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Extract from the Register of European Patents

EP About this file: EP3389669

EP3389669 - TRITERPENE SAPONIN VARIANTS, METHODS OF SYNTHESIS AND USE THEREOF [Right-click to bookmark this link]
StatusNo opposition filed within time limit
Status updated on  19.01.2024
Database last updated on 26.07.2024
FormerThe patent has been granted
Status updated on  10.02.2023
FormerGrant of patent is intended
Status updated on  22.09.2022
FormerExamination is in progress
Status updated on  03.04.2021
FormerRequest for examination was made
Status updated on  21.09.2018
FormerThe international publication has been made
Status updated on  23.06.2017
Most recent event   Tooltip09.02.2024Lapse of the patent in a contracting state
New state(s): SI		published on 13.03.2024  [2024/11]
Applicant(s)For all designated states
Memorial Sloan-Kettering Cancer Center
Office of Technology Development
1275 York Avenue
Box 524
New York, NY 10065 / US
[2023/11]
Former [2018/43]For all designated states
Memorial Sloan-Kettering Cancer Center
Office of TechnologyDevelopment
1275 York Avenue
Box 524
New York, NY 10065 / US
Inventor(s)01 / TAN, Derek S.
c/o Memorial Sloan-Kettering Cancer Center
1275 York Avenue
New York City NY 10065 / US
02 / GIN, David Y.
c/o Mary Gin
209 Young Ave
Pelham, NY 10803 / US
03 / WALKOWICZ, William E.
684 Lincoln Pl Apt 1
Brooklyn
New York City NY 11216 / US
04 / FERNANDEZ-TEJADA, Alberto
Poeta Prudencio 13, 4ºD
26007 Logrono (La Rioja) / ES
05 / RAGUPATHI, Govindaswami
c/o Memorial Sloan-Kettering Cancer Center
1275 York Avenue
New York City NY 10065 / US
 [2018/52]
Former [2018/43]01 / TAN, Derek S.
c/o Memorial Sloan-Kettering Cancer Center
1275 York Avenue
New York City NY 10065 / US
02 / GIN, David Y.
c/o Memorial Sloan-Kettering Cancer Center
1275 York Avenue
New York City NY 10065 / US
03 / WALKOWICZ, William E.
c/o Memorial Sloan-Kettering Cancer Center
1275 York Avenue
New York City NY 10065 / US
04 / FERNANDEZ-TEJADA, Alberto
c/o Memorial Sloan-Kettering Cancer Center
1275 York Avenue
New York City NY 10065 / US
05 / RAGUPATHI, Govindaswami
c/o Memorial Sloan-Kettering Cancer Center
1275 York Avenue
New York City NY 10065 / US
Representative(s)Maiwald GmbH
Elisenhof
Elisenstraße 3
80335 München / DE
[2023/11]
Former [2018/43]Hansen, Norbert
Maiwald Patentanwalts- und
Rechtsanwaltsgesellschaft mbH
Elisenhof
Elisenstraße 3
80335 München / DE
Application number, filing date16876910.719.12.2016
[2018/43]
WO2016US67530
Priority number, dateUS201562268837P17.12.2015         Original published format: US 201562268837 P
[2018/43]
Filing languageEN
Procedural languageEN
PublicationType: A1 Application with search report
No.:WO2017106836
Date:22.06.2017
Language:EN
[2017/25]
Type: A1 Application with search report 
No.:EP3389669
Date:24.10.2018
Language:EN
The application published by WIPO in one of the EPO official languages on 22.06.2017 takes the place of the publication of the European patent application.
[2018/43]
Type: B1 Patent specification 
No.:EP3389669
Date:15.03.2023
Language:EN
[2023/11]
Search report(s)International search report - published on:US22.06.2017
(Supplementary) European search report - dispatched on:EP05.09.2019
ClassificationIPC:C07J63/00, A61K31/7024
[2019/41]
CPC:
C07J63/008 (EP,US); C07H15/256 (US); C07H13/06 (US);
C07H15/18 (US); A61K2039/55577 (US); A61K39/39 (US);
Y02A50/30 (EP) (-)
Former IPC [2018/43]A61K31/7024, C07H13/02, C07H13/06
Designated contracting statesAL,   AT,   BE,   BG,   CH,   CY,   CZ,   DE,   DK,   EE,   ES,   FI,   FR,   GB,   GR,   HR,   HU,   IE,   IS,   IT,   LI,   LT,   LU,   LV,   MC,   MK,   MT,   NL,   NO,   PL,   PT,   RO,   RS,   SE,   SI,   SK,   SM,   TR [2018/43]
Extension statesBANot yet paid
MENot yet paid
Validation statesMANot yet paid
MDNot yet paid
TitleGerman:TRITERPEN-SAPONIN-VARIANTEN, SYNTHESEVERFAHREN UND VERWENDUNG DAVON[2018/43]
English:TRITERPENE SAPONIN VARIANTS, METHODS OF SYNTHESIS AND USE THEREOF[2018/43]
French:VARIANTS DE SAPONINE TRITERPÈNE, PROCÉDÉS DE SYNTHÈSE ET LEUR UTILISATION[2018/43]
Entry into regional phase16.07.2018National basic fee paid 
16.07.2018Search fee paid 
16.07.2018Designation fee(s) paid 
16.07.2018Examination fee paid 
Examination procedure16.07.2018Examination requested  [2018/43]
16.07.2018Date on which the examining division has become responsible
17.04.2020Amendment by applicant (claims and/or description)
08.04.2021Despatch of a communication from the examining division (Time limit: M06)
05.10.2021Reply to a communication from the examining division
23.09.2022Communication of intention to grant the patent
31.01.2023Fee for grant paid
31.01.2023Fee for publishing/printing paid
31.01.2023Receipt of the translation of the claim(s)
Opposition(s)18.12.2023No opposition filed within time limit [2024/08]
Fees paidRenewal fee
12.12.2018Renewal fee patent year 03
13.12.2019Renewal fee patent year 04
14.12.2020Renewal fee patent year 05
30.11.2021Renewal fee patent year 06
14.11.2022Renewal fee patent year 07
Opt-out from the exclusive  Tooltip
competence of the Unified
Patent Court		 See the Register of the Unified Patent Court for opt-out data
Responsibility for the accuracy, completeness or quality of the data displayed under the link provided lies entirely with the Unified Patent Court.
Lapses during opposition  TooltipAT15.03.2023
CZ15.03.2023
EE15.03.2023
FI15.03.2023
HR15.03.2023
LT15.03.2023
LV15.03.2023
PL15.03.2023
RO15.03.2023
RS15.03.2023
SI15.03.2023
SK15.03.2023
SM15.03.2023
GR16.06.2023
IS15.07.2023
PT17.07.2023
[2024/11]
Former [2023/50]AT15.03.2023
CZ15.03.2023
EE15.03.2023
FI15.03.2023
HR15.03.2023
LT15.03.2023
LV15.03.2023
PL15.03.2023
RO15.03.2023
RS15.03.2023
SK15.03.2023
SM15.03.2023
GR16.06.2023
IS15.07.2023
PT17.07.2023
Former [2023/49]AT15.03.2023
CZ15.03.2023
EE15.03.2023
FI15.03.2023
HR15.03.2023
LT15.03.2023
LV15.03.2023
RO15.03.2023
RS15.03.2023
SM15.03.2023
GR16.06.2023
PT17.07.2023
Former [2023/48]AT15.03.2023
EE15.03.2023
FI15.03.2023
HR15.03.2023
LT15.03.2023
LV15.03.2023
RS15.03.2023
SM15.03.2023
GR16.06.2023
PT17.07.2023
Former [2023/46]FI15.03.2023
HR15.03.2023
LT15.03.2023
LV15.03.2023
RS15.03.2023
SM15.03.2023
GR16.06.2023
PT17.07.2023
Former [2023/37]FI15.03.2023
HR15.03.2023
LT15.03.2023
LV15.03.2023
RS15.03.2023
GR16.06.2023
Former [2023/36]FI15.03.2023
HR15.03.2023
LT15.03.2023
LV15.03.2023
RS15.03.2023
Former [2023/35]HR15.03.2023
LT15.03.2023
RS15.03.2023
Former [2023/34]LT15.03.2023
RS15.03.2023
Former [2023/33]LT15.03.2023
Documents cited:Search[X]  - ERIC K. CHEA ET AL, "Synthesis and Preclinical Evaluation of QS-21 Variants Leading to Simplified Vaccine Adjuvants and Mechanistic Probes", JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, (20120815), vol. 134, no. 32, doi:10.1021/ja305121q, ISSN 0002-7863, pages 13448 - 13457, XP055239148 [X] 1,2,7,8,13-15 * page 13449; compounds 1, 2, 5 * * page 13450; figure 3; compound 9 10 * * page 13451; compounds 13-15 * * page 13453; figure 5; compounds 33-35 * * page 13454; figure 6; compounds 38, 39 * * page 13455; figure 7 *

DOI:   http://dx.doi.org/10.1021/ja305121q
 [X]  - ALBERTO FERN?NDEZ-TEJADA ET AL, "Design, synthesis, and immunologic evaluation of vaccine adjuvant conjugates based on QS-21 and tucaresol", BIOORGANIC & MEDICINAL CHEMISTRY : A TETRAHEDRON PUBLICATION FOR THE RAPID DISSEMINATION OF FULL ORIGINAL RESEARCH PAPERS AND CRITICAL REVIEWS ON BIOMOLECULAR CHEMISTRY, MEDICINAL CHEMISTRY AND RELATED DISCIPLINES, NL, (20140917), vol. 22, no. 21, doi:10.1016/j.bmc.2014.09.016, ISSN 0968-0896, pages 5917 - 5923, XP055423243 [X] 1,2,7,13-15 * page 5918; figures 1, 2; compounds 1, 2, 4-7 *

DOI:   http://dx.doi.org/10.1016/j.bmc.2014.09.016
 [XP]  - WILLIAM E. WALKOWICZ ET AL, "Quillaja saponin variants with central glycosidic linkage modifications exhibit distinct conformations and adjuvant activities", CHEMICAL SCIENCE, United Kingdom, (20160101), vol. 7, no. 3, doi:10.1039/C5SC02978C, ISSN 2041-6520, pages 2371 - 2380, XP055615922 [XP] 1-15 * page 2373; compounds 2-9 * * page 2375, column 2, paragraph 2 - page 2376, column 1, paragraph 2 *

DOI:   http://dx.doi.org/10.1039/C5SC02978C
 [XP]  - ALBERTO FERNÁNDEZ-TEJADA ET AL, "Development of Improved Vaccine Adjuvants Based on the Saponin Natural Product QS-21 through Chemical Synthesis", ACCOUNTS OF CHEMICAL RESEARCH., US, (20160828), vol. 49, no. 9, doi:10.1021/acs.accounts.6b00242, ISSN 0001-4842, pages 1741 - 1756, XP055594497 [XP] 1-15 * page 1747; compounds 32, 44-51 * * page 1749, column 1, paragraph 2 *

DOI:   http://dx.doi.org/10.1021/acs.accounts.6b00242
International search[Y]US2005026982  (JOHANNSEN SOENKE [DE], et al) [Y] 9 * ; paragraphs [0018]-[0019] *;
 [Y]US7645454  (DANISHEFSKY SAMUEL J [US], et al) [Y] 5, 6/5, 7/5 * ; column 53, lines 20-55; column 54, lines 20-55; column 82, lines 25-30 *;
 [A]AU2015203675  (SLOAN KETTERING INST CANCER) [A] 1* ; entire publication *;
 [XY]WO2015184451  (SLOAN KETTERING INST CANCER [US]) [X] 1-4, 6/1-4, 7/1-4, 10-12 * ; abstract; paragraphs [0080], [0097], [0106], [0159]-[0161], [0165]-[0166], [0180]-[0181] * [Y] 5, 6/5, 7/5, 9;
 [Y]  - DIAZ, C et al., "Rosacea: A Cutaneous Marker of Helicobacter pylori Infection? Results of a Pilot Study.", Acta Dermatology Venereology, (20030000), vol. 83, no. 4, pages 282 - 286, XP055391237 [Y] 9 * ; abstract *

DOI:   http://dx.doi.org/10.1080/00015550310016544
 [A]  - FERNANDEZ-TEJADA, A et al., "Development of a minimal saponin vaccine adjuvant based on QS-21.", Nature Chemistry, (20140700), vol. 6, no. 7, pages 635 - 643, XP055381370 [A] 1 * ; entire publication *

DOI:   http://dx.doi.org/10.1038/nchem.1963
by applicant   - E.K. CHEA et al., J. Am. Chem. Soc., (20120000), vol. 134, no. 32, pages 13448 - 13457
    - A. FERNANDEZ-TEJADA et al., Bioorg. Med. Chem., (20140000), vol. 22, no. 21, pages 5917 - 5923
    - Nature Chemistry, (20140000), vol. 6, no. 7, pages 635 - 645
    - S. M. BERGE et al., J. Pharmaceutical Sciences, (19770000), vol. 66, pages 1 - 19
The EPO accepts no responsibility for the accuracy of data originating from other authorities; in particular, it does not guarantee that it is complete, up to date or fit for specific purposes.