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Extract from the Register of European Patents

EP About this file: EP3360574

EP3360574 - MEDICINAL COMPOSITION FOR AMELIORATING AND TREATING INTERVERTEBRAL DISC DEGENERATION AND LOW BACK PAIN, AND METHOD FOR SCREENING THERAPEUTIC AGENT [Right-click to bookmark this link]
StatusNo opposition filed within time limit
Status updated on  08.07.2022
Database last updated on 14.11.2024
FormerThe patent has been granted
Status updated on  30.07.2021
FormerGrant of patent is intended
Status updated on  15.04.2021
FormerExamination is in progress
Status updated on  26.06.2020
FormerRequest for examination was made
Status updated on  13.07.2018
FormerThe international publication has been made
Status updated on  21.04.2017
Most recent event   Tooltip06.09.2024Lapse of the patent in a contracting state
New state(s): MT		published on 09.10.2024  [2024/41]
Applicant(s)For all designated states
Keio University
15-45 Mita 2-chome Minato-ku
Tokyo 108-8345 / JP
[2018/33]
Inventor(s)01 / MATSUMOTO Morio
c/o School of Medicine
KEIO UNIVERSITY
35
Shinanomachi, Shinjuku-ku
Tokyo 160-8582 / JP
02 / NAKAMURA Masaya
c/o School of Medicine
KEIO UNIVERSITY
35
Shinanomachi, Shinjuku-ku
Tokyo 160-8582 / JP
03 / FUJITA Nobuyuki
c/o School of Medicine
KEIO UNIVERSITY
35
Shinanomachi, Shinjuku-ku
Tokyo 160-8582 / JP
04 / SUZUKI Satoshi
c/o School of Medicine
KEIO UNIVERSITY
35
Shinanomachi, Shinjuku-ku
Tokyo 160-8582 / JP
05 / NAKASHIMA Daisuke
c/o School of Medicine
KEIO UNIVERSITY
35
Shinanomachi, Shinjuku-ku
Tokyo 160-8582 / JP
 [2018/33]
Representative(s)Prüfer & Partner mbB Patentanwälte · Rechtsanwälte
Sohnckestraße 12
81479 München / DE
[2018/33]
Application number, filing date16855498.813.10.2016
[2018/33]
WO2016JP80452
Priority number, dateJP2015020182913.10.2015         Original published format: JP 2015201829
[2018/33]
Filing languageJA
Procedural languageEN
PublicationType: A1 Application with search report
No.:WO2017065245
Date:20.04.2017
Language:JA
[2017/16]
Type: A1 Application with search report 
No.:EP3360574
Date:15.08.2018
Language:EN
[2018/33]
Type: B1 Patent specification 
No.:EP3360574
Date:01.09.2021
Language:EN
[2021/35]
Search report(s)International search report - published on:JP20.04.2017
(Supplementary) European search report - dispatched on:EP03.06.2019
ClassificationIPC:A61K31/198, A61K31/355, A61K45/00, G01N33/15, G01N33/50, A61P19/00, A61P29/00, A61P39/06, A61B5/055, A61B5/00
[2019/27]
CPC:
A61K31/198 (EP); A61B5/055 (EP); A61B5/4566 (EP);
A61B5/4848 (EP); A61K31/355 (EP); A61P19/00 (EP);
A61P29/00 (EP); A61P39/06 (EP); G01N33/5008 (EP);
G01N33/5044 (EP); A61B2576/02 (EP); G16H30/40 (EP);
Y02A90/10 (EP) (-)
Former IPC [2018/33]A61K45/00, A61K31/198, A61K31/355, A61P19/02
Designated contracting statesAL,   AT,   BE,   BG,   CH,   CY,   CZ,   DE,   DK,   EE,   ES,   FI,   FR,   GB,   GR,   HR,   HU,   IE,   IS,   IT,   LI,   LT,   LU,   LV,   MC,   MK,   MT,   NL,   NO,   PL,   PT,   RO,   RS,   SE,   SI,   SK,   SM,   TR [2018/33]
Extension statesBANot yet paid
MENot yet paid
Validation statesMANot yet paid
MDNot yet paid
TitleGerman:MEDIZINISCHE ZUSAMMENSETZUNG ZUR VERBESSERUNG UND BEHANDLUNG VON BANDSCHEIBENDEGENERATION UND SCHMERZEN IM UNTEREN RÜCKENBEREICH SOWIE VERFAHREN ZUM SCREENING EINES THERAPEUTISCHEN MITTELS[2018/33]
English:MEDICINAL COMPOSITION FOR AMELIORATING AND TREATING INTERVERTEBRAL DISC DEGENERATION AND LOW BACK PAIN, AND METHOD FOR SCREENING THERAPEUTIC AGENT[2018/33]
French:COMPOSITION MÉDICINALE POUR AMÉLIORER ET TRAITER UNE DÉGÉNÉRESCENCE DE DISQUE INTERVERTÉBRAL ET UNE LOMBALGIE, ET PROCÉDÉ DE CRIBLAGE D'AGENT THÉRAPEUTIQUE[2018/33]
Entry into regional phase11.05.2018Translation filed 
11.05.2018National basic fee paid 
11.05.2018Search fee paid 
11.05.2018Designation fee(s) paid 
11.05.2018Examination fee paid 
Examination procedure11.05.2018Examination requested  [2018/33]
11.05.2018Date on which the examining division has become responsible
18.12.2019Amendment by applicant (claims and/or description)
30.06.2020Despatch of a communication from the examining division (Time limit: M04)
29.10.2020Reply to a communication from the examining division
16.04.2021Communication of intention to grant the patent
22.07.2021Fee for grant paid
22.07.2021Fee for publishing/printing paid
22.07.2021Receipt of the translation of the claim(s)
Opposition(s)02.06.2022No opposition filed within time limit [2022/32]
Fees paidRenewal fee
29.10.2018Renewal fee patent year 03
29.10.2019Renewal fee patent year 04
27.10.2020Renewal fee patent year 05
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Responsibility for the accuracy, completeness or quality of the data displayed under the link provided lies entirely with the Unified Patent Court.
Lapses during opposition  TooltipHU13.10.2016
AL01.09.2021
AT01.09.2021
CY01.09.2021
CZ01.09.2021
DK01.09.2021
EE01.09.2021
ES01.09.2021
FI01.09.2021
HR01.09.2021
IT01.09.2021
LT01.09.2021
LV01.09.2021
MC01.09.2021
MK01.09.2021
MT01.09.2021
NL01.09.2021
PL01.09.2021
RO01.09.2021
RS01.09.2021
SE01.09.2021
SI01.09.2021
SK01.09.2021
SM01.09.2021
IE13.10.2021
LU13.10.2021
BE31.10.2021
CH31.10.2021
LI31.10.2021
BG01.12.2021
NO01.12.2021
GR02.12.2021
IS01.01.2022
PT03.01.2022
[2024/41]
Former [2024/22]HU13.10.2016
AL01.09.2021
AT01.09.2021
CY01.09.2021
CZ01.09.2021
DK01.09.2021
EE01.09.2021
ES01.09.2021
FI01.09.2021
HR01.09.2021
IT01.09.2021
LT01.09.2021
LV01.09.2021
MC01.09.2021
MK01.09.2021
NL01.09.2021
PL01.09.2021
RO01.09.2021
RS01.09.2021
SE01.09.2021
SI01.09.2021
SK01.09.2021
SM01.09.2021
IE13.10.2021
LU13.10.2021
BE31.10.2021
CH31.10.2021
LI31.10.2021
BG01.12.2021
NO01.12.2021
GR02.12.2021
IS01.01.2022
PT03.01.2022
Former [2023/30]HU13.10.2016
AL01.09.2021
AT01.09.2021
CY01.09.2021
CZ01.09.2021
DK01.09.2021
EE01.09.2021
ES01.09.2021
FI01.09.2021
HR01.09.2021
IT01.09.2021
LT01.09.2021
LV01.09.2021
MC01.09.2021
NL01.09.2021
PL01.09.2021
RO01.09.2021
RS01.09.2021
SE01.09.2021
SI01.09.2021
SK01.09.2021
SM01.09.2021
IE13.10.2021
LU13.10.2021
BE31.10.2021
CH31.10.2021
LI31.10.2021
BG01.12.2021
NO01.12.2021
GR02.12.2021
IS01.01.2022
PT03.01.2022
Former [2023/29]HU13.10.2016
AL01.09.2021
AT01.09.2021
CZ01.09.2021
DK01.09.2021
EE01.09.2021
ES01.09.2021
FI01.09.2021
HR01.09.2021
IT01.09.2021
LT01.09.2021
LV01.09.2021
MC01.09.2021
NL01.09.2021
PL01.09.2021
RO01.09.2021
RS01.09.2021
SE01.09.2021
SI01.09.2021
SK01.09.2021
SM01.09.2021
IE13.10.2021
LU13.10.2021
BE31.10.2021
CH31.10.2021
LI31.10.2021
BG01.12.2021
NO01.12.2021
GR02.12.2021
IS01.01.2022
PT03.01.2022
Former [2022/48]AL01.09.2021
AT01.09.2021
CZ01.09.2021
DK01.09.2021
EE01.09.2021
ES01.09.2021
FI01.09.2021
HR01.09.2021
IT01.09.2021
LT01.09.2021
LV01.09.2021
MC01.09.2021
NL01.09.2021
PL01.09.2021
RO01.09.2021
RS01.09.2021
SE01.09.2021
SI01.09.2021
SK01.09.2021
SM01.09.2021
IE13.10.2021
LU13.10.2021
BE31.10.2021
CH31.10.2021
LI31.10.2021
BG01.12.2021
NO01.12.2021
GR02.12.2021
IS01.01.2022
PT03.01.2022
Former [2022/37]AL01.09.2021
AT01.09.2021
CZ01.09.2021
DK01.09.2021
EE01.09.2021
ES01.09.2021
FI01.09.2021
HR01.09.2021
IT01.09.2021
LT01.09.2021
LV01.09.2021
MC01.09.2021
NL01.09.2021
PL01.09.2021
RO01.09.2021
RS01.09.2021
SE01.09.2021
SI01.09.2021
SK01.09.2021
SM01.09.2021
LU13.10.2021
BE31.10.2021
CH31.10.2021
LI31.10.2021
BG01.12.2021
NO01.12.2021
GR02.12.2021
IS01.01.2022
PT03.01.2022
Former [2022/36]AL01.09.2021
AT01.09.2021
CZ01.09.2021
DK01.09.2021
EE01.09.2021
ES01.09.2021
FI01.09.2021
HR01.09.2021
IT01.09.2021
LT01.09.2021
LV01.09.2021
MC01.09.2021
NL01.09.2021
PL01.09.2021
RO01.09.2021
RS01.09.2021
SE01.09.2021
SI01.09.2021
SK01.09.2021
SM01.09.2021
LU13.10.2021
BE31.10.2021
BG01.12.2021
NO01.12.2021
GR02.12.2021
IS01.01.2022
PT03.01.2022
Former [2022/35]AL01.09.2021
AT01.09.2021
CZ01.09.2021
DK01.09.2021
EE01.09.2021
ES01.09.2021
FI01.09.2021
HR01.09.2021
LT01.09.2021
LV01.09.2021
MC01.09.2021
NL01.09.2021
PL01.09.2021
RO01.09.2021
RS01.09.2021
SE01.09.2021
SK01.09.2021
SM01.09.2021
LU13.10.2021
BE31.10.2021
BG01.12.2021
NO01.12.2021
GR02.12.2021
IS01.01.2022
PT03.01.2022
Former [2022/33]AL01.09.2021
AT01.09.2021
CZ01.09.2021
EE01.09.2021
ES01.09.2021
FI01.09.2021
HR01.09.2021
LT01.09.2021
LV01.09.2021
MC01.09.2021
NL01.09.2021
PL01.09.2021
RO01.09.2021
RS01.09.2021
SE01.09.2021
SK01.09.2021
SM01.09.2021
BE31.10.2021
BG01.12.2021
NO01.12.2021
GR02.12.2021
IS01.01.2022
PT03.01.2022
Former [2022/29]AL01.09.2021
AT01.09.2021
CZ01.09.2021
EE01.09.2021
ES01.09.2021
FI01.09.2021
HR01.09.2021
LT01.09.2021
LV01.09.2021
NL01.09.2021
PL01.09.2021
RO01.09.2021
RS01.09.2021
SE01.09.2021
SK01.09.2021
SM01.09.2021
BG01.12.2021
NO01.12.2021
GR02.12.2021
IS01.01.2022
PT03.01.2022
Former [2022/25]AT01.09.2021
CZ01.09.2021
EE01.09.2021
ES01.09.2021
FI01.09.2021
HR01.09.2021
LT01.09.2021
LV01.09.2021
NL01.09.2021
PL01.09.2021
RO01.09.2021
RS01.09.2021
SE01.09.2021
SK01.09.2021
SM01.09.2021
BG01.12.2021
NO01.12.2021
GR02.12.2021
IS01.01.2022
PT03.01.2022
Former [2022/24]AT01.09.2021
CZ01.09.2021
EE01.09.2021
ES01.09.2021
FI01.09.2021
HR01.09.2021
LT01.09.2021
LV01.09.2021
NL01.09.2021
PL01.09.2021
RO01.09.2021
RS01.09.2021
SE01.09.2021
SK01.09.2021
BG01.12.2021
NO01.12.2021
GR02.12.2021
IS01.01.2022
PT03.01.2022
Former [2022/21]AT01.09.2021
ES01.09.2021
FI01.09.2021
HR01.09.2021
LT01.09.2021
LV01.09.2021
PL01.09.2021
RS01.09.2021
SE01.09.2021
BG01.12.2021
NO01.12.2021
GR02.12.2021
Former [2022/10]ES01.09.2021
FI01.09.2021
HR01.09.2021
LT01.09.2021
LV01.09.2021
PL01.09.2021
RS01.09.2021
SE01.09.2021
BG01.12.2021
NO01.12.2021
GR02.12.2021
Former [2022/09]ES01.09.2021
FI01.09.2021
LT01.09.2021
RS01.09.2021
SE01.09.2021
BG01.12.2021
NO01.12.2021
Former [2022/08]ES01.09.2021
FI01.09.2021
LT01.09.2021
SE01.09.2021
BG01.12.2021
NO01.12.2021
Former [2022/07]LT01.09.2021
NO01.12.2021
Documents cited:Search[A]US4039682  (AUSMAN ROBERT K, et al) [A] 1 * column 1, line 55 - page 2, line 28; claim - *;
 [X]DE102011006425  (AWD PHARMA GMBH & CO KG [DE]) [X] 1 * abstract * * page 7, paragraphs 58,63; example -; claims 1,8 *;
 [A]  - BALTZER WENDY I ET AL, "Randomized, blinded, placebo-controlled clinical trial of N-acetylcysteine in dogs with spinal cord trauma from acute intervertebral disc disease.", MEDLINE, US NATIONAL LIBRARY OF MEDICINE (NLM), BETHESDA, MD, US, (20080601), Database accession no. NLM18520934, XP002791481 [A] 1 * abstract *

DOI:   http://dx.doi.org/10.1097/BRS.0b013e3181753c37
International search[XY]JP2003088329  (YAMAGAMI CHIZUKO) [X] 1, 2 * , examples; tables 1, 2 (Family: none) * [Y] 1, 2, 4;
 [XY]WO2006031376  (DEPUY SPINE INC [US], et al) [X] 1, 2 * , claims 1, 5, 8, 56 & US 2005/0100538 A1 & US 2004/0229878 A1 & AU 2007203631 A * [Y] 1, 2, 4-7;
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 [XY]  - SATOSHI SUZUKI et al., "Kassei Sansoshu wa Tsuikanban Hensei ni Taisuru Chiryo Hyoteki to Nariuru ka", The Journal of the Japanese Orthopaedic Association, (20150800), vol. 89, no. 8, page S1781, XP 009509605 [X] 1-3 * , Method.Result, Conclusion * [Y] 1-7
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 [XY]  - YANG X et al., "Antioxidative nanofullerol prevents intervertebral disk degeneration", Int J Nanomedicine, (20140000), vol. 15, no. 9, pages 2419 - 2430, XP 055380874 [X] 1 * , Abstract * [Y] 1, 4-7
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 [XY]  - LI Y et al., "Piperine mediates LPS induced inflammatory and catabolic effects in rat intervertebral disc", Int J Clin Exp Pathol, (20150500), vol. 8, no. 6, pages 6203 - 6213, XP 055380913 [X] 1 * , Abstract * [Y] 1, 4-7
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The EPO accepts no responsibility for the accuracy of data originating from other authorities; in particular, it does not guarantee that it is complete, up to date or fit for specific purposes.