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Extract from the Register of European Patents

EP About this file: EP3386994

EP3386994 - 4,6-DI-(O-THIOPHOSPHATE)-INOSITOL-1,2,3,5-TETRA-O-SULFATE FOR C. DIFFICILE INFECTION [Right-click to bookmark this link]
Status	Opposition rejected Status updated on 10.06.2022 Database last updated on 08.04.2026
Former	The patent has been granted Status updated on 08.11.2019
Former	Grant of patent is intended Status updated on 27.06.2019
Former	Examination is in progress Status updated on 16.03.2019
Former	Request for examination was made Status updated on 14.09.2018
Former	The international publication has been made Status updated on 16.06.2017
Former	unknown Status updated on 16.12.2016
Most recent event Tooltip	08.07.2022	Lapse of the patent in a contracting state New state(s): MK	published on 10.08.2022 [2022/32]
Applicant(s)	For all designated states ETH Zürich Rämistrasse 101 8092 Zürich / CH
	[2018/42]
Inventor(s)	01 / IVARSSON, Mattias Josefstrasse 17 8005 Zürich / CH
	02 / LEROUX, Jean-Christophe In der Sommerau 8 8053 Zürich / CH
	03 / CASTAGNER, Bastien 4519 rue de Mentana Montreal Québec H2J 387 / CA
	[2018/42]
Representative(s)	Schulz Junghans Patentanwälte PartGmbB Großbeerenstraße 71 10963 Berlin / DE
	[2018/42]
Application number, filing date	16808705.4	12.12.2016
	[2018/42]
	WO2016EP80545
Priority number, date	EP20150199681	11.12.2015 Original published format: EP 15199681
	EP20160164300	07.04.2016 Original published format: EP 16164300
	[2018/42]
Filing language	EN
Procedural language	EN
Publication	Type:	A1 Application with search report
	No.:	WO2017098033
	Date:	15.06.2017
	Language:	EN
	[2017/24]
	Type:	A1 Application with search report
	No.:	EP3386994
	Date:	17.10.2018
	Language:	EN
	The application published by WIPO in one of the EPO official languages on 15.06.2017 takes the place of the publication of the European patent application.
	[2018/42]
	Type:	B1 Patent specification
	No.:	EP3386994
	Date:	11.12.2019
	Language:	EN
	[2019/50]
Search report(s)	International search report - published on:	EP	15.06.2017
Classification	IPC:	C07F9/177, A61K31/6615, A61P31/04	[2018/42]
	CPC:	C07F9/177 (EP,US); A61P31/04 (EP,US)
Designated contracting states	AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LI, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR [2018/42]
Extension states	BA	Not yet paid
	ME	Not yet paid
Validation states	MA	Not yet paid
	MD	Not yet paid
Title	German:	4,6-DI-(O-THIOPHOSPHAT)-INOSITOL-1,2,3,5-TETRA-O-SULFAT FÜR INFEKTIONEN MIT C. DIFFICILE	[2018/42]
	English:	4,6-DI-(O-THIOPHOSPHATE)-INOSITOL-1,2,3,5-TETRA-O-SULFATE FOR C. DIFFICILE INFECTION	[2018/42]
	French:	4,6-DI- (O-THIOPHOSPHATE) -INOSITOL-1,2,3,5-TETRA-O-SULFATE POUR INFECTION C. DIFFICILE	[2019/27]
	Former [2018/42]	4,6-DI-(O-THIOPHOSPHATE)-INOSITOL-1,2,3,5-TÉTRA-O-SULFATE POUR UNE INFECTION À C DIFFICILE
Entry into regional phase	25.06.2018	National basic fee paid
	25.06.2018	Designation fee(s) paid
	25.06.2018	Examination fee paid
Examination procedure	25.06.2018	Examination requested [2018/42]
	25.06.2018	Date on which the examining division has become responsible
	24.01.2019	Amendment by applicant (claims and/or description)
	20.03.2019	Despatch of a communication from the examining division (Time limit: M02)
	12.04.2019	Reply to a communication from the examining division
	28.06.2019	Communication of intention to grant the patent
	01.11.2019	Fee for grant paid
	01.11.2019	Fee for publishing/printing paid
	01.11.2019	Receipt of the translation of the claim(s)
Opposition(s)	Opponent(s)	01 05.08.2020 HGF Limited 1 City Walk Leeds Yorkshire LS11 9DX / GB Opponent's representative HGF HGF Limited 4th Floor, 1 City Square Leeds LS1 2ES / GB
		[N/P]
	Former [2020/38]
	Opponent(s)	01 05.08.2020 HGF Limited 1 City Walk Leeds Yorkshire LS11 9DX / GB Opponent's representative HGF 1 City Walk Leeds LS11 9DX / GB
	01.10.2020	Invitation to proprietor to file observations on the notice of opposition
	11.11.2020	Legal effect of rejection of opposition [2022/28]
	11.02.2021	Reply of patent proprietor to notice(s) of opposition
	11.11.2021	Date of oral proceedings
	22.02.2022	Despatch of minutes of oral proceedings
	22.02.2022	Date of despatch of rejection of opposition
Fees paid	Renewal fee
	21.12.2018	Renewal fee patent year 03
Opt-out from the exclusive Tooltip competence of the Unified Patent Court	See the Register of the Unified Patent Court for opt-out data
	Responsibility for the accuracy, completeness or quality of the data displayed under the link provided lies entirely with the Unified Patent Court.
Lapses during opposition Tooltip	HU	12.12.2016
	AL	11.12.2019
	AT	11.12.2019
	CY	11.12.2019
	CZ	11.12.2019
	EE	11.12.2019
	FI	11.12.2019
	HR	11.12.2019
	LT	11.12.2019
	LV	11.12.2019
	MC	11.12.2019
	MK	11.12.2019
	MT	11.12.2019
	RO	11.12.2019
	RS	11.12.2019
	SI	11.12.2019
	SK	11.12.2019
	SM	11.12.2019
	TR	11.12.2019
	IE	12.12.2019
	LU	12.12.2019
	BE	31.12.2019
	BG	11.03.2020
	NO	11.03.2020
	GR	12.03.2020
	IS	11.04.2020
	PT	06.05.2020
	[2022/32]
Former [2022/27]	HU	12.12.2016
	AL	11.12.2019
	AT	11.12.2019
	CY	11.12.2019
	CZ	11.12.2019
	EE	11.12.2019
	FI	11.12.2019
	HR	11.12.2019
	LT	11.12.2019
	LV	11.12.2019
	MC	11.12.2019
	MT	11.12.2019
	RO	11.12.2019
	RS	11.12.2019
	SI	11.12.2019
	SK	11.12.2019
	SM	11.12.2019
	TR	11.12.2019
	IE	12.12.2019
	LU	12.12.2019
	BE	31.12.2019
	BG	11.03.2020
	NO	11.03.2020
	GR	12.03.2020
	IS	11.04.2020
	PT	06.05.2020
Former [2021/34]	HU	12.12.2016
	AL	11.12.2019
	AT	11.12.2019
	CY	11.12.2019
	CZ	11.12.2019
	EE	11.12.2019
	FI	11.12.2019
	HR	11.12.2019
	LT	11.12.2019
	LV	11.12.2019
	MC	11.12.2019
	MT	11.12.2019
	RO	11.12.2019
	RS	11.12.2019
	SI	11.12.2019
	SK	11.12.2019
	SM	11.12.2019
	IE	12.12.2019
	LU	12.12.2019
	BE	31.12.2019
	BG	11.03.2020
	NO	11.03.2020
	GR	12.03.2020
	IS	11.04.2020
	PT	06.05.2020
Former [2021/32]	HU	12.12.2016
	AL	11.12.2019
	AT	11.12.2019
	CY	11.12.2019
	CZ	11.12.2019
	EE	11.12.2019
	FI	11.12.2019
	HR	11.12.2019
	LT	11.12.2019
	LV	11.12.2019
	MC	11.12.2019
	RO	11.12.2019
	RS	11.12.2019
	SI	11.12.2019
	SK	11.12.2019
	SM	11.12.2019
	IE	12.12.2019
	LU	12.12.2019
	BE	31.12.2019
	BG	11.03.2020
	NO	11.03.2020
	GR	12.03.2020
	IS	11.04.2020
	PT	06.05.2020
Former [2021/26]	AL	11.12.2019
	AT	11.12.2019
	CY	11.12.2019
	CZ	11.12.2019
	EE	11.12.2019
	FI	11.12.2019
	HR	11.12.2019
	LT	11.12.2019
	LV	11.12.2019
	MC	11.12.2019
	RO	11.12.2019
	RS	11.12.2019
	SI	11.12.2019
	SK	11.12.2019
	SM	11.12.2019
	IE	12.12.2019
	LU	12.12.2019
	BE	31.12.2019
	BG	11.03.2020
	NO	11.03.2020
	GR	12.03.2020
	IS	11.04.2020
	PT	06.05.2020
Former [2020/51]	AL	11.12.2019
	AT	11.12.2019
	CZ	11.12.2019
	EE	11.12.2019
	FI	11.12.2019
	HR	11.12.2019
	LT	11.12.2019
	LV	11.12.2019
	MC	11.12.2019
	RO	11.12.2019
	RS	11.12.2019
	SI	11.12.2019
	SK	11.12.2019
	SM	11.12.2019
	IE	12.12.2019
	LU	12.12.2019
	BE	31.12.2019
	BG	11.03.2020
	NO	11.03.2020
	GR	12.03.2020
	IS	11.04.2020
	PT	06.05.2020
Former [2020/46]	AL	11.12.2019
	CZ	11.12.2019
	EE	11.12.2019
	FI	11.12.2019
	HR	11.12.2019
	LT	11.12.2019
	LV	11.12.2019
	MC	11.12.2019
	RO	11.12.2019
	RS	11.12.2019
	SK	11.12.2019
	SM	11.12.2019
	IE	12.12.2019
	LU	12.12.2019
	BG	11.03.2020
	NO	11.03.2020
	GR	12.03.2020
	IS	11.04.2020
	PT	06.05.2020
Former [2020/45]	AL	11.12.2019
	CZ	11.12.2019
	EE	11.12.2019
	FI	11.12.2019
	HR	11.12.2019
	LT	11.12.2019
	LV	11.12.2019
	MC	11.12.2019
	RO	11.12.2019
	RS	11.12.2019
	SK	11.12.2019
	SM	11.12.2019
	BG	11.03.2020
	NO	11.03.2020
	GR	12.03.2020
	IS	11.04.2020
	PT	06.05.2020
Former [2020/40]	AL	11.12.2019
	CZ	11.12.2019
	EE	11.12.2019
	FI	11.12.2019
	HR	11.12.2019
	LT	11.12.2019
	LV	11.12.2019
	RO	11.12.2019
	RS	11.12.2019
	SK	11.12.2019
	SM	11.12.2019
	BG	11.03.2020
	NO	11.03.2020
	GR	12.03.2020
	IS	11.04.2020
	PT	06.05.2020
Former [2020/37]	AL	11.12.2019
	CZ	11.12.2019
	EE	11.12.2019
	FI	11.12.2019
	HR	11.12.2019
	LT	11.12.2019
	LV	11.12.2019
	RO	11.12.2019
	RS	11.12.2019
	SK	11.12.2019
	SM	11.12.2019
	BG	11.03.2020
	NO	11.03.2020
	GR	12.03.2020
	PT	06.05.2020
Former [2020/36]	AL	11.12.2019
	CZ	11.12.2019
	EE	11.12.2019
	FI	11.12.2019
	HR	11.12.2019
	LT	11.12.2019
	LV	11.12.2019
	RO	11.12.2019
	RS	11.12.2019
	BG	11.03.2020
	NO	11.03.2020
	GR	12.03.2020
	PT	06.05.2020
Former [2020/35]	AL	11.12.2019
	CZ	11.12.2019
	FI	11.12.2019
	HR	11.12.2019
	LT	11.12.2019
	LV	11.12.2019
	RO	11.12.2019
	RS	11.12.2019
	BG	11.03.2020
	NO	11.03.2020
	GR	12.03.2020
Former [2020/32]	AL	11.12.2019
	FI	11.12.2019
	HR	11.12.2019
	LT	11.12.2019
	LV	11.12.2019
	RS	11.12.2019
	BG	11.03.2020
	NO	11.03.2020
	GR	12.03.2020
Former [2020/25]	FI	11.12.2019
	HR	11.12.2019
	LT	11.12.2019
	LV	11.12.2019
	RS	11.12.2019
	BG	11.03.2020
	NO	11.03.2020
	GR	12.03.2020
Former [2020/23]	FI	11.12.2019
	LT	11.12.2019
	LV	11.12.2019
	BG	11.03.2020
	NO	11.03.2020
	GR	12.03.2020
Former [2020/22]	FI	11.12.2019
	LT	11.12.2019
	BG	11.03.2020
	NO	11.03.2020
Former [2020/21]	NO	11.03.2020
Cited in	International search	[AD] WO2013045107 (ETH ZUERICH et al.)
		[A] ESTELLE DURANTIE ET AL: "New Paradigms for the Chiral Synthesis of Inositol Phosphates", CHEMBIOCHEM - A EUROPEAN JOURNAL OF CHEMICAL BIOLOGY., vol. 16, no. 7, 12 March 2015 (2015-03-12), DE, pages 1030 - 1032, XP055289967, ISSN: 1439-4227, DOI: 10.1002/cbic.201500071 DOI: http://dx.doi.org/10.1002/cbic.201500071
		[A] E DURANTIE: "Chemical Synthesis of Biomolecules Analogs: Inositol Phosphate/Sulfate Hybrids And Fluorinated Carbohydrates", DISS. ETH NO. 22532, 1 January 2015 (2015-01-01), ETH Zrich, pages 1 - 84, XP055333064
	Examination	US9200015
		EP0269105
		THOMAS S. ELLIOTT ET AL: "The use of phosphate bioisosteres in medicinal chemistry and chemical biology", MEDCHEMCOMM, vol. 3, no. 7, 1 January 2012 (2012-01-01), United Kingdom, pages 735, XP055569563, ISSN: 2040-2503, DOI: 10.1039/c2md20079a DOI: http://dx.doi.org/10.1039/c2md20079a
		M R HAMBLIN ET AL: "myo -Inositol phosphorothioates, phosphatase-resistant analogues of myo -inositol phosphates. Synthesis of dl- myo -inositol 1,4-bisphosphate and dl- myo -inositol 1,4-bisphosphorothioate", BIOCHEMICAL JOURNAL, vol. 246, no. 3, 15 September 1987 (1987-09-15), GB, pages 771 - 774, XP055569564, ISSN: 0264-6021, DOI: 10.1042/bj2460771 DOI: http://dx.doi.org/10.1042/bj2460771
	by applicant	WO2013045107
		JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, vol. 127, 2005, pages 5288
		OHNISHI., ANA/. BIOCHEM., vol. 85, 1978, pages 165
		PROTEOMICS, vol. 1, 2001, pages 1359
	Opposition	WO2013045107
		WO2012138963
		THOMAS S. ELLIOTT, AINE SLOWEY, YULIN YE, STUART J. CONWAY: "The use of phosphate bioisosteres in medicinal chemistry and chemical biology", MEDCHEMCOMM, ROYAL SOCIETY OF CHEMISTRY, UNITED KINGDOM, vol. 3, no. 7, 1 January 2012 (2012-01-01), United Kingdom, pages 735 - 751, XP055569563, ISSN: 2040-2503, DOI: 10.1039/c2md20079a DOI: http://dx.doi.org/10.1039/c2md20079a
		E DURANTIE: "Chemical Synthesis of Biomolecules Analogs: Inositol Phosphate/Sulfate Hybrids And Fluorinated Carbohydrates", DISS. ETH NO. 22532, ETH ZRICH, ETH ZRICH, 1 January 2015 (2015-01-01), ETH Zrich, pages 1 - 84, XP055333064
		M R HAMBLIN, J S FLORA, B V L POTTER: "myo -Inositol phosphorothioates, phosphatase-resistant analogues of myo -inositol phosphates. Synthesis of dl- myo -inositol 1,4-bisphosphate and dl- myo -inositol 1,4-bisphosphorothioate", BIOCHEMICAL JOURNAL, PUBLISHED BY PORTLAND PRESS ON BEHALF OF THE BIOCHEMICAL SOCIETY., GB, vol. 246, no. 3, 15 September 1987 (1987-09-15), GB, pages 771 - 774, XP055569564, ISSN: 0264-6021, DOI: 10.1042/bj2460771 DOI: http://dx.doi.org/10.1042/bj2460771
		COOKE ALLAN M, ET AL: "myo-lnositol 1,4,5-Trisphosphorothioate: A Novel Analogue of a Biological Second Messenger", J. CHEM. SOC., CHEM. COMMUN, 1 January 1987 (1987-01-01), pages 1525 - 1526, XP055815959, Retrieved from the Internet [retrieved on 20210621]
		SMITH S. W.: "Chiral Toxicology: It's the Same Thing...Only Different", TOXICOLOGICAL SCIENCES, vol. 110, no. 1, 2009, pages 4 - 30, XP055172718, DOI: 10.1093/toxsci/kfp097 DOI: http://dx.doi.org/10.1093/toxsci/kfp097
		COOKE A. M.: "Synthesis and Biology of Inositol Phosphates and Thiophosphates", PHD THESIS, 1991, pages 1 - 203

The EPO accepts no responsibility for the accuracy of data originating from other authorities; in particular, it does not guarantee that it is complete, up to date or fit for specific purposes.