EP3356370 - 11,13-MODIFIED SAXITOXINS FOR THE TREATMENT OF PAIN [Right-click to bookmark this link] | Status | No opposition filed within time limit Status updated on 24.06.2022 Database last updated on 02.11.2024 | |
Former | The patent has been granted Status updated on 16.07.2021 | ||
Former | Grant of patent is intended Status updated on 15.03.2021 | ||
Former | Examination is in progress Status updated on 28.03.2020 | ||
Former | Request for examination was made Status updated on 06.07.2018 | ||
Former | The international publication has been made Status updated on 08.04.2017 | ||
Former | unknown Status updated on 04.11.2016 | Most recent event Tooltip | 13.09.2024 | Lapse of the patent in a contracting state New state(s): MT | published on 16.10.2024 [2024/42] | Applicant(s) | For all designated states Siteone Therapeutics, Inc. 203 Enterprise Blvd., Suite 3 Bozeman MT 59718 / US | For all designated states The Board of Trustees of the Leland Stanford Junior University Office of the General Counsel Building 170, Third Floor, Main Quad P.O. Box 20386 Stanford, CA 94305-2038 / US | [2019/38] |
Former [2018/32] | For all designated states Siteone Therapeutics, Inc. 203 Enterprise Blvd., Suite 3 Bozeman MT 59718 / US | ||
For all designated states The Board of Trustees of the Leland Stanford Junior University Office of the General Counsel Building 170, 3rd Floor, Main Quad P.O. Box 20386 Stanford, CA 94305-2038 / US | Inventor(s) | 01 /
MULCAHY, John 203 Enterprise Blvd. Suite 3 Bozeman, Montana 59718 / US | 02 /
PAJOUHESH, Hassan 203 Enterprise Blvd. Suite 3 Bozeman, Montana 59718 / US | 03 /
SHIBUYA, Grant Masaaki 203 Enterprise Blvd. Suite 3 Bozeman, Montana 59718 / US | 04 /
DELWIG, Anton 203 Enterprise Blvd. Suite 3 Bozeman, Montana 59718 / US | 05 /
DUBOIS, Justin 203 Enterprise Blvd. Suite 3 Bozeman, Montana 59718 / US | [2018/32] | Representative(s) | Petty, Catrin Helen, et al Venner Shipley LLP 200 Aldersgate London EC1A 4HD / GB | [2018/32] | Application number, filing date | 16785597.2 | 30.09.2016 | [2018/32] | WO2016US55050 | Priority number, date | US201562235412P | 30.09.2015 Original published format: US 201562235412 P | [2018/32] | Filing language | EN | Procedural language | EN | Publication | Type: | A1 Application with search report | No.: | WO2017059385 | Date: | 06.04.2017 | Language: | EN | [2017/14] | Type: | A1 Application with search report | No.: | EP3356370 | Date: | 08.08.2018 | Language: | EN | The application published by WIPO in one of the EPO official languages on 06.04.2017 takes the place of the publication of the European patent application. | [2018/32] | Type: | B1 Patent specification | No.: | EP3356370 | Date: | 18.08.2021 | Language: | EN | [2021/33] | Search report(s) | International search report - published on: | EP | 06.04.2017 | Classification | IPC: | C07D487/14, A61K31/519, A61P25/00 | [2018/32] | CPC: |
C07D487/14 (EP,US);
A61P15/00 (EP);
A61P19/02 (EP);
A61P21/02 (EP);
A61P25/00 (EP);
A61P25/02 (EP);
A61P25/04 (EP);
A61P25/06 (EP);
A61P25/08 (EP);
A61P25/16 (EP);
A61P25/18 (EP);
A61P25/20 (EP);
A61P25/22 (EP);
A61P27/06 (EP);
A61P29/02 (EP);
| Designated contracting states | AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LI, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR [2018/32] | Extension states | BA | Not yet paid | ME | Not yet paid | Validation states | MA | Not yet paid | MD | Not yet paid | Title | German: | 11,13-MODIFIZIERTE SAXITOXINE ZUR BEHANDLUNG VON SCHMERZEN | [2018/32] | English: | 11,13-MODIFIED SAXITOXINS FOR THE TREATMENT OF PAIN | [2018/32] | French: | SAXITOXINES 11,13-MODIFIÉES DESTINÉES AU TRAITEMENT DE LA DOULEUR | [2018/32] | Entry into regional phase | 10.04.2018 | National basic fee paid | 10.04.2018 | Designation fee(s) paid | 10.04.2018 | Examination fee paid | Examination procedure | 10.04.2018 | Examination requested [2018/32] | 10.04.2018 | Date on which the examining division has become responsible | 13.12.2018 | Amendment by applicant (claims and/or description) | 01.04.2020 | Despatch of a communication from the examining division (Time limit: M06) | 07.10.2020 | Reply to a communication from the examining division | 16.03.2021 | Communication of intention to grant the patent | 09.07.2021 | Fee for grant paid | 09.07.2021 | Fee for publishing/printing paid | 09.07.2021 | Receipt of the translation of the claim(s) | Opposition(s) | 19.05.2022 | No opposition filed within time limit [2022/30] | Fees paid | Renewal fee | 27.09.2018 | Renewal fee patent year 03 | 27.09.2019 | Renewal fee patent year 04 | 28.09.2020 | Renewal fee patent year 05 |
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Responsibility for the accuracy, completeness or quality of the data displayed under the link provided lies entirely with the Unified Patent Court. | Lapses during opposition Tooltip | HU | 30.09.2016 | AL | 18.08.2021 | AT | 18.08.2021 | CY | 18.08.2021 | CZ | 18.08.2021 | DK | 18.08.2021 | EE | 18.08.2021 | FI | 18.08.2021 | HR | 18.08.2021 | IT | 18.08.2021 | LT | 18.08.2021 | LV | 18.08.2021 | MC | 18.08.2021 | MK | 18.08.2021 | MT | 18.08.2021 | NL | 18.08.2021 | PL | 18.08.2021 | RO | 18.08.2021 | RS | 18.08.2021 | SE | 18.08.2021 | SI | 18.08.2021 | SK | 18.08.2021 | SM | 18.08.2021 | BE | 30.09.2021 | IE | 30.09.2021 | LU | 30.09.2021 | BG | 18.11.2021 | NO | 18.11.2021 | GR | 19.11.2021 | IS | 18.12.2021 | PT | 20.12.2021 | [2024/42] |
Former [2024/22] | HU | 30.09.2016 | |
AL | 18.08.2021 | ||
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CY | 18.08.2021 | ||
CZ | 18.08.2021 | ||
DK | 18.08.2021 | ||
EE | 18.08.2021 | ||
FI | 18.08.2021 | ||
HR | 18.08.2021 | ||
IT | 18.08.2021 | ||
LT | 18.08.2021 | ||
LV | 18.08.2021 | ||
MC | 18.08.2021 | ||
MK | 18.08.2021 | ||
NL | 18.08.2021 | ||
PL | 18.08.2021 | ||
RO | 18.08.2021 | ||
RS | 18.08.2021 | ||
SE | 18.08.2021 | ||
SI | 18.08.2021 | ||
SK | 18.08.2021 | ||
SM | 18.08.2021 | ||
BE | 30.09.2021 | ||
IE | 30.09.2021 | ||
LU | 30.09.2021 | ||
BG | 18.11.2021 | ||
NO | 18.11.2021 | ||
GR | 19.11.2021 | ||
IS | 18.12.2021 | ||
PT | 20.12.2021 | ||
Former [2023/33] | HU | 30.09.2016 | |
AL | 18.08.2021 | ||
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CY | 18.08.2021 | ||
CZ | 18.08.2021 | ||
DK | 18.08.2021 | ||
EE | 18.08.2021 | ||
FI | 18.08.2021 | ||
HR | 18.08.2021 | ||
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LV | 18.08.2021 | ||
MC | 18.08.2021 | ||
NL | 18.08.2021 | ||
PL | 18.08.2021 | ||
RO | 18.08.2021 | ||
RS | 18.08.2021 | ||
SE | 18.08.2021 | ||
SI | 18.08.2021 | ||
SK | 18.08.2021 | ||
SM | 18.08.2021 | ||
BE | 30.09.2021 | ||
IE | 30.09.2021 | ||
LU | 30.09.2021 | ||
BG | 18.11.2021 | ||
NO | 18.11.2021 | ||
GR | 19.11.2021 | ||
IS | 18.12.2021 | ||
PT | 20.12.2021 | ||
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FI | 18.08.2021 | ||
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MC | 18.08.2021 | ||
NL | 18.08.2021 | ||
PL | 18.08.2021 | ||
RO | 18.08.2021 | ||
RS | 18.08.2021 | ||
SE | 18.08.2021 | ||
SI | 18.08.2021 | ||
SK | 18.08.2021 | ||
SM | 18.08.2021 | ||
BE | 30.09.2021 | ||
IE | 30.09.2021 | ||
LU | 30.09.2021 | ||
BG | 18.11.2021 | ||
NO | 18.11.2021 | ||
GR | 19.11.2021 | ||
IS | 18.12.2021 | ||
PT | 20.12.2021 | ||
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RO | 18.08.2021 | ||
RS | 18.08.2021 | ||
SE | 18.08.2021 | ||
SI | 18.08.2021 | ||
SK | 18.08.2021 | ||
SM | 18.08.2021 | ||
BE | 30.09.2021 | ||
IE | 30.09.2021 | ||
LU | 30.09.2021 | ||
BG | 18.11.2021 | ||
NO | 18.11.2021 | ||
GR | 19.11.2021 | ||
IS | 18.12.2021 | ||
PT | 20.12.2021 | ||
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SM | 18.08.2021 | ||
BE | 30.09.2021 | ||
IE | 30.09.2021 | ||
LU | 30.09.2021 | ||
BG | 18.11.2021 | ||
NO | 18.11.2021 | ||
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IS | 18.12.2021 | ||
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SE | 18.08.2021 | ||
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SM | 18.08.2021 | ||
BE | 30.09.2021 | ||
LU | 30.09.2021 | ||
BG | 18.11.2021 | ||
NO | 18.11.2021 | ||
GR | 19.11.2021 | ||
IS | 18.12.2021 | ||
PT | 20.12.2021 | ||
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SM | 18.08.2021 | ||
BG | 18.11.2021 | ||
NO | 18.11.2021 | ||
GR | 19.11.2021 | ||
IS | 18.12.2021 | ||
PT | 20.12.2021 | ||
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SM | 18.08.2021 | ||
BG | 18.11.2021 | ||
NO | 18.11.2021 | ||
GR | 19.11.2021 | ||
IS | 18.12.2021 | ||
PT | 20.12.2021 | ||
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BG | 18.11.2021 | ||
NO | 18.11.2021 | ||
GR | 19.11.2021 | ||
IS | 18.12.2021 | ||
PT | 20.12.2021 | ||
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PL | 18.08.2021 | ||
RS | 18.08.2021 | ||
SE | 18.08.2021 | ||
BG | 18.11.2021 | ||
NO | 18.11.2021 | ||
GR | 19.11.2021 | ||
IS | 18.12.2021 | ||
PT | 20.12.2021 | ||
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RS | 18.08.2021 | ||
SE | 18.08.2021 | ||
BG | 18.11.2021 | ||
NO | 18.11.2021 | ||
GR | 19.11.2021 | ||
IS | 18.12.2021 | ||
PT | 20.12.2021 | ||
Former [2022/09] | AT | 18.08.2021 | |
FI | 18.08.2021 | ||
LT | 18.08.2021 | ||
RS | 18.08.2021 | ||
SE | 18.08.2021 | ||
BG | 18.11.2021 | ||
NO | 18.11.2021 | ||
PT | 20.12.2021 | ||
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Former [2022/07] | AT | 18.08.2021 | |
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NO | 18.11.2021 | Cited in | International search | [I]WO2010129864 (UNIV LELAND STANFORD JUNIOR [US], et al) [I] 1-26 * claim 1 *; | [A]WO2011098539 (PHYTOTOX LTD, et al) [A] 1-26* claim 1 *; | [A] - TAKAFUMI AKIMOTO ET AL, "Synthesis of saxitoxin derivatives bearing guanidine and urea groups at C13 and evaluation of their inhibitory activity on voltage-gated sodium channels", ORGANIC & BIOMOLECULAR CHEMISTRY, GB, (20130101), vol. 11, no. 38, doi:10.1039/c3ob41398e, ISSN 1477-0520, page 6642, XP055318484 [A] 1-26 * the whole document * DOI: http://dx.doi.org/10.1039/c3ob41398e | [A] - TORU NISHIKAWA ET AL, "Synthesis of an Advanced Model of Zetekitoxin AB Focusing on the N -Acylisoxazolidine Amide Structure Corresponding to C13-C17", ASIAN JOURNAL OF ORGANIC CHEMISTRY , 1(2), 160-165 CODEN: AJOCC7; ISSN: 2193-5807, Germany, (20141023), vol. 3, no. 12, doi:10.1002/ajoc.201402206, ISSN 2193-5807, pages 1308 - 1311, XP055318510 [A] 1-26 * the whole document * DOI: http://dx.doi.org/10.1002/ajoc.201402206 | by applicant | US3536809 | US3598123 | US3845770 | US3916899 | US4008719 | US5059595 | US5073543 | US5120548 | US5354556 | US5591767 | US5639476 | US5639480 | US5674533 | US5733566 | US5739108 | US5891474 | US5922356 | US5972891 | US5980945 | US5993855 | US6045830 | US6087324 | US6113943 | US6197350 | US6248363 | US6264970 | US6267981 | US6376461 | US6419961 | US6589548 | US6613358 | US6699500 | US2010284913 | - OGATA ET AL., JPN. J. PHARMACOL., (2002), vol. 88, no. 4, pages 365 - 77 | - MOMIN ET AL., CURR OPIN NEUROBIOL., (2008), vol. 18, no. 4, pages 383 - 8 | - RUSH ET AL., J. PHYSIOL., (2007), vol. 579, pages 1 - 14 | - COX ET AL., NATURE, (2006), vol. 444, no. 7121, pages 894 - 898 | - LIJINSKY, FOOD COSMET. TOXICOL., (1982), vol. 20, page 393 | - LIJINSKY, J. NAT. CANCER INST., (1982), vol. 69, page 1127 | - MANGOLD, MUTATION RES., (1994), vol. 308, page 33 | - GORDON, DRUG METAB. DISPOS., (1987), vol. 15, page 589 | - ZELLO, METABOLISM, (1994), vol. 43, page 487 | - GATELY, J. NUCL. MED., (1986), vol. 27, page 388 | - WADE D, CHEM. BIOL. INTERACT., (1999), vol. 117, page 191 | - FOSTER ET AL., ADV. DRUG RES., (1985), vol. 14, pages 1 - 36 | - KUSHNER ET AL., CAN. J. PHYSIOL. PHARMACOL., (1999), vol. 77, pages 79 - 88 | - JENS T. CARSTENSEN, Drug Stability: Principles & Practice, MARCEL DEKKER, NEW YORK, (1995), page 379 80 | - SEFTON, CRC CRIT. REF. BIOMED. ENG., (1987), vol. 14, page 201 | - BUCHWALD ET AL., SURGERY, (1980), vol. 88, page 507 | - SAUDEK ET AL., N. ENGL. J. MED., (1989), vol. 321, page 574 | - GOODSON, MEDICAL APPLICATIONS OF CONTROLLED RELEASE, (1984), vol. 2, pages 115 - 138 | - LANGER, SCIENCE, (1990), vol. 249, pages 1527 - 1533 | - MORAN O; PICOLLO A; CONTI F, "Tonic and phasic guanidinium toxin-block of skeletal muscle Na channels expressed in Mammalian cells", BIOPHYS J, (2003), vol. 84, no. 5, doi:doi:10.1016/S0006-3495(03)70026-5, pages 2999 - 3006, XP029291930 DOI: http://dx.doi.org/10.1016/S0006-3495(03)70026-5 | - FLEMING JJ; MCREYNOLDS MD; DU BOIS J, "+)-saxitoxin: a first and second generation stereoselective synthesis", JAM CHEM SOC., (2007), vol. 129, no. 32, doi:doi:10.1021/ja071501o, pages 9964 - 9975, XP055034206 DOI: http://dx.doi.org/10.1021/ja071501o | - MULCAHY JV; DU BOIS J, "A stereoselective synthesis of (+)-gonyautoxin 3", JAM CHEM SOC., (2008), vol. 130, pages 12630 - 12631 |