO01.03.2022
GR02.03.2022
GB25.03.2022
IE25.03.2022
LU25.03.2022
ES26.03.2022
BE31.03.2022
CH31.03.2022
FR31.03.2022
LI31.03.2022
IS01.04.2022
PT01.04.2022
Former [2023/33]AL01.12.2021
AT01.12.2021
CZ01.12.2021
DK01.12.2021
EE01.12.2021
FI01.12.2021
HR01.12.2021
IT01.12.2021
LT01.12.2021
LV01.12.2021
MC01.12.2021
NL01.12.2021
PL01.12.2021
RO01.12.2021
RS01.12.2021
SE01.12.2021
SI01.12.2021
SK01.12.2021
SM01.12.2021
BG01.03.2022
NO01.03.2022
GR02.03.2022
GB25.03.2022
IE25.03.2022
LU25.03.2022
ES26.03.2022
BE31.03.2022
CH31.03.2022
FR31.03.2022
LI31.03.2022
IS01.04.2022
PT01.04.2022
Former [2023/27]AL01.12.2021
AT01.12.2021
CZ01.12.2021
DK01.12.2021
EE01.12.2021
FI01.12.2021
HR01.12.2021
IT01.12.2021
LT01.12.2021
LV01.12.2021
MC01.12.2021
NL01.12.2021
PL01.12.2021
RO01.12.2021
RS01.12.2021
SE01.12.2021
SI01.12.2021
SK01.12.2021
SM01.12.2021
BG01.03.2022
NO01.03.2022
GR02.03.2022
GB25.03.2022
IE25.03.2022
LU25.03.2022
BE31.03.2022
CH31.03.2022
FR31.03.2022
LI31.03.2022
IS01.04.2022
PT01.04.2022
Former [2023/10]AL01.12.2021
AT01.12.2021
CZ01.12.2021
DK01.12.2021
EE01.12.2021
FI01.12.2021
HR01.12.2021
LT01.12.2021
LV01.12.2021
MC01.12.2021
NL01.12.2021
PL01.12.2021
RO01.12.2021
RS01.12.2021
SE01.12.2021
SI01.12.2021
SK01.12.2021
SM01.12.2021
BG01.03.2022
NO01.03.2022
GR02.03.2022
GB25.03.2022
IE25.03.2022
LU25.03.2022
BE31.03.2022
CH31.03.2022
FR31.03.2022
LI31.03.2022
IS01.04.2022
PT01.04.2022
Former [2023/09]AL01.12.2021
AT01.12.2021
CZ01.12.2021
DK01.12.2021
EE01.12.2021
FI01.12.2021
HR01.12.2021
LT01.12.2021
LV01.12.2021
MC01.12.2021
NL01.12.2021
PL01.12.2021
RO01.12.2021
RS01.12.2021
SE01.12.2021
SI01.12.2021
SK01.12.2021
SM01.12.2021
BG01.03.2022
NO01.03.2022
GR02.03.2022
GB25.03.2022
IE25.03.2022
LU25.03.2022
CH31.03.2022
FR31.03.2022
LI31.03.2022
IS01.04.2022
PT01.04.2022
Former [2023/08]AL01.12.2021
AT01.12.2021
CZ01.12.2021
DK01.12.2021
EE01.12.2021
FI01.12.2021
HR01.12.2021
LT01.12.2021
LV01.12.2021
MC01.12.2021
NL01.12.2021
PL01.12.2021
RO01.12.2021
RS01.12.2021
SE01.12.2021
SI01.12.2021
SK01.12.2021
SM01.12.2021
BG01.03.2022
NO01.03.2022
GR02.03.2022
GB25.03.2022
IE25.03.2022
LU25.03.2022
FR31.03.2022
IS01.04.2022
PT01.04.2022
Former [2023/06]AL01.12.2021
AT01.12.2021
CZ01.12.2021
DK01.12.2021
EE01.12.2021
FI01.12.2021
HR01.12.2021
LT01.12.2021
LV01.12.2021
MC01.12.2021
NL01.12.2021
PL01.12.2021
RO01.12.2021
RS01.12.2021
SE01.12.2021
SI01.12.2021
SK01.12.2021
SM01.12.2021
BG01.03.2022
NO01.03.2022
GR02.03.2022
FR31.03.2022
IS01.04.2022
PT01.04.2022
Former [2023/01]AL01.12.2021
AT01.12.2021
CZ01.12.2021
DK01.12.2021
EE01.12.2021
FI01.12.2021
HR01.12.2021
LT01.12.2021
LV01.12.2021
MC01.12.2021
NL01.12.2021
PL01.12.2021
RO01.12.2021
RS01.12.2021
SE01.12.2021
SI01.12.2021
SK01.12.2021
SM01.12.2021
BG01.03.2022
NO01.03.2022
GR02.03.2022
IS01.04.2022
PT01.04.2022
Former [2022/49]AL01.12.2021
AT01.12.2021
CZ01.12.2021
DK01.12.2021
EE01.12.2021
FI01.12.2021
HR01.12.2021
LT01.12.2021
LV01.12.2021
MC01.12.2021
NL01.12.2021
PL01.12.2021
RO01.12.2021
RS01.12.2021
SE01.12.2021
SK01.12.2021
SM01.12.2021
BG01.03.2022
NO01.03.2022
GR02.03.2022
IS01.04.2022
PT01.04.2022
Former [2022/47]AT01.12.2021
CZ01.12.2021
DK01.12.2021
EE01.12.2021
FI01.12.2021
HR01.12.2021
LT01.12.2021
LV01.12.2021
MC01.12.2021
NL01.12.2021
PL01.12.2021
RO01.12.2021
RS01.12.2021
SE01.12.2021
SK01.12.2021
SM01.12.2021
BG01.03.2022
NO01.03.2022
GR02.03.2022
IS01.04.2022
PT01.04.2022
Former [2022/46]AT01.12.2021
CZ01.12.2021
DK01.12.2021
EE01.12.2021
FI01.12.2021
HR01.12.2021
LT01.12.2021
LV01.12.2021
NL01.12.2021
PL01.12.2021
RO01.12.2021
RS01.12.2021
SE01.12.2021
SK01.12.2021
SM01.12.2021
BG01.03.2022
NO01.03.2022
GR02.03.2022
IS01.04.2022
PT01.04.2022
Former [2022/42]AT01.12.2021
CZ01.12.2021
EE01.12.2021
FI01.12.2021
HR01.12.2021
LT01.12.2021
LV01.12.2021
NL01.12.2021
PL01.12.2021
RO01.12.2021
RS01.12.2021
SE01.12.2021
SK01.12.2021
SM01.12.2021
BG01.03.2022
NO01.03.2022
GR02.03.2022
IS01.04.2022
PT01.04.2022
Former [2022/35]AT01.12.2021
CZ01.12.2021
EE01.12.2021
FI01.12.2021
HR01.12.2021
LT01.12.2021
LV01.12.2021
NL01.12.2021
PL01.12.2021
RO01.12.2021
RS01.12.2021
SE01.12.2021
SK01.12.2021
SM01.12.2021
BG01.03.2022
NO01.03.2022
GR02.03.2022
PT01.04.2022
Former [2022/34]AT01.12.2021
EE01.12.2021
FI01.12.2021
HR01.12.2021
LT01.12.2021
LV01.12.2021
NL01.12.2021
PL01.12.2021
RO01.12.2021
RS01.12.2021
SE01.12.2021
SM01.12.2021
BG01.03.2022
NO01.03.2022
GR02.03.2022
PT01.04.2022
Former [2022/33]AT01.12.2021
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HR01.12.2021
LT01.12.2021
LV01.12.2021
NL01.12.2021
PL01.12.2021
RS01.12.2021
SE01.12.2021
SM01.12.2021
BG01.03.2022
NO01.03.2022
GR02.03.2022
Former [2022/30]AT01.12.2021
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HR01.12.2021
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NL01.12.2021
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BG01.03.2022
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BG01.03.2022
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BG01.03.2022
GR02.03.2022
Former [2022/23]AT01.12.2021
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Former [2022/19]BG01.03.2022
Documents cited:Search[XI]US2012164136  (PINSKI JACEK [US]) [X] 1,9,15,18-20,25 * Paragraphs 61 and 62, example 1 on page 8 * [I] 2-8,10-14,16,17,21-24,26,27;
 [XI]  - FUNARO ADA ET AL, "Functional, structural, and distribution analysis of the chorionic gonadotropin receptor using murine monoclonal antibodies.", MEDLINE, US NATIONAL LIBRARY OF MEDICINE (NLM), BETHESDA, MD, US, (200311), Database accession no. NLM14602802, XP002783240 [X] 1,9,15,18-20,25 * abstract * [I] 2-8,10-14,16,17,21-24,26,27
    [ ] - FUNARO ADA ET AL, "Functional, structural, and distribution analysis of the chorionic gonadotropin receptor using murine monoclonal antibodies.", THE JOURNAL OF CLINICAL ENDOCRINOLOGY AND METABOLISM NOV 2003, (200311), vol. 88, no. 11, ISSN 0021-972X, pages 5537 - 5546
 [XI]  - BUKOVSKY ANTONIN ET AL, "Multiple luteinizing hormone receptor (LHR) protein variants, interspecies reactivity of anti-LHR mAb clone 3B5, subcellular localization of LHR in human placenta, pelvic floor and brain, and possible role for LHR in the development of abnormal pregnancy, pelvic floor disorders and Alzheimer's disea", MEDLINE, US NATIONAL LIBRARY OF MEDICINE (NLM), BETHESDA, MD, US, (20030603), Database accession no. NLM12816543, XP002783241 [X] 1,9,15,18-20,25 * abstract * [I] 2-8,10-14,16,17,21-24,26,27
    [ ] - BUKOVSKY ANTONIN ET AL, "Multiple luteinizing hormone receptor (LHR) protein variants, interspecies reactivity of anti-LHR mAb clone 3B5, subcellular localization of LHR in human placenta, pelvic floor and brain, and possible role for LHR in the development of abnormal pregnancy, pelvic floor disorders and Alzheimer's disea", REPRODUCTIVE BIOLOGY AND ENDOCRINOLOGY : RB&E 03 JUN 2003, (20030603), vol. 1, ISSN 1477-7827, page 46
 [A]  - A. A. CHEKMASOVA ET AL, "Successful Eradication of Established Peritoneal Ovarian Tumors in SCID-Beige Mice following Adoptive Transfer of T Cells Genetically Targeted to the MUC16 Antigen", CLINICAL CANCER RESEARCH, US, (20100713), vol. 16, no. 14, doi:10.1158/1078-0432.CCR-10-0192, ISSN 1078-0432, pages 3594 - 3606, XP055344554 [A] 1

DOI:   http://dx.doi.org/10.1158/1078-0432.CCR-10-0192
International search[XYA]US2012164136  (PINSKI JACEK [US]) [X] 1, 9/1 * . Especially para [0062], [0065]. * [Y] 2, 9/2 [A] 5, 6, 9/(5,6);
 [A]US2012177664  (YOKOSEKI TATSUKI [JP], et al) [A] 5, 9/5* . Especially SEQ 10 NO: 2438 *;
 [YA]US2015030600  (MARKS JAMES D [US], et al) [Y] 2, 9/2 * . Especially para [0016]; SEC ID NO: 244. * [A] 6, 9/6
by applicantUS707993
 US3791932
 US3817837
 US3839153
 US3850752
 US3850578
 US3853987
 US3867517
 US3879262
 US3901654
 US3935074
 US3984533
 US3996345
 US4034074
 US4098876
 US4683195
 WO9002809
 WO9110737
 WO9117271
 WO9201047
 WO9218619
 WO9222324
 WO9311236
 US5223409
 US5403484
 WO9515982
 US5427908
 WO9520401
 WO9606213
 US5516637
 US5571698
 US5580717
 WO9708320
 US5658727
 US5686281
 US5698426
 US5733743
 US5750753
 US5780225
 US5821047
 US5858358
 US5883223
 US6352694
 US6534055
 US6692964
 US6753136
 WO2004061104
 US6797514
 US6867041
 US6887466
 US6905680
 US6905681
 US6905874
 US6924123
 US7056699
 US7067318
 US7144575
 US7172869
 US7175843
 US7232566
 US7419829
 US7442551
 US2012148552
 US2013287748
 US2015017141
    - SIEGEL, R. et al., CA Cancer J. Clin., (20120000), vol. 62, pages 10 - 29
    - MARCUS, C.S. et al., J. Cancer, (20140000), vol. 5, pages 25 - 30
    - GEIGER, T. L. et al., Blood, (20010000), vol. 98, pages 2364 - 2371
    - JALKANEN, M. et al., J. Cell. Biol., (19870000), vol. 105, pages 3087 - 3096
    - KETTLEBOROUGH et al., Eur. J. Immunol., (19940000), vol. 24, pages 952 - 958
    - PERSIC et al., Gene, (19970000), vol. 187, pages 9 - 18
    - "GenBank", Database accession no. XM_009444056.1
    - PINTO, R.D. et al., Vet. Immunol. Immunopathol., (20060000), vol. 110, pages 169 - 177
    - HOMBACH, A. et al., J Immunol, (20010000), vol. 167, pages 6123 - 6131
    - MAHER, J. et al., Nat Biotechnol, (20020000), vol. 20, pages 70 - 75
    - HAYNES, N. M. et al., J Immunol, (20020000), vol. 169, pages 5780 - 5786
    - HAYNES, N. M. et al., Blood, (20020000), vol. 100, pages 3155 - 3163
    - Journal of Virology, (19980000), vol. 72, pages 5085 - 5092
    - Journal of Virology, (19990000), vol. 73, pages 2886 - 2892
    - MAHER, J., ISRN Oncol., (20120000), vol. 2012, page 278093
    - J. Gene Med., (20120000), vol. 14, pages 405 - 415
    - FEDOROV, V.D. et al., Cancer J., (20140000), vol. 20, pages 160 - 165
    - BARRETT, D.M. et al., Annu. Rev. Med., (20140000), vol. 65, pages 333 - 347
    - JAKOBSEN, M.K. et al., J. Immunother. Emphasis Tumor Immunol., (19950000), vol. 17, pages 222 - 228
    - LOU, Y. et al., Clin. Cancer Res., (20080000), vol. 14, pages 1494 - 1501
    - SINGH, R. et al., Cancer Res., (20070000), vol. 67, pages 1887 - 1892
    - CHU, C.S. et al., Expert Rev. Anticancer Ther., (20080000), vol. 8, pages 243 - 257
    - CHEKMASOVA, A.A. et al., Discov. Med., (20100000), vol. 9, pages 62 - 70
    - PORTER, D.L. et al., NEJM, (20110000), vol. 365, pages 725 - 733
    - KELLY, R.J. et al., Mol. Cancer Ther., (20120000), vol. 11, pages 517 - 525
    - BEATTY, G.L. et al., Cancer Immunol. Res., (20140000), vol. 2, pages 112 - 120
    - KANDALAFT, L.E. et al., J. Transl. Med., (20120000), vol. 10, pages 157 - 167
    - CHEKMASOVA, A.A. et al., Clin. Cancer Res., (20100000), vol. 16, pages 3594 - 606
    - RAO, T.D. et al., Appl. Immunohistochem. Mol. Morphology, (20100000), vol. 18, pages 462 - 472
    - "Uniprot", Database accession no. P01834
    - HUSTON et al., Proc. Natl. Acad. Sci. U.S.A., (19880000), vol. 349, pages 5879 - 5883
    - KOHLERMILSTEIN, Nature, (19750000), vol. 256, pages 495 - 497
    - KOZBOR et al., Immunol. Today, (19830000), vol. 4, page 72
    - JALKANEN, M. et al., J. Cell. Biol., (19850000), vol. 101, pages 976 - 985
    - COTE et al., Proc. Natl. Acad. Sci., (19830000), vol. 80, pages 2026 - 2030
    - GALFREMILSTEIN, Methods Enzymol, (19810000), vol. 73, pages 3 - 46
    - HAMMERLING et al., Monoclonal Antibodies And T-Cell Hybridomas, (19810000), pages 563 - 681
    - HUSE et al., Science, (19890000), vol. 256, pages 1275 - 1281
    - CHAUDHARY et al., Proc. Natl. Acad. Sci. U.S.A., (19900000), vol. 87, pages 1066 - 1070
    - BRINKMAN et al., J. Immunol. Methods, (19950000), vol. 184, pages 177 - 186
    - BURTON et al., Advances in Immunology, (19940000), vol. 57, pages 191 - 280
    - MULLINAX et al., BioTechniques, (19920000), vol. 12, pages 864 - 869
    - SAWAI et al., AJRI, (19950000), vol. 34, pages 26 - 34
    - BETTER et al., Science, (19880000), vol. 240, pages 1041 - 1043
    - ORLANDI et al., PNAS, (19890000), vol. 86, pages 3833 - 3837
    - WINTER, G. et al., Nature, (19910000), vol. 349, pages 293 - 299
    - MADDOX et al., J. Exp. Med., (19830000), vol. 158, pages 1211 - 1216
    - S. W. BURCHIEL et al., Tumor Imaging: The Radiochemical Detection of Cancer, (19820000), vol. 13
    - "GeneBank", Database accession no. Y14837
    - WILKIE, S. et al., J. Clin. Immunol., (20120000), vol. 32, pages 1059 - 1070
    - LANITIS, E. et al., Cancer Immunol. Res., (20130000), vol. 1, pages 45 - 53
    - KLOSS, C.C. et al., Nat. Biotechnol., (20130000), vol. 31, pages 71 - 75
 WO1991GB01134
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