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Extract from the Register of European Patents

EP About this file: EP3294716

EP3294716 - META-AZACYCLIC AMINO BENZOIC ACID DERIVATIVES AS PAN INTEGRIN ANTAGONISTS [Right-click to bookmark this link]
StatusNo opposition filed within time limit
Status updated on  19.02.2021
Database last updated on 03.01.2025
FormerThe patent has been granted
Status updated on  13.03.2020
FormerGrant of patent is intended
Status updated on  12.11.2019
FormerExamination is in progress
Status updated on  07.12.2018
FormerRequest for examination was made
Status updated on  16.02.2018
FormerThe international publication has been made
Status updated on  07.07.2017
Formerunknown
Status updated on  01.02.2017
Most recent event   Tooltip15.07.2022Lapse of the patent in a contracting state
New state(s): BE		published on 17.08.2022  [2022/33]
Applicant(s)For all designated states
Saint Louis University
221 North Grand Boulevard
St. Louis, MO 63103 / US
[2018/12]
Inventor(s)01 / RUMINSKI, Peter, G.
33 Blackwolf Run Court
Wildwood, MO 63040 / US
02 / GRIGGS, David, W.
1237 Oak Borough Drive
Ballwin, MO 63021 / US
 [2018/12]
Representative(s)Potter Clarkson
Chapel Quarter
Mount Street
Nottingham NG1 6HQ / GB
[N/P]
Former [2020/16]Potter Clarkson
The Belgrave Centre
Talbot Street
Nottingham NG1 5GG / GB
Former [2018/12]Potter Clarkson LLP
The Belgrave Centre
Talbot Street
Nottingham NG1 5GG / GB
Application number, filing date16829387.630.12.2016
[2018/12]
WO2016US69511
Priority number, dateUS201562273246P30.12.2015         Original published format: US 201562273246 P
[2018/12]
Filing languageEN
Procedural languageEN
PublicationType: A1 Application with search report
No.:WO2017117538
Date:06.07.2017
Language:EN
[2017/27]
Type: A1 Application with search report 
No.:EP3294716
Date:21.03.2018
Language:EN
The application published by WIPO in one of the EPO official languages on 06.07.2017 takes the place of the publication of the European patent application.
[2018/12]
Type: B1 Patent specification 
No.:EP3294716
Date:15.04.2020
Language:EN
[2020/16]
Search report(s)International search report - published on:EP06.07.2017
ClassificationIPC:C07D239/16, C07D239/14, C07D239/02, C07D401/12, C07D233/28, A61K31/44
[2018/12]
CPC:
C07D239/14 (EP,KR,US); C07D233/28 (EP,KR,US); A61K31/495 (KR);
A61K31/505 (RU); A61K31/506 (RU); A61P1/02 (EP);
A61P1/16 (EP); A61P1/18 (EP); A61P11/00 (EP);
A61P13/12 (EP); A61P17/00 (EP); A61P17/02 (EP);
A61P17/06 (EP); A61P19/02 (EP); A61P19/10 (EP);
A61P25/00 (EP); A61P27/02 (EP); A61P29/00 (EP,RU);
A61P3/10 (EP,RU); A61P3/14 (EP); A61P31/00 (EP);
A61P35/00 (EP,RU); A61P35/02 (EP); A61P37/02 (EP);
A61P43/00 (EP); A61P9/00 (EP); A61P9/10 (EP,RU);
C07D239/02 (EP,KR,US); C07D239/16 (EP,KR,US); C07D239/47 (RU);
C07D401/04 (RU); C07D401/12 (EP,KR,US) (-)
Designated contracting statesAL,   AT,   BE,   BG,   CH,   CY,   CZ,   DE,   DK,   EE,   ES,   FI,   FR,   GB,   GR,   HR,   HU,   IE,   IS,   IT,   LI,   LT,   LU,   LV,   MC,   MK,   MT,   NL,   NO,   PL,   PT,   RO,   RS,   SE,   SI,   SK,   SM,   TR [2018/12]
Extension statesBANot yet paid
MENot yet paid
Validation statesMANot yet paid
MDNot yet paid
TitleGerman:META-AZYKLISCHE AMINOBENZOESÄUREDERIVATE ALS PAN-INTEGRIN-ANTAGONISTEN[2018/12]
English:META-AZACYCLIC AMINO BENZOIC ACID DERIVATIVES AS PAN INTEGRIN ANTAGONISTS[2018/12]
French:DÉRIVÉS D'ACIDE AMINOBENZOÏQUE MÉTA-AZACYCLIQUE À TITRE D'ANTAGONISTES DE PAN-INTÉGRINE[2018/12]
Entry into regional phase15.12.2017National basic fee paid 
15.12.2017Designation fee(s) paid 
15.12.2017Examination fee paid 
Examination procedure15.12.2017Examination requested  [2018/12]
15.12.2017Date on which the examining division has become responsible
29.05.2018Amendment by applicant (claims and/or description)
06.12.2018Despatch of a communication from the examining division (Time limit: M04)
03.04.2019Reply to a communication from the examining division
21.05.2019Despatch of a communication from the examining division (Time limit: M04)
18.09.2019Reply to a communication from the examining division
13.11.2019Communication of intention to grant the patent
09.03.2020Fee for grant paid
09.03.2020Fee for publishing/printing paid
09.03.2020Receipt of the translation of the claim(s)
Divisional application(s)EP20169477.5  / EP3738953
Opposition(s)18.01.2021No opposition filed within time limit [2021/12]
Fees paidRenewal fee
07.12.2018Renewal fee patent year 03
05.12.2019Renewal fee patent year 04
Opt-out from the exclusive  Tooltip
competence of the Unified
Patent Court		 See the Register of the Unified Patent Court for opt-out data
Responsibility for the accuracy, completeness or quality of the data displayed under the link provided lies entirely with the Unified Patent Court.
Lapses during opposition  TooltipHU30.12.2016
AL15.04.2020
AT15.04.2020
CY15.04.2020
CZ15.04.2020
DK15.04.2020
EE15.04.2020
FI15.04.2020
HR15.04.2020
LT15.04.2020
LV15.04.2020
MC15.04.2020
MK15.04.2020
MT15.04.2020
NL15.04.2020
PL15.04.2020
RO15.04.2020
RS15.04.2020
SE15.04.2020
SI15.04.2020
SK15.04.2020
SM15.04.2020
TR15.04.2020
BG15.07.2020
NO15.07.2020
GR16.07.2020
PT17.08.2020
GB30.12.2020
IE30.12.2020
IT30.12.2020
LU30.12.2020
BE31.12.2020
CH31.12.2020
ES31.12.2020
FR31.12.2020
LI31.12.2020
[2022/33]
Former [2022/32]HU30.12.2016
AL15.04.2020
AT15.04.2020
CY15.04.2020
CZ15.04.2020
DK15.04.2020
EE15.04.2020
FI15.04.2020
HR15.04.2020
LT15.04.2020
LV15.04.2020
MC15.04.2020
MK15.04.2020
MT15.04.2020
NL15.04.2020
PL15.04.2020
RO15.04.2020
RS15.04.2020
SE15.04.2020
SI15.04.2020
SK15.04.2020
SM15.04.2020
TR15.04.2020
BG15.07.2020
NO15.07.2020
GR16.07.2020
PT17.08.2020
GB30.12.2020
IE30.12.2020
IT30.12.2020
LU30.12.2020
CH31.12.2020
ES31.12.2020
FR31.12.2020
LI31.12.2020
Former [2022/27]HU30.12.2016
AL15.04.2020
AT15.04.2020
CY15.04.2020
CZ15.04.2020
DK15.04.2020
EE15.04.2020
FI15.04.2020
HR15.04.2020
LT15.04.2020
LV15.04.2020
MC15.04.2020
MT15.04.2020
NL15.04.2020
PL15.04.2020
RO15.04.2020
RS15.04.2020
SE15.04.2020
SI15.04.2020
SK15.04.2020
SM15.04.2020
TR15.04.2020
BG15.07.2020
NO15.07.2020
GR16.07.2020
PT17.08.2020
GB30.12.2020
IE30.12.2020
IT30.12.2020
LU30.12.2020
CH31.12.2020
ES31.12.2020
FR31.12.2020
LI31.12.2020
Former [2022/23]AL15.04.2020
AT15.04.2020
CZ15.04.2020
DK15.04.2020
EE15.04.2020
FI15.04.2020
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LV15.04.2020
MC15.04.2020
NL15.04.2020
PL15.04.2020
RO15.04.2020
RS15.04.2020
SE15.04.2020
SI15.04.2020
SK15.04.2020
SM15.04.2020
BG15.07.2020
NO15.07.2020
GR16.07.2020
PT17.08.2020
GB30.12.2020
IE30.12.2020
IT30.12.2020
LU30.12.2020
CH31.12.2020
ES31.12.2020
FR31.12.2020
LI31.12.2020
Former [2022/10]AL15.04.2020
AT15.04.2020
CZ15.04.2020
DK15.04.2020
EE15.04.2020
FI15.04.2020
HR15.04.2020
LT15.04.2020
LV15.04.2020
MC15.04.2020
NL15.04.2020
PL15.04.2020
RO15.04.2020
RS15.04.2020
SE15.04.2020
SI15.04.2020
SK15.04.2020
SM15.04.2020
BG15.07.2020
NO15.07.2020
GR16.07.2020
PT17.08.2020
GB30.12.2020
IE30.12.2020
IT30.12.2020
LU30.12.2020
CH31.12.2020
FR31.12.2020
LI31.12.2020
Former [2021/52]AL15.04.2020
AT15.04.2020
CZ15.04.2020
DK15.04.2020
EE15.04.2020
FI15.04.2020
HR15.04.2020
LT15.04.2020
LV15.04.2020
MC15.04.2020
NL15.04.2020
PL15.04.2020
RO15.04.2020
RS15.04.2020
SE15.04.2020
SI15.04.2020
SK15.04.2020
SM15.04.2020
BG15.07.2020
NO15.07.2020
GR16.07.2020
IS15.08.2020
PT17.08.2020
GB30.12.2020
IE30.12.2020
LU30.12.2020
CH31.12.2020
FR31.12.2020
LI31.12.2020
Former [2021/49]AL15.04.2020
AT15.04.2020
CZ15.04.2020
DK15.04.2020
EE15.04.2020
FI15.04.2020
HR15.04.2020
LT15.04.2020
LV15.04.2020
MC15.04.2020
NL15.04.2020
PL15.04.2020
RO15.04.2020
RS15.04.2020
SE15.04.2020
SI15.04.2020
SK15.04.2020
SM15.04.2020
BG15.07.2020
NO15.07.2020
GR16.07.2020
IS15.08.2020
PT17.08.2020
GB30.12.2020
IE30.12.2020
LU30.12.2020
FR31.12.2020
Former [2021/48]AL15.04.2020
AT15.04.2020
CZ15.04.2020
DK15.04.2020
EE15.04.2020
FI15.04.2020
HR15.04.2020
LT15.04.2020
LV15.04.2020
MC15.04.2020
NL15.04.2020
PL15.04.2020
RO15.04.2020
RS15.04.2020
SE15.04.2020
SI15.04.2020
SK15.04.2020
SM15.04.2020
BG15.07.2020
NO15.07.2020
GR16.07.2020
IS15.08.2020
PT17.08.2020
IE30.12.2020
LU30.12.2020
FR31.12.2020
Former [2021/46]AL15.04.2020
AT15.04.2020
CZ15.04.2020
DK15.04.2020
EE15.04.2020
FI15.04.2020
HR15.04.2020
LT15.04.2020
LV15.04.2020
MC15.04.2020
NL15.04.2020
PL15.04.2020
RO15.04.2020
RS15.04.2020
SE15.04.2020
SI15.04.2020
SK15.04.2020
SM15.04.2020
BG15.07.2020
NO15.07.2020
GR16.07.2020
IS15.08.2020
PT17.08.2020
IE30.12.2020
LU30.12.2020
Former [2021/40]AL15.04.2020
AT15.04.2020
CZ15.04.2020
DK15.04.2020
EE15.04.2020
FI15.04.2020
HR15.04.2020
LT15.04.2020
LV15.04.2020
MC15.04.2020
NL15.04.2020
PL15.04.2020
RO15.04.2020
RS15.04.2020
SE15.04.2020
SI15.04.2020
SK15.04.2020
SM15.04.2020
BG15.07.2020
NO15.07.2020
GR16.07.2020
IS15.08.2020
PT17.08.2020
Former [2021/24]AL15.04.2020
AT15.04.2020
CZ15.04.2020
DK15.04.2020
EE15.04.2020
FI15.04.2020
HR15.04.2020
LT15.04.2020
LV15.04.2020
NL15.04.2020
PL15.04.2020
RO15.04.2020
RS15.04.2020
SE15.04.2020
SI15.04.2020
SK15.04.2020
SM15.04.2020
BG15.07.2020
NO15.07.2020
GR16.07.2020
IS15.08.2020
PT17.08.2020
Former [2021/10]AL15.04.2020
AT15.04.2020
CZ15.04.2020
DK15.04.2020
EE15.04.2020
FI15.04.2020
HR15.04.2020
LT15.04.2020
LV15.04.2020
NL15.04.2020
PL15.04.2020
RO15.04.2020
RS15.04.2020
SE15.04.2020
SK15.04.2020
SM15.04.2020
BG15.07.2020
NO15.07.2020
GR16.07.2020
IS15.08.2020
PT17.08.2020
Former [2021/09]AL15.04.2020
AT15.04.2020
CZ15.04.2020
DK15.04.2020
EE15.04.2020
FI15.04.2020
HR15.04.2020
LT15.04.2020
LV15.04.2020
NL15.04.2020
RO15.04.2020
RS15.04.2020
SE15.04.2020
SM15.04.2020
BG15.07.2020
NO15.07.2020
GR16.07.2020
IS15.08.2020
PT17.08.2020
Former [2021/08]AL15.04.2020
DK15.04.2020
FI15.04.2020
HR15.04.2020
LT15.04.2020
LV15.04.2020
NL15.04.2020
RO15.04.2020
RS15.04.2020
SE15.04.2020
SM15.04.2020
BG15.07.2020
NO15.07.2020
GR16.07.2020
IS15.08.2020
PT17.08.2020
Former [2021/04]AL15.04.2020
FI15.04.2020
HR15.04.2020
LT15.04.2020
LV15.04.2020
NL15.04.2020
RS15.04.2020
SE15.04.2020
BG15.07.2020
NO15.07.2020
GR16.07.2020
IS15.08.2020
PT17.08.2020
Former [2021/01]FI15.04.2020
HR15.04.2020
LT15.04.2020
LV15.04.2020
NL15.04.2020
RS15.04.2020
SE15.04.2020
BG15.07.2020
NO15.07.2020
GR16.07.2020
IS15.08.2020
PT17.08.2020
Former [2020/51]FI15.04.2020
HR15.04.2020
LT15.04.2020
LV15.04.2020
NL15.04.2020
RS15.04.2020
SE15.04.2020
NO15.07.2020
GR16.07.2020
IS15.08.2020
PT17.08.2020
Former [2020/50]FI15.04.2020
HR15.04.2020
LT15.04.2020
LV15.04.2020
NL15.04.2020
SE15.04.2020
NO15.07.2020
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IS15.08.2020
PT17.08.2020
Former [2020/48]FI15.04.2020
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IS15.08.2020
PT17.08.2020
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IS15.08.2020
Former [2020/46]IS15.08.2020
Cited inInternational search[Y]US6013651  (ROGERS THOMAS E [US], et al) [Y] 1-74 * column 2, lines 54-67; column 46, line 65 - column 54, line 63; column 57, lines 41-61, Table; claims *;
 [X]US2005020505  (ROGERS THOMAS [US], et al) [X] 1-74 * [0003]-[0004]; [0080]-[0092]; [0121]-[0134]; [0135]-[0146]; [0349]; [0357]-[0358]; [0971]-[0972]; claims *;
 [X]WO2014015054  (UNIV SAINT LOUIS [US]) [X] 1-74 * page 8, compound (II) and page 10, lines 1 to 3; page 14, lines 3-6; pages 14-26, compounds; pages 83-141, Table A; pages 201-304, Examples 1-26; pages 305-309, Example 3 and page 310, Table 2, "Biological Assay Results"; claims, e.g. claim 3 *;
 [Y]US2014051715  (RUMINSKI PETER [US], et al) [Y] 1-74 * [0011]-[0012]; pages 10-11, Scheme IV and Scheme V; page 11, Scheme VI; [0069], Biological Activity; Examples 1 and 2; page 23, Table 2; claims *;
 [Y]  - NAGARAJAN ET AL, "R-Isomers of Arg-Gly-Asp (RGD) mimics as potent alphavbeta3 inhibitors", BIOORGANIC & MEDICINAL CHEMISTRY, PERGAMON, GB, (20070426), vol. 15, no. 11, doi:10.1016/J.BMC.2007.03.034, ISSN 0968-0896, pages 3783 - 3800, XP022047564 [Y] 1-74 * page 3784, compounds 1a-1d; page 3787, Scheme 5; page 3789, Scheme 9; page 3790, Table 2, IC50 values as well as compounds 129-133 *

DOI:   http://dx.doi.org/10.1016/j.bmc.2007.03.034
The EPO accepts no responsibility for the accuracy of data originating from other authorities; in particular, it does not guarantee that it is complete, up to date or fit for specific purposes.