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Extract from the Register of European Patents

EP About this file: EP3331852

EP3331852 - SUBSTITUTED MALONAMIDES AND THEIR USE AS ANTIBACTERIAL DRUGS [Right-click to bookmark this link]
StatusNo opposition filed within time limit
Status updated on  29.10.2021
Database last updated on 05.10.2024
FormerThe patent has been granted
Status updated on  20.11.2020
FormerGrant of patent is intended
Status updated on  02.07.2020
FormerExamination is in progress
Status updated on  07.01.2020
FormerRequest for examination was made
Status updated on  11.05.2018
FormerThe international publication has been made
Status updated on  25.02.2017
Most recent event   Tooltip06.09.2024Lapse of the patent in a contracting state
New state(s): MT		published on 09.10.2024 [2024/41]
Applicant(s)For all designated states
National Taiwan University
No. 1, Sec.4, Roosevelt Road
Taipei 10617 / TW
For all designated states
National Yang-Ming University
No. 155, Sec. 2, Linong Street
Taipei 112 / TW
[2020/01]
Former [2018/24]For all designated states
National Taiwan University
No. 1, Sec.4, Roosevelt Road
Taipei 10617 / TW
Inventor(s)01 / SHIAU, Chung-Wai
No. 155, Sec.2, Linong Street
Taipei, Taiwan 112 / CN
02 / CHIU, Hao-Chieh
No. 1, Changde St.
Zhongzheng Dist.
Taipei, Taiwan 10048 / CN
 [2018/24]
Representative(s)Lang, Christian
LangPatent Anwaltskanzlei IP Law Firm
Ingolstädter Straße 5
80807 München / DE
[2020/52]
Former [2018/24]Lang, Christian
LangPatent Anwaltskanzlei
IP Law Firm
Rosenheimer Straße 139
81671 München / DE
Application number, filing date16836609.412.08.2016
[2018/24]
WO2016CN94855
Priority number, dateUS201562206251P17.08.2015         Original published format: US 201562206251 P
[2018/24]
Filing languageEN
Procedural languageEN
PublicationType: A1 Application with search report
No.:WO2017028745
Date:23.02.2017
Language:EN
[2017/08]
Type: A1 Application with search report 
No.:EP3331852
Date:13.06.2018
Language:EN
The application published by WIPO in one of the EPO official languages on 23.02.2017 takes the place of the publication of the European patent application.
[2018/24]
Type: B1 Patent specification 
No.:EP3331852
Date:23.12.2020
Language:EN
[2020/52]
Search report(s)International search report - published on:CN23.02.2017
(Supplementary) European search report - dispatched on:EP12.02.2019
ClassificationIPC:C07C233/05, C07C233/06, C07C233/07, C07C381/00, C07C233/09, C07C233/15, C07C233/25, C07C233/58, C07C233/59, A61K31/165, A61K31/16, A61P31/04
[2020/29]
CPC:
C07C233/59 (EP,US); A61K31/165 (US); A61P31/04 (EP,US);
C07C231/02 (US); C07C233/05 (EP,US); C07C233/06 (EP,US);
C07C233/07 (EP,US); C07C233/09 (EP,US); C07C233/15 (EP,US);
C07C233/25 (EP,US); C07C233/58 (EP,US); C07C381/00 (EP,US);
C07C2601/02 (EP,US); C07C2601/14 (EP,US) (-)
Former IPC [2019/11]C07C233/05, C07C233/06, C07C233/07, C07C231/02, A61K31/165, A61K31/16, A61P31/04, C07C381/00, C07C233/09, C07C233/15, C07C233/25, C07C233/58, C07C233/59
Former IPC [2018/24]C07C233/05, C07C233/06, C07C233/07, C07C231/02, A61K31/165, A61K31/16, A61P31/04
Designated contracting statesAL,   AT,   BE,   BG,   CH,   CY,   CZ,   DE,   DK,   EE,   ES,   FI,   FR,   GB,   GR,   HR,   HU,   IE,   IS,   IT,   LI,   LT,   LU,   LV,   MC,   MK,   MT,   NL,   NO,   PL,   PT,   RO,   RS,   SE,   SI,   SK,   SM,   TR [2018/24]
Extension statesBANot yet paid
MENot yet paid
Validation statesMANot yet paid
MDNot yet paid
TitleGerman:SUBSTITUIERTE MALONAMIDE UND DEREN VERWENDUNG ALS ANTIBAKTERIELLE ARZNEIMITTEL[2018/24]
English:SUBSTITUTED MALONAMIDES AND THEIR USE AS ANTIBACTERIAL DRUGS[2018/24]
French:MALONAMIDES SUBSTITUÉS ET LEUR UTILISATION COMME MÉDICAMENTS ANTIBACTÉRIENS[2018/24]
Entry into regional phase05.03.2018National basic fee paid 
05.03.2018Search fee paid 
05.03.2018Designation fee(s) paid 
05.03.2018Examination fee paid 
Examination procedure19.06.2017Request for preliminary examination filed
International Preliminary Examining Authority: CN
16.01.2018Date on which the examining division has become responsible
05.03.2018Examination requested  [2018/24]
30.08.2019Amendment by applicant (claims and/or description)
10.01.2020Despatch of a communication from the examining division (Time limit: M04)
11.05.2020Reply to a communication from the examining division
03.07.2020Communication of intention to grant the patent
23.10.2020Fee for grant paid
23.10.2020Fee for publishing/printing paid
13.11.2020Receipt of the translation of the claim(s)
Opposition(s)24.09.2021No opposition filed within time limit [2021/48]
Fees paidRenewal fee
29.08.2018Renewal fee patent year 03
26.08.2019Renewal fee patent year 04
24.08.2020Renewal fee patent year 05
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Responsibility for the accuracy, completeness or quality of the data displayed under the link provided lies entirely with the Unified Patent Court.
Lapses during opposition  TooltipHU12.08.2016
AL23.12.2020
AT23.12.2020
CY23.12.2020
CZ23.12.2020
DK23.12.2020
EE23.12.2020
ES23.12.2020
FI23.12.2020
HR23.12.2020
IT23.12.2020
LT23.12.2020
LV23.12.2020
MC23.12.2020
MK23.12.2020
MT23.12.2020
NL23.12.2020
PL23.12.2020
RO23.12.2020
RS23.12.2020
SE23.12.2020
SI23.12.2020
SK23.12.2020
SM23.12.2020
BG23.03.2021
NO23.03.2021
GR24.03.2021
IS23.04.2021
PT23.04.2021
IE12.08.2021
LU12.08.2021
BE31.08.2021
CH31.08.2021
LI31.08.2021
[2024/41]
Former [2024/22]HU12.08.2016
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CZ23.12.2020
DK23.12.2020
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BG23.03.2021
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IE12.08.2021
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BE31.08.2021
CH31.08.2021
LI31.08.2021
Former [2023/30]HU12.08.2016
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FI23.12.2020
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MC23.12.2020
NL23.12.2020
PL23.12.2020
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SK23.12.2020
SM23.12.2020
BG23.03.2021
NO23.03.2021
GR24.03.2021
IS23.04.2021
PT23.04.2021
IE12.08.2021
LU12.08.2021
BE31.08.2021
CH31.08.2021
LI31.08.2021
Former [2023/29]HU12.08.2016
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MC23.12.2020
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SI23.12.2020
SK23.12.2020
SM23.12.2020
BG23.03.2021
NO23.03.2021
GR24.03.2021
IS23.04.2021
PT23.04.2021
IE12.08.2021
LU12.08.2021
BE31.08.2021
CH31.08.2021
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Former [2022/35]AL23.12.2020
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DK23.12.2020
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IT23.12.2020
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LV23.12.2020
MC23.12.2020
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PL23.12.2020
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SI23.12.2020
SK23.12.2020
SM23.12.2020
BG23.03.2021
NO23.03.2021
GR24.03.2021
IS23.04.2021
PT23.04.2021
IE12.08.2021
LU12.08.2021
BE31.08.2021
CH31.08.2021
LI31.08.2021
Former [2022/34]AL23.12.2020
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DK23.12.2020
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IT23.12.2020
LT23.12.2020
LV23.12.2020
MC23.12.2020
NL23.12.2020
PL23.12.2020
RO23.12.2020
RS23.12.2020
SE23.12.2020
SI23.12.2020
SK23.12.2020
SM23.12.2020
BG23.03.2021
NO23.03.2021
GR24.03.2021
IS23.04.2021
PT23.04.2021
LU12.08.2021
BE31.08.2021
CH31.08.2021
LI31.08.2021
Former [2022/23]AL23.12.2020
AT23.12.2020
CZ23.12.2020
DK23.12.2020
EE23.12.2020
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IT23.12.2020
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LV23.12.2020
MC23.12.2020
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PL23.12.2020
RO23.12.2020
RS23.12.2020
SE23.12.2020
SI23.12.2020
SK23.12.2020
SM23.12.2020
BG23.03.2021
NO23.03.2021
GR24.03.2021
IS23.04.2021
PT23.04.2021
LU12.08.2021
CH31.08.2021
LI31.08.2021
Former [2022/21]AL23.12.2020
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DK23.12.2020
EE23.12.2020
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IT23.12.2020
LT23.12.2020
LV23.12.2020
MC23.12.2020
NL23.12.2020
PL23.12.2020
RO23.12.2020
RS23.12.2020
SE23.12.2020
SI23.12.2020
SK23.12.2020
SM23.12.2020
BG23.03.2021
NO23.03.2021
GR24.03.2021
PT23.04.2021
CH31.08.2021
LI31.08.2021
Former [2022/18]AL23.12.2020
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CZ23.12.2020
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EE23.12.2020
ES23.12.2020
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IT23.12.2020
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MC23.12.2020
NL23.12.2020
PL23.12.2020
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SI23.12.2020
SK23.12.2020
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BG23.03.2021
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NL23.12.2020
PL23.12.2020
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RS23.12.2020
SE23.12.2020
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SM23.12.2020
BG23.03.2021
NO23.03.2021
GR24.03.2021
PT23.04.2021
Former [2022/08]AL23.12.2020
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CZ23.12.2020
DK23.12.2020
EE23.12.2020
ES23.12.2020
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NO23.03.2021
GR24.03.2021
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PT23.04.2021
Former [2021/49]AL23.12.2020
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LV23.12.2020
NL23.12.2020
PL23.12.2020
RO23.12.2020
RS23.12.2020
SE23.12.2020
SK23.12.2020
SM23.12.2020
BG23.03.2021
NO23.03.2021
GR24.03.2021
IS23.04.2021
PT23.04.2021
Former [2021/48]AL23.12.2020
AT23.12.2020
CZ23.12.2020
EE23.12.2020
FI23.12.2020
HR23.12.2020
IT23.12.2020
LT23.12.2020
LV23.12.2020
NL23.12.2020
PL23.12.2020
RO23.12.2020
RS23.12.2020
SE23.12.2020
SK23.12.2020
SM23.12.2020
BG23.03.2021
NO23.03.2021
GR24.03.2021
IS23.04.2021
PT23.04.2021
Former [2021/45]AL23.12.2020
AT23.12.2020
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FI23.12.2020
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NL23.12.2020
PL23.12.2020
RO23.12.2020
RS23.12.2020
SE23.12.2020
SK23.12.2020
SM23.12.2020
BG23.03.2021
NO23.03.2021
GR24.03.2021
IS23.04.2021
PT23.04.2021
Former [2021/42]AT23.12.2020
CZ23.12.2020
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FI23.12.2020
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PL23.12.2020
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SE23.12.2020
SK23.12.2020
SM23.12.2020
BG23.03.2021
NO23.03.2021
GR24.03.2021
IS23.04.2021
PT23.04.2021
Former [2021/39]AT23.12.2020
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EE23.12.2020
FI23.12.2020
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PL23.12.2020
RO23.12.2020
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BG23.03.2021
NO23.03.2021
GR24.03.2021
PT23.04.2021
Former [2021/37]AT23.12.2020
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EE23.12.2020
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RO23.12.2020
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SK23.12.2020
SM23.12.2020
BG23.03.2021
NO23.03.2021
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PT23.04.2021
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BG23.03.2021
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PT23.04.2021
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Documents cited:Search[X]GB774802  (GEIGY AG J R) [X] 6,9-11 * examples 1-8 * * pages 4-5, table * * claim 2 * * page 2, lines 80-82 *;
 [E]WO2017207556  (TECHNISCHE UNIVERSITÄT MÜNCHEN [DE]) [E] 6,10,11 * page 69; example 13 * * page 71; example 16 ** claim 13 *;
 [I]  - BLOCK ET AL, "Antibacterial and antifungal activity of kepone derivatives", DEVELOPMENTS IN INDUSTRIAL MICROBIOLOGY, ELSEVIER SCIENCE BV, AMSTERDAM, NL, (1968), vol. 9, ISSN 0070-4563, pages 430 - 436, XP009510118 [I] 1-8,10-13 * abstract * * page 433; compounds 19-22 *
International search[A]WO0200650  (GENELABS TECH INC [US], et al) [A] 1-13 * the whole document *;
 [A]WO2010028193  (REPLIGEN CORP [US], et al) [A] 1-13 * the whole document *;
 [A]CN102503869  (UNIV SHENYANG PHARMACEUTICAL) [A] 1-13* the whole document *;
 [XYA]  - WEN, JIA-CHEN et al., "Synthesis and antitumor activity of S-hexyl(heptyl)substituted ethanethioate derivatives", Acta Pharmaceutica Sinica, (20140331), vol. 49, no. 3, ISSN 0513-4870, pages 352 - 358, XP009508785 [X] 1-2 [Y] 12-13 [A] 3-11
 [XYA]  - OELS, RICHARD et al., "Reinvestigation of the Synthesis of 3-Dimethylallyl-4-hydroxy-2- quinolones.A Novel Route to Tetracyclic Heteroaromatic Compounds", J.C.S.Perkirc I, (19770101), ISSN 0300-922X, pages 2546 - 2551, XP 055365157 [X] 1-2 [Y] 12-13 [A] 3-11
 [XYA]  - KAPPE, THOMAS et al., "Synthesis of Benzo-halogenated 4-Hydroxy-2(1H)-quinolones", J.Heterocyclic Chem., (19880630), vol. 25, ISSN 0022-152X, pages 857 - 862, XP 055365159 [X] 1-2 [Y] 12-13 [A] 3-11
 [Y]  - DAUBINET, ANDRÊ et al., "DESIGNER LIGANDS. VII.THERMAL AND MILKUWAVE- ASSISTED SYNTHESIS OF SILVER(I)-SELECTIVE LIGANDS", SYNTHETIC COMMUNICATIONS, (20021231), vol. 32, no. 20, ISSN 0039-7911, pages 3207 - 3217, XP 055515123 [Y] 12-13
 [A]  - DAUBINET, ANDRÊ et al., "DESIGNER LIGANDS.VIII.THERMAL AND MICROWAVE- ASSISTED SYNTHESIS OF SILVERS-SELECTIVE LIGANDS", SYNTHETIC COMMUNICATIONS, (20021231), vol. 32, no. 20, ISSN 0039-7911, XP 055515123 [A] 1-11
 [PX]  - CHANG HAN-CHU et al., "In vitro and in vivo activity of a novel sorafenib derivative SC5005 against MRSA", J.Antimicrob Chemother, (20151108), vol. 71, no. 2, ISSN 0305-7453, pages 449 - 459, XP 002760421 [PX] 1-11
by applicantGB774802
    - "Antibacterial and antifungal activity of kepone derivatives", BLOCK et al., DEVELOPMENTS IN INDUSTRIAL MICROBIOLOGY, ELSEVIER SCIENCE BV, (19680000), vol. 9, pages 430 - 436
The EPO accepts no responsibility for the accuracy of data originating from other authorities; in particular, it does not guarantee that it is complete, up to date or fit for specific purposes.